• Journal of the Korean Society for Precision Engineering
• /
• v.32 no.7
• /
• pp.661-666
• /
• 2015

This paper presents control performance improvement by modifying center of gravity (COG) of an underwater robotic platform. To reduce the oscillation or to increase the positioning accuracy, it is important to accurately know the COG of an underwater robotic platform. The COG is determined by the three measured tilting angles of the platform in different postures. The tilting angle is measured while the platform is hanged by two strings. Using coordinate transformation, the plane of intersection is defined from the angle of the platform and the position of the string. The COG of the robotic platform is directly calculated by the intersected point in three defined planes. The measured COG is implemented to the control algorithm that is pre-designed in the previous research, and the empirical result on tilting gives 48.26% improved oscillation performance comparing to the oscillation result with the ideal COG position.

• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.1 no.2
• /
• pp.80-87
• /
• 2015

Carbon-fluorine (C-F) bonds have been found ubiquitously in pharmaceuticals, radiopharmaceuticals, agrochemicals, and material science due to their unique properties such as thermal and oxidative stability and lipophilicity to improve bioavailability. For the past five years, there have been significant advances in F-18 fluorination of aromatic complex molecules combined with the development of late-stage fluorination reactions. More recently, direct incorporation of F-18 to fluorinated aromatic molecules via borylation of C-F bonds has been developed by Niwa and Hosoya. In this minireview, we will discuss the progress of C-F bondborylation of fluorinated arenes utilizing transition metal catalysts and the impact on the development of F-18 radiotracers for positron emission tomography (PET).

• Journal of Korean Public Health Nursing
• /
• v.37 no.1
• /
• pp.136-146
• /
• 2023

This cross-sectional design study was undertaken to determine the factors associated with suicidal ideation in human immunodeficiency virus (HIV)-infected older adults. Data from a city-wide representative sample collected by the Seoul Metropolitan Government were used. The cross-sectional survey was conducted between February and March 2013. Participants selected and included in the analysis were HIV-infected adults living in Seoul, and aged 50 years and older. The overall adjusted model showed that being unemployed (adjusted odds ratio [aOR], 3.34; 95% confidence interval [CI], 1.16-9.57), a history of depression treatment (aOR, 4.61; 95% CI, 1.02-20.66), perceived belongingness (aOR, 0.63; 95% CI, 0.41-0.99), and psychological functioning (aOR, 0.85; 95% CI, 0.73-0.99) were significantly related to suicidal ideation. Psychosocial features were found to be strongly associated with suicidal ideation among HIV-infected older adults. The findings could be useful for HIV nursing consultants to identify HIV-infected older adults who are vulnerable to suicidal ideation. Comprehensive mental health services should be provided as coping resources for HIV-infected older adults who have suicidal ideation.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.11
• /
• pp.1814-1822
• /
• 2018

Most people use cosmetics to protect their skin. Preservatives are often used to prevent their contamination upon use. There has been a great demand for natural preservatives due to recent reports on the side effects of parabens. Therefore, we evaluated the antimicrobial activities of Lonicera japonica and Magnolia obovata extracts and determined their potential as natural preservatives. We found that the 50% ethanol extract from L. japonica had antibacterial activity only against S. aureus and P. aeruginosa, while the ethyl acetate fraction showed antimicrobial activity against all six microbial strains tested. On the other hand, the 70% ethanol extract and the ethyl acetate fraction from M. obovata showed antimicrobial activity against all six strains. A synergistic effect against S. aureus, B. subtilis, and C. albicans was confirmed when two ethyl acetate fractions having antimicrobial activity against all six strains were used in combination. Synergistic activity against B. subtilis was also confirmed through kill-time analysis. High-performance liquid chromatography was performed to identify the components of each extract. Based on the minimum inhibitory concentration and the results of a disc diffusion assay, we confirmed that caffeic acid and luteolin influenced the antimicrobial activity of L. japonica and that the antimicrobial activity of M. obovata was influenced by the interaction of magnolol and honokiol with other components. Therefore, this study suggests that the combination of L. japonica and M. obovata extracts may be used as a plant-derived natural preservative.

• Journal of Korean Neurosurgical Society
• /
• v.63 no.1
• /
• pp.26-33
• /
• 2020

Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.

• Journal of Korean Academy of Nursing Administration
• /
• v.8 no.2
• /
• pp.309-321
• /
• 2002

Purpose: A cost analysis for nursing services in operative nursing unit, emergency nursing unit, and ambulatory nursing unit was performed using patient classification system by nursing intensity in order to determine an appropriate nursing fee schedule. Method: The data were collected from 4 secondary hospitals and 5 tertiary hospitals from November 14th 2000 to January 15th 2001. The study was conducted through four phases as follows: 1) Nursing hours of each nursing service in special nursing units were measured using three kinds of patient classification systems by nursing intensity. 2) The nursing cost of nursing services in operative nursing unit, emergency nursing unit, and ambulatory nursing units was estimated based on patient classification system by nursing intensity. Results: As a result, nursing hours by nursing intensity of each special nursing unit were measured, and every nursing cost by nursing intensity in operation room and emergency room was estimated, meanwhile, the cost of nursing services in ambulatory care units was estimated only per visit as shown in chapter 4. Conclusion: Future research on nursing cost should be extended to other special nursing units such as various intensive nursing care units, delivery room, and so on. In addition, the patient classification system should be refined for its appropriateness to apply all levels of medical institutions.

• Journal of Biosystems Engineering
• /
• v.37 no.1
• /
• pp.11-18
• /
• 2012

Purpose: Short-circuit current of a solar module that is widely used as a power source for wireless environmental sensors is proportional to solar radiation although there are a lot of factors affecting the short-circuit current. The objective of this study is to develop a model for estimating solar radiation for using the solar module as a power source and an irradiance sensor. Methods: An experiment system collected data on the short-circuit current and environmental factors (ambient temperature, cloud cover and solar radiation) during 65 days. Based on these data, two linear regression models and a non-linear regression model were developed and evaluated. Results: The best model was a linear regression model with short-circuit current, angle of incidence and cloud cover and its overall RMSE(Root Means Square Error) was 66.671 $W/m^2$. The other linear model (RMSE 69.038 $W/m^2$) was also acceptable when the cloud cover data is not available.

• Journal of Korean Neurosurgical Society
• /
• v.65 no.3
• /
• pp.439-448
• /
• 2022

Objective : Craniopharyngiomas (CPs) are associated with hypothalamic damage that causes hypothalamic obesity, however, the mechanisms underlying CP-related postoperative weight gain remain debatable. This study aimed to elucidate whether the major determinant of postoperative weight gain in patients with CP is hypothalamic injury or steroid replacement therapy. Methods : We included 48 adult patients with CP (age ≥18 years) who underwent transsphenoidal surgery between 2010 and 2018 in a single tertiary center, and whose body weight was measured pre- and postoperatively (<120 days after the surgery). We recruited 144 age- and body mass index-matched patients with non-functioning pituitary adenoma (NFPA) as controls. Results : Patients with CP experienced greater postoperative weight gain than patients with NFPA (3.0±5.1 vs. 0.1±3.6 kg, p<0.001). The prevalence of postoperative steroid use was significantly higher in patients with CP than in those with NFPA (89.6% vs. 34.0%, p<0.001). Steroid replacement therapy and CP were associated with postoperative weight gain after adjusting for covariates in overall patients (p=0.032 and 0.007, respectively). In subgroup analysis with postoperative steroid users, weight gain was significantly greater in patients with CP (n=43, 0.96±0.25 kg/month) than in patients with NFPA (n=49, 0.26±0.23 kg/month) even after adjusting for the daily steroid dose (p=0.048). Conclusion : Patients with CP experience greater postoperative weight gain than those with NFPA. Hypothalamic damage itself as well as steroid replacement may contribute to the postoperative weight gain in patients with CP.

• Korean Journal of Health Education and Promotion
• /
• v.24 no.3
• /
• pp.99-118
• /
• 2007

There are little program and services that have been developed to address the health and health care needs of vulnerable women. The access for their timely and appropriate health care and health promotion services have been a increasing concern. The purpose of this study was to suggest health promotion program for vulnerable women with collaboration of women's NGOs. At the first part of this study, we reviewed a conceptual framework for identifying vulnerable population, and issues regarding health problems, unmet needs, policies and programs that have been developed to address their need. In second part, we focused on investigating the role, subjects and activities of women's NGOs and their capacity for health promotion program. The last part of this study proposed health promotion programme with integrating above two parts of study. In describing what type of health promotion program available in women's NCOs, eight major programs and services were summarized. 1. Direct health promotion program and collaborating program with other services. 2. Education and training for empowerment of vulnerable women 3. Organizing mutual support system such as self-help group 4. Community supports. Vulnerable women living at home may benefit from linkage to community services as much as women living in facility 5. Organizing collaboration system with program for economic support and job training, social rehabilitation 6. Trainer's training for practitioners in NGOs 7. Technical, informational support from professional groups 8. A national coordinating policies for vulnerable population should be established at the central level. National support for NGOs' health promotion program are needed hi solving unmet needs of vulnerable women.

• Journal of Korean Neurosurgical Society
• /
• v.66 no.4
• /
• pp.382-392
• /
• 2023

Objective : The use of indocyanine green videoangiography (ICG-VA) to assess blood flow in the brain during cerebrovascular surgery has been increasing. Clinical studies on ICG-VA have predominantly focused on qualitative analysis. However, quantitative analysis numerical modelling for time profiling enables a more accurate evaluation of blood flow kinetics. In this study, we established a multiple exponential modified Gaussian (multi-EMG) model for quantitative ICG-VA to understand accurately the status of cerebral hemodynamics. Methods : We obtained clinical data of cerebral blood flow acquired the quantitative analysis ICG-VA during cerebrovascular surgery. Varied asymmetric peak functions were compared to find the most matching function form with clinical data by using a nonlinear regression algorithm. To verify the result of the nonlinear regression, the mode function was applied to various types of data. Results : The proposed multi-EMG model is well fitted to the clinical data. Because the primary parameters-growth and decay rates, and peak center and heights-of the model are characteristics of model function, they provide accurate reference values for assessing cerebral hemodynamics in various conditions. In addition, the primary parameters can be estimated on the curves with partially missed data. The accuracy of the model estimation was verified by a repeated curve fitting method using manipulation of missing data. Conclusion : The multi-EMG model can possibly serve as a universal model for cerebral hemodynamics in a comparison with other asymmetric peak functions. According to the results, the model can be helpful for clinical research assessment of cerebrovascular hemodynamics in a clinical setting.