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E-Smart Health Information Adoption Processes: Central versus Peripheral Route

  • Koo, Chulmo;Lim, Min Kyung;Park, Keeho
    • Asia pacific journal of information systems
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    • v.24 no.1
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    • pp.65-91
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    • 2014
  • Our study adopted ELM (Elaboration Likelihood Model) to measure the impact of central and peripheral cues on e-healthcare website behavior and its consequence on perceived loyalty of users. While most of ELM studies did not elaborate the antecedent of both central and peripheral cues, we measured the antecedents of those information processing routes to clarify how technical and quality factors (i.e. information organization, security concern, and website attractiveness) develop the nature of either central or peripheral route. We found that information organization was the main antecedent of information quality presented on the website. Second, the results revealed that website security has a positive effect on website credibility. Third, we also found that website attractiveness was positively associated with website credibility. Fourth, consistent with elaboration likelihood model, the empirical findings suggested that information quality (central cue) and website credibility (peripheral cue) were strong predictors of behavior intention to use health website. Our findings also suggested that behavior intention to use health website significantly influenced perceived loyalty.

Ablation of Arg-tRNA-protein transferases results in defective neural tube development

  • Kim, Eunkyoung;Kim, Seonmu;Lee, Jung Hoon;Kwon, Yong Tae;Lee, Min Jae
    • BMB Reports
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    • v.49 no.8
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    • pp.443-448
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    • 2016
  • The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals. Here, we characterized the ATE1−/− mice and identified the essential role of N-terminal arginylation in neural tube development. ATE1-null mice showed severe intracerebral hemorrhages and cystic space near the neural tubes. Expression of ATE1 was prominent in the developing brain and spinal cord, and this pattern overlapped with the migration path of neural stem cells. The ATE1−/− brain showed defective G-protein signaling. Finally, we observed reduced mitosis in ATE1−/− neuroepithelium and a significantly higher nitric oxide concentration in the ATE1−/− brain. Our results strongly suggest that the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.

Anti-mechanical Hyperalgesic Effect of Lonicera Japonica in Neuropathic Pain Rats

  • Hwang, Hye-Jeong;Kim, Hee-Young;Lee, Hye-Jung;Lee, Bae-Hwan;Shim, In-Sop
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.4
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    • pp.895-897
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    • 2009
  • Lonicera japonica has been widely used for chronic inflammatory diseases in many Asian countries. Its analgesic effect has not been explored yet. This study aimed to test the analgesic potential of methanol extracts from Lonicera japonica (MELJ) in rat neuropathic mctel. Neuropathic pain was pacts ed by partial sciatic nerve injury. Two weeks after surgery, neuropathic rats received oral administration of MELJ at doses of either 0.0 g/kg, 0.2 g/kg or 0.4 g/kg. At dose of 0.0 g, rats were administered with saline only and used as conracl. The behavioral tests for f 0.0 g, raand ccld hs were adma were weformed up to 2 hours after treatment. The MELJ at the dose 0.4 g/kg dmg gfg, ntly alleviated f 0.0 g, rahyperalgesia, but not cold hyperalgesia. These results showed that the MELJ had, although transient, analgesic effect on mechanical hyperalgesia in the rat neuropathic model.

Comparison of dynamic behavior of shallow foundations based on pile and geosynthetic materials in fine-grained clayey soils

  • Shariati, Mahdi;Azar, Sadaf Mahmoudi;Arjomand, Mohammad-Ali;Tehrani, Hesam Salmani;Daei, Mojtaba;Safa, Maryam
    • Geomechanics and Engineering
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    • v.19 no.6
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    • pp.473-484
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    • 2019
  • In this paper, the geotechnical report of the Northern Fereshteh area in Tabriz is used and the characteristics of shallow foundation of a single pile and compared pile group and geogrid in terms of the settlement of a building foundation on clayey soil. Additionally, impacts of existing variables such as the number of geogrid layers, the length of the pile, and the depth of groundwater level affected by the dynamic load caused by the Taiwan Jiji earthquake via numerical analysis using PLAXIS software are examined. The results of fifty-four models indicated that the construction of a pile group with a diameter of 1 meter and a length of 14 meters significantly diminished the consolidation settlement of the soil in the Northern Fereshteh area, where the settlement value has been triggered by the load inflicted by earthquake. Moreover, the construction of four layers of geogrid at intervals of one meter led to a significant decrease in the settlement. Finally, after reaching a maximum depth, it had no reducing effects on the foundation settlement.

A Combustion Instability Analysis of a Model Gas Turbine Combustor for Co-generation (열병합발전용 모델 가스터빈 연소기의 연소불안정 해석)

  • Cha, Dong-Jin;Shin, Dong-Myung
    • Proceedings of the SAREK Conference
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    • 2009.06a
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    • pp.1449-1457
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    • 2009
  • Combustion instability is a major issue in design of co-generation gas turbine combustors for efficient operation with low emissions. Combustion instability is induced by the interaction of the unsteady heat release of the combustion process and the change in the acoustic pressure in the combustion chamber. In an effort to develop a technique to predict self-excited combustion instability of co-generation gas turbine combustors, a new stability analysis method based on the transfer matrix method is developed. The method views the combustion system as a one-dimensional acoustic system with a side branch and describes the heat source as the input to the system. This approach makes it possible to use not only the advantages of the transfer matrix method but also well established classic control theories. The approach is applied to a simple co-generation gas turbine combustion system, which shows the validity and effectiveness of the approach.

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A Case Study on Traditional Korean Medicine Therapy in an Elderly Patient with a Traumatic Intracerebral Hemorrhage (의식장애를 동반한 외상성 뇌내출혈 노인 환자의 한방치료 치험 1례)

  • Lim, Myong-ah;Kang, Da-hyun;Lee, Hee-jung;Kim, Du-ri;Seo, Ho-seok;Kim, Jin-won;Kim, Pan-gyu
    • The Journal of Internal Korean Medicine
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    • v.37 no.5
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    • pp.885-892
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    • 2016
  • Few studies have reported the effects of traditional Korean medical (TKM) therapy in patients with traumatic brain hemorrhage. The patient was a 93-year-old female who was unconscious after a traumatic intracerebral hemorrhage (ICH) and was not a candidate for any surgical treatment because of her age. We treated her with acupuncture and herbal medicine. After 28 days of treatment, we observed an improvement in consciousness on the Glasgow Coma Scale (GCS) and in other symptoms (aphasia, weakness in both legs, and headache).

Ultrasonic Tracking of Movements of Striped Jack ( Caranx Delicatissimus ) in the Nunoura Bay , Japan (초음파 표지를 이용한 양식어의 유영행동 추적)

  • 신현옥
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.28 no.4
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    • pp.347-359
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    • 1992
  • The movements of three striped jack (Caranx delicatissimus, 24cm of body length) were tracked by ultrasonic telemetry in the Nunoura Bay in August 1990. A school of the striped jack has been released near by the fish farming rafts by Goto branch of the Fisheries Agency and Japan Sea-Farming Association. To investigate the staying area and the swimming pattern of the fish, small size pinger($\Phi$8.5$\times$L35mm, 140dB re 1$\mu$Pa at 1m, 69kHz) was tagged on the dorsal fin without any anesthesia. The movements of three tagged fish are monitored at the same time with four omni-directional hydrophones. The locations of the fish are calculated by the hyperbolic method and tracked by a technique so called time division scheme which uses both the pulse interval and the phase. Three pingers used have the pulse interval of 1.7, 1.8 and 1.9sec, respectively, and the common pulse duration of 15ms. In results it was capable to estimate behavior right after the release, swimming speeds and approximate moving area of the fish. The movements were tracked for a week continuously, and it was found out that the staying area of the fish was around or under the farming rafts. Sometimes they swam together but most of the time they move separately. The average swimming speed of those fish was about two times of the body length.

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Improving cyclic behavior of multi-level pipe damper using infill or slit diaphragm inside inner pipe

  • Zahrai, Seyed Mehdi;Cheraghi, Abdullah
    • Structural Engineering and Mechanics
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    • v.64 no.2
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    • pp.195-204
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    • 2017
  • Analytical and experimental studies of the innovative pipe in pipe damper have been recently investigated by the authors. In this paper, by adding lead or zinc infill or slit diaphragm inside the inner pipe, it is tried to increase the equivalent viscous damping ratio improving the cyclic performance of the recently proposed multi-level control system. The damper consists of three main parts including the outer pipe, inner pipe and added complementary damping part. At first plastic deformations of the external pipe, then the internal pipe and particularly the added core and friction between them make the excellent multi-level damper act as an improved energy dissipation system. Several kinds of added lead or zinc infill and also different shapes of slit diaphragms are modeled inside the inner pipe and their effectiveness on hysteresis curves are investigated with nonlinear static analyses using finite element method by ABAQUS software. Results show that adding lead infill has no major effect on the damper stiffness while zinc infill and slit diaphragm increase damper stiffness sharply up to more than 10 times depending on the plate thickness and pipe diameter. Besides, metal infill increases the viscous damping ratio of dual damper ranging 6-9%. In addition, obtained hysteresis curves show that the multi-level control system as expected can reliably dissipate energy in different imposed energy levels.

Cap truss and steel strut to resist progressive collapse in RC frame structures

  • Zahrai, Seyed Mehdi;Ezoddin, Alireza
    • Steel and Composite Structures
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    • v.26 no.5
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    • pp.635-647
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    • 2018
  • In order to improve the efficiency of the Reinforced Concrete, RC, structures against progressive collapse, this paper proposes a procedure using alternate path and specific local resistance method to resist progressive collapse in intermediate RC frame structures. Cap truss consists of multiple trusses above a suddenly removed structural element to restrain excessive collapse and provide an alternate path. Steel strut is used as a brace to resist compressive axial forces. It is similar to knee braces in the geometry, responsible for enhancing ductility and preventing shear force localization around the column. In this paper, column removals in the critical position at the first story of two 5 and 10-story regular buildings strengthened using steel strut or cap truss are studied. Based on nonlinear dynamic analysis results, steel strut can only decrease vertical displacement due to sudden removal of the column at the first story about 23%. Cap truss can reduce the average vertical displacement and column axial force transferred to adjacent columns for the studied buildings about 56% and 61%, respectively due to sudden removal of the column. In other words, using cap truss, the axial force in the removed column transfers through an alternate path to adjacent columns to prevent local or general failure or to delay the progressive collapse occurrence.

Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

  • Zeng, Hui;Wang, Xue-Bin;Cui, Ning-Hua;Nam, Seungyoon;Zeng, Tuo;Long, Xinghua
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.15
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    • pp.6211-6217
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    • 2014
  • Previous genome-wide association studies (GWAS) have implicated several single nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene with childhood acute lymphoblastic leukemia (ALL). However, replicated studies reported some inconsistent results in different populations. Using meta-analysis, we here aimed to clarify the nature of the genetic risks contributed by the two polymorphisms (rs10994982, rs7089424) for developing childhood ALL. Through searches of PubMed, EMBASE, and manually searching relevant references, a total of 14 articles with 16 independent studies were included. Odds ratios (ORs) with 95% confidence intervals (95%CI) were calculated to assess the associations. Both SNPs rs10994982 and rs7089424 showed significant associations with childhood ALL risk in all genetic models after Bonferroni correction. Furthermore, subtype analyses of B-lineage ALL provided strong evidence that SNP rs10994982 is highly associated with the risk of developing B-hyperdiploid ALL. These results indicate that SNPs rs10994982 and rs7089424 are indeed significantly associated with increased risk of childhood ALL.