• Journal of Life Science
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• v.24 no.5
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• pp.573-587
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• 2014

Angiogenesis, the formation of new capillary blood vessels, is a tightly regulated process. Under normal physiological conditions, angiogenesis only takes place during embryonic development, wound healing, and female menstruation. Dysregulation of angiogenesis is associated with many diseases, such as cancer, rheumatoid arthritis, psoriasis, and proliferative retinopathy. The growth and expansion of adipose tissue require the formation of new blood vessels. Adipose tissue is probably the most highly vascularized tissue in the body, as each adipocyte is surrounded by capillaries, and the angiogenic vessels supply nutrients and oxygen to adipocytes. Accumulating evidence shows that capillary endothelial cells communicate with adipocytes via paracrine signaling pathways, extracellular components, and direct cell-cell interactions. Activated adipocytes produce multiple angiogenic factors, including VEGF, FGF-2, leptin, and HGF, which either alone or cooperatively stimulate the expansion and metabolism of adipose tissue by increasing adipose tissue vasculature. Recently, it was demonstrated that antiangiogenic herbal Ob-X extracts and Korean red ginseng extracts reduce adipose tissue mass and suppress obesity by inhibiting angiogenesis in obese mice. Thus, angiogenesis inhibitors provide a promising therapeutic approach for controlling human obesity and related disorders.

• Asian-Australasian Journal of Animal Sciences
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• v.32 no.8
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• pp.1172-1185
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• 2019

Objective: Meat quality attributes in postmortem muscle tissues depend on skeletal muscle metabolites. The objective of this study was to determine the key metabolic compounds and pathways that are associated with postmortem aging and beef quality in Japanese Black cattle (JB; a Japanese Wagyu breed with highly marbled beef). Methods: Lean portions of Longissimus thoracis (LT: loin) muscle in 3 JB steers were collected at 0, 1, and 14 days after slaughter. The metabolomic profiles of the samples were analyzed by capillary electrophoresis time-of-flight mass spectrometry, followed by statistical and multivariate analyses with bioinformatics resources. Results: Among the total 171 annotated compounds, the contents of gluconic acid, gluconolactone, spermidine, and the nutritionally vital substances (choline, thiamine, and nicotinamide) were elevated through the course of postmortem aging. The contents of glycolytic compounds increased along with the generation of lactic acid as the beef aging progressed. Moreover, the contents of several dipeptides and 16 amino acids, including glutamate and aromatic and branched-chain amino acids, were elevated over time, suggesting postmortem protein degradation in the muscle. Adenosine triphosphate degradation also progressed, resulting in the generation of inosine, xanthine, and hypoxanthine via the temporal increase in inosine 5'-monophosphate. Cysteine-glutathione disulfide, thiamine, and choline increased over time during the postmortem muscle aging. In the Kyoto encyclopedia of genes and genomes database, a bioinformatics resource, the postmortem metabolomic changes in LT muscle were characterized as pathways mainly related to protein digestion, glycolysis, citric acid cycle, pyruvate metabolism, pentose phosphate metabolism, nicotinamide metabolism, glycerophospholipid metabolism, purine metabolism, and glutathione metabolism. Conclusion: The compounds accumulating in aged beef were shown to be nutritionally vital substances and flavor components, as well as potential useful biomarkers of aging. The present metabolomic data during postmortem aging contribute to further understanding of the beef quality of JB and other breeds.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.369-369
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• 2012

The present work deals with selective deposition of copper on fluoropolymers patterned silicon (111) surfaces. The pattern of fluoropolymer was fabricated by nanoimprint lithography (NIL) and plasma reactive ion etching (RIE) was used to remove the residuals layers. Copper was electrochemically deposited in bare Si regions which were not covered with fluoropolymers. The patterns of fluoropolymers and copper have been investigated by scanning electron microscopy (SEM). In this work, we used two deposition methods. One is galvanic displacement method and another is electrodeposition. Selective deposition works in both cases and it shows applicability to other materials. By optimization of the deposition conditions can be achieved therefore this process represents a simple approach for a direct high resolution patterning of silicon surfaces.

• Architectural research
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• v.12 no.2
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• pp.93-98
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• 2010

This paper describes a numerical method for estimating the elastic moduli of cement paste. The cement paste is modeled as a unit cell which consists of three components: the unhydrated cement grain, the gel, and the capillary pore. In the unit cell, the volume fractions of the constituents are quantified using a single kinetic function calculating the degree of hydration. The elastic moduli of cement paste are calculated from the total displacements of constituents when a uniform pressure is applied to the gel contact area. The cement paste is assumed to be a homogenous isotropic matrix. Numerical simulations were conducted through the finite element analysis of the three-dimensional periodic unit cell. The model predictions are compared with experimental results. The predicted trends are in good agreement with experimental observations. This approach and some of the results might also be relevant for other technical applications.

• Korean Journal of Hydrosciences
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• v.4
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• pp.33-49
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• 1993

The Purpose of this study is to classify existing hysteresis models and to discuss a possibility of a new type of the hysteresis model. The existing hysteresis models are classified into three types: the interpolation model, the scaling model and the domain model, of which only domain model is to simulate hysteresis curves based on the theoretical approach, It is useful to develop a hysteresis model that requires only one branch of hysteresis curves for the model calibration because obtaining hysteresis curves by experiments is expensive and time-concept by many investigators, however their models are not successful to accurately simulate real data of Rubicon Sandy Loam and Dune Sand. There is a possibility that a new model is based on the dependent domain concept considering the weighting factor, $P_a$($\theta$), which accounts for the pore blockage effect against air entry. Conclusively, a new model where the weighting factor $P_a$($\theta$) in Model III-1 (Mualem, 1984) reduces to a known variable through an appropriate method is an alternative model which required only one branch of main curves for the model calibration.

• Korea-Australia Rheology Journal
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• v.16 no.4
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• pp.227-233
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• 2004

Simplified model of slide-fed curtain coating flow has been developed and tested in this study. It rests on the sheet profile equations for curtain thickness in curtain flow and its trajectory derived by the integral momentum balance approach of Higgins and Scriven (1979) and Kistler (1983). It also draws on the film profile equation of film thickness variation in flow down a slide. The equations have been solved in finite difference approximation by Newton iteration with continuation. The results show that how inertia (Rey­nolds number), surface tension (capillary number), inclination angle of the slide, and air pressure difference across the curtain affect sheet trajectory and thickness profile. It has been revealed that approximate models can be useful to easily analyze coating flow dynamics without complex computations, giving qualitative agreement with full theory and with experiment.

• Proceedings of the Korea Water Resources Association Conference
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• 1991.07a
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• pp.221-230
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• 1991

Various Models of the moisture content-capillary pressure hysteresie based on the approach of domain concept in porous media are compared with each other, Model III-1(Mualem, 1984) is superio to others as expected. A new model based on Model III-1 is proposed of which asuumption is the linearization of P$$($\theta$) accounting for the pore blockage effect against air-entry. The feature of this model is that only one branch of boundary curve is needed to calibrate it, which is the advantage to Model III-1. The prediction of boundary drying curve from boundary wetting curve using this model is better than that using Model I-1, II-1 compared with the experimental data. This model is to simulate scanning curves, while Model I-1, II-1 is not.

• Korea-Australia Rheology Journal
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• v.15 no.1
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• pp.1-7
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• 2003

A new method is introduced to build up organic/organic multilayer films composed of cationic poly(allylamine hydrochloride) (PAH) and negatively charged poly (sodium 4-styrenesulfonate) (PSS) using the spinning process. The adsorption process is governed by both the viscous force induced by fast solvent elimination and the electrostatic interaction between oppositely charged species. On the other hand, the centrifugal and air shear forces applied by the spinning process significantly enhances desorption of weakly bound polyelectrolyte chains and also induce the planarization of the adsorbed polyelectrolyte layer. The film thickness per bilayer adsorbed by the conventional dipping process and the spinning process was found to be about 4 ${\AA}$ and 24 ${\AA}$, respectively. The surface of the multilayer films prepared with the spinning process is quite homogeneous and smooth. Also, a new approach to create multilayer ultrathin films with well-defined micropatterns in a short process time is Introduced. To achieve such micropatterns with high line resolution in organic multilayer films, microfluidic channels were combined with the convective self-assembly process employing both hydrogen bonding and electrostatic intermolecular interactions. The channels were initially filled with polymer solution by capillary pressure and the residual solution was then removed by the .spinning process.

• Water for future
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• v.25 no.3
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• pp.65-77
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• 1992

The purpose of this study is to analyse existing hysteresis models and to propose a new type of model. The existing hysteresis models are classified by three types: interpolation model, scaling model and domain model, of which the domain model is based on the theoretical approach. Models which need one branch of hysteresis loop for calibration are developed based on the independent domain concept, however, they are not successful to accurately simulate the real data and Rubicon Sandy Loam and Dune Sand. There is a possibility that a new model is based on the dependent domain model considering the pore blockage effect against air entry for homogeneous porous media(modelIII-1, Mualem, 1984). Concludingly, a new type of hysteresis model is proposed by simplifying ModelIII-1 using a proper assumption.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.26 no.1
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• pp.45-54
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• 2002

The breakup phenomena of a vertical laminar jet issuing from capillary tubes in a quiescent ambient air are investigated using a forced vibration analysis of the surface wave. Using a linear approach to the transient jet velocity, an approximate solution fur the longitudinal motion of a vertical liquid jet is theoretically derived, thus performing an instability analysis by a vibration method. The damping term of this equation is nonlinear as it depends on dimensionless parameters, a Weber number, and an Ohnesorge number. The instability condition is determined based on whether the coefficient of the damping term is less than zero or not. Uniform drop formation is dependent on the vibration frequency fur the forced vibration case.