• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.2-6
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• 2006

Ever since the foundation of the Korean Society for Preventive Medicine in 1947, members of the Society had made remarkable contributions to the public health development and national health promotion. They had played key roles in establishing national health system, improving environmental hygiene, controlling infectious and chronic diseases, promoting family planning, improving industrial and environmental health, and developing health service management. However, the Society had less actively responded to the changes in health service needs of the population that were caused by a rapid epidemiologic transition in last a few decades. Early detection and treatment of chronic diseases including cancer and cardiovascular diseases and risk reduction by the life style modification are major approaches to the contemporary national health problems and they are the core contents of preventive medicine. The author proposed to develop the clinical preventive medicine specialist who will have additional training in clinical medicine for health screening and life style modification to the current preventive medicine training program and thus will be able to provide comprehensive preventive medical services. Another area that the Society may take the initiative is training preventive medicine specialist in the disaster, including bioterrorism, preparedness and management. The Society should be more active in proposing health policy and health service program and also participate collectively in a large scale health research project of the government. These approaches may not only contribute more effectively to the national health promotion but also improve the identity of the Society.

• Journal of Multimedia Information System
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• 제6권2호
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• pp.81-86
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• 2019

Deep learning is emerging as one of the best tool in processing data related to medical imaging. In our research work, we have proposed a deep learning based framework CNN (Convolutional Neural Network) for the classification of dysplastic tissue images. The CNN has classified the given images into 4 different classes namely normal tissue, mild dysplastic tissue, moderate dysplastic tissue and severe dysplastic tissue. The dataset under taken for the study consists of 672 tissue images of epithelial squamous layer of oral cavity captured out of the biopsy samples of 52 patients. After applying the data pre-processing and augmentation on the given dataset, 2688 images were created. Further, these 2688 images were classified into 4 categories with the help of expert Oral Pathologist. The classified data was supplied to the convolutional neural network for training and testing of the proposed framework. It has been observed that training data shows 91.65% accuracy whereas the testing data achieves 89.3% accuracy. The results produced by our proposed framework are also tested and validated by comparing the manual results produced by the medical experts working in this area.

• Imaging Science in Dentistry
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• 제54권2호
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• pp.211-220
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• 2024

Non-secretory multiple myeloma (NSMM) is a rare cancer of plasma cells characterized by the absence of detectable monoclonal M protein in the blood or urine. A 57-year-old woman presented with mandibular pain but without intraoral swelling. Imaging studies revealed multiple osteolytic lesions in her mandible and pronounced root resorption of the left mandibular second molar. Biopsy results showed atypical plasmacytoid cells positive for anti-kappa, CD138, MUM1, and CD79a antibodies, but negative for anti-lambda and CD20. These results were indicative of a malignant plasma cell neoplasm. No abnormalities were revealed by free light chain assay or by serum or urine protein electrophoresis, leading to a diagnosis of NSMM. The patient began chemotherapy in conjunction with bisphosphonate therapy and achieved remission following treatment. This case underscores the critical role of dentists in the early detection and prevention of NSMM complications, as the disease can initially present in the oral cavity.

• 대한영상의학회지
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• 제85권4호
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• pp.727-745
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• 2024

대장과 직장 수술 후 영상 검사는 수술 후 생기는 합병증과 특정 질환의 재발을 발견하는 데 있어 중요한 역할을 한다. 이 임상화보에서는 개략적인 대장과 직장 수술 방법, 영상 기법, 수술 후 조기 및 후기 합병증의 특징적 영상 소견, 암 재발 또는 염증성 대장 질환의 특징적 영상 소견에 대해서 다룰 것이다.

• Journal of Chest Surgery
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• 제20권1호
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• pp.81-91
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• 1987

During the period of 10 years from July, 1976 to July, 1986, 154 cases of primary carcinoma of the lung - by the cell type, stage, operability, and survival rate in the resectable cases - are analyzed at the Dept. of Thoracic Surgery, Paik Hospital in Seoul. The results are as follows: 1] Histopathological types are squamous cell carcinoma 49% [76 cases], adenocarcinoma 25% [39 cases], undifferentiated large cell carcinoma 9% [14 cases], undifferentiated small cell carcinoma 6% [9 cases], bronchioloalveolar carcinoma 4% [6 cases] and adenosquamous carcinoma 3% [4 cases]. 2] Peak incidence is observed in the 4th decade of life [33%], then 5th [29%] and 3rd [21%] respectively. Male to female ratio is 4 to 1. 3] Evidence of inoperability is observed in 64% [99 cases] by clinical staging workup. Thirty six percent [55 cases] were operated. Of these, post-surgical stage I was 5% [3 cases], stage II, 64% [35 cases] and stage III, 31% [17 cases]. Among total 17 cases of stage III, 14 cases were unresectable with evidence of T2N2M0, while 3 cases were resectable. Resectability is 27%, [41 cases] from the total number of 154 cases. And the resectability for the ex 55 cases is 75% [41 cases]. 4] By cell type, highest resectabitity is the squamous cell carcinoma, 49% [20 cases]. Adenocarcinoma is 32% [13 cases] and bronchioloalveolar, 12% [5 cases]. 5] Survival rate is evaluated for 38 cases of 41 resectable stage I, II and III. Overall 5 year survival rate is 24%, 3 year 32% and 10 year 8%. Survival rate in stage II for 5 year is 25%. In squamous cell type for, 5 year is 42%. Authors believe when surgeons continuous effort of early detection is met with patients early visit, 5 year survival rate for the stage I K II resectable patients will improve more effectively. As well, When the efforts are added to combined modality with radiotherapy and chemotherapy for the stage III selected cases of non-small cell carcinoma patients, the enhancement in survival rate is expected.

• 한국의학물리학회지:의학물리
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• 제20권1호
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• pp.21-29
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• 2009

유방암은 우리나라 여성에게 발생하는 암 중에서 발병률이 높은 암이다. 따라서 유방자가진단, 임상적 검사, 유방 X선촬영 등과 같은 유방암 초기 검출검사는 중요하다. 이들 중 유방 X선촬영은 무자각증상 시기에 유방암 초기 검출을 위해 40대 이상의 여성들에게 매년마다 시행하기를 권고하고 있다. 그러나 유방의 유선조직은 방사선 민감성 조직이다. 이에 유방 X선촬영장치의 평가 중 평균 유선선량 측정은 매우 중요한 부분이 된다. 평균 유선선량의 직접측정은 어렵기 때문에 incident air kerma 측정, 적절한 변환계수 등을 적용하여 계산하게 된다. 따라서 본 연구의 첫 번째 목적은 평균 유선선량의 측정 방법의 표준화이다. 두 번째는 몬테칼로 시뮬레이션을 이용하여 평균 유선선량과 유방 실질양상 및 두께와 의 상관관계를 분석하고자 했다. 본 연구 결과, IAEA 가이드라인(CoP)에 따라 평균 유선선량 측정방법을 제시하였다. 전반적으로 우리나라는 유방촬영 시 받는 평균 유선선량이 식품의약품안전청 및 한국의료영상품질관리원에서 제시하는 3mGy 이하로 측정되었다. 측정된 평균 유선선량과 시뮬레이션된 평균 유선선량은 각각 1.7과 1.6 mGy로 큰 차이를 보이지 않았다. 시뮬레이션된 평균 유선선량은 주로 유방의 유선조직의 비율에 따라 의존한다. 유방의 glandularity 증가에 따라 낮은 에너지의 광자의 흡수가 증가하여 평균 유선선량도 증가하였다. 또한 유방의 두께가 두꺼울수록 평균 유선선량은 증가하였다. 결과적으로, 본 연구는 유방촬영의 진단 참고준위 확립을 위한 기초자료로 활용될 것이다.

• 대한후두음성언어의학회지
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• 제29권2호
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• pp.98-102
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• 2018

Background and Objectives : Detection of vascular abnormalities in vocal cord (VC) leukoplakia is important for the diagnosis of neoplastic change of the mucosa. The aim of this study was to investigate the value of i-scan in the differential diagnosis of VC leukoplakia based on visualization of abnormal vascular features. Material and Methods : Fifty-two patients with leukoplakia were enrolled in the study. Images of their larynx obtained using conventional white light endoscopy and an i-scan-enhanced endoscopy (Pentax DEFINA EPK-3000 Video Processors, with Pentax VNLJ10) were reviewed. The microvascular features of the lesions and vascular changes were analyzed and the results were compared with the histopathologic diagnosis. Results : Among the 52 leukoplakia patients, 7 (13.5%) patients had squamous hyperplasia, 10 (19.3%) mild dysplasia, 2 (3.8%) moderate dysplasia, 14 (26.9%) severe dysplasia, 4 (7.7%) carcinoma in situ, and 15 (28.8%) invasive squamous cell carcinoma on histopathologic examination. Using i-scan-enhanced endoscopy, abnormal vascular change with neoplastic neoangiogenesis was detected in most cases of malignant VC lesion [severe dysplasia : 9/14 (64.3%), carcinoma in situ: 2/4 (50.0%), and invasive squamous cell carcinoma : 11/15 (73.4%)]. Conclusion : i-scan-enhanced endoscopy is a useful optical technique for the diagnosis of VC leukoplakia. Our results suggest that i-scan may be a promising diagnostic tool in the early detection of laryngeal cancer.

• Journal of Gastric Cancer
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• 제8권2호
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• pp.91-96
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• 2008

목적: 최근 내시경 및 각종 영상진단 기술의 발달로 위암의 조기 발견 및 수술 전 병기의 진단율이 높아지고 있으나 여전히 초진 시 진행 위암 상태로 진단되는 경우가 많고 개복 수술 후 병리조직 검사에서 4기 위암으로 진단이 되는 경우도 있다. 4기 위암은 예후가 극히 불량하지만 임상 분석을 통해 적극적인 치료 효과에 대한 의의를 찾아 보고자 본 연구를 시행하였다. 대상 및 방법: 1994년 1월부터 2006년 12월까지 위암으로 진단되어 개복수술을 받은 1,376명의 환자들 중 4기 위암으로 진단된 150명의 환자를 대상으로 후향적 연구를 시행하였다. 결과: 개복술을 시행 받은 4기 위암환자 150명의 평균 나이는 57.8세(28~93세)였으며 이 중 남자가 104명, 여자가 46명이었다. 119명은 위아전절제술 또는 위전절제술을 시행하였으며 31명은 절제 불가하였다. 절제술을 시행한 환자의 생존기간은 평균 722일(14일~4,559일)로 그렇지 않은 환자의 173일(16일~374일)과 통계적으로 유의한 차이를 보였다. 위절제술을 시행한 4기 위암 환자를 TNM 병기로 세분하였을 때 T4 환자들은 33명으로 평균 생존일은 534일(17일~3,378일)이었으며, N3 환자들은 63명으로 평균 생존일은 521일(14일~4,190일)이었으나 통계적 의미는 없었다. 항암화학요법을 시행한 환자는 98명이었고 52명에 대해서는 항암화학요법을 시행하지 않았으며 생존기간은 각각 792일, 243일로 통계적으로 의미 있는 차이를 보였다. 결론: 4기 위암에 대해서도 원격 장기 전이의 증거가 없는 한 확대 림프절제술을 포함한 근치적 위절제술과 항암화학요법 등 적극적인 치료를 시도함으로써 생존율의 향상을 기대할 수 있다.

• Journal of Chest Surgery
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• 제37권3호
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• pp.261-266
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• 2004

식도암 환자에서 조기진단 및 수술적 치료 방법의 상당한 진전에도 불구하고 환자의 예후는 여전히 좋지 않다. p53 종양 억제유전자는 세포의 성장과 증식을 조절하는 것으로 알려져 있고 nm23 유전자는 설치류 흑색종에서 종양의 전이억제 효과가 있다고 알려져 있다. 이 실험은 p53과 nm23유전자 발현과 식도암 환자의 임상병리학적인 특징상의 관련성을 알아보고자 하였다. 가톨릭대학교 의과대학 부속 성모병원에서 수술한 식도암 환자 40명의 조직을 대상으로 하였고, p53 변이형 단백질과 nm23단백질을 면역화학적 염색을 시행하여 <10% 양성 종양세포 : negative ; 10∼30% 양성 종양세포: ＋; 30∼50% 양성 종양세포 : ＋＋; >50% 양성 종양세포: ＋＋＋의 4개의 군으로 분류하였고, 또한 종양의 침습 정도는 none, mild, moderate, severe로 분류하여 평가하였다. p53 변이형 단백질과 nm23 단백질의 과발현은 생존율 및 임상병리학적 특징과 연관성이 없었고, 또한 p53 및 nm23유전자 발현의 조합 분석에서도 유의한 상관관계를 발견하지 못하였다.

• 핵의학기술
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• 제19권2호
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• pp.102-107
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• 2015

Purpose Serum Thyroglobulin measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients. Thyroglobulin is Normal thyroid tissue, or thyroid cancer tissue produced only. Thyroid hormone to a halt without Tg differentiation of thyroid cancer recurrence just by measuring how to decide whether there was increasing expectations if I can do it instead. Therefore, in excellent sensitivity Tg new inspection of the functional sensitivity by measuring the looked to evaluate the usefulness of reagents. Thyroidectomy is measuring the numbers Tg (total thyroidectomy) remaining thyroid ablation and radioactive iodine (radioactive iodine remnant ablation, RRA) DTC in patients being diagnosed with or help predict the remaining early detection of thyroid cancer recurrence. Materials and Methods Agent that I'm currently using Tg of the measurements of low clinical specimen for a second drainage of the three (0.08 0.17, 0.98, ng/mL) within the scope of the dilute magnification (2, 4, 8, 16, 32 times) by dilute Intraassy (n=10) and Interassay (n=10) out in no time. Concentration value according to the coefficient of variation and the mean and standard deviation of each measurement (Coefficient of variation, CV) the absolute value of the measured values that corresponds to 20 percent target a coefficient of variation of CV Find the value of the concentration of the functional sensitivity measurement did. Also, analytical sensitivity with recovery rates, Dilution test inspections, and interrelationship, compared. Results Sensitivity is an excellent analytical sensitivity within the prosecutor kit Tg 0.006 ng/mL, and core analytical sensitivity, conducted by the 0.006 ng/mL to same conclusion. Be rather high to 142 percent recovery rate was 60 to measurement and functional sensitivity, 0.01766 ng/mL(Intraassay n=10) was measured at. CBC is relatively good correlation as ($R^2=0.949$) the correlation. Conclusion Recently ultrasensitive thyroglobulin this clinically important indicators of the previous kit and demands are lower than sensitivity to the measurement results. Therefore, ultrasensitive thyroglobulin test is correlated that there would be useful in value in nuclear medicine the thyroid gland.