• Journal of Periodontal and Implant Science
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• v.50 no.6
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• pp.392-405
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• 2020

Purpose: Titanium implants are widely used in the treatment of dentition defects; however, due to problems such as osseointegration failure, peri-implant bone resorption, and periimplant inflammation, their application is subject to certain restrictions. The surface modification of titanium implants can improve the implant success rate and meet the needs of clinical applications. The goal of this study was to evaluate the effect of the use of porous titanium with a chitosan/hydroxyapatite coating on osseointegration. Methods: Titanium implants with a dense core and a porous outer structure were prepared using a computer-aided design model and selective laser sintering technology, with a fabricated chitosan/hydroxyapatite composite coating on their surfaces. In vivo and in vitro experiments were used to assess osteogenesis. Results: The quasi-elastic gradient and compressive strength of porous titanium implants were observed to decrease as the porosity increased. The in vitro experiments demonstrated that, the porous titanium implants had no biological toxicity; additionally, the porous structure was shown to be superior to dense titanium with regard to facilitating the adhesion and proliferation of osteoblast-like MC3T3-E1 cells. The in vivo experimental results also showed that the porous structure was beneficial, as bone tissue could grow into the pores, thereby exhibiting good osseointegration. Conclusions: Porous titanium with a chitosan/hydroxyapatite coating promoted MC3T3-E1 cell proliferation and differentiation, and also improved osseointegration in vitro. This study has meaningful implications for research into ways of improving the surface structures of implants and promoting implant osseointegration.

• Genomics & Informatics
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• v.19 no.1
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• pp.6.1-6.10
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• 2021

Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by VEGF and VEGFR (a tyrosine kinase receptor) signaling. The angiogenic effects of the VEGF family are thought to be primarily mediated through the interaction of VEGF with VEGFR-2. Targeting this signaling molecule and its receptor is a novel approach for blocking angiogenesis. In recent years virtual high throughput screening has emerged as a widely accepted powerful technique in the identification of novel and diverse leads. The high resolution X-ray structure of VEGF has paved the way to introduce new small molecular inhibitors by structure-based virtual screening. In this study using different alkaloid molecules as potential novel inhibitors of VEGF, we proposed three alkaloid candidates for inhibiting VEGF and VEGFR mediated angiogenesis. As these three alkaloid compounds exhibited high scoring functions, which also highlights their high binding ability, it is evident that these alkaloids can be taken to further drug development pipelines for use as novel lead compounds to design new and effective drugs against cancer.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.1
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• pp.110-117
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• 2019

Objective: An experiment was conducted to evaluate the effects of dietary glutamine (Gln) and arginine (Arg) supplementation on performance, intestinal morphology and ascites mortality in broilers. Methods: A total of 675 day old chicks were randomly allocated to 9 experimental groups in a $3{\times}3$ factorial arrangement based on a completely randomized design with 5 replicates of 15 chicks. Three levels of dietary Gln (0%, 0.5%, and 1%) and Arg (100%, 130%, and 160% of Ross recommendation) supplementation were used in ascites inducing condition ($15^{\circ}C{\pm}1^{\circ}C$) from 7 to 42 days of age. Results: Dietary supplementation of Gln increased body weight gain during grower, finisher and total periods (p<0.05) and increased feed intake during total period. Ascites mortality was decreased by Gln supplementation (p<0.05). Gln supplementation increased the villus height (VH) and crypt depth (CD) in duodenum and jejunum (p<0.05). Arg supplementation decreased CD in duodenum and jejunum, and increased ileum villus width (VW) and also VH/CD ratio in duodenum and jejunum (p<0.05). Both Gln and Arg increased the goblet cell number (GCN) in duodenum whereas Gln supplementation decreased GCN in jejunum and ileum (p<0.05). The $Gln{\times}Arg$ interaction were observed for right ventricle (RV)/total ventricular (TV) ratio, VH, VW, CD, VH/CD. Conclusion: It was concluded that dietary 0.5% Gln alone or along with 130% Arg of Ross requirement, improve the intestinal morphology and performance and hence decrease the ascites mortality in broiler chickens with cold induced ascites.

• Archives of Craniofacial Surgery
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• v.19 no.4
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• pp.260-263
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• 2018

Background: The alar and nasal tip are important subunits of the nose. Determining the optimal procedure for reconstructing a cutaneous defect in a nasal subunit depends on several factors including size, location, and involvement of deep underlying structures. We treated cutaneous defects after tumor ablation in the alar and nasal tip with a local flap, using an S-shaped design and a modified V-Y advancement flap with a croissant shape. Methods: We analyzed 36 patients with skin tumors who underwent flap coverage after tumor ablation. Rotation flaps were used in 26 cases and croissant-shaped V-Y advancement flaps were used in 10 cases. The primary cause of the defects was skin cancer, except for one benign tumor. Results: The mean patient age was 71 years. The size of the defects ranged from $0.49cm^2$ to $3.5cm^2$. No recurrence of skin cancer was noted and all flaps lasted until the end of follow-up. Partial desquamation of the epidermis was noted in one case. The postoperative appearance for most patients was excellent, objectively and subjectively. Conclusion: For cutaneous defects of up to about $4.0cm^2$ of the alar and nasal tip, local flaps using our methods offered a good cosmetic and therapeutic result. The main advantage of our flaps is the minimal dissection required compared to bilobed and other local flap methods. We believe our flaps are a suitable option for alar and nasal tip reconstruction.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.1
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• pp.225-234
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• 2019

By using the Triboelectric nanogenerators, known as TENG, we can take advantages of high conversion efficiency and continuous power output even with small vibrating energy sources. Nonlinear energy extraction techniques for Triboelectric vibration energy harvesting usually requires synchronized active electronic switches in most electronic interface circuits. This study presents a nonlinear energy harvesting with high energy conversion efficiency to harvest and save energies from human active motions. Moreover, the proposed design can harvest and store energy from sway motions around different directions on a horizontal plane efficiently. Finally, we conducted a comparative analysis of a multi-mode energy storage board developed by a silicon-based piezoelectricity and a transparent TENG cell. As a result, the experiment showed power generation of about 49.2mW/count from theses multi-fully harvesting source with provision of stable energy storages.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.30 no.5
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• pp.407-417
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• 2019

When a free-falling ballistic missile intercepts a maritime target in a sea clutter environment at high grazing angle, detection performance of the ballistic missile's seeker can be rapidly degraded by the effect of sea clutter. To solve this problem, it is necessary to verify the performance of maritime target detection via simulations based on various scenarios. We accomplish this by applying a two-dimensional cell -averaging constant false alarm rate detector to a two-dimensional radar image, which is generated by merging a sea clutter signal at high grazing angle with a maritime target signal corresponding to the signal-to-clutter ratio. Simulation results using a computer-aided design model and commercial numerical electromagnetic solver in various scenarios show that the performance of maritime target detection significantly depends on the grazing and azimuth angles.

• Journal of IKEEE
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• v.23 no.1
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• pp.58-67
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• 2019

A design of an elliptic curve cryptography (ECC) processor that supports both pseudo-random curves and Koblitz curves over $GF(2^m)$ defined by the NIST standard is described in this paper. A finite field arithmetic circuit based on a word-based Montgomery multiplier was designed to support five key lengths using a datapath of fixed size, as well as to achieve a lightweight hardware implementation. In addition, Lopez-Dahab's coordinate system was adopted to remove the finite field division operation. The ECC processor was implemented in the FPGA verification platform and the hardware operation was verified by Elliptic Curve Diffie-Hellman (ECDH) key exchange protocol operation. The ECC processor that was synthesized with a 180-nm CMOS cell library occupied 10,674 gate equivalents (GEs) and a dual-port RAM of 9 kbits, and the maximum clock frequency was estimated at 154 MHz. The scalar multiplication operation over the 223-bit pseudo-random elliptic curve takes 1,112,221 clock cycles and has a throughput of 32.3 kbps.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.11
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• pp.1470-1476
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• 2020

This paper describes a design of a lightweight security system-on-chip (SoC) suitable for the implementation of security protocols for IoT and mobile devices. The security SoC using Cortex-M0 as a CPU integrates hardware crypto engines including an elliptic curve cryptography (ECC) core, a SHA3 hash core, an ARIA-AES block cipher core and a true random number generator (TRNG) core. The ECC core was designed to support twenty elliptic curves over both prime field and binary field defined in the SEC2, and was based on a word-based Montgomery multiplier in which the partial product generations/additions and modular reductions are processed in a sub-pipelining manner. The H/W-S/W co-operation for elliptic curve digital signature algorithm (EC-DSA) protocol was demonstrated by implementing the security SoC on a Cyclone-5 FPGA device. The security SoC, synthesized with a 65-nm CMOS cell library, occupies 193,312 gate equivalents (GEs) and 84 kbytes of RAM.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.2
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• pp.268-275
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• 2020

A lightweight hardware design of self-timed ring based true random number generator (TRNG) suitable for information security applications is described. To reduce hardware complexity of TRNG, an entropy extractor with feedback structure was proposed, which minimizes the number of ring stages. The number of ring stages of the FSTR-TRNG was determined to be a multiple of eleven, taking into account operating clock frequency and entropy extraction circuit, and the ratio of tokens to bubbles was determined to operate in evenly-spaced mode. The hardware operation of FSTR-TRNG was verified by FPGA implementation. A set of statistical randomness tests defined by NIST 800-22 were performed by extracting 20 million bits of binary sequences generated by FSTR-TRNG, and all of the fifteen test items were found to meet the criteria. The FSTR-TRNG occupied 46 slices of Spartan-6 FPGA device, and it was implemented with about 2,500 gate equivalents (GEs) when synthesized in 180 nm CMOS standard cell library.

• Journal of IKEEE
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• v.24 no.4
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• pp.961-968
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• 2020

This paper describes a design of high performance modular multiplier that is essentially used for elliptic curve cryptography. Our modular multiplier supports modular multiplications for five field sizes over GF(p), including 192, 224, 256, 384 and 521 bits as defined in NIST FIPS 186-2, and it calculates modular multiplication in two steps with integer multiplication and reduction. The Karatsuba-Ofman multiplication algorithm was used for fast integer multiplication, and the Lazy reduction algorithm was adopted for reduction operation. In addition, the Nikhilam division algorithm was used for the division operation included in the Lazy reduction. The division operation is performed only once for a given modulo value, and it was designed to skip division operation when continuous modular multiplications with the same modulo value are calculated. It was estimated that our modular multiplier can perform 6.4 million modular multiplications per second when operating at a clock frequency of 32 MHz. It occupied 456,400 gate equivalents (GEs), and the estimated clock frequency was 67 MHz when synthesized with a 180-nm CMOS cell library.