• Title/Summary/Keyword: causes of migration

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Inhibitory Effects of Zerumbone on MCP-1-Induced THP-1 Migration (MCP-1에 의해 유도된 THP-1 유주에 미치는 Zerumbone의 영향)

  • Kim, Sa Hyun;Kim, Si Hyun;Ryu, Sung Ryul;Lee, Pyeongjae;Moon, Cheol
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.2
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    • pp.177-182
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    • 2018
  • This study examined the effects of zerumbone on monocyte migration. Monocytes are recognized as important mediators of various inflammatory diseases, and the possibility of controlling inflammatory diseases by regulating the monocyte functions, such as activity and mobility, has been reported. MCP-1, which is a chemokine with levels that increase upon inflammation, causes the migration of the monocyte cell line, THP-1. Migration occurred at a concentration of 10 ng/mL MCP-1, and the highest migration occurred at 100 ng/mL and 200 ng/mL. MCP-1-induced THP-1 migration decreased by more than 40% in the presence of zerumbone. The concentration of cAMP, an important secondary messenger of the CCR2 signaling pathway, the MCP-1 receptor, was increased in the culture medium after a zerumbone treatment. The concentrations of cAMP decreased significantly under the MCP-1 treatment condition only. On the other hand, an increase in cAMP was observed when zerumbone and MCP-1 were treated simultaneously. Erk phosphorylation induced by an MCP-1 treatment was also found to decrease with the zerumbone treatment. This study introduces the possibility of controlling inflammatory diseases through the function of zerumbone, which regulates the migration of monocytes.

Reverse-time migration using the Poynting vector (포인팅 벡터를 이용한 역시간 구조보정)

  • Yoon, Kwang-Jin;Marfurt, Kurt J.
    • Geophysics and Geophysical Exploration
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    • v.9 no.1
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    • pp.102-107
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    • 2006
  • Recently, rapid developments in computer hardware have enabled reverse-time migration to be applied to various production imaging problems. As a wave-equation technique using the two-way wave equation, reverse-time migration can handle not only multi-path arrivals but also steep dips and overturned reflections. However, reverse-time migration causes unwanted artefacts, which arise from the two-way characteristics of the hyperbolic wave equation. Zero-lag cross correlation with diving waves, head waves and back-scattered waves result in spurious artefacts. These strong artefacts have the common feature that the correlating forward and backward wavefields propagate in almost the opposite direction to each other at each correlation point. This is because the ray paths of the forward and backward wavefields are almost identical. In this paper, we present several tactics to avoid artefacts in shot-domain reverse-time migration. Simple muting of a shot gather before migration, or wavefront migration which performs correlation only within a time window following first arriving travel times, are useful in suppressing artefacts. Calculating the wave propagation direction from the Poynting vector gives rise to a new imaging condition, which can eliminate strong artefacts and can produce common image gathers in the reflection angle domain.

MicroRNA-122 Promotes Proliferation, Invasion and Migration of Renal Cell Carcinoma Cells Through the PI3K/Akt Signaling Pathway

  • Lian, Ji-Hu;Wang, Wei-Hua;Wang, Jia-Qiang;Zhang, Yu-Hong;Li, Yi
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.9
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    • pp.5017-5021
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    • 2013
  • Objective: MicroRNAs (miRNAs) are a small class of non-coding, single-stranded RNAs with a critical role in genesis and maintenance of renal cancer mainly through binding to 3'-untranslated regions (3'UTR) of target mRNAs, which causes a block of translation and/or mRNA degradation. The aim of the present study was to investigate the potential effects of miR-122 in human renal cell carcinomas. Methods: The expression level of miR-122 was quantified by qRT-PCR. MTT, colony formation, invasion and migration assays were used to explore the potential functions of miR-122 in human renal cell carcinoma cells. Results: Cellular growth, invasion and migration in two A498 and 786-O cells were significantly increased after miR-122 transfection. Further experiments demonstrated that overexpression of miR-122 resulted in the increase of phospho-Akt (Ser473) and phospho-mTOR (Ser2448), then activation of mTOR targets, p70S6K and 4E-BP1. Conclusions: The up-regulation of miR-122 may play an important role in the progress of renal cancer through activating PI3K/Akt signal pathway and could be a potential molecular target for anti-cancer therapeutics.

Study of Kaolin Particle Migration and Clogging Using a Micromodel (마이크로 모델을 이용한 고령토 입자의 유동 특성 연구)

  • Ha, Minkyu;Jung, Jongwon
    • Journal of the Korean Geotechnical Society
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    • v.35 no.4
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    • pp.37-42
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    • 2019
  • Hydrate dissociation is required to produce methane, which generates both water and methane. Thus, multiphase fluid flow and desalination are expected during methane production, which causes the fine migration and clogging in pores. The goal of this study is to explore the effects of both multiphase fluid flow and desalination on the migration and clogging of kaolin particles as typical fines. The results are as follows : (1) the larger the pore size is, the more mounting the critical clogging concentration is, (2) kaolin particles are more easily clustering and clogging in deionized water than salty water, and (3) the critical clogging concentration of kaolin in multiphase fluid flow is lower than in singlephase fluid flow. Therefore, clustering and clogging of kaolin within pore occur easily due to desalination and multiphase fluid flow when methane is produced from hydrates, and the efficiency of methane production is expected to decrease due to the degradation of permeability coefficient.

The Origin and Diffusion of 'Southeast Asian Phenomena' in Korea: Focusing on Human Movement (인간의 이동을 중심으로 본 한국 속 '동남아 현상')

  • Kim, Hong-koo
    • The Southeast Asian review
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    • v.21 no.2
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    • pp.77-123
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    • 2011
  • Recently, Southeast Asian people, its food, natural sceneries and so on have been increasingly exposed to Korean people through mass media and multi-cultural events. At the same time, Koreans can frequently encounter Southeast Asians in their everyday lives. Thus, specific images and discourses of Southeast Asia has been established in our society, which creates a new social trend called 'Southeast Asia phenomena'. In short, 'Southeast Asia phenomena' means a totality of Korean people's experience of Southeast Asian and their perception on the region. On the one hand, 'Southeast Asia phenomena' is a result of inflow of Southeast Asians and their culture into Korea. On the other hand, it is also a consequence of Korean people's understanding of Southeast Asia from their trip to Southeast Asia or from their interactions with Southeast Asian people. This article aims to analyze the origin and diffusion of 'Southeast Asian Phenomena' in Korea in the context of Southeast Asia focusing on 4 topics, that is, migrant workers, overseas investments, retirement migration, study-abroad categorized as human movement. This article is also about a country-by-country comparative analysis both at the macro level and the micro level. At the macro level, overseas investments and trade, human exchanges, positive perception to Koreans which considered to be the structural causes become a strong mechanism playing a important bridge role between Korea and Southeast Asia. So these create the high probability of the emergence of 'Southeast Asian Phenomena' At the micro level which is more direct causes of 'Southeast Asian Phenomena', the economic cause is the most important common cause for 4 Southeast Asian Phenomena. Additionally, Korean wave is also remarkable common cause creating 'Southeast Asian Phenomena' even it is not the origin in the context of Southeast Asia. The diffusion of 'Southeast Asian Phenomena' is different by the topics and the elements contributing to create the favorable situation for the diffusion are not only overseas investments and trade, human exchanges at the macro level but also policy elements at the micro level. The relative differences of the causes of 'Southeast Asian Phenomena' in the country-by-country analysis are found. Regarding overseas investments in Vietnam and Cambodia, the economic degree of freedom in Cambodia is higher than in Vietnam. Even Korean Wave has had the longer history in Vietnam, but the favorable perspectives on Korean Wave are stronger in Cambodia. For migrant workers from Vietnam and Indonesia, the economic causes in Vietnam are more significant than in Indonesia. The impact of Korean Wave is stronger in Vietnam than in Indonesia. In case of study-abroad, the social-cultural elements and policy elements are more diverse in Malaysia than in Korea. For the Korean retirees who immigrate to the Philippines and Malaysia, the economic causes in the Philippines is more significant in Malaysia.

Retrovirus-mediated Delivery of TIMP-2 Inhibits Migration. Invasion and Angiogenesis

  • Ahn, Seong-Min;Sohn, Yeo-Won;Kim, Yun-Soo;Moon , A-Ree
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.325.3-326
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    • 2002
  • An imbalance between matrix metalloproteinase (MMP)-2 and its endogenous inhibitor. tissue inhibitor of metalloproteinase (TIMP)-2 causes the degradation of the extracellular matrix associated with pathological events including invasion. metastasis and angiogenesis. Since TIMPs are secreted molecules. they have the potential to be used for gene therapy of certain tumors. (omitted)

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Selectivity and Reasons for Move of Inter_Provincial Migrants in Korea: With Special Reference to the Capital Region (한국 지역 간 인구이동의 선별성과 이동 이유: 수도권을 중심으로)

  • Choi, Jin-Ho
    • Korea journal of population studies
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    • v.31 no.3
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    • pp.159-178
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    • 2008
  • The main purpose of this paper is to examine selectivity and rasons for move of internal migrants in Korea. There have only been a few studies available on the issues of selectivity and reasons for move of internal migration in Korea, mainly due to the lack of appropriate data. The main source of data for this analysis come from the raw data set of the 1997 Special Migration Survey conducted by the National Statistical Office. Analysis of selectivity of those who moved across the provincial boundary revealed that females, young adults, singles in their marital status and more educated are more likely to move. Among various reasons for move, employment related reason is the most important for all migration streams. But with different migration streams, diverse patterns are emerged. For those who moved into the Capital Region, employment related reason is outstanding. But those who moved out from the Capital Region, moved for employment as well as family related reasons. For movement within the Capital Region, housing related reason is equally important together with employment and family reason. The analysis also found that among individual attributes, age and marital status affect most significantly to the reasons for move. Education level and housing ownership are also important for explaining for variations in reasons for move.

Change of Hydraulic Properties of Sand due to Fine Diatom Particle Migration (미세 Diatom 입자 이동에 의한 모래지반의 투수 특성 변화)

  • Pyo, Won-Mi;Lee, Jong-Sub;Lee, Joo Yong;Hong, Won-Taek
    • Journal of the Korean Geotechnical Society
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    • v.34 no.2
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    • pp.19-32
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    • 2018
  • During the process of gas hydrate extraction in the deep seabed, fine diatom particle migration occurs, which causes the seabed slope failure and the productivity deterioration of the gas hydrate. Therefore, a study related with the changes of the ground characteristics due to the fine particle migration is required. The objective of this study is to investigate the change of hydraulic properties of sand due to the migration of fine diatom particle in sandy soils. In order to simulate the sediments of the Ulleung basin gas hydrate in the East Sea, fifteen sand-diatom mixtures that have different diatom volume fractions (DVF) are prepared. During the falling head permeability tests, the coefficients of permeability are measured according to the DVF. In addition, for the simulation of the fine diatom particle migration, constant head permeability tests are conducted by applying the hydraulic pressures of 3 kPa, 6kPa, and 9 kPa on a specimen composed of two layers: a specimen with 50% DVF in upper layer and a specimen with 0% DVF in lower layer. Furthermore, the coefficient of permeability and the electrical resistivity of the migration zone are measured during the constant head permeability test. The falling head permeability tests show that the coefficient of permeability decreases as the DVF of the specimen increases. In addition, the gradient of the coefficient of permeability curve decreases in the DVF range of 10%~50% compared with that of 0%~10%, and increases above 50% in DVF. The result of constant head permeability tests shows that the coefficient of permeability decreases and electrical resistivity increases in the migration zone due to the fine diatom particle migration. This study demonstrates that fine diatom particle migration reduces the permeability of the soils and the behavior of the migration zone due to the fine diatom particle migration may be estimated based on the reversal relationship between the coefficient of permeability and the electrical resistivity.

Rapid Rural-Urban Migration and the Rural Economy in Korea (한국(韓國)의 급격(急激)한 이촌향도형(離村向都型) 인구이동(人口移動)과 농촌경제(農村經濟))

  • Lee, Bun-song
    • KDI Journal of Economic Policy
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    • v.12 no.3
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    • pp.27-45
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    • 1990
  • Two opposing views prevail regarding the economic impact of rural out-migration on the rural areas of origin. The optimistic neoclassical view argues that rapid rural out-migration is not detrimental to the income and welfare of the rural areas of origin, whereas Lipton (1980) argues the opposite. We developed our own alternative model for rural to urban migration, appropriate for rapidly developing economies such as Korea's. This model, which adopts international trade theories of nontraded goods and Dutch Disease to rural to urban migration issues, argues that rural to urban migration is caused mainly by two factors: first, the unprofitability of farming, and second, the decrease in demand for rural nontraded goods and the increase in demand for urban nontraded goods. The unprofitability of farming is caused by the increase in rural wages, which is induced by increasing urban wages in booming urban manufacturing sectors, and by the fact that the cost increases in farming cannot be shifted to consumers, because farm prices are fixed worldwide and because the income demand elasticity for farm products is very low. The demand for nontraded goods decreases in rural and increases in urban areas because population density and income in urban areas increase sharply, while those in rural areas decrease sharply, due to rapid rural to urban migration. Given that the market structure for nontraded goods-namely, service sectors including educational and health facilities-is mostly in monopolistically competitive, and that the demand for nontraded goods comes only from local sources, the urban service sector enjoys economies of scale, and can thus offer services at cheaper prices and in greater variety, whereas the rural service sector cannot enjoy the advantages offered by scale economies. Our view concerning the economic impact of rural to urban migration on rural areas of origin agrees with Lipton's pessimistic view that rural out-migration is detrimental to the income and welfare of rural areas. However, our reasons for the reduction of rural income are different from those in Lipton's model. Lipton argued that rural income and welfare deteriorate mainly because of a shortage of human capital, younger workers and talent resulting from selective rural out-migration. Instead, we believe that rural income declines, first, because a rapid rural-urban migration creates a further shortage of farm labor supplies and increases rural wages, and thus reduces further the profitability of farming and, second, because a rapid rural-urban migration causes a further decline of the rural service sectors. Empirical tests of our major hypotheses using Korean census data from 1966, 1970, 1975, 1980 and 1985 support our own model much more than the neoclassical or Lipton's models. A kun (county) with a large out-migration had a smaller proportion of younger working aged people in the population, and a smaller proportion of highly educated workers. But the productivity of farm workers, measured in terms of fall crops (rice) purchased by the government per farmer or per hectare of irrigated land, did not decline despite the loss of these youths and of human capital. The kun having had a large out-migration had a larger proportion of the population in the farm sector and a smaller proportion in the service sector. The kun having had a large out-migration also had a lower income measured in terms of the proportion of households receiving welfare payments or the amount of provincial taxes paid per household. The lower incomes of these kuns might explain why the kuns that experienced a large out-migration had difficulty in mechanizing farming. Our policy suggestions based on the tests of the currently prevailing hypotheses are as follows: 1) The main cause of farming difficulties is not a lack of human capital, but the in­crease in production costs due to rural wage increases combined with depressed farm output prices. Therefore, a more effective way of helping farm economies is by increasing farm output prices. However, we are not sure whether an increase in farm output prices is desirable in terms of efficiency. 2) It might be worthwhile to attempt to increase the size of farmland holdings per farm household so that the mechanization of farming can be achieved more easily. 3) A kun with large out-migration suffers a deterioration in income and welfare. Therefore, the government should provide a form of subsidization similar to the adjustment assistance provided for international trade. This assistance should not be related to the level of farm output. Otherwise, there is a possibility that we might encourage farm production which would not be profitable in the absence of subsidies. 4) Government intervention in agricultural research and its dissemination, and large-scale social overhead projects in rural areas, carried out by the Korean government, might be desirable from both efficiency and equity points of view. Government interventions in research are justified because of the problems associated with the appropriation of knowledge, and government actions on large-scale projects are justified because they required collective action.

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From Excluded Ghettos to Exclusionary Enclaves: A Private Sector Initiative in Guangzhou, China

  • Chen, Huiwei;Chan, Roger C.K.;He, Qicong
    • Land and Housing Review
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    • v.4 no.3
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    • pp.211-223
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    • 2013
  • Massive migration is underway in rapidly urbanizing Guangzhou, the south gate of P. R. China. Over half the migrants choose to rent in "villages-in-the-city" in the downtown area because of the low-cost and prime location. The overpopulation and resulting poor environment and high crime-rate turn villages-in-the-city into de facto ghettos. As a result, these ghettos are undergoing a manner of demolition-development, leaving migrants' housing needs unmet. A private-sector initiative-the Tulou Commune-intends to address this considerable market potential. Targeting low-income groups, the Tulou Commune creates a socio-spatially exclusionary enclave. This paper analyzes the Tulou Commune and the implications if more low-income migrants shifting from village-in-the-city (excluded ghetto) to Tulou Commune (exclusionary enclave). This study argues that the intervention of the private sector causes the demographic, social, and spatial similarities and differences of the two living arrangements. Socioeconomic and institutional factors also affect the initiative. This study also provides more empirical evidence in the field of low-cost housing and socio-spatial development in transitional Chinese cities. As the first project of its kind, the analysis of the case can suggest how to improve strategies for accommodating migrants in the future.