• Molecules and Cells
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• v.38 no.12
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• pp.1037-1043
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• 2015

The TAZ activator 2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine] (TM-25659) inhibits adipocyte differentiation by interacting with peroxisome proliferator-activated receptor gamma. 1 TM-25659 was previously shown to decrease weight gain in a high fat (HF) diet-induced obesity (DIO) mouse model. However, the fundamental mechanisms underlying the effects of TM-25659 remain unknown. Therefore, we investigated the effects of TM-25659 on skeletal muscle functions in C2 myotubes and C57BL/6J mice. We studied the molecular mechanisms underlying the contribution of TM-25659 to palmitate (PA)-induced insulin resistance in C2 myotubes. TM-25659 improved PA-induced insulin resistance and inflammation in C2 myotubes. In addition, TM-25659 increased FGF21 mRNA expression, protein levels, and FGF21 secretion in C2 myotubes via activation of GCN2 pathways (GCN2-$phosphoelF2{\alpha}$-ATF4 and FGF21). This beneficial effect of TM-25659 was diminished by FGF21 siRNA. C57BL/6J mice were fed a HF diet for 30 weeks. The HF-diet group was randomly divided into two groups for the next 14 days: the HF-diet and HF-diet + TM-25659 groups. The HF diet + TM-25659-treated mice showed improvements in their fasting blood glucose levels, insulin sensitivity, insulin-stimulated Akt phosphorylation, and inflammation, but neither body weight nor food intake was affected. The HF diet + TM-25659-treated mice also exhibited increased expression of both FGF21 mRNA and protein. These data indicate that TM-25659 may be beneficial for treating insulin resistance by inducing FGF21 in models of PA-induced insulin resistance and HF diet-induced insulin resistance.

• Journal of the Korean Geographical Society
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• v.51 no.2
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• pp.283-303
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• 2016

The concept of a risk society, which was originally suggested by German sociologist Ulrich Beck, is insufficient to reveal how a certain risk materially and discursively unfolds on the ground and how its various dynamics are recognised by diverse actors because of the concept's spatial insensitivity. As an alternative approach, this paper introduces the concept of the riskscape, which was suggested by German geographer Detlef $M{\ddot{u}}ller$-Mahn, and analyses this concept in the context of the East Asian developmental state. It is meaningful that the East Asian developmental state thesis has strongly promoted the role of the state in stimulating national economic development in underdeveloped countries. However, it should also be noted that an active state role in encouraging modernisation and economic growth within a very short time produces consequences of what Beck calls 'manufactured risks', such as nuclear power plants. Therefore, it is essential to analyse the state in comprehending modernisation and the risk society in East Asia. More specifically, using the case of the location policy for nuclear power facilities, this article reveals how dominant social forces acting in and through the state constructed a national riskscape that minimises the gravity of local risks while prioritising the economic value of the national economy over local risks to produce rapid modernisation. Additionally, it is argued that a dominant national riskscape may become weak from competing with different riskscapes that are constructed based on contingency factors (e.g., political democratisation or a natural disaster). Based on these analyses, the article emphasises that interdisciplinary research using the concept of the riskscape is required to better explain the risks in East Asia.

• Journal of the Korean association of regional geographers
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• v.10 no.3
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• pp.606-623
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• 2004

Emergency medical service pertains highly to the public service sector which has to be provided equally in a society and evenly in a spatial dimension by the government. However, emergency medical centers in Korea are inequally distributed in a space and also human capital, facility, and equipment for emergency medical centers show clear disparity among regions. This research analyzed the spatial balance of the demand supply level for emergency medical service in Seoul by constructing the potential demand surface map and supply surface map for this service. The surface map of demand-supply balance for emergency medical service was constructed by GIS based map algebra algorism. The results by this analysis very clearly reveal the spatial disparity of emergency medical service. The places where are over-represented by demand level compared to their supply level are estimated to require an additional establishment of emergency medical centers in the near future. While, the places where are over-represented by supply level compared to their potential demand for emergency medical services indicate the possibility of problems in the management of emergency medical centers because of a surplus in the supply of emergency medical services. The results of this research can be utilized in providing valuable information for the adequate provision of emergency medical centers and for the estimation of range on the service area of emergency medical services.

• Radiation Oncology Journal
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• v.7 no.2
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• pp.305-311
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• 1989

Fletcher-Suit colpostat has an internal structure to reduce dose to bladder and rectum. Some programs were developed to calculate dose at any point in water in three dimension around the colpostat containing Cs-137 tube, to find the shielding effect to dose by the internal structure, and to draw isodose curves and iso-shielding effect curves. Computer was an IBM compatible AT with EGA card and language was MS-Basic V6.0, Material, shape and geometry of the strucure, tube and colpostat were considered in algorithm for calculation of dose. Dose rates per unit mg. Ra. eq. in water calculated by a program were stored in auxiliary memory devices and retrieved in another programs. Isodose curves on medial side shrinked. Dose distribution was not symmetric about a transverse axis bisecting the colpostat. Reduction of dose was more excessive on top side than on bottom. Iso-shielding effect curve showed that the shielding effect was higher on top side than on bottom, and that there was shielding effect over almost all area of medial side. Such results were related to both shifted position of tube in the colpostat and asymmetric distribution of active source in the tube. Maximum of shielding effect was $49\%$ on top side and $44\%$ on bottom side. The direction of iso-shielding effect curve was generally radial from the center of active source. In treatment planning using Fletcher-Suit colpostat, the internal structure should be considered to find precise doses to bladder and rectum, etc.

• Journal of Nutrition and Health
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• v.46 no.5
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• pp.461-469
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• 2013

This study was conducted in order to investigate body awareness and dietary life according to gender. Subjects of the study were 120 men and 127 women aged 20 to 30 years, who exercise regularly at a fitness center in Seoul. The subjects were asked to fill out a questionnaire on body awareness, reason for regular exercise, dietary behaviors, and nutrition knowledge. The percentage of overweight and obesity was 69.2% in men, and 25.2% in women. The percentage of subjects who considered themselves as overweight was 38.3% in men and 59.8% in women. Intake of protein in men was higher than the recommended nutrient intake (RNI). Intake of energy in women was lower than the estimated energy requirement (EER). Men who considered themselves as overweight showed lower energy intake than men who considered their body weight as under and normal, whereas no difference in energy intake was observed between women who considered themselves as overweight and women who considered their body weight as under and normal.

• Journal of Practical Engineering Education
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• v.9 no.1
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• pp.69-75
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• 2017

In this paper, we analyzed the factors influencing the size of Korea Polytechnic as a public vocational education and training institution through analysis of demand, region, industry, and demand with established existing campus and new campus in Korea Polytechnic. By analyzing data on admission, training, and employment for 3 years out of 37 campuses, we have sampled 5 campuses by type of Korea Polytechnic, fused with the results derived from the literature analysis and in-depth analysis results, so that the regional campus will play a leading role and the direction of development. The selection of five campuses by type is a precedent study to analyze 37 campuses in the future. As a result of the study, the demand analysis through objective indicators such as the number of high school graduates, the number of employed persons, the presence of nearby industrial complexes, and policy variables is very important and reflects the reality well. Therefore, it is necessary to analyze the demand through the objective indicators in decision making related to the new campus at the pre-analysis stage. In addition to the general data proposed in this paper, that is, common variables in all regions, it is important to consider the factors that can reflect local demand characteristics when considering specific locations.

• Journal of Environmental Health Sciences
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• v.47 no.1
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• pp.64-77
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• 2021

Objective: Biological monitoring of trace elements in human blood samples has become an important indicator of the health environment. The purpose of this study was to detect and evaluate multiple metal items in blood samples based on ICP-MS, to perform comparative evaluation with the existing analysis method, and to develop and verify a new method. Methods: 100 μL of whole blood from 80 healthy subjects was used to analyze ten metals (Sb, tAs, Cd, Pb, Mn, Hg, Mo, Ni, Se, Tl) using ICP-MS. Verification of the analysis method included calculation of linearity, accuracy, precision and detection limits. In addition, a comparative test with the conventional graphite furnace atomic absorption spectroscopy (GF-AAS) method was performed. In the case of Pb, Cd, and Hg in whole blood, cross-analysis between Pb, Cd, and Hg analysis methods was performed to confirm the difference between the existing method and the new method (ICP-MS). Results: The coefficient of determination (R2) was 0.999 or higher in seven items and 0.995 or higher in three items. The Pb result showed that Pearson's correlation coefficient was very high at 0.983, and the intraclass correlation coefficient was 0.966. The Cd result showed that Pearson's correlation coefficient was 0.917 between the existing method and the new analysis concentration value. Its intraclass correlation coefficient was 0.960, and there was no significant difference between the two groups. Hg had a low correlation at 0.687, and the intraclass correlation coefficient was 0.761, which was lower than that of Pb and Cd. The intra-day and inter-day accuracy of Pd and Cd were satisfactory, but Hg did not meet the criteria for both accuracy and precision when compared with the conventional analysis method. Conclusion: This study can be meaningful in that it proposes a more efficient and feasible analysis method by verifying a blood heavy metal concentration experiment using multiple simultaneous analyses. All samples were processed and analyzed using the new ICP-MS. It was confirmed that the agreement between the two methods was very high, with the agreement between the current and new methods being 0.769 to 0.998. This study proposes an efficient simultaneous methodology capable of analyzing multiple elements with small samples. In the future, studies of various applications and the reliability of ICP-MS analysis methods are required, and research on the verification of accurate, precise, and continuous analysis methods is required.

• 한국노년학
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• v.28 no.4
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• pp.847-863
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• 2008

This study aimed to measure the health literacy among Korean elderly living in the community, and to explore the factors influencing health literacy of the elderly. A descriptive correlational research design was used. The sample consisted of 411 elders who were conveniently selected from the community welfare center users in Seoul and Gyeong-gi province. Data were collected from face-to-face interviews by trained interviewers between January, 7 and February, 4, in 2008. Health literacy was measured by Korean Health Literacy Scale developed by Lee(2008). Descriptive statistics, ANOVA, t-test, and multiple regression were used to analyse the data. In result, the mean score of health literacy was 17.46(${\pm}5.73$) with a range of 0 to 25, 42.8% of elderly had limited health literacy problems. Multiple regression showed that 26.5% of variance in health literacy was accounted for by the combination of education, age, living arrangement, and income. In conclusion, various strategies to improve health literacy in elderly population in the areas of health education and disease management should be needed to reduce health disparities among elderly.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.39 no.2
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• pp.93-101
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• 2021

Recently, with the urban redevelopment and the spread of the planned cities, there is increasing interest in the wind environment, which is related not only to design of buildings and landscaping but also to the comfortability of pedestrians. Numerical analysis for wind environment prediction is underway in many fields, such as dense areas of high-rise building or composition of the apartment complexes, a precisive 3D building model is essentially required in this process. Many studies conducted for wind environment analysis have typically used the method of creating a 3D model by utilizing the building layer included in the GIS (Geographic Information System) data. These data can easily and quickly observe the flow of atmosphere in a wide urban environment, but cannot be suitable for observing precisive flow of atmosphere, and in particular, the effect of a complicated structure of a single building on the flow of atmosphere cannot be calculated. Recently, drone photogrammetry has shown the advantage of being able to automatically perform building modeling based on a large number of images. In this study, we applied photogrammetry technology using a drone to evaluate the flow of atmosphere around two buildings located close to each other. Two 3D models were made into an automatic modeling technique and manual modeling technique. Auto-modeling technique is using an automatically generates a point cloud through photogrammetry and generating models through interpolation, and manual-modeling technique is a manually operated technique that individually generates 3D models based on point clouds. And then the flow of atmosphere for the two models was compared and analyzed. As a result, the wind environment of the two models showed a clear difference, and the model created by auto-modeling showed faster flow of atmosphere than the model created by manual modeling. Also in the case of the 3D mesh generated by auto-modeling showed the limitation of not proceeding an accurate analysis because the precise 3D shape was not reproduced in the closed area such as the porch of the building or the bridge between buildings.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.1
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• pp.96-104
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• 2021

There will be many changes in job consciousness and job satisfaction due to changes in various job fields and social interests, and it is necessary to manage them efficiently for the organization to continue to grow. By analyzing factors influencing job satisfaction by occupation, the study intended to provide the necessary data for an efficient management plan. 400 Employees working at S tertiary hospital in Seoul from April 1st to April 15th, 2015 were targeted. An analysis of the validity and reliability of the influencing factors was conducted, and the allied health profession which showed the highest level of satisfaction in overall job satisfaction and influencing factors were identified. It was found that achievement, compensation and working environment in the medical doctor profession, achievement, compensation and job stability in the nursing profession, achievement and working environment in the allied health profession, achievement, interpersonal relationships, working environment, and job stability in the administrative profession, were the main influencing factors for job satisfaction. It can be seen that not only motivation factors but also hygiene factors affect job satisfaction. To increase the level of satisfaction, it is judged that systematic management of hygiene factors as well as motivation factors is necessary.