• Journal of Chest Surgery
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• 제27권8호
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• pp.695-699
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• 1994

Pectus excavatum. the most common congenital chest wall deformity, is manifested by deformity of the costal cartilages resulting in a depressed and often rotated sternum. Surgical correction of this disease is frequently indicated for aesthetic improvement. The most popular current repair involves resection of abnormal costal cartilages, sternal osteotomy and mobilization, followed by fixation of the sternum in the corrected position.12 patients have been operated upon for pectus excavatum by the Adkins` method for 8 years in our hospital and the results were as follows: 1. All the patients were male. Age distribution was 2-26 years[average 10.8 years] and 69.2% were below 7 years. 2. The deformity was found at neonate or infant in the most of the patients [92.3 %] 3. The subjective symptoms were frequent URI[35.7%], dyspena on exertion[21.4%], chest dis comfort[7.1%], asthma [7.1%] and most of the patients didn`t like their appearance. 4. Combined diseases were urticaria in 2 cases, bilateral cryptomhism and pulmonary tuberculosis in 1 case each other. 5. Welch index ranged from 1.7 to 5.0 with the average of 3.47. 6. Postoperative complications were pneumothorax [45.5%], wound infection [36.4%] and skin necrosis [18.2%]. Although the period of follow-up was short in some cases there was no relapse.

• 한국잠사학회:학술대회논문집
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• 한국잠사학회 1997년도 Progress and Future Development of Sericultural Science and Technology 40th Anniversary Commemoration Symposium
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• pp.119-131
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• 1997

As the average span of human life is continuously increasing, especially the old aged groups, are suffering from various chronic and critical diseases e.g. cardiovascular diseases, coronary heart disease, diabetes, atherosclerosis and alzheimer's etc. However, effective and safe treatment methods have not yet been investigated threathening old aged groups. This research was planned to isolate compounds with the therapeutic potential for the above mentioned chronic diseases from the mulberry leaves. Biological screenings were carried out for the following categories; anti-atherogenic, anti-diabetic and antihypertensive effects. The results were as follows; Mulberry leaves, 20% $\alpha$-treated Gaelyrangppong showed significant 81% of blood glucose lowering effects in alloxan-induced hyperglycemic mice. Particularly, butanol-soluble fractions of mulberry leaves showed the more significant hypoglycemic activity than other fractions in alloxan induced hyperhlycemic mice. Also in the group given 1g/kg doses of extract of mulberry leaves, total cholesterol level was decreased significantly by as much as 49% in hyperlipidemia-induced rats. In Mulberry leaves post-treated group, the atheroscelosis index, HDL-cholesterol/Total-cholesterol, was increased significantly by as much as 91%.

• Journal of Animal Science and Technology
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• 제63권5호
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• pp.955-976
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• 2021

The aim of this study was to investigate the effects of dietary sodium nitrite and meat on human health. Sodium nitrite in processed meat is known to be one of the main precursors of carcinogens, such as N-nitroso compounds. However, we previously found that processed meat is not the primary source of sodium nitrite; nitrate or the conversion of nitrate in vegetables are contribute to generate more than 70% Sodium nitrite or nitrate containing compounds in body. Although the heavy consumption of meat is likely to cause various diseases, meat intake is not the only cause of colorectal cancer. Our review indicates that sodium nitrite derived from foods and endogenous nitric oxide may exhibit positive effects on human health, such as preventing cardiovascular disease or improving reproductive function. Therefore, further epidemiological studies considering various factors, such as cigarette consumption, alcohol consumption, stress index, salt intake, and genetic factors, are required to reliably elucidate the effects of dietary sodium nitrite and meat on the incidence of diseases, such as colorectal cancer.

• 한국보건간호학회지
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• 제33권1호
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• pp.20-32
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• 2019

Objectives: This study identified biopsychosocial factors associated with metabolic syndrome among Korean men and women aged over 40 years. Methods: Secondary data from the 2010-2016 Korean National Health and Nutrition Examination Survey were used for this study. Based on the biopsychosocial model, psychosocial factors (stress, depression, smoking, binge alcohol consumption, physical activity) were assessed with control of biomedical (age, body mass index, family history of hypertension, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease) and biosocial factors (educational level and economic status). Data from 8,624 men and 7,321 women were analyzed by logistic regression analysis using a complex sample procedure. Results: Among men, current or past smoking habits (Adjusted Odds Ratio [AOR]: 1.349; 95% Confidence Interval [CI]: 1.155-1.575, p<.001) and binge alcohol consumption (AOR: 1.570, CI: 1.389-1.774, p<.001) were associated with metabolic syndrome. In addition, moderate (AOR: 1.205, CI: 1.038-1.400, p=.014) and low levels of physical activity (AOR: 1.296, CI: 1.109-1.514, p=.001) were associated with metabolic syndrome. Among women, low level of physical activity (AOR: 1.276, CI: 1.017-1.602, p=.036) was associated with metabolic syndrome. Conclusion: Gender specific interventions such as encouraging physical activity and prevention of smoking and excessive alcohol drinking are important to prevention of metabolic syndrome.

• Imaging Science in Dentistry
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• 제53권4호
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• pp.283-289
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• 2023

The apnea-hypopnea index is widely regarded as a measure of the severity of obstructive sleep apnea (OSA), a condition characterized by recurrent episodes of apnea or hypopnea during sleep that induce airway collapse. OSA is a catastrophic problem due to the wide range of health issues it can cause, including cardiovascular disease and memory loss. This review was conducted to clarify the roles of various imaging modalities, particularly cone-beam computed tomography (CBCT), in the diagnosis of and preoperative planning for OSA. Unfortunately, 2-dimensional imaging techniques yield insufficient data for a comprehensive diagnosis, given the complex anatomy of the airway. Three-dimensional (3D) imaging is favored as it more accurately represents the patient's airway structure. Although computed tomography and magnetic resonance imaging can depict the actual 3D airway architecture, their use is limited by factors such as high radiation dose and noise associated with the scans. This review indicates that CBCT is a low-radiation imaging technique that can be used to incidentally identify patients with OSA, thereby facilitating early referral and ultimately enhancing the accuracy of surgical outcome predictions.

• 근관절건강학회지
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• 제31권1호
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• pp.53-63
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• 2024

Purpose: This study aimed to determine the prevalence of dizziness in adults and to identify factors associated with dizziness. Methods: This cross-sectional study used secondary data from the Eighth Korea National Health and Nutrition Examination Survey. Participants included 10,265 older adults aged≥40 years. Data were analyzed using descriptive statistics, the chi-squared test, and multinomial logistic regression with the SPSS/WIN 27.0 program. Results: The prevalence of dizziness was 26.2%, with 20.9% reporting episodic dizziness and 5.3% reporting chronic dizziness. Compared to that noted in the control group participants without dizziness, the risk of episodic or chronic dizziness was higher in women and in participants with older age, low education level, low income level, high perceived stress level, depression, tinnitus, and occupational noise exposure. Moreover, the risk of chronic dizziness was higher among those with a body mass index of <25 kg/m², stroke, cardiovascular disease, or severe hearing loss. Conclusion: The study underscores the need to comprehensively identify risk factors associated with dizziness and to develop interventions to prevent and manage the occurrence and chronicity of dizziness in the general population.

• Nutrition Research and Practice
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• 제18권1호
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• pp.78-87
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• 2024

BACKGROUND/OBJECTIVES: The prevalence of obesity, a worldwide pandemic, has been increasing steadily in Korea. Reports have shown that increased intermuscular adipose tissue (IMAT) is associated with an increased risk of cardiovascular disease, independent of body mass index. However, the relationship between dietary intake and IMAT accumulation in the Korean population remains undetermined. The objective of this study was to evaluate regional fat compartments using advanced magnetic resonance imaging (MRI) techniques. We also aimed to investigate the association between IMAT amounts and dietary intake, including carbohydrate intake, among Korean individuals with obesity. SUBJECTS/METHODS: This cross-sectional study, performed at a medical center in South Korea, recruited 35 individuals with obesity (15 men and 20 women) and classified them into 2 groups according to sex. Anthropometry was performed, and body fat distribution was measured using MRI. Blood parameters, including glucose and lipid profiles, were analyzed using commercial kits. Linear regression analysis was used to test whether the IMAT was associated with daily carbohydrate intake. RESULTS: Carbohydrate intake was positively associated with IMAT in all individuals, with adjustments for age, sex, height, and weight. No significant differences in blood indicators were found between the sexes. CONCLUSIONS: Regardless of sex and age, higher carbohydrate intake was strongly correlated with greater IMAT accumulation. This suggests the need to better understand sex differences and high carbohydrate diet patterns in relation to the association between obesity and metabolic risk, which may help reduce obesity prevalence.

• 대한임상검사과학회지
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• 제52권1호
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• pp.45-52
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• 2020

고혈압은 종종 심혈관 질환 및 신장 질환으로 이어지며 전 세계적으로 중요한 문제이다. 유전적으로 많은 단일 염기 다형성이 고혈압과 관련이 있다. 많은 GWAS 연구에서 ATP2B1 유전자가 혈압과 연관성이 높다는 것을 발견했다. 본 연구에서는 한국인 994명을 대상으로 수축기 혈압, 이완기 혈압과 ATP2B1 유전자의 SNP와 연관성을 분석하였다. 또한, BMI수치에 따라 하위그룹으로 계층화하여 차이가 있는지 확인하고자 하였다. 다중선형회귀분석에서 수축기 혈압 및 이완기 혈압과 가장 높은 통계적 유의성을 보인 SNP를 선정하였다. 수축기 혈압과 이완기 혈압에서의 one-way analysis of variance를 시행하였고, 고혈압 발생 위험에 대한 다중로지스틱회귀분석을 시행하였다. 다중로지스틱회귀분석은 연령 기준으로 구분하여 시행하였으며, 연령, BMI, 공복 시 혈당을 통제한 방법에서 비교하였다. 수축기 혈압에서는 4개의 SNP (rs10506974, rs7136259, rs17249754, rs17836882)가, 이완기 혈압에서는 6개의 SNP(rs10506974, rs10777237, rs7136259, rs17249754, rs1371075, rs10506983)가 유의하게 관련성을 보였다. 추가적으로, 유전자형(genotype)에 따른 분석에서는 남성에게서 고혈압 위험에 대한 유의한 odd ratio 값을 보였다. 본 연구는 ATP2B1 다형성이 수축기 혈압과 이완기 혈압에 영향을 미치는 것을 제안한다.

• Journal of Chest Surgery
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• 제40권1호
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• pp.45-51
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• 2007

배경: 좌심실 기능의 평가는 대개 심초음파를 이용하여 시행되고 있으나, 최근 개발된 16채널 Multi-detector 컴퓨터 단층촬영(MDCT)은 관상동맥에 대한 평가뿐만 아니라 좌심실 기능의 측정이 가능하다. 따라서 MDCT를 이용한 측정결과를 심초음파 결과와 비교분석하여 MDCT의 좌심실 기능 평가에 대한 임상적 적용 가능성을 조사해 보고자 하였다. 대상 및 방법: 2003년 11월 1일부터 2005년 1월 31일까지 본원에서 MDCT를 시행한 49명의 환자중 동일시기에 심초음파를 시행한 26명의 환자를 대상으로 하였다. 이완기말 좌심실 용적지수(LVEDVI), 수축기말 좌심실 용적지수(LVESVI), 심박출량지수(SVI), 좌심실 부피지수(LVMI) 및 심박출계수(EF)를 조사하였다. 결과: 평균이완기말 좌심실 용적지수($80.86{\pm}34.69mL$ for MDCT vs $60.23{\pm}29.06mL$ for Echocardiography, p<0.01), 평균수축기말 좌심실 용적지수($37.96{\pm}24.32mL$ for MDCT vs $25.68{\pm}16.57ml$ for Echocardiography, p<0.01), 평균심박출량지수($42.90{\pm}15.86mL$ for MDCT vs $34.54{\pm}17.94mL$ for Echocardiography, p<0.01), 평균좌심실 부피지수($72.14{\pm}25.35mL$ for MDCT vs $130.35{\pm}53.10mL$ for Echocardiography, p<0.01) 및 평균심박출계수($55.63{\pm}12.91mL$ for MDCT vs $59.95{\pm}12.75mL$ for Echocardiography, p<0.05)로 양군간에 유의한 차이를 보였으며, 평균이완기말 좌심실 용적지수, 평균수축기말 좌심실 용적지수, 평균심박출량지수는 MDCT군이 높게 나타났으며, 평균좌심실 부피지수, 평균심박출계수는 심초음파군이 높게 나타났다. 각 변수에서 양군의 상관관계를 보면, 이완기말 좌심실 용적지수$(r^2=0.74,\;p<0.0001)$, 수축기말 좌심실 용적지수$(r^2=0.69,\; p<0.0001)$, 심박출량지수$(r^2=0.55,\;p<0.0001)$는 높은 상관관계를 보였으며, 좌심실 부피지수$(r^2=0.84,\;p<0.0001)$는 아주 높은 상관관계를, 심박출계수$(r^2=0.45,\;p<0.0002)$는 다소 높은 상관관계를 나타내었다. 결론: 16채널 MDCT를 이용한 좌심실 용적 및 기능의 평가는 심초음파의 결과와 비교하여 높은 상관관계를 보여 유용한 검사방법으로 생각된다 그러나, 각 항목의 평균값에서는 유의한 차이를 보여 임상적 적용을 위하여는 양 검사의 절대적 결과치를 병용하여 사용할 수는 없을 것으로 생각되며, 향후 MDCT의 기술적 개발을 고려할 때 관상동맥 환자에 있어 관상동맥의 협착의 검사와 함께 좌심실 기능의 측정도 함께 간편하게 이루어질 수 있을 것으로 기대된다.

• 한방비만학회지
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• 제13권2호
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• pp.66-73
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• 2013

Objectives: The purpose of this study was to investigate the characteristics in elderly population with obesity by analyzing their blood test. Methods: Included 130 subjects of aged 60 or older went through body composition test, and blood test. We divided them into obesity group and normal group based on body mass index (BMI) results, and then the blood test results were compared between the groups. Results: Forty out of 130 subjects had BMI of 25 or more. Two groups showed significant difference in bilirubin total, alanine aminotransferase (ALT), cholesterol total, triglyceride, high density lipoprotein (HDL), red blood cell (RBC), hematocrite, mean corpuscular hemoglobin concentration, and platelet. All but HDL levels showed significantly higher results in obesity group than normal group. When compared with BMI, blood urea nitrogen, creatinine, ALT, cholesterol total, triglyceride, white blood cell (WBC), and RBC had significant positive correlations. Among those, cholesterol total, triglyceride, WBC, and RBC showed significant difference between two groups, with correlation to BMI. Especially, the average of triglyceride was higher than normal limit in obesity group, whereas it was lower than normal limit in normal group. Conclusions: Triglyceride, cholesterol total, WBC, and RBC are highly related to obese elderly in this study. Old people with obesity need to be careful of cardiovascular and metabolic disease that can be caused by these factors.