• 한국CDE학회논문집
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• 제2권3호
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• pp.142-149
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• 1997

This study is intended to develop a Feature based modeler. It is difficult to integrate CAD and CAM/CAPP with information that is given only by a conventional CAD system. Therefore a lot of studies have concentrated on a Feature based CAD system. But conventional Feature based modelers have had limitation on providing sufficient information related to Feature interaction. If a Feature based modeler is to be used in assembly simulation, a new Feature-based modeling method needs to be developed. Also to support collision detection between parts, we have to handle Feature interaction systematically. Therefore we suggest Cell data structure which handles interaction of Features by volume. The volume created by Feature interaction is saved as a Cell. With the Cell structure we solve problems involved with Feature interaction. This study shows how the Cell data structure can manage Feature interaction and give enough information in assembly simulation.

• Communications for Statistical Applications and Methods
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• 제10권2호
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• pp.291-303
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• 2003

This work is proposed an alternative identification method of outlying cell which is one of important issues in categorical data analysis. One finds that there is a strong relationship between the location of an outlying cell and the corresponding parameter estimates of the well-fitted log-linear model. Among parameters of log-linear model, an outlying cell is affected by interaction terms rather than main effect terms. Hence one could identify an outlying cell by investigating of parameter estimates in an appropriate log-linear model.

• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.94-101
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• 2022

Recent advancement of micro/nano technology enables the development of diverse micro/nano particle-based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.

• Interaction and multiscale mechanics
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• 제2권1호
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• pp.15-30
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• 2009

The theoretical framework of the interaction fields for multiple scales based on field theory is applied to one-dimensional problem mimicking dislocation substructure sensitive intra-granular inhomogeneity evolution under fatigue of Cu-added steels. Three distinct scale levels corresponding respectively to the orders of (A)dislocation substructures, (B)grain size and (C)grain aggregates are set-up based on FE-RKPM (reproducing kernel particle method) based interpolated strain distribution to obtain the incompatibility term in the interaction field. Comparisons between analytical conditions with and without the interaction, and that among different cell size in the scale A are simulated. The effect of interaction field on the B-scale field evolution is extensively examined. Finer and larger fluctuation is demonstrated to be obtained by taking account of the field interactions. Finer cell size exhibits larger field fluctuation whereas the coarse cell size yields negligible interaction effects.

• 대한의용생체공학회:의공학회지
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• 제43권2호
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• pp.71-80
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• 2022

The interaction between dual-ligand decorated particle-based delivery system and target cell under shear flow is predicted using probability model developed. We assumed the two kinds of ligand are decorated on the surface of the particle with 10% length difference. Fixed with other biophysical parameters, a study on the particle-cell interaction for the different non-specific interaction parameter is performed. To induce the firm adhesion, short ligand-receptor should be engaged. Also, it is shown that the rational design of ligand-receptor interaction, including receptor number, specific interaction parameter, kinds of ligand-receptor, etc., should be considered.

• 대한기계학회논문집A
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• 제35권11호
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• pp.1355-1360
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• 2011

흡착형 세포의 이동에 있어 세포와 바닥면간의 상호작용은 매우 중요한 역할을 한다. 본 논문은 주화성에 의한 흡착형 세포의 이동에 있어 세포와 바닥면과의 상호작용에 따른 영향을 보이기 위해 확산계면모델을 바탕으로 한 3 차원의 입체 모델을 제안한다. 세포와 바닥면간의 영향을 표현하기 위해 세포 주위 물질과의 관계를 고려한 경계에너지를 고려하였다. 본 연구에서 적용한 확산계면모델은 경계에너지, 주화성, 확산성을 모두 고려한 다중 메커니즘 모델로서 흡착형 세포이동의 역학적 특성을 정확히 예측하는데 있어 높은 신뢰성을 보일 것이라 기대된다.

• The Journal of the Acoustical Society of Korea
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• 제29권1E호
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• pp.28-37
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• 2010

This article reviews recent developments in the emerging field of cellular-level biomedical ultrasonics with the specific focus on the mechanics of ultrasound-cell interaction. Due to the nature of the field at its relative infancy, the review poses more questions than it provides answers. Discussed are topics such as the basic structure of a biological cell, the origin of cell's elasticity, a theoretical framework for ultrasound-cell interaction, and shape deformation of cells and its measurement, Some interesting problems for future study are proposed.

• BMB Reports
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• 제44권3호
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• pp.199-204
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• 2011

Ephrin signaling is involved in various morphogenetic events, such as axon guidance, hindbrain segmentation, and angiogenesis. We conducted a yeast two-hybrid screen using the intracellular domain (ICD) of EphrinB1 to gain biochemical insight into the function of the EphrinB1 ICD. We identified the transcriptional co-repressor xTLE1/Groucho as an EphrinB1 interacting protein. Whole-mount in situ hybridization of Xenopus embryos confirmed the co-localization of EphrinB1 and a Xenopus counterpart to TLE1, xTLE4, during various stages of development. The EphrinB1/xTLE4 interaction was confirmed by co-immunoprecipitation experiments. Further characterization of the interaction revealed that the carboxy-terminal PDZ binding motif of EphrinB1 and the SP domain of xTLE4 are required for binding. Additionally, phosphorylation of EphrinB1 by a constitutively activated fibroblast growth factor receptor resulted in loss of the interaction, suggesting that the interaction is modulated by tyrosine phosphorylation of the EphrinB1 ICD.

• Journal of the Korean Data and Information Science Society
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• 제9권2호
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• pp.119-138
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• 1998

The case of proportional cell frequencies for the two-way cross-classification with interaction is considered. Several types of hypotheses for the general unbalanced data that are commonly used in the literature are shown, and they are written out for this particular case. A reparameterized form of the cell means model is defined to establish the reparameterized model, and orthogonal property of the model is shown using the augmented matrix and the numerator sums of squares are computed. Different ways of producing the same analysis of variance tables are shown in both orthogonal and nonorthogonal situations.

• Biomolecules & Therapeutics
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• 제26권5호
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• pp.458-463
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• 2018

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.