• Journal of the Korean Society for Precision Engineering
• /
• v.23 no.8 s.185
• /
• pp.108-118
• /
• 2006

Reusing is one of the most environmentally friendly recycling methods. For the economical remanufacturing of used cellular phone, the cellular phones should be design for easy disassembly. In this paper, we analyzed the components and connecting elements of cellular phones and developed a guideline for the design of the cellular phones. A software for the disassembly assessment was also developed. Redesigned cellular phone by the developed guideline and its original phone was analyzed by the disassembly assessment software. Disassembly time could be reduced about 40% and reusing rate could be improved about 37%.

• Journal of Korean Society for Quality Management
• /
• v.33 no.4
• /
• pp.103-110
• /
• 2005

Advanced function has been considered to be the most important aspect of the cellular phone. However, leading companies are now implementing the fashion branding strategy which stresses both high technology and appealing design. By means of the conjoint analysis, this research focuses on identifying the preferred design profile related to style of the key cover, color and texture of the case, and presence or absence of the noctilucent material coated on the part of surface. We also evaluate the relative importance of factors to determine the design concept of new cellular phone. Results indicate that consumers most prefer the silver-colored, sliding key cover phone with soft and noctilucent surface.

• Molecules and Cells
• /
• v.40 no.9
• /
• pp.607-612
• /
• 2017

When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins. These seemingly opposite roles of autophagy may reflect a complex picture of autophagic regulation on cellular senescence, including different types of autophagy or a unique spatiotemporal activation of autophagy. Thus, a better understanding of autophagy process will lead us to not only elucidate the conundrum how autophagy plays dual roles in the regulation of cellular senescence but also helps the development of new therapeutic strategies for many human diseases associated with cellular senescence. We address the pro-senescence and anti-senescence roles of autophagy while focusing on the potential mechanistic aspects of this complex relationship between autophagy and cellular senescence.

• Molecules and Cells
• /
• v.41 no.2
• /
• pp.103-109
• /
• 2018

Calcium ions are involved in the regulation of diverse cellular processes. Fourteen genes encoding calcium binding proteins have been identified in Dictyostelium. CBP7, one of the 14 CBPs, is composed of 169 amino acids and contains four EF-hand motifs. Here, we investigated the roles of CBP7 in the development and cell migration of Dictyostelium cells and found that high levels of CBP7 exerted a negative effect on cells aggregation during development, possibly by inhibiting chemoattractant-directed cell migration. While cells lacking CBP7 exhibited normal development and chemotaxis similar that of wild-type cells, CBP7 overexpressing cells completely lost their chemotactic abilities to move toward increasing cAMP concentrations. This resulted in inhibition of cellular aggregation, a process required for forming multicellular organisms during development. Low levels of cytosolic free calcium were observed in CBP7 overexpressing cells, which was likely the underlying cause of their lack of chemotaxis. Our results demonstrate that CBP7 plays an important role in cell spreading and cell-substrate adhesion. cbp7 null cells showed decreased cell size and cell-substrate adhesion. The present study contributes to further understanding the role of calcium signaling in regulation of cell migration and development.

• IMMUNE NETWORK
• /
• v.9 no.1
• /
• pp.1-3
• /
• 2009

• 대한약리학회:학술대회논문집
• /
• 2006.10a
• /
• pp.98.1-98.1
• /
• 2006

• IMMUNE NETWORK
• /
• v.13 no.2
• /
• pp.43-54
• /
• 2013

Over the past 40 years, flow cytometry has emerged as a leading, application-rich technology that supports high-resolution characterization of individual cells which function in complex cellular networks such as the immune system. This brief overview highlights advances in multiparameter flow cytometric technologies and reagent applications for characterization and functional analysis of cells modulating the immune network. These advances significantly support highthroughput and high-content analyses and enable an integrated understanding of the cellular and molecular interactions that underlie complex biological systems.

• BMB Reports
• /
• v.46 no.9
• /
• pp.429-438
• /
• 2013

Aging is the strongest risk factor for cancer development, suggesting that molecular crosstalks between aging and tumorigenesis exist in many cellular pathways. Recently, Sirtuins (Sirt1-7), the mammalian homologues of aging-related $sir2{\alpha}$ in yeast, have been shown to modulate several major cellular pathways, such as DNA repair, inflammation, metabolism, cell death, and proliferation in response to diverse stresses, and may serve as a possible molecular link between aging and tumorignenesis. In addition, growing evidence suggests that sirtuins are directly implicated in the development of cancer, and they can act as either a tumor suppressor or promoter, depending on the cellular context and tumor types. While the functions of Sirt1 in tumorigenesis have been reported and reviewed in many studies, the connection between sirtuins 2-7 and the development of cancer is less established. Thus, this review will present the recent updates on the emerging roles of Sirt2-7 members in carcinogenesis.

• Molecules and Cells
• /
• v.22 no.3
• /
• pp.247-253
• /
• 2006

Protein modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of protein targets including transcription factors and coregulators mainly in the nucleus and participates in maintaining cellular homeostasis. In addition, SUMO system plays important roles in DNA damage repair and maintaining genome integrity. Thus, in some cases, the loss of control on SUMOylation or deSUMOylation processes causes a defect in maintaining homeostasis and hence gives a cue to cancer development. Furthermore, recent study showed that SUMO system is also involved in cancer metastasis. In this review, we will summarize and discuss the possible role of SUMO system in cancer development and metastasis.

• Journal of Communications and Networks
• /
• v.7 no.2
• /
• pp.192-206
• /
• 2005

Integration of mobile networks and Internet has started with 2.5 generation of mobile cellular networks. Internet traffic is today dominant traffic type worldwide. The hanger for higher data rates needed for data traffic and new IP based services is essential in the development of future wireless networks. In such situation, even 3G with up to 2 Mbit/s has not provided data rates that are used by Internet users with fixed broadband dial-up or through wired local area networks. The solution to provide higher bit rates in wireless access network has been found in wireless LAN although initially it has been developed to extend wired LAN into wireless domain. In this paper, we propose and describe a solution created for interoperability between mobile cellular network and WLAN. The integration between two networks, cellular and WLAN, is performed on the authentication, authorization, and accounting, i.e., AAA side. For that purpose we developed WLAN access controller and WLAN AAA gateway, which provide gateway-type access control as well as charging and billing functionalities for the WLAN service. In the development process of these elements, we have considered current development stadium of all needed network entities and protocols. The provided solution provides cost-effective and easy-to-deploy PLMN-WLAN Internetworking scenario.