• 제목/요약/키워드: burn test

검색결과 218건 처리시간 0.028초

화상 및 창상에 대한 자근.치자 복합제제의 경피 흡수 및 치료효과 (Transdermal Drug Delivery & Therapeutic Effect of the Preparations of Lithospermi Radix and Gardeniae Fructus Extracts on the Burn & Wound Healing)

  • 민동훈;김대근;임종필;양재헌
    • Journal of Pharmaceutical Investigation
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    • 제35권4호
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    • pp.255-263
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    • 2005
  • Research was undertaken to compare the pharmacological activity of Lithospermi radix (LR) reported as an oriental medicine for classical uses. LR contains naphthoquinone pigments : shikonin, acetylshikonin, isobutylshikonin, etc. LR is used for the treatment of excision wound, burn, eczema, blister, scarlatina and septicemia as antifebrile, antidotic and antiphlogistic. Gardeniae fructus (GF) has been used for the treatment to jaundice, hepatic disease, anti-inflammatory and analgesic effects, and it contains crocin, geniposide and its derivatives. The therapeutic effects of burn and excision wound healing from LR & GF hydrogel with $Nano-ATP^{\circledR}$ (GLN) were investigated. To evaluate the therapeutic value of various hydrogels, thermal burn model and excision wound mouse model were used. The burn and wound reduction rate and therapeutic period were measured to calculate the healing extent after 5 experiments. The 2nd degree burn was prepared on hairless mouse back skin and dressing with collagen. The burn and wound reduction rate of GLN hydrogel treated group decreased more rapidly than that of other gel group in animal model. Furthermore therapeutic periods of GLN hydrogel treated group was shorter than that of other gel group. In anti-inflammatory test, GLN hydrogel treated group decreased edema rapidly than that of other gel group. These results suggest that the GLN hydrogel treatment has an therapeutic effect on burn and excision wound healing.

Bee venom reduces burn-induced pain via the suppression of peripheral and central substance P expression in mice

  • Kang, Dong-Wook;Choi, Jae-Gyun;Kim, Jaehyuk;Park, Jin Bong;Lee, Jang-Hern;Kim, Hyun-Woo
    • Journal of Veterinary Science
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    • 제22권1호
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    • pp.9.1-9.11
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    • 2021
  • Background: Scalding burn injuries can occur in everyday life but occur more frequently in young children. Therefore, it is important to develop more effective burn treatments. Objectives: This study examined the effects of bee venom (BV) stimulation on scalding burn injury-induced nociception in mice as a new treatment for burn pain. Methods: To develop a burn injury model, the right hind paw was immersed temporarily in hot water (65℃, 3 seconds). Immediately after the burn, BV (0.01, 0.02, or 0.1 mg/kg) was injected subcutaneously into the ipsilateral knee area once daily for 14 days. A von Frey test was performed to assess the nociceptive response, and the altered walking parameters were evaluated using an automated gait analysis system. In addition, the peripheral and central expression changes in substance P (Sub P) were measured in the dorsal root ganglion and spinal cord by immunofluorescence. Results: Repeated BV treatment at the 2 higher doses used in this study (0.02 and 0.1 mg/kg) alleviated the pain responses remarkably and recovered the gait performances to the level of acetaminophen (200 mg/kg, intraperitoneal, once daily), which used as the positive control group. Moreover, BV stimulation had an inhibitory effect on the increased expression of Sub P in the peripheral and central nervous systems by a burn injury. Conclusions: These results suggest that a peripheral BV treatment may have positive potency in treating burn-induced pain.

화상치료제의 조직학적 수복효과 (A Study on Histological Recuperative Effect of Burn Remedies)

  • 지규용
    • 동의생리병리학회지
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    • 제16권4호
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    • pp.774-781
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    • 2002
  • This study was carried out to test the recuperative effect of 2 types of sample drugs for 3 degree burn. The burn injury was made by iron plate heated in the boiling water. The Sprague Dawley rats were shaven with a razor preliminarily and burned by direct contact method for 10 seconds. The experimental groups were classified with 5 each-normal, control, MEBO ointment, sample A, sample B. The effect of the sample drugs were decided by histological results after 3 week application. The results were as following. The 3 treatment groups recovered the burn injury faster than control group. The recuperative effect precedes about 4-5 days at the time of 15th day and 1 week at the time of 3rd week. The therapeutical procedure of 3 treatment groups was similar with naked eye and with microscopic histology in the 1 st, 2nd and 3rd specimens. So there weren't significant differences in curative effect in 3 treatment groups of this experiment. But a regeneration of hair follicle was noted in Sample B uniquely. These results suggested that 3 burn remedies have similar effect of therpy, but sample B containing yolk sac oil has slightly better effect in part of hair regeneration.

희박연소기관의 혼합기형성 및 연소특성에 관한 연구 (A Study on the Mixture Formation and Combustion Characteristics in Lean Burn Engine)

  • 이창식;서영호;조행묵;김현정
    • 한국자동차공학회논문집
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    • 제4권4호
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    • pp.80-86
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    • 1996
  • In order to decrease fuel comsumption rate and emissions, lean burn engine which has equipped swirl control valve, is investigated experimentally on the test bench. Single cylinder engine was used to test the combustion and emission performance with 4 kinds of swirl valve. Decrease in the carbon monoxide, hyerocarbon and specific fuel consumption was shown at the lean condition, which means that a good choice of swirl valve on the given intake port geometry can be used to increase the combustion efficiency and lean limit.

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중정비 신뢰성 향상을 위한 Burn-in 시험 적용 사례연구 (Burn-in Test Case Study for Heavy Maintenance to Improve the Reliability)

  • 김한영;이진춘
    • 한국철도학회논문집
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    • 제15권6호
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    • pp.566-571
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    • 2012
  • 도시철도차량의 출입문 장치는 중정비 6년 검사에서 총 75종 단위부품 중 34종 75개의 부품을 정기적으로 교체하며, 나머지 비정기 교환부품인 40종 68개 부품도 필요 시 교체하고 있어 사실상 초기제품에 가까운 상태가 되며, 한편으로는 기존 부품과 다수의 교환된 부품이 혼용 사용되면서 완전한 신품과는 또 다른 제품특성을 가지게 된다. 본 연구는 이러한 출입문 장치의 정비 후 특징을 고려하여 도시철도차량의 신뢰성을 향상하는 방법으로 번인시험을 제안하며 시험에 적합한 조건과 목표 값을 새롭게 제시하였다.

재활단계 화상 환자의 가려움증 (Itching among Burn Patients in the Rehabilitation Phase)

  • 김경자;서정훈;김은정
    • 근관절건강학회지
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    • 제23권1호
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    • pp.28-38
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    • 2016
  • Purpose: The purpose of this study was to investigate post-burn itching relevant characteristics in the rehabilitation phase. Methods: Ninety four burn patients who were hospitalized in the rehabilitation phase participated in the study. Self-reported Leuven itch scale-Korean was used to evaluate itching related characteristics. Data were analyzed with descriptive analysis, $x^2$ test, and Kruskal-Wallis test. Results: All subjects except two had the itching. Itching frequency revealed that 68.1% of subjects experienced itching one or more episodes a day or always, and 18.7% had episode durations lasting more than 2 hours per incidence. Mean severity and distress of itching was $5.3{\pm}2.4$ and $5.2{\pm}2.5$, respectively. Itching sensation dimension of tickling was 56.4%. More than 25% of subjects "often" or "always" affected reduced quality of life, loss of concentration, bad mood, and difficulty in falling asleep. Satisfaction with itching treatment was intermediate level. Conclusion: Post-burn itching in the rehabilitation phase was a significant problem despite pruritus treatment. Based on the finding of this study, development of comprehensive and tailored nursing intervention programs for itching could be suggested.

호스피스.완화의료에 개입하는 사회복지사의 소진과 보호요인에 관한 연구 (The Korean Social Workers' Burn-out Factors and Personal Traits in the Hospice and Palliative Care)

  • 김윤섭
    • Journal of Hospice and Palliative Care
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    • 제13권3호
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    • pp.161-168
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    • 2010
  • 목적: 본 연구는 한국 호스피스 완화의료에 개입하고 있는 사회복지사의 소진에 관한 요인과 보호요인에 관한 연구이며 요인분석에 있어서는 전문적 역량, 사회적 지지 그리고 수퍼비전으로 구분하여 상관관계를 살펴보았다. 방법: 표집대상은 사회복지 활동을 시행하고 있는 의료기관을 주요 대상 기관으로 선정하고, 46부의 설문지가 분석 자료로 활용되었다. SPSS 12.0 통계 프로그램을 이용하여 기술통계분석, T-test, ANOVA 그리고 다중회귀분석(Multiple Regression)을 활용하였다. 결과: 전문적 역량에 따른 사회복지사의 소진 분석에서는 대체적으로 유의미한 부적 상관관계가 있음으로 조사되었으며 회귀분석 결과 서비스 신념, 자기규제 신념 그리고 직업 소명의식이 소진보호요인으로 분석되었고, 사회적 지지에서는 상사의 지지가 신체적 소진과 정서적 소진을 보호요인으로 분석되었다. 슈퍼비전의 지식, 평가, 귄위 항목이 사회복지사의 비인간화를 보호하는 중요 변수임을 또한 확인할 수 있었다. 결론: 사회복지사의 소진 극복을 위하여 전문적 교육, 사회적 지지 그리고 수퍼비전의 체계적 구축을 위한 구조적 지원과 개인이 극복하고자 노력하는 적극적인 요인들이 복합적으로 이루어질 때, 소진에 대한 극복과 전문가로서의 자리매김이 가능할 것으로 사료된다.

Cycle-to-Cycle Variations Under Cylinder- Pressure- Based Combustion Analysis in Spark Ignition Engines

  • Han, Sung-Bin
    • Journal of Mechanical Science and Technology
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    • 제14권10호
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    • pp.1151-1158
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    • 2000
  • Combustion analysis based on cylinder-pressure provides a mechanism through which a combustion researcher can understand the combustion process. The objective of this paper was to identify the most significant sources of cycle-to-cycle combustion variability in a spark ignition engine at idle. To analyse the cyclic variation in a test engine, the burn parameters are determined on a cycle-to-cycle basis through the analysis of the engine pressure data. The burn rate analysis program was used here and the burn parameters were used to determine the variations in the input parameter-i. e., fuel, air, and residual mass. In this study, we investigated the relationship of indicated mean effective pressure (IMEP), coefficient of variation (COV) of IMEP, burn angles, and lowest normalized value (LNV) in a spark ignition engine in a view of cyclic variations.

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스파크 점화기관의 공회전 시 싸이클 변동에 영향을 주는 인자 고찰 (Study on Factors Influencing Cyclic Variations at Idle in Spark Ignition Engine)

  • D.H. Kwon;Park, Y.K.;Kim, J.M.
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 2003년도 춘계학술대회 논문집
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    • pp.1249-1252
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    • 2003
  • To analyse the cyclic variations in a test engine, the burn parameters are determined on a cycle-to-cycle basis through the analysis of the engine pressure data. Combustion analysis based on cylinder-pressure provides a mechanism through which a combustion researcher can understand the combustion process. The objective of this paper is to identify the most significant sources of cycle-to-cycle combustion variability in a spark ignition engine at idle. The burn rate analysis program was used and the burn parameters were used to determine the variations in the input parameter. In this study, the author investigated the relationship of indicated mean effective pressure, coefficient of variation of indicated mean effective pressure and burn angles, and lowest normalized value in a spark ignition engine for the cyclic variations.

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