• Korean Journal of Oriental Medicine
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• v.1 no.1
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• pp.289-319
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• 1995

The clinical studies were performed on 301 cases who took Yongkakkyo-tang from June 1993 to December 1994 The results were as follows: 1. About 80%(239 cases) patients who took Yongkakkyo-tang were improved. 2. The ratio of male to female patients was 106:133. In the age distribution, it was found that under 20's were 8%(24/301), 30's and 40's were 33%(98/301), and over 50's was 39%(117/301). 3. In the regional distribution, it was found that Cervical region was 22 cases, thoracic region was 12 cases, cervical & lumbar region complex was 50 cases, upper limbs region was 6 cases, lower limbs region was 12 cases, and lumbar region was 153 cases(64%). 4. Among improved cases, the cases treated only with Yongkakkyo-tang were 16(5%), the cases treated with Yongkakkyo-tang, and treated with Chiropractic were 19(6%), the cases treated with Yongkakkyo-tang and Yanggun-tang chiropratic were 133(44%). 5. Among improved cases, the number of Chiropractic treatment, less then 15 teimes were 69 cases, 15 to 30 times were 91cases. Basedon these results, it was shown that Yongkakkyo-tang could be used for the treatment of degenerative disease of vertebra, and the treatment with Yongkakkyo-tang, Yanggun-tang and Chiropratic is more effective.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.31 no.6
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• pp.499-504
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• 2009

We investigated 52 cases of 42 patients who were diagnosed as odontogenic keratocyst in the department of Oral and maxillofacial Surgery of Kyungpook National University from 2006 to 2008, and following results were obtained. 1. Among 52 cases of OKCs, all cases were parakeratinzied. 2. Among 52 cases of OKCs, 42 cases were type I, 9 cases were type II and 1 case was type V. 3. Among 52 cases of OKCs, there were bud-like proliferation of basal cell layer on connective tissue area on 10 cases, satellite cysts on overlying oral mucosa or connective tissue area on 6 cases and rests of epithelium on connective tissue area on 6 cases. 4. Among 52 cases of OKCs, there were focal inflammation on the epithelium of the OKCs on 6 cases and diffuse inflammation on 8 cases. 5. Among 52 cases of OKCs, cytokeratin-10 was expressioned on superficial and intermediate layer on all cases. Accordingly, the presence or absence of cytokeration-10 on the epithelium of the cyst will be good differential diagnosis of between OKC and dentigerous cyst.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.25 no.1
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• pp.115-125
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• 1995

Forty-four cases of developmental salivary gland defects in 43 patients were analysed radiologically. The obtained results were as follows ; 1. It occurred more frequently in males(86 ％) than in females(14 ％). The age distribution of patients ranged from 20 to 74 years with the average being 52.7 years. 2. All but one were located between the angle of the mandible and the molar tooth. Only one patient showed bilateral occurrence. 3. The shape of the defect was ovoid(15 cases), round(10 cases), or half-ovoid(5 cases) 4. Their size ranged from 5 x 6 mm to 16 x 30 mm with the average around 9 x 14 mm. 5. Twenty-eight cases appeared to be surrounded partially(1/3 - 2/3) by a hyperostotic border. The thickness of the hyperostotic border varied ; thick(14 cases), moderate(l1 cases), thin(9 cases), or mixed(6 cases) 6. Thirteen cases were in contact with the superior border of the mandibular inferior cortex, 11 cases partially eroded the cortical plate, and 7 cases showed discontinuity of the mandibular inferior cortex. 7. Twenty-three cases were located below the mandibular canal, 13 cases overlapped the mandibular canal, and 2 cases showed slight deviation of the mandibular canal.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.12 no.1
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• pp.27-33
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• 1982

The purpose of this study is to obtain some informations for the differential diagnosis of ameloblastoma from dentigerous cyst by analysis of the radiographic findings of these lesions. The author studied age and sex distribution, the site of the lesion, tooth behavior and several radiographic features of ameloblastoma and dentigerous cyst. The material consisted of 65 patients of ameloblastoma and 37 patients of dentigerous cyst. The results were obtained as followings. 1) The incidence was highest in 2nd decade (29.2%) and total 65 cases consists of 35 males (53.8%) and 30 females (46.2%) in ameloblastoma. 62 cases were found in lower jaw (95.4%) and the highest site of occurence of ameloblastoma was mandibular molar. region 27 cases. (41.5%) 2) In 65 cases of amelobl!!stoma, 18 cases were seen in association with tooth and 15 cases (83.2%) out of those were associated with mandibular molar teeth. Mandibular molar were most frequently involved in dentigerous cyst (11/31 cases, 29.7%). 3) (a) 23 cases (35.3%) of tooth resorption were found in ameloblastoma and 11 cases (29.7%) of tooth resorption were found in dentigerous cyst. (b) 15 cases (23.1%) of tooth migration were found in ameloblastoma and 10 cases (27.0%) of tooth migration were found in dentigerous cyst. 4) Several radiographic features. (a) Monolocular type ameloblastoma were seen in 23 cases (35.4) and multilocular type of ameloblastoma were seen in 42 cases (64.6%). Monolocular type of dentigerous cyst were seen in 33 cases (89.2%) and multilocular type was seen in 4 cases. (b) Monolocular type ameloblastoma showed 20 cases (87.0%) of scalloped border but 32 cases (97.0%) of dentigerous cyst showed smooth border. (c) 34 cases (81.0%) of ameloblastoma showed honey-comb appearance, soap-bubble appearance or mixed appearance. but all 4 cases of dentigerous cyst showed multicystic appearance. (d) 12 cases (52.2%) of monolocular type ameloblastoma showed slightly increased radiopacity in surrounding bone, and 22 cases (66.7%) of monolocular type dentigerous cyst showed sharp osteosclerotic border. 27 cases (64.3%) of multilocular type ameloblastoma and 3 cases (75.0%) of multilocular type dentigerous cyst showed no changes in surrounding bone.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.18 no.3
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• pp.75-83
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• 2005

Objective: The purpose of this study is to investigate the clinical studies on 254 cases of patient with facial paralysis. Methods: We examined the sex, age, region, month, season, physical condition, attened symptoms, the period before admission, the period of treatment the times of treatment, the point of the recovery Results: 1. The distribution of sex was male 119 cases, female 125 cases(1.032:1). The distribution of age was disclosed that fifty was the most in 53 cases(20.9%) 2. In distribution of the region of facial palsy, the ratio of the male-left was 27.6%(70 cases), female-left was 24.4%(62cases), male-right was 23.2%(59 cases), female-right was 24.8%(63 cases). 3. In distribution of contributing frequence in month, January was the most in number(29 cases, 11.4%), In distribution of contributing number in season winter was the most in number(76 cases, 29.9%). 4. In distribution of physical condition, fatigue(99 cases, 40.0%), stress(66 cases 26.0%), cold exposure(43 cases, 16.9%) were investigated highly than other conditions. 5. In distribution of attended symptoms, stylomastoid pain(91 cases, 35.8%), tears(40 cases 15.7%). taste paralysis(29 cases, 11.4%) were investigated highly than other symptoms. 6. In distribution of the period before admission in descending order the first under the third day was the most number in 92 cases(62.2%), over two weeks 22 cases(14.9%) 7. In distribution of the period of treatment, over eight weeks was the most number in 91 cases(35.8%), under a week in 50 cases(19.7%). In distribution of the times of treatment under five times was the most number in 56 cases(14.2%). 8. In distribution of the point of the recovery, under two weeks was the most number in 77 cases(52%).

• Maxillofacial Plastic and Reconstructive Surgery
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• v.12 no.1
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• pp.82-95
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• 1990

A clinico-statistical study was made of 237 case, 186 male and 51 female of oral and maxillofacial malignant cancer patients at Presbyterian Medical Center in Chon-ju between 1984 January and 1988 December. In 204 cases of the carcinoma, 154 cases were pathologically diagnosed as squamous cell carcinoma. More than 65% of the cases were clinically adbanced cases (stage III or IV), and 154 cases of 237 cases were treated. Most cases were treated by surgery (S)+radiation (R)+chemotherapy (C) or S+R or R+C. The expired cases were 20 cases. 11 cases of them were found in stage III.

• Journal of Chest Surgery
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• v.23 no.1
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• pp.152-157
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• 1990

A clinical study for thymectomy for 23 patients in Myasthenia Gravis was done between May, 1982 and July, 1989. at the department of Thoracic and Cardiovascular Surgery, College of Medicine, Han Yang University. Among Z3 patients, male to female ratio was 11: 12 and Age of onset was ranged from 15 years-old to 52 years-old. Previous symptom duration from diagnosis until operation was ranged from 2 months to 96 months, and Mean duration was 28.74 months. The severity of disease was classified by Osserman`s classification preoperatively. In histopathology of thymus, Thymic hyperplasia 7 cases, Thymoma 7 cases, Invasive thymoma 3 cases, Within Normal Limit 5 cases, and Thymic Atrophy 1 case. Correlation between preoperative symptom duration and postoperative clinical course was statistically significant. The shorter of preoperative symptom duration, The better of postoperative clinical course. Grading of postoperative course was classified by Papatestas in 1975. Follow-up for postoperative course was ranged from 3 months to 7 year and 4 months, Cases of complete remission 1 year postoperative period were 9 cases and cases of Improvement were 8 cases, So totally 17 cases among 23 cases[73.91%] found good results.

• Journal of Gastric Cancer
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• v.3 no.3
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• pp.145-150
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• 2003

Purpose: The p53 tumor suppressor gene is believed to play a pivotal role in preventing the uncontrolled cellular growth characteristic of cancer. Mutation of the p53 gene represent one of the most common genetic alterations in human cancers, and the acquisition of such defects is strongly associated with tumor progression and metastasis. The aim of this study was to evaluate the relation between p53 immunoreactivity and the mutation of p53 gene in gastric adenocarcinoma obtained by laser capture microscope. Materials and Methods: Formalin fixed paraffin embedded tissue specimens were obtained from 20 patients who underwent surgery for gastric cancer. According to UICC TNM system, 3 of the cases were Ia, 2 cases II, 4 cases IIIa, 5 cases IIIb, and 6 cases IV. Results: Immunohistochemical staining revealed eight cases as negative (less than $10\%$), twelve cases as postive (more than $10\%$). The locations of mutations were as follows; 7 cases had point mutation at exon 4, and 3 cases point mutation at exon 8. There was no mutation at exon 5, 6, 7 and 9. The mutation was observed in 1 case out of 8 p53 oncoprotein negative cases, and 7 cases out of 12 p53 positive cases. The mutation was more common in p53 positive cases (P<0.05), However, there was no significant correlation between p53 mutation observed by DNA sequencing after laser capture microdissection and expression of p53 oncoprotein. Conclusion: These result suggest that he expression of p53 oncoprotein not to be related to the mutation of p53 gene at exons 4 through 9 in gastric cancer.

• Korean Journal of Head & Neck Oncology
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• v.9 no.2
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• pp.234-243
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• 1993

The thyroid nodules are the most common endocrine disease requiring surgical management. Up to date, various diagnostic techniques and surgical management have been developed. Authors analysed 2285 cases of thyroid nodules who were treated at Department of Surgery, Pusan National University for the duration of 10 years from January 1980 to December 1989 and the results obtained were summerized as follows: 1) Patients were composed of 1727 cases(75.8%) of benign nodule and 558 cases(24.5%) of malignant nodule. Benign nodule was prevalent in forth and fifth decade comparing with malignant nodule was sixth and fifth decade. The sexual distribution revealed female preponderance with 1:10.8 in benign nodule and 1:9.3 in malignant nodule. 2) The histopathologic classfication of benign nodule in decreasing order of frequency were follicular adenoma 1009 cases(54.8%), adenomatous goiter 573 cases(33.3%), simple cyst 65 cases(3.8%), and Hashimoto's thyroiditis 52 cases(3.0%). The malignant disease were papillary adenocarcinoma 460 cases(82.4%), follicular adenocarcinoma 69 cases(12.4%), undifferentiated carcinoma 13 cases (2.0%), and medullary carcinoma 7 cases(1.0%). 3) Fine needle aspiration cytology was performed in 1758 cases and it showed 80.5% of sensitivity, 96.5% of specificity, 19.5% of false negative and 80% of accuracy. 4) The location of nodule was 87.7%, in unilateral, 12.2% in bilateral. 5) On the radioiodine scanning, the incidence of benign nodule with cold nodule was 83.9% and the incidence of benign nodule with hot nodule was 7.5%. The incidence of thyroid carcinoma with cold nodule was 88.3% and the incidence of thyroid carcinoma with hot nodule was 4.6%. 6) Most cases of benign nodules were treated with lobectomy 82.6%, subtotal thyroidectomy 10.1% and subtotal lobectomy 3.0%. Malignant nodules were treated with lobectomy and/or isthmusectomy 37.6%, total thyroidectomy 17.7%, subtotal thyroidectomy 15.4%, and any thyroidectomy and neck dissection 13.5%. 7) Postoperative complications were developed in 3.8% of benign nodules and 13.8% of malignant nodules.

• Journal of Chest Surgery
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• v.14 no.4
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• pp.369-380
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• 1981

In this department 504 cases of valve replacement were done since 1968 to the end of October 1981. Since October 31, 1978 to the end of October 1981 ,333 Ionescu-Shiley bovine pericardial xenograft bioprosthetic cardiac valves were replaced in 265 patients. There were 149 males and 116 female. Ages ranged from 2 to 63 years with 25 cases under 15 years of age. Among 265 cases of Ionescu valve replacement there were 157 MVR, 36 VAR, 6 TVR, 45 MVR+ AVR, 16 MVR+TVR and 5 MVR+AVR+TVR cases with mortality of 5.7%, 8.3%, 16.7%, 8.9%, 18.8% and 20% for each group respectively. Over all mortality rate in 265 Ionescu valve replacement cases was 7.9% with 21 total deaths. Main causes of operative deaths were due to LCOS in 7, bleeding in 5, arrhythmia in 3, air embolism in 2,and heart block in 2 cases. There were 12 late complications with 6 deaths. Over all long-term survival rate was 89.8%. MVR showed the highest long-term survival rate with 92.4%, and MVR+AVR+TVR the lower with 80% lower with 80%.Average follow-up period was 14 month duration. Twenty five congenital anomaly cases were operated with Ionescu-valve replacement that consisted of 7 VSD+AI, and 5 Ebstein anomaly cases with over all operative mortality of 16% and late mortality of 14.3% among 21 operative survivors. There were 25 Ionescu valve replacement cases in pediatric patients under the age of 15 years, with 4 operative deaths. Fourteen MVR, 7 AVR, and 3 TVR cases were found. Even though long-term follow-up study was short in postoperative period with total of 33~.0 months among 244 operative survivors ranging one to 36 months, the late survivors showed beneficial long-term results two thromboembolic episodes in 244 patients were found. More cases and longer term follow-up study are warranted for valve replacement in pediatric and TVR cases with Ionescu-valves which have advantageous hemodynamic structures compared with other bio-prosthetic heart valves.