• Women's Health Nursing
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• v.9 no.1
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• pp.61-69
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• 2003

Fatigue is a universally common word. The subject has been studied in different disciplines, but the basic concept of the term still remains unidentified. It becomes especially important for the medical communications between nurses and clients. Based on the framework outlined by Walker and Avant (1995), this analysis attempts to clarify and examine the symptoms of fatigue. The attributes of fatigue identified in this paper were exhaustion, weighted psychological burden, shortage in capacity or lack of energy, shortage incapacity(motivation and excitement), and imbalance of energy. Therefore, the definition of fatigue refers to a subjective feeling from various internal or external stresses. The consequences of fatigue bring reduced capacity and imbalance of energy. The symptoms show a homeostatic disability or shortage of capacity (physical, psychological, environmental and physiological factors). A precise understanding of "fatigue" will be utilized in defining the causes and measuring outcomes. Also, it will enhance the effective medical communications with client s and nurses. In conclusion, more work is needed to develop objective measurement and effect ivenursing intervention.

• Journal of Microbiology and Biotechnology
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• v.29 no.7
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• pp.1014-1021
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• 2019

In the bacterial community, unicellular organisms act together as a multicellular being. Bacteria interact within the community and programmed cell death (PCD) in prokaryotes is a sort of altruistic action that enables the whole population to thrive. Genetically, encoded cell death pathways are triggered by DNA damage or nutrient starvation. Given the environmental and bacterial diversity, different PCD mechanisms are operated. Still, their biochemical and physiological aspects remain unrevealed. There are three main pathways; thymineless death, apoptosis-like death, and toxin-antitoxin systems. The discovery of PCD in bacteria has revealed the possibility of developing new antibiotics. In this review, the molecular and physiological characteristics of the three types of PCD and their development potential as antibacterial agents are addressed.

• BMB Reports
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• v.36 no.1
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• pp.138-143
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• 2003

Of many viral causes of human cancer, few are of greater global importance than the hepatitis B virus (HBV). Over 250 million people worldwide are persistently infected with HBV. A significant minority of these develop severe pathologic consequences, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Earlier epidemiological evidence suggested a link between chronic HBV infection and HCC. Further, the existence of related animal viruses that induce acute and chronic infections of the liver, and eventually HCC, confirms the concept that HBV belongs to one of the few human oncogenic viruses. Although it is clear that chronic HBV infections are major risk factors, relatively little is understood about how the viral factors contribute to hepatocarcinogenesis. This review will introduce molecular aspects of the viral infection, and highlight recent findings on the viral contribution to hepatocarcinogenesis.

• Korean Journal of Biological Psychiatry
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• v.10 no.2
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• pp.97-106
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• 2003

Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that the neurofibrillary tangle formation seems to predate plaque formation. In addition, neurofibrillary tangle counts correlate well with the degree of cognitive impairment. These findings suggest the independent importance of tau abnormality in AD research which is involved in the neurofibrillary tangle formation. Recently, tau pathology without amyloid deposits and mutations in tau protein gene were reported to be the major pathogenic mechanism in Pick's disease, progressive supranuclear palsy, corticobasal degeneration and FTDP-17(frontotemporal dementia and parkinsonism linked with chromosome 17). These data suggest that understanding the causes and consequences of tau dysfunction might give new clinical and therapeutic solutions to many known tauopathies.

• BMB Reports
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• v.56 no.4
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• pp.216-224
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• 2023

Centrosome abnormalities are hallmarks of human cancers. Structural and numerical centrosome abnormalities correlate with tumor aggressiveness and poor prognosis, implicating that centrosome abnormalities could be a cause of tumorigenesis. Since Boveri made his pioneering recognition of the potential causal link between centrosome abnormalities and cancer more than a century ago, there has been significant progress in the field. Here, we review recent advances in the understanding of the causes and consequences of centrosome abnormalities and their connection to cancers. Centrosome abnormalities can drive the initiation and progression of cancers in multiple ways. For example, they can generate chromosome instability through abnormal mitosis, accelerating cancer genome evolution. Remarkably, it is becoming clear that the mechanisms by which centrosome abnormalities promote several steps of tumorigenesis are far beyond what Boveri had initially envisioned. We highlight various cancer-promoting mechanisms exerted by cells with centrosome abnormalities and how these cells possessing oncogenic potential can be monitored.

• Sleep Medicine and Psychophysiology
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• v.29 no.1
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• pp.9-14
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• 2022

Dental sleep medicine is an up-and-coming discipline of dentistry, more specifically an offshoot of oral medicine. It traditionally focuses on sleep-related breathing disorders, such as snoring and obstructive sleep apnea. However, everyday practice shows that also other sleep disorders touch on dentistry, including orofacial pain, xerostomia, and bruxism. Therefore, a new definition has been formulated for dental sleep medicine as following; 'Dental sleep medicine is the discipline concerned with the study of the oral and maxillofacial causes and consequences of sleep-related problems'. It is this article's aim to further introduce the emerging discipline of dental sleep medicine to all professionals working in sleep medicine. This article briefly describes the different dental sleep disorders with special focus on the more remarkable associations between orofacial pain and sleep.

• Korean Journal of Construction Engineering and Management
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• v.24 no.6
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• pp.91-98
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• 2023

Construction accidents result from a combination of factors, including both the actions of workers and the safety conditions on site. Despite advancements in enhancing construction site safety, there remains a gap in comprehending the cognitive processes underlying workers' unsafe behavior. This paper investigates and validates a qualitative model that delves into the potential causes of workers' unsafe actions by examining their cognitive processes, employing a system dynamics approach. By analyzing the interplay of various loops within this model, it offers both short- and long-term safety strategies for managers intent on minimizing unsafe behavior among workers. Specifically, safety managers should prioritize increasing workers' awareness of hazards through education and fostering a positive safety mindset. Moreover, they should task frontline supervisors with directly addressing and rectifying instances of unsafe behavior by workers. Lastly, construction safety managers ought to formulate safety strategies that take into account the cognitive states of workers to mitigate any adverse consequences of biased safety management. The outcomes of this research contribute to our comprehension of methods to enhance hazard perception among workers, curtail unsafe actions, and ultimately reduce construction accidents from a cognitive standpoint.

• Journal of Preventive Medicine and Public Health
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• v.13 no.1
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• pp.97-104
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• 1980

A few years ago a WHO Expert Committee stated: 'Smoking related diseases are such important causes of disability and premature death in developed countries that the control of cigarette smoking could do more to improve health and prolong life in these countries than any other single action in the whole field of preventive medicine.' (WHO TRS 568/1975) Indeed, so serious have been the consequences of smiting in the developed countries of North America and Europe that they could not be ignored. Let us look at the action taken in some of these countries. We may then be able to draw up some guidelines for the formulation of a national anti-smoking policy-guidelines applicable both to countries which already are experiencing the dreadful consequances of long-established and wide-spread smoking habits, and applicable also to countries where the 'smoking epidemic' is only noly beginning to bring its burden of disability and early death.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.293-299
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• 2021

This study is caused by the urgent need to constantly fight against such a shameful phenomenon of society as corruption, the flourishing of which cannot be overlooked. This phenomenon has many negative manifestations and consequences, undermines the national security of the state, slows down the development of democracy, worsens the state of all spheres of life (economic, political, administrative, etc.), worsens relations with foreign partners, forms tolerance for corruption in the public consciousness. Today, the process of fighting corruption is extremely important for our country, because it depends on the independence, democracy, sustainability of Ukraine. However, there is a complex and ambiguous situation regarding this process, as there is a clear coordination of state policy in the fight against corruption, insufficient and narrow understanding of ways to combat it. There is a lack of efforts by the authorities to overcome corruption challenges and use ineffective means of combating them. Instead, corruption causes great material and moral damage to states as a whole and many of its citizens.

• Journal of Ship and Ocean Technology
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• v.1 no.1
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• pp.57-72
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• 1997

The larger trends related to cracking in ocean going vessels (primarily tankers and bulk carriers) are reviewed on the basis of available data. The typical interrelated causes of such cracking are: high local stresses, extensive use of higher strength steels, inadequate treatment of dynamic loads, adverse operational factors (harsh weather, improper vessel handling), and controllable structural degradation (corrosion, wear, stevedore damage). Three consequences of cracking are then discussed: structural failure, pollution, and increased maintenance. The first two, while rare, are potentially of high consequence including loss of life. The types of solutions that can be employed to improve the durability of ships in the face of fatigue cracking are then presented. For existing vessels, these solutions range from repairs based on structural analysis or service experience, control of corrosion, and enhanced surveys. For new vessels, the use of advanced design procedures that specifically address dynamic loads and fatigue cracking is necessary. As the preferred solution to the problem of cracking in ships, this paper advocates prevention by explicit design by first principles.