• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.179-183
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• 2016

Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.167-174
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• 2016

One of the major causes of morbidity and mortality in breast cancer patients is delay in seeking help. Leventhal's self-regulation model provides an appropriate framework to assess delay in seeking help. The aim of this study was to investigate the relationship between "illness perception" and "help seeking delay" in breast cancer patients based on Leventhal's self-regulation model. In this correlational descriptive study with convenience sampling conducted in 2013, participants were 120 women with breast cancer who were diagnosed in the last year and referred to chemotherapy and radiotherapy centers in Rasht, Iran. Data collection scales included demographic data, Revised Illness Perception Questionnaire (IPQ-R)and a researcher made questionnaire to measure the delay in seeking help. Pre-hospital delay (help seeking delay) was evaluated in 3 phases (assessment, disease, behavior). The data were analyzed using SPSS-19. The mean (SD) age calculated for the patients was $47.3{\pm}10.2$. Some 43% of the patients had a high school or higher education level and 82% were married. The "pre-hospital delay" was reported ${\geq}3months$. Logistic regression analysis showed that none of the illness perception components were correlated with appraisal and behavioral delay phases. In the illness delay phase, "time line" (p-value =0.04) and "risk factors"(p-value=0.03) had significant effects on reducing and "psychological attributions" had significant effects on increasing the delay (p-value =0.01). "Illness coherence" was correlated with decreased pre-hospital patient delay (p-value<0.01). Women's perceptions of breast cancer influences delay in seeking help. In addition to verifying the validity of Leventhal's self-regulation model in explaining delay in seeking help, the results signify the importance of the "illness delay phase" (decision to seek help) and educational interventions-counseling for women in the community.

• Journal of Oral Medicine and Pain
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• v.33 no.4
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• pp.295-303
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• 2008

The lingual branch of the trigeminal nerve transmitts general sensation from anterior two thirds of the tongue, also bearing within sheath fibers of chordal tympani branch of the facial nerve. Chorda tympani nerve carries special taste sensations from the anterior two thirds of the tongue and sub-serves the existing trigeminal pathway. Chorda tympani nerve and the lingual nerve innervate to fungiform papilla and distribution of fungiform papilla on tongue dorsum is variable according to anatomical location. The purpose of this report is to assess that the relationship of the number of fungiform papilla and the ability of two-point discrimination of tongu dorsum. Twenty-six healthy students(male:female=13:13) whose mean age was $30{\pm}3$ participated in our study. Two-point discrimination thresholds were measured to evaluate the spatial acuity of touch sensation. The measurement was carried out at the tip and posterolateral region of dorsal tongue. After two-point discrimination test, we took the pictures of their dorsal tongue dyed with methylene blue with digital camera. There were no significant differences between the number of fungiform papilla and the two-point discrimination threshold. But, we found that there were the intraregional and intersubject variations of spatial acuity of the tongue. During the test on the posterolateral region of the dorsal tongue, students appealed the difficulty of discrimination of one point and two point.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.2
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• pp.545-552
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• 2012

This study evaluated the validity and reliability of applying a newly developed dish-based, semi-quantitative food frequency questionnaire (FFQ) for Korean diet and cancer research. The subjects in the present study were 288 Korean adults over 30 years of age who had completed two FFQs and four 3-day diet records (DRs) from May 2008 to February 2009. Student's t-tests, Chi-square tests, and Spearman's rank correlation coefficients were used to estimate and compare intakes from different dietary assessment tools. Agreement in quintiles was calculated to validate agreement between the results of the second FFQ (FFQ-2) conducted in February 2009 and the DRs. Median Spearman's correlation coefficients between the intake of nutrients and foods assessed by the FFQ-1 and FFQ-2 were 0.59 and 0.57, respectively, and the coefficients between the intake of nutrients and foods assessed by the FFQ-2 and the DRs were 0.31 and 0.29, respectively. The quintile classifications of same or adjacent quintile for intake of nutrients and foods were 64% and 65%, respectively. Misclassification into opposite quintiles occurred in less than 5% for all dietary factors. Thus this newly-developed, Korean dish-based FFQ demonstrated moderate correspondence with the four 3-day DRs. Its reliability and validity are comparable to those reported in other studies.

• Ocean and Polar Research
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• v.39 no.3
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• pp.169-179
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• 2017

The "GeoDrifter" is a newly-developed surface drifter with high temporal resolution. It is the first time that high-frequency drifters have been deployed in the East/Japan Sea. The purpose of this study is to introduce the phenomena experienced by these drifters flowing along with the Tsushima Current across the East/Japan Sea, focusing on high-frequency variability, and to discuss them in comparison with previous observations. The observed basin-scale circulation of the Tsushima Current generally coincides well with the known schematic circulation. The GeoDrifter trajectories also show inertial oscillations almost everywhere in the oceanic regions of the East/Japan Sea, strong semi-diurnal tidal currents in the western part of Korea Strait, diurnal currents much stronger than semi-diurnal currents in the upstream region of the Nearshore Branch off the Japanese coast, and many warm eddies in the Yamato Basin, all comparable to the observational results reported in the previous studies. An interesting point is that the semi-diurnal tidal currents undergo a great spatial variation in the western part of the Korea Strait. The observed features that cannot be explained are, among others, strong counter-clockwise motions with oscillating period about 51 hours appearing in the upstream region of the Nearshore Branch off the Japanese coast and the different tidal behaviors between upstream and downstream regions of the latter.

• Journal of the Korea Society of Computer and Information
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• v.19 no.10
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• pp.125-133
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• 2014

This paper develops a bankruptcy prediction model on an Artificial Neural Network for hotel management. A bankruptcy prediction model has a specific feature to predict a bankruptcy of the whole hotel business after evaluate bankruptcy possibility on the basis of business performance data of each branch. here are many traditional statistical models for bankruptcy prediction such as Multivariate Discriminant Analysis or Logit Analysis. However, we chose Artificial Neural Network because the method has accuracy rates of prediction better than those of other methods. We first selected 100 good enterprises and 100 bankrupt enterprises as experimental data and set up a bankruptcy prediction model by use of a tool for Artificial Neural Network, NeuroShell. The model and its experiments, which demonstrated high efficiency, can certainly provide great help in decision making in the field of hotel management and in deciding on the bankruptcy or financial solidity of each branch of serviced residence hotel.

• Journal of Mechanical Science and Technology
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• v.16 no.12
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• pp.1702-1709
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• 2002

This paper analyzes heterogeneous distribution of branch-like structure at the downstream region of the spray. The liquid and vapor phase of the spray are obtained using a 35㎜ still camera and CCD camera in order to investigate spray structure of evaporating diesel spray. There have been many studies conducted on diesel spray structure but have yet only focused on the analyses of 2-D structure. There are a few information which is concerned with 3-D structure analysis of evaporating spray. The heterogeneous distribution of droplets in inner spray affects the mixture formation of diesel spray and the combustion characteristics of the diesel engines. In this study, the laser beam of 2-D plane was used in order to investigate 3-D structure of evaporating spray The incident laser beam was offset on the central axis of the spray. From the analysis of images taken by offset laser beam, we will examine the formation mechanism of heterogeneous distribution of the diesel spray by vortex flow at the downstream of the spray. The images of liquid and vapor phase of free spray are simultaneously taken through an exciplex fluorescence method. Through this, the branch-like structure consisting of heterogeneous distribution of the droplets forms high concentrated vapor phase at the periphery of droplets and at the spray tip.

• Journal of Intelligence and Information Systems
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• v.9 no.1
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• pp.71-89
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• 2003

Although many studies demonstrate that one technique outperforms the others for a given data set, there is often no way to tell a priori which of these techniques will be most effective in the classification problems. Alternatively, it has been suggested that a better approach to classification problem might be to integrate several different forecasting techniques. This study proposes the linearly combining methodology of different classification techniques. The methodology is developed to find the optimal combining weight and compute the weighted-average of different techniques' outputs. The proposed methodology is represented as the form of mixed integer programming. The objective function of proposed combining methodology is to minimize total misclassification cost which is the weighted-sum of two types of misclassification. To simplify the problem solving process, cutoff value is fixed and threshold function is removed. The form of mixed integer programming is solved with the branch and bound methods. The result showed that proposed methodology classified more accurately than any of techniques individually did. It is confirmed that Proposed methodology Predicts significantly better than individual techniques and the other combining methods.

• Steel and Composite Structures
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• v.36 no.2
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• pp.213-228
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• 2020

Shape Memory Alloys (SMAs) are new materials used in various fields of science and engineering, one of which is civil engineering. Owing to their distinguished capabilities such as super elasticity, energy dissipation, and tolerating cyclic deformations, these materials have been of interest to engineers. On the other hand, the connections of a steel structure are of paramount importance because of their vulnerabilities during an earthquake. Therefore, it is indispensable to find approaches to augment the efficiency and safety of the connection. This research investigates the behavior of steel connections with extended end plates equipped hybridly with 8 rows of high strength bolts as well as Nitinol superelastic SMA bolts. The connections are studied using component method in dual form. In this method, the components affecting the connections behavior, such as beam flange, beam web, column web, extended end plate, and bolts are considered as parallel and series springs according to the Euro-Code3. Then, the nonlinear force- displacement response of the connection is presented in the form of moment-rotation curve. The results obtained from this survey demonstrate that the connection has ductility, in addition to its high strength, due to high ductility of SMA bolts.

• The Korean Journal of Pain
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• v.30 no.4
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• pp.296-303
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• 2017

Background: To achieve a prolonged therapeutic effect in patients with lumbar facet joint syndrome, radiofrequency medial branch neurotomy (RF-MB) is commonly performed. The purpose of this study was to evaluate the prognostic value of paravertebral muscle twitching when performing RF-MB in patients with lumbar facet joint syndrome. Methods: We collected and analyzed data from 68 patients with confirmed facet joint syndrome. Sensory stimulation was performed at 50 Hz with a 0.5 V cut-off value. Patients were divided into 3 groups according to the twitching of the paravertebral muscle during 2 Hz motor stimulation: 'Complete', when twitching was observed at all needles; 'Partial', when twitching was present at 1 or 2 needles; and 'None', when no twitching was observed. The relationship between the long-term effects of RF-MB and paravertebral muscle twitching was analyzed. Results: The mean effect duration of RF-MB was 4.6, 5.8, and 7.0 months in the None, Partial, and Complete groups, respectively (P = 0.47). Although the mean effect duration of RF-MB did not increase significantly in proportion to the paravertebral muscle twitching, the Complete group had prolonged effect duration (> 6 months) than the None group in subgroup analysis. (P = 0.03). Conclusions: Paravertebral muscle twitching while performing lumbar RF-MB may be a reliable predictor of long-term efficacy when sensory provocation under 0.5 V is achieved. However, further investigation may be necessary for clarifying its clinical significance.