• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.75-82
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• 2010

Specific diseases like cancer and acquired immune deficiency syndrome (AIDS) occur at various organs including lymphatics and spread through lymphatic system. Thus, if therapeutic agents for such diseases are more distributed or targeted to lymphatic system, we can obtain several advantages like reduction of systemic side effect and increase of efficacy. For these reasons, much interest has been focused on the nature of lymphatics and a lot of studies for lymphatic delivery of drugs have been carried out. Because lymphatics consist of single layer endothelium and have high permeability compared with blood capillaries, especially, the studies using nano-sized carriers have been performed. Polymeric nano-particle, liposome, and lipid-based vehicle have been adopted for lymphatic delivery as carriers. According to the administration route and the kind of carrier, the extent of lymphatic delivery efficiency of nano-sized carriers has been changed and influenced by several factors such as size, charge, hydrophobicity and surface feature of carrier. In this review, we summarized the key factors which affect lymphatic uptake and the major features of carriers for achieving the lymphatic delivery. Lymphatic delivery of drug using nano-sized carriers has many fold improved ability of lymphatic delivery compared with that of conventional dosage forms, but it has not shown whole lymph selectivity yet. Even though nano-sized carriers still have the potential and worth to study as lymphatic drug delivery technology as before, full understanding of delivery mechanism and influencing factors, and setting of pharmacokinetic model are required for more ideal lymphatic delivery of drug.

• Journal of the Korean Solar Energy Society
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• v.34 no.4
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• pp.23-29
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• 2014

Recently, in power system studies, Multiple Energy Carriers (MECs) such as Energy Hub has been broadly utilized in power system planners and operators. Particularly, Energy Hub performs one of the most important role as the intermediate in implementing the MECs. However, it still needs to be put under examination in both modeling and operating concerns. For instance, a probabilistic optimization model is treated by a robust global optimization technique such as multi-agent genetic algorithm (MAGA) which can support the online economic dispatch of MECs. MAGA also reduces the inevitable uncertainty caused by the integration of selected input energy carriers. However, MAGA only considers current state of the integration of selected input energy carriers in conjunctive with the condition of smart grid environments for decision making in Energy Hub. Thus, in this paper, we propose an immune algorithm based Multiple Energy Carriers System which can adopt the learning process in order to make a self decision making in Energy Hub. In particular, the proposed immune algorithm considers the previous state, the current state, and the future state of the selected input energy carriers in order to predict the next decision making of Energy Hub based on the probabilistic optimization model. The below figure shows the proposed immune algorithm based Multiple Energy Carriers System. Finally, we will compare the online economic dispatch of MECs of two algorithms such as MAGA and immune algorithm based MECs by using Real Time Digital Simulator (RTDS).

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.16
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• pp.155-181
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• 2001

International Trade has led to the increase of the demand of international transport, and also the development of international transport not only incurs claims concerning transportation but also establishes various international rules to settle the claims between the shippers and carriers incurred in the course of transport. With a view to settling the claims successfully, the men who are concerned in the transport have to know the principle and scopes of carrier's liability. In this paper, I would like to find out the scopes of liability of multimodal carriers based on the principles of liability. In order to perform the purpose of this study, I classify the liability principle of the international carrier under the UNs Convention on International Multimodal Transport of Good(1980) and UNCTDAD/ICC Rules(1991) in three system-Network Liability System, Uniform Liability System and Modified Liability System. And that I show the results-the scopes of multimodal carriers' liability based on the UN's Multimodal Convention(1980) and the ICC/UNCTAD Rules(1991), and transport vehicles.

• Journal of the Korean Institute of Navigation
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• v.23 no.3
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• pp.17-28
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• 1999

Concerns related to the safety of bulk carriers we, most of all, the increasing number of bulk carrier accidents which amount to 425 during last 20 years; half of them are totally lost. A number of bulk tarriers are still missing. Bulk carrier safety has become an international issue since 1995. The International Maritime Organization (IMO) embarked on the legislation as a countermeasure to the increasing number of the bulk carrier accidents. The IMO discussed in the safety of bulk carriers including the strength of transverse watertight bulkheads, especially when the ship carries high density cargoes and the damage stability of bulk carriers in the flooded condition. In this study, statistics and causes of accidents of bulk carriers are analyzed in order to identify special features of bulk carrier accident and causes of the casualty. This study examines certain cases of hull collapses and severence which resulted in sinking to infer possible causes of missing ships.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.10a
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• pp.34-37
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• 2005

While all-aluminum front end carriers have been frequently used by major foreign auto-makers, the carriers domestically produced are typically hybrid types. It is understood that higher fuel efficiency due to weight reduction can be achieved by using aluminum carriers because of aluminum's light weight. Moreover, aluminum is expected to posess high corrosion resistance and recyling rate. As a first step to enhance feasibility of domestic production of all-aluminum carriers, several carriers made by advanced auto makers are examined and compared. Besides basic characteristics such as appearance and weight, physical properties including composition, strength and elongation are carefully analyzed to obtain critical design and process factors.

• Journal of agricultural medicine and community health
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• v.17 no.2
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• pp.129-136
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• 1992

To evaluate the possible route of intrafamilial transmission among carriers of hepatitis B surface antigen ($HB_sAg$), epidemiologic and serologic data were obtained on 107 household contacts of 35 carriers of HBsAg and on 71 household contacts of 25 controls who were negative for serologic markers of hepatitis B virus. The HBsAg prevalence was 26.5% among the contacts of carriers compared to 0.0% among the contacts of controls. And the combined prevalence for all hepatitis markers was 48.5% among the contacts of carriers compared to 26.0% among the contacts of controls(p<0.05). Especially the offspring of carriers showed significantly higher risk in the combined prevalence for all hepatitis markers (p<0.05). There were no significant relationship between HBV infection and past history like acupuncture, transfusion, operation and tattooed. Factors associated with the risk of intrafamilial transmission of HBV were not found in the sharing of household articles such as razor, towel, drinking glass, nail clippers, toothbrush and tableware.

• Journal of Distribution Science
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• v.11 no.12
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• pp.39-49
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• 2013

Purpose - This study attempts to examine the underlying dimensions of service quality (tangibility, reliability, responsiveness, assurance, and empathy) for low-cost carriers. It subsequently seeks to determine the effect of the relationships of the dimensions of service quality, airline image, and behavioral intentions on airline services to provide adequate basic information and attributes for developing differentiated and competitive service marketing strategies. Research design, data, and methodology - The survey for this study was conducted on patrons with low-cost carrier boarding experiences in districts near universities and central businesses of Seoul and Busan from 5/10/2012 to 16/10/2012. Out of 346 questionnaires, 20 questionnaires with missing data and insincere answers were excluded for this study. Collected data were processed using SPSS 18.0, and the hypothesis was verified by analyzing the structural equation model with Lisrel 8.54. First, the frequency analysis was conducted to identify universal characteristics. Second, the exploratory factor analysis and reliability analysis were conducted to identify the accuracy of the variable measurements of the construct. Third, to assess uni-dimensionality and reliability, confirmatory factor analysis was conducted. Finally, to verify the adequacy of the research model and research hypothesis, the structural model was employed. Results - The results revealed that the factors, "tangibility, reliability, responsiveness, assurance, and empathy" were shown to be the most important dimensions of service quality for the airline image of the low-cost carrier which was consistent with previous studies. Therefore, it is fair to suggest that these verified factors are crucial attributes for the brand image of low-cost carriers. Second, as reliability and responsiveness were shown to be the most important factors for behavioral intentions, it is viable to suggest that these two attributes are crucial for the sales value of low-cost carriers. Further, it was found that the brand image of low-cost carriers was closely related to behavioral intentions. Therefore, in order to ensure the competitiveness and loyalty of patrons, the airline image value is a crucial attribute. Conclusions - The result of this study established that service quality is the most important attribute for marketing to ensure competitiveness, and intensive and differentiated service marketing play a crucial role in creating profits for low-cost carrier companies. First, as tangibility is found to be the most crucial factor in ensuring service quality, quality control and maintenance of medium and small carriers must be provided to ensure reliability, as they are the main attributes of low-cost carriers. Second, in order to promote positive behavioral intentions, it is essential to enhance the value of airline image. Third, in order to ensure competitiveness, it is imperative to carry out intensive and differentiated service marketing. Therefore, to promote the image of low-cost carriers and enhance behavioral intentions, the level of service quality must be secured by developing appropriate service improvement programs.

• Korea Trade Review
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• v.43 no.3
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• pp.125-145
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• 2018

The Baltic Shipping Exchange is reporting the Baltic Dry Index (BDI) which represents the average charter rate for bulk carriers transporting major cargoes such as iron ore, coal, grain, and so on. And the current BDI index is reflected in the proportion of capesize 40%, panamax 30% and spramax 30%. Like mentioned above, the capesize plays a major role among the various sizes of bulk carriers and this study is to analyze the influence of the factors influencing on charter rate of capesize carriers which transport iron ore and coal as the major cargoes. For this purpose, this study verified causality between variables using Vector Error Correction Model (VECM) and tried to derive a long-run equilibrium model between the dependent variable and independent variables. Regression analysis showed that every six independent variable has a significant effect on the capesize charter rate, even at the 1% level of significance. Charter rate decreases by 0.08% when capesize total fleet increases by 1%, charter rate increases by 0.04% when bunker oil price increases by 1%, and charter rate decreases by 0.01% when Yen/Dollar rate increases by 1%. And charter rate increases by 0.02% when global GDP increases by one unit (1%). In addition, the increase in cargo volume of iron ore and coal which are major transportation items of capesize carriers has also been shown to increase charter rates. Charter rate increases by 0.11% in case of 1% increase in iron ore cargo volume, and 0.09% in case of 1% increase in coal cargo volume. Although there have been some studies to analyze the influence of factors affecting the charterage of bulk carriers in the past, there have been few studies on the analysis of specific size vessels. At present moment when ship size is getting bigger, this study carried out research on capesize vessels, which are biggest among bulk carriers, and whose utilization is continuously increasing. This study is also expected to contribute to the establishment of trade policies for specific cargoes such as iron ore and coal.

• Bulletin of the Korean Chemical Society
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• v.32 no.5
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• pp.1465-1470
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• 2011

In this study, a poly(lactic-co-glycolic acid) (PLGA) microspheres was fabricated using emulsion solvent evaporation technique. During the procedure fabrication, some parameters process have effected on the formation of micro-carriers. The structure and morphology of micro-carriers were evaluated by SEM observation. Beside, heparin incorporated into microspheres was determined using toluidine blue method. Specifically, the effects of some parameters process such as ultrasonic levels, PLGA concentrations and freeze-dry times on the size, structure, porous formation and heparin entrapment of micro-carriers were studied carefully. We found that, the morphology and structure of carriers were influenced by the all above parameters. The diameter of the carriers varied from 20 to 400 ${\mu}M$ depending on experimental conditions. At suitable freeze-dry time, the pores were automatically formation on surface of microspheres with a significantly in the numbers of pore. After heparin incorporated porous PLGA microspheres, it was suggested that the highly heparin incorporated into porous PLGA microspheres could enhance of angiogenesis for tissue regeneration easily.

• Journal of the Society of Naval Architects of Korea
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• v.43 no.3 s.147
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• pp.331-339
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• 2006

The objective of this paper is to calculate the fatigue strength for upper deck hatch corner insert plate of large container carriers without wave load analysis and global finite element analysis at the initial design stage. Wave load analysis and global F.E. analysis for three container carriers have been performed by GL(Germanischer Lloyd) procedure to propose the equation for hatch corner stress range which is the important factor in fatigue strength calculation. Considering the restraining effect of bulkhead, three types of equation, that is, single tight bulkhead, double tight bulkhead and support bulkhead have been proposed. Using the proposed equations, a simplified fatigue analysis based on GL rules has been performed for two container carriers of which fatigue strength analysis was carried out by GL. From the comparison between fatigue strength result of using the proposed equations and that of GL, it has been found that proposed stress range equations are useful for scantling of upper deck hatch corner insert plates for over 8,000 TEU class container carriers.