• 한국환경보건학회지
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• 제36권2호
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• pp.82-94
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• 2010

This study was undertaken in an attempt to provide scientific grounds in explaining the causes of environmental and respiratory diseases resulting from air pollutants in Gyeongju and its neighboring areas. In relation to heavy metals, lead (Pb) was $0.0135{\sim}0.1744\;{\mu}g/m^3$ and high in order of Pohang, Ulsan, and Gyeongju while nickel (Ni) was $0.0023{\sim}0.0115\;{\mu}g/m^3$. The concentrations of heavy metals in the investigated areas did not exceed the environmental standards or Guideline Value of Korea or other countries. However, it is considered necessary to apply intensive control to some heavy metals including cadmium (Cd) that show a relatively high level of hazard. Based on the responses to the survey, measured personal interest in environmental pollution and the basic knowledge of the causes of the respiratory diseases was higher in those with a family history of allergic reactions to metals and bronchial asthma. The incidence of allergic disease was higher in those who are currently in poor health state. In addition, the general knowledge of environmental pollutants was higher in those with higher educational level and those with a higher interest in environmental pollution. Personal interest in environmental pollution was higher in those with higher basic knowledge of environmental pollutants. Therefore, it is necessary to increase the awareness through better education and campaigns on environmental pollution.

• Journal of Preventive Medicine and Public Health
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• 제39권3호
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• pp.205-212
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• 2006

Objectives: In spite of the recent increased concern for Asian dust storms, there are few studies concerning how dangerous the general public recognizes these dust storms to be. This study examined the public's perceptions of the risk of the Asian dust storms and also the source of the information concerning the risk. Methods: A telephone interview survey using a standardized questionnaire was done for the adults living in Seoul and its metropolitan area from May 15th, 2003 to May 16th, 2003. The contents of the questionnaire were the sociodemographic characteristics, the perceptions of risk to the Asian dust storms, and the coping strategy of the study participants. Results: The study participants get their information on Asian dust storms mainly from TV newscasts and they have a good knowledge of them. They regard it as one of the most dangerous health risks, along with dioxin. They think that it is associated with allergic rhinitis, conjunctivitis and bronchial asthma, etc. Of the 500 study participants, 201 (40.2%) persons suffered bodily discomforts during the Asian dust storm period. Conclusions: Although there are uncertainties about the health risks of Asian dust storms, the public thinks these dust storms are very dangerous to health in many ways This negative perception will not disappear easily. To fill the gap of the public's perceptions of the risk and the objective evidence of its health effects, more studies about its health effects and the methods to reduce exposure are required.

• Journal of Chest Surgery
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• 제53권6호
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• pp.400-402
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• 2020

Primary tracheobronchial lipoma is an extremely rare entity, the diagnosis of which is often missed initially. Cases are generally diagnosed late after initial treatment for asthma and bronchitis. We report a case of a 42-year-old man with a left main bronchus lipoma that caused near-total obstruction. The lipoma was treated by bronchoscopic resection with an electrosurgical snare and cryoablation.

• Clinical and Experimental Pediatrics
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• 제51권4호
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• pp.351-354
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• 2008

Anaphylaxis is an acute systemic reaction caused by IgE-mediated immunological release of mediators from mast cells and basophils to allergenic triggers, such as food, insect venoms, and medications. An alternative definition was recently proposed as follows: anaphylaxis is a "condition caused by an IgE mediated reaction" that is "often life threatening and almost always unanticipated." The reaction can be severe enough to lead to the rapid onset of symptoms, including dizziness, upper airway occlusion, bronchial constriction, hypotension, urticaria, cardiovascular arrhythmias and possible cardiac arrest. The incidence or prevalence of anaphylaxis in Korean pediatrics has not known. Thus, Epidemiology of Anaphylaxis in Pediatrics based on the data from Korean Health Insurance Review and Assessment Service (KHIRA) from 2001 to 2007 and questionnaire to the member of Korean Academy of Pediatric Allergy and Respiratory Disease (KAPARD) who are working at the training hospitals was studied. The incidence of anaphylaxis under age 19 is 0.7-1.0 per 100,000 year-person. The causes of anaphylaxis based on data from KHIRA were unknown (61.7%), food (24.9%), medications (12.4%), and serum (1.0%).

• Advances in Traditional Medicine
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• 제7권1호
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• pp.11-25
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• 2007

Bronchial asthma is a major public health problem worldwide and the morbidity and mortality of asthma have increased in last few decades. There is high prevalence of usage of alternative traditional system of medicines for the treatment of asthma. Large numbers of medicinal plant preparations have been reported to possess anti-asthmatic effects. Plant cells are now considered to be the chemical factories synthesizing a large variety of chemical compounds. Further, Ayurvedic system of medicine has an elaborate description of asthma from the earliest times describing it as 'Shwasa' meaning disease pertaining to breathing. This review classifies the antiasthmatics herbs based on the possible mechanism of action reported. Thus, these plants can be used to obtain a polyherbal formulation which contains various herbs acting at particular sites of the pathophysiological cascade of asthma for prophylaxis as well as for the treatment of asthma.

• Journal of Plant Biotechnology
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• 제49권1호
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• pp.3-14
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• 2022

Leonotis nepetifolia (L.) R. Br, commonly called dagga, klip dagga, or lion's ear, has been used to effectively treat various diseases and other health problems for a long time because of its antimicrobial, anti-inflammatory, antioxidant, and analgesic activities. Several studies have attributed these biological activities to L. nepetifolia's constituent secondary metabolites, such as alkaloids, phenolics, flavonoids, tannins, steroids, glycosides, coumarins, anthocyanins, and saponins. This review aims to examine the evidence-based ethnopharmacological uses of L. nepetifolia in the treatment of bronchial asthma, diarrhea, skin diseases, malaria, burns, cancer, diabetes mellitus, and rheumatism. However, although L. nepetifolia has great potential to treat these diseases, further isolation and identification of its therapeutic phytochemical constituents are required. In addition, the performance of its extracts and phytochemicals should be thoroughly tested in preclinical and clinical trials in order to ascertain their safety and efficacy, which will prove valuable in developing new medicines.

• 한국환경보건학회지
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• 제36권4호
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• pp.271-278
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• 2010

The appearance of Asian Dust (AD) originating from China and Mongolia during spring each year is a meteorological phenomenon periodically observed in extensive regions of East Asia. According to a previous epidemiological study, AD has adverse effects on both human beings and ecosystems. In this study, we collected total suspension particles (TSP) in the AD period and Non-AD (NAD) period. We extracted organic components from TSP using dichloromethane (DCM), and the polyaromatic hydrocarbons (PAHs) were analyzed. The DCM extracts contained PAHs such as benzo(b)fluoranthene, benzo[g,h,i]perylene, benzo(k)fluoranthene, benzo(a)pyrene, and pyrene. No significant difference was observed in cytotoxicity of the DCM extracts from AD versus NAD when tested on the human bronchial epithelial cells, BEAS-2B. e also examined the toxic mechanisms of AD extracts in cultured BEAS-2B cells and RAW264.7 cells, and in BEAS-2B cells observed increased levels of reactive oxygen species (ROS), decreased glutathione (GSH), and induced caspase-3 activity. Increased expression of oxidative stress-related and inflammation- related genes were also observed in BEAS-2B cells, while nitric oxide (NO) levels were increased in RAW264.7 cells. Taken together, the results suggest that in these cultured cells, AD may induce cytotoxicity through oxidative stress and pro-inflammatory signals.

• 한국환경보건학회지
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• 제46권6호
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• pp.685-693
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• 2020

Objectives: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. The aim of this study was to investigate relationships between indoor mold concentrations and pulmonary function parameters in asthmatic children with mold sensitization. Methods: Asthmatic subjects who had a positive result in skin-prick testing to more than one mold allergen, such as Alternaria, Aspergillus, or Penicillium, were enrolled. Their pulmonary function and methacholine challenge test results were collected. Measurements of blood eosinophil, serum IgE, and fractional exhaled nitric oxide (FeNO) were taken. Indoor levels of VOC, CO2, PM10 and PM2.5 in each subject's house were measured. We counted mold and bacteria colonies from the subjects' house air samples. Results: The mean levels of FEV1, FVC, FEV1/FVC, and FEF25-75 were 82.8±19.7, 87.3±17.9, 85.8±8.3, and 82.3±28.9%, respectively. The mean FeNO level was 19.8±11.2 ppb and the geometric mean (range of one SD) of methacholine PC20 was 3.99 mg/mL (0.67-23.74 mg/mL). The average indoor air pollutant levels were below the recommended levels set by the Ministry of Environment for multiplex buildings. Indoor mold levels showed a significant inverse correlation with methacholine PC20, but not with the baseline pulmonary function parameters. Conclusion: Indoor mold concentrations are a risk factor for increased bronchial hyperresponsiveness among asthmatic children with mold sensitization. Targeted environmental intervention should be considered for selected asthmatic children with mold sensitization for avoiding severe airway hyperresponsiveness.

• 농촌의학ㆍ지역보건
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• 제21권2호
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• pp.209-220
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• 1996

경상북도 문경시지역 중 9개 읍면에 거주하는 30세이상 주민 28.883명을 대상으로 1993년 10월 1일부터 1994년 2월 28일까지 건강면접조사한 자료중 5,797명을 무작위로 추출하여 만성퇴행성질환 유병률과 이용의료기관실태를 분석하였다. 인당유병률은 1,000명 당 336이었고 남녀별로는 남자는 278, 여자는 388이었다. 건당유병률은 367이었으며 남자 300, 여자 425였다. 건당유병률은 여자가 남자보다 유의하게 높았다(p<0.05). 연령별 인당 유병률은 30대는 106, 40대 223, 50대 366, 60대 407, 70세 이상 457로서 연령이 높아짐에 따라 유병률도 증가하였다. 만성퇴행성질환 건당유병률 1위는 신경통(128), 2위 만성위염(64), 3위 관절염(54), 4위 고혈압(44), 5위 당뇨(14) 순이었다. 남자는 1위가 신경통, 2위 위염, 3위 관절염, 4위 고혈압, 5이 천식이었고, 여자는 1위 신경통, 2위 관절염, 3위 위염, 4위 고혈압, 5위 당뇨였다. 신경통, 관절염, 고혈압 등의 질환은 남자보다 여자의 유병률이 유의하게 높았으며, 주풍(뇌졸증), 결핵, 간경화증 등의 유병률은 여자보다 남자가 유의하게 높았다. 만성퇴행성질환자의 이용의료기관은 최초에는 병 의원 이용율이 높았고, 최종 또는 현재는 보건(지)소, 의원 및 보건진료소를 많이 이용하였다. 질병별로는 신경통, 관절염 천식은 최초에는 의원을, 최종 또는 현재는 보건(지)소, 조건진료소를 많이 이용하였다. 고혈압과 결핵은 최초, 최종 모두 보건(지)소를 가장 많이 이용하였고, 당뇨, 중풍, 암, 심부전증, 간 경화증, 신부전증은 병원을 가장 많이 이용하였다.

• Journal of Preventive Medicine and Public Health
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• 제10권1호
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• pp.16-24
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• 1977

${\ulcorner}$크롬${\lrcorner}$과 ${\ulcorner}$니켈${\lrcorner}$등의 도금(鍍金)을 하는 도금공(鍍金工)에 대하여 그 직업성질환(職業性疾患)을 관찰(觀察)하고 저 1976년(年) 6(월)月 대구시내(大邱市內) 소재(所在)하는 서로 유사한 종류와 방법으로 작업하고 있는 중소기업체(中小企業體) 중 작업환경개선(作業環境改善)이 어느 정도 되어 있는 곳과 전연 되어있지 않는 곳을 각각 1개소(個所)씩 선택(選擇)하며 비교해 본 결과 다음과 같이 요약(要約)할 수 있었다. 전반적(全般的)으로 비강내(鼻腔內) 증상(症狀)이 총출현빈도(總出現頻度) 중 50%이상을 점하며 다음 현기증(眩氣症)이 문제(文題)로 되어 있으며 환경개선(環境改善)을 함에 따라 비강내증세(鼻腔內症勢)중에서 괴양성 병변(病變)을 줄이어 증상(症狀)은 가볍게 되었으나 개입보호구사용(個入保護具使用)을 소홀히 함으로써 점차 만성적인 변화(變化)를 초래할 염려가 있었다. 각종 혈액상(血液相)중 ${\ulcorner}$헤모글로번${\lrcorner}$, ${\ulcorner}$헤마토크리트${\lrcorner}$ 적혈구(赤血球)와 요소견(尿所見)중 단백질당(蛋白質糖), ${\ulcorner}$우로비리노겐${\lrcorner}$등에는 큰 영향을 미치지 않고 있다고 생각된다.