• Journal of Pharmacopuncture
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• v.18 no.4
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• pp.7-11
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• 2015

Objectives: Bee venom (BV) is a complex mixture of proteins and contains proteins such as phospholipase and melittin, which have an effect on blood clotting and blood clots. The mechanism of action of honey bee venom (HBV, Apis mellifera) on human plasma proteins and its anti-thrombotic effect were studied. The purpose of this study was to investigate the anti-coagulation effect of BV and its effects on blood coagulation and purification. Methods: Crude venom obtained from Apis mellifera was selected. The anti-coagulation factor of the crude venom from this species was purified by using gel filtration chromatography (sephadex G-50), and the molecular weights of the anti-coagulants in this venom estimated by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Blood samples were obtained from 10 rabbits, and the prothrombin time (PT) and the partial thromboplastin time (PTT) tests were conducted. The approximate lethal dose (LD) values of BV were determined. Results: Crude BV increased the blood clotting time. For BV concentrations from 1 to 4 mg/mL, clotting was not observed even at more than 300 seconds, standard deviations $(SDs)={\pm}0.71$; however, clotting was observed in the control group 13.8 s, $SDs={\pm}0.52$. Thus, BV can be considered as containing anti-coagulation factors. Crude BV is composed 4 protein bands with molecular weights of 3, 15, 20 and 41 kilodalton (kDa), respectively. The $LD_{50}$ of the crude BV was found to be $177.8{\mu}g/mouse$. Conclusion: BV contains anti-coagulation factors. The fraction extracted from the Iranian bees contains proteins that are similar to anti-coagulation proteins, such as phospholipase $A_2(PLA_2)$ and melittin, and that can increase the blood clotting times in vitro.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9093-9099
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• 2014

A growing body of evidence suggests that the peroxisome proliferator-activated receptor-gamma ($PPAR{\gamma}$) gene may harbor targets for the chemoprevention of breast cancer. However, it is unclear whether polymorphisms in the $PPAR{\gamma}$ gene are associated with the susceptibility of breast cancer. We performed a candidate gene association study between $PPAR{\gamma}$ polymorphisms and breast cancer and a meta-analysis on the association of breast cancer with selected $PPAR{\gamma}$ variants. Six single nucleotide polymorphisms (SNPs) in the $PPAR{\gamma}$ gene were analyzed among 456 breast cancer patients and 461 controls from the National Cancer Center in Korea. Association between the polymorphisms and breast cancer risk were assessed using the Cochrane-Armitage test for trend and a multivariate logistic regression model. Two SNPs, rs3856806 and rs1801282, had been previously analyzed, thus enabling us to perform pooled analyses on their associations with breast cancer susceptibility. Our findings from the candidate gene association study showed no association between the $PPAR{\gamma}$ gene polymorphisms and breast cancer risk. A meta-analysis combining existing studies and our current study also refuted an association of the $PPAR{\gamma}$ gene with breast cancer. Our findings suggest that the $PPAR{\gamma}$ gene may not harbor variants that alter breast cancer susceptibility, although a moderate sample size might have precluded a decisive conclusion.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.1 s.92
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• pp.66-77
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• 2005

This paper proposed a novel broadband PIFA(Planar Inverted-F Antenna) for IMT-2000/WLAN/DMB terminal. Two branch lines for meander line were utilized in order to improve the characteristics of PIFA which usually has a narrow band. The shorting strip between the ground plane and meander-type radiation elements were used in order to minimize the size of the antenna. The -10 dB return loss bandwidth of a realized antenna was $38.2{\%}$(1.84~2.71 GHz), which contains the broadband bandwidth with triple band. And the simulated and measured values of 1 g and 10 g averaged peak SAR on human head caused by the triple band PIFA mounted on folder-type handsets were analyzed and discussed. As a result, the measured 1 g and 10 g averaged peak SARs of PIFA were similar with the simulated values and were lower than the 1.6 W/kg and 2 W/kg of 1 g and 10 g averaged peak SAR limits.

• Research in Community and Public Health Nursing
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• v.27 no.2
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• pp.183-192
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• 2016

Purpose: The purpose of this study was to seek the direction of community health nursing practice education focus on the nursing education accreditation criteria. Methods: We collected data through e-mail survey to all of 202 Korean nursing baccalaureate education institute in April, 2016. The 93 professors teaching community health nursing was responded about their affiliated institute (response rate 46.0%). Results: The Korean nursing graduates in Feb. 2016 was practiced 3.01 credits, 131.6 hours in community health nursing course. Community health nursing practice agency was public health center (98.9%), Public health center post (43.0%), Public health center branch (32.3%) in order. The possibility to achieve the course objectives up to national examination was recognised Public health center (3.4), Public health center post (3.3), Public health center branch and school (3.2) from 5 score likert scale. A lot of nursing education institute have difficulty in clinical placement in community health nursing practice agency that meet eligibility of preceptor and space gaining for only nursing students. Conclusion: The nursing education accreditation criteria in 3rd cycle have to be considered real community health nursing practice situation and newly emerging community health nursing fields.

• Journal of Digital Convergence
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• v.18 no.2
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• pp.103-110
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• 2020

The fire incident of KT's Ahyun branch occurred last year indicates that hyper-connected society led by 5G technology would be a dystopia instead of a utopia unless seamless connection of 5G service is well secured. Looking backward on 1999, we could peacefully and happily greet the new millennium by making a great effort to prevent the millennium bugs(Y2K) from causing the catastrophe such as a shut-down of banking system. Likewise, we should make a great effort to keep 5G networks and 5G service continuously working without the disruption of even just a second, which would enable us to avoid facing any catastrophes caused by the disruption of 5G service. As a way to do so, it can be considered that 5G service is designated as universal service because it has the key features of public goods like telephone and high-speed internet services.

• Korean Journal of Veterinary Service
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• v.33 no.3
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• pp.271-274
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• 2010

With deer farming now becoming recognized as one of the alternative livestock farming practices, there has been much attention on infectious diseases of cattle, but less awareness of these diseases in deer. Serum samples were randomly collected from 78 deer from 31 farms and 7 wild water deer from wild animal medical center during 2005 to 2007, respectively. A total 85 sera were tested for Neospora caninum antibodies by ELISA. Fourteen farmed deer(17.9%) were positive to N. caninum but no antibodies were found in sera from wild water deer. The sera from all of the area for these study showed positive in the range from 6.7 to 30.7%. On the basis of these study, farmed deer in Jeonbuk province were exposed extensively and seriously to N. caninum which might present a risk to other species included cattle and dog.

• Korean journal of communication and information
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• v.40
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• pp.7-44
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• 2007

This study aims to review the socialist news magazines between 1925 and 1936 under the Japanese regime, then to analyze how they published and how they managed the branch. The socialist magazines appeared legally and officially right after the 3 1 movement when the ownership and publishing of newspapers and news magazines was partially allowed. However, there were many obstacles because the permission by the Japanese regime was a result of deceptive cultural policy. The Japanese government more sensitively responded to the socialists' related news stories rather than other types of publications. Due to over-censorship and financial difficulty, the life time of most socialists' news magazines was very short. However, these news magazines did play an important role to disseminate socialism. In doing so, because the news magazines were a part of social movements, the delivery network was also maintained based on social movements.

• Journal of The Korean Astronomical Society
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• v.49 no.5
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• pp.175-192
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• 2016

CCD photometric observations of the globular cluster (GC), M53 (NGC 5024), are performed using the 1.8 m telescope at the Bohyunsan Optical Astronomy Observatory in Korea on the same nights (2002 April and 2003 May) as the observations of the GC M92 (NGC 6341) reported by Cho and Lee using the same instrumental setup. The data for M53 is reduced using the same method as used for M92 by Cho and Lee, including preprocessing, point-spread function fitting photometry, and standardization etc. Therefore, M53 and M92 are on the same photometric system defined by Landolt, and the photometry of M53 and M92 is tied together as closely as possible. After complete photometric reduction, the V versus B − V , V versus V − I, and V versus B − I color-magnitude diagrams (CMDs) of M53 are produced to derive the relative ages of M53 and M92 and derive the various characteristics of its CMDs in future analysis. From the present analysis, the relative ages of M53 and M92 are derived using the Δ(B − V ) method reported by VandenBerg et al. The relative age of M53 is found to be 1.6 ± 0.85 Gyr younger than that of M92 if the absolute age of M92 is taken to be 14 Gyr. This relative age difference between M53 and M92 causes slight differences in the horizontal-branch morphology of these two GCs.

• Journal of Ocean Engineering and Technology
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• v.26 no.2
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• pp.20-25
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• 2012

During drilling, the precipitation velocity of cuttings within an annulus depends on the density and configuration of the cuttings, and on the density, viscosity, and rheological characteristics of the drilling fluid. In directional drilling in particular, it is difficult to adjust and control the cuttings. In contrast to vertical drilling, it is very important to evaluate the flow characteristics of a drilling flow field. However, research on the transfer features of cuttings is inadequate. In this study, in order to identify transfer features of cuttings, an experiment was performed under wide-ranging conditions by constructing a slim hole annulus ($44mm{\times}30mm$) device. In this experiment, the particle volume fraction were influenced by particle size, particle concentration within the flow, pipe rotation, flow volume, and inclination of the annulus. In addition, a mathematical formula for volumetric concentration was deduced and compared to the test results and behavior of cuttings under the other drilling condition was made to be predicted. Therefore, this study can provide meaningful data for vertical and horizontal drilling, and for directional drilling.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3072-3081
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• 2011

The purpose of this study was to investigate the association of blood pressures, hematological and blood biochemical properties according to the degree of obesity based on differential combinations of BMI in health checkup examinees. Study subjects were 3,731 adults of 20 years and over (2,312 males, 1,419 females), not recognized as taking medicines for or having cardiovascular diseases, who underwent health package check-up at the Korea Association of Health Promotion, Daejeon Branch from Jan. 2007 to Dec. 2009. As a results, the mean values of SBP, DBP, TG, TC, LDL-C, ALT, AST, GGT, ALP were significantly increased with higher level of BMI, but the HDL-C was significantly decreased with higher level of BMI. On correlation of BMI with various factors, the BMI was positively correlated with SBP, DBP, TG, TC, LDL-C and GGT, while the HDL-C was negatively correlated. Based on the result of ordinal logistic regression analysis, the risk ratio to the abnormal level of SBP, DBP, TG, ALT and GGT were significantly increased as BMI increased.