• The Korean Journal of Physiology and Pharmacology
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• v.23 no.3
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• pp.171-179
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• 2019

Pituitary tumors are usually benign but can occasionally exhibit hormonal and proliferative behaviors. Dysregulation of the G1/S restriction point largely contributes to the over-proliferation of pituitary tumor cells. F-box protein S-phase kinase-interacting protein-2 (SKP2) reportedly targets and inhibits the expression of $p27^{Kip1}$, a well-known negative regulator of G1 cell cycle progression. In this study, SKP2 expression was found to be upregulated while $p27^{Kip1}$ expression was determined to be downregulated in rat and human pituitary tumor cells. Furthermore, SKP2 knockdown induced upregulation of $p27^{Kip1}$ and cell growth inhibition in rat and human pituitary tumor cells, while SKP2overexpression elicited opposite effects on $p27^{Kip1}$ expression and cell growth. The expression of microRNA-186 (miR-186) was reported to be reduced in pituitary tumors. Online tools predicted SKP2 to be a direct downstream target of miR-186, which was further confirmed by luciferase reporter gene assays. Moreover, miR-186 could modulate the cell proliferation and $p27^{Kip1}$-mediated cell cycle alternation of rat and human pituitary tumor cells through SKP2. As further confirmation of these findings, miR-186 and $p27^{Kip1}$ expression were downregulated, while SKP2 expression was upregulated in human pituitary tumor tissue samples; thus, SKP2 expression negatively correlated with miR-186 and $p27^{Kip1}$ expression. In contrast, miR-186 expression positively associated with $p27^{Kip1}$ expression. Taken together, we discovered a novel mechanism by which miR-186/SKP2 axis modulates pituitary tumor cell proliferation through $p27^{Kip1}$-mediated cell cycle alternation.

• Korean Journal of Comparative Education
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• v.28 no.4
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• pp.1-21
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• 2018

The OECD ITP project has looked at the black box of each participating countries' teacher education system. In the 2000s, various countries have tried to reform their professional development systems for teachers, including teacher education and induction, as an initial yet crucial step to improve the quality of education. Since 2015, OECD member countries have been conducting an international comparison study on teacher education and induction programs(i.e. ITP). The ITP project is an in-depth comparative study among the member countries that have expressed willingness to participate voluntarily. This paper introduces the progress of the ITP project and analyzed the national background report on the teacher education and induction system of the participating countries and compared the features of the systems. In addition, this study explores the common issues surrounding the teacher education and induction system. Moreover, the researcher has tried to derive some suggestions for improvement of teacher education and induction system in Korea.

• Korean Journal of Cognitive Science
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• v.32 no.3
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• pp.117-139
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• 2021

The way of change detection in which presence of a different item is determined between memory and test arrays with a brief in-between time interval resembles how visual search is done considering that the different item is searched upon the onset of a test array being compared against the items in memory. According to the resemblance, the present study examined whether varying the probability of change occurrence in a visual short-term memory-based change detection task can influence the aspect of response-decision making (i.e., change prevalence effect). The simple-feature change detection task in the study consisted of a set of four colored boxes followed by another set of four colored boxes between which the participants determined presence or absence of a color change from one box to the other. The change prevalence was varied to 20, 50, or 80% in terms of change occurrences in total trials, and their change detection errors, detection sensitivity, and their subsequent RTs were analyzed. The analyses revealed that as the change prevalence increased, false alarms became more frequent while misses became less frequent, along with delayed correct-rejection responses. The observed change prevalence effect looks very similar to the target prevalence effect varying according to probability of target occurrence in visual search tasks, indicating that the background principles deriving these two effects may resemble each other.

• Korean Journal of Biological Psychiatry
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• v.27 no.2
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• pp.94-100
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• 2020

Objectives Amyloid β positron emission tomography (Aβ PET) is widely used as a diagnostic tool in patients who have symptoms of cognitive impairment, however, this diagnostic examination is too expensive. Thus, predicting the positivity of Aβ PET before patients undergo the examination is essential. We aimed to analyze clinical predictors of patients who underwent Aβ PET retrospectively, and to develop a predicting model of Aβ PET positivity. Methods 468 patients who underwent Aβ PET with cognitive impairment were recruited and their clinical indicators were analyzed retrospectively. We specified the primary outcome as Aβ PET positivity, and included variables such as age, sex, body mass index, diastolic blood pressure, systolic blood pressure, education, dementia family history, Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating-Sum of Box (CDR-SB), hypertension (HTN), diabetes mellitus (DM) and presence of apolipoprotein E (ApoE) E4 as potential predictors. We developed three final models of amyloid positivity prediction for total subjects, mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using a multivariate stepwise logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) value was calculated for the ROC curve. Results Aβ PET negative patients were 49.6% (n = 232), and Aβ PET positive patients were 50.4% (n = 236). In the final model of all subjects, older age, female sex, presence of ApoE E4 and lower MMSE are associated with Aβ PET positivity. The AUC value was 0.296. In the final model of MCI subjects (n = 244), older age and presence of ApoE E4 are associated with Aβ PET positivity. The AUC value was 0.725. In the final model of AD subjects (n = 173), lower MMSE scores, the presence of ApoE E4 and history of HTN are associated with Aβ PET positivity. The AUC value was 0.681. Conclusions The cerebral amyloid positivity model, which was based on commonly available clinical indicators, can be useful for prediction of amyloid PET positivity in MCI or AD patients.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.31 no.5
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• pp.320-333
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• 2019

In this study, a physics-based 3D morphology model for the estimation of an erosion rate of nourished beach is newly proposed. As a hydrodynamic module, IHFOAM toolbox having its roots on the OpenFoam is used. On the other hand, the morphology model comprised a transport equation for suspended sediment, and Exner type equation derived from the viewpoint of sediment budget with the bed load being taken to accounted. In doing so, the incipient motion of sediment is determined based on the Shields Diagram, while the bottom suspended sediment concentration, the bed load transport rate is figured out using the bottom shearing stress directly calculated from the numerically simulated flow field rather than the conventional quadratic law and frictional coefficient. In order to verify the proposed morphology model, we numerically simulate the nonlinear shoaling, breaking over the uniform beach of 1/m slope, and its ensuing morphology change. Numerical results show that the partially skewed, and asymmetric bottom shearing stresses can be successfully simulated. It was shown that sediments suspended and eroded at the foreshore by wave breaking are gradually drifted toward a shore and accumulated in the process of up-rush, which eventually leads to the formation of swash bar. It is also worth mentioning that the breaker bar formed by the sediments dragged by the back-wash flow which commences at the pinnacle of up-rush as the back-wash flow gets weakened due to the increased depth was successfully duplicated in the numerical simulation.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.11
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• pp.113-123
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• 2018

First of all, the multi-story Housing applying resident's participation in europe was classified by the menu selection method, the two-step supply method and the cooperative method. And then I analyzed flexible unit plan of cases for deriving the planning methode and the characteristics of flexibility. First, I analyzed the area and form of the unit plan, structure and Installation, fixed and variable elements to derive the planning method. The area of units are distributed from a minimum of $35m^2$ to a maximum of $150m^2$, and many of the unit planes have a narrow front and a deep depth. The structure is a long-span wall-structure or a skeleton structure, and is designed without any columns and bearing walls in the interior space for flexibility in spatial composition. The vertical shafts are located in the center of the unit in a box-form or in the corner at the unit dividing wall for free placement of interior wall. Fixed elements are framework and facility systems. Most of the future residents in the two-steps supply method and the cooperative method were able to freely design the internal space within the zoning concept proposed by the architect and change the location of the facade element within module system proposed by the architect. Second, the characteristics of the flexibility applied to the unit plan were divided in integrated flexibility, functional flexibility, construction flexibility, and supply flexibility. The integrated flexibility enables residents to give the variable space combination based on the complex structure of the inner space for providing various living experiences. Regarding functional flexibility, the three-dimensional spatial structure with neutral space has multi-functionality according to the needs of residents and easily accepts mixing of hybrid programs such as work and residence. Constructive flexibility allows residents to create identity by freely planning interior space and changing the size or location of facade components in a determined system of architects. Finally, various types of size and space composition are proposed and realized in the whole building applying menu selection method, so that flexibility in the offer can accommodate and integrate various types of living.

• Journal of Radiation Protection and Research
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• v.45 no.4
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• pp.178-186
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• 2020

Background: Reactor pressure vessel (RV) with internals (RVI) are activated structures by neutron irradiation and volume contaminated wastes. Thus, to develop safe and optimized disposal plan for them at a disposal site, it is important to perform exact activation calculation and evaluate the dose rate on the surface of casks which contain cut-off pieces. Materials and Methods: RV and RVI are subjected to neutron activation calculation via Monte Carlo methodology with MCNP6 and ORIGEN-S program-neutron flux, isotopic specific activity, and gamma spectrum calculation on each component of RV and RVI, and dose rate evaluation with MCNP6. Results and Discussion: Through neutron activation analysis, dose rate is evaluated for the casks containing cut-off pieces produced from decommissioned RV and RVI. For RV cut-off ones, the highest value of dose rate on the surface of cask is 6.97 × 10-1 mSv/hr and 2 m from it is 3.03 × 10-2 mSv/hr. For RVI cut-off ones, on the surface of it is 0.166 × 10-1 mSv/hr and 2 m from it is 1.04 × 10-1 mSv/hr. Dose rates for various RV and RVI cut-off pieces distributed lower than the limit except the one of 2 m from the cask surface of RVI. It needs to adjust contents in cask which carries highly radioactive components in order to decrease thickness of cask. Conclusion: Two types of casks are considered in this paper: box type for very-low-level waste (VLLW) as well as low-level waste (LLW) and cylinder type for intermediate-level waste (ILW). The results will contribute to the development of optimal loading plans for RV and RVI cut-off pieces during the decommissioning of nuclear power plant that can be used to prepare radioactive waste disposal plans for the different types of wastes-ILW, LLW, and VLLW.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.36-43
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• 2021

Because bridges are major national infrastructure, regular safety inspections or diagnoses for bridges have been conducted in accordance with the "Special Act on the Safety and Maintenance of Facilities." Accordingly, the condition and safety assessments of the bridge are conducted to derive the condition and safety rating, respectively. A lower result is determined to be the safety grade of the bridge. In this study, the relationship between the condition rating and safety rating, which are the core of the bridge safety grade, was analyzed by the representative superstructure types of bridges, such as RC slab, PSCI girder, Steel box girder, Rhamen, and Preflex girder, to identify the correlation status and range between each rating. A reasonable improvement direction for establishing existing maintenance policies was suggested by proposing an alternative plan to change the proper implementation cycle of the inspection and diagnosis of bridge superstructure types. As a result of the research, it is necessary to adjust the inspection and diagnosis cycle according to the superstructure type and safety grade. In addition, maintenance policies need to be improved through detailed research on more diverse bridge types in the future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.19-26
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• 2021

The lattice structure is attracting attention from industry because of its excellent strength and stiffness, ultra-lightweight, and energy absorption capability. Despite these advantages, widespread commercialization is limited by the difficult manufacturing processes for complex shapes. Additive manufacturing is attracting attention as an optimal technology for manufacturing lattice structures as a technology capable of fabricating complex geometric shapes. In this study, a unit cell was formed using a three-dimensional coordinate method. The relative density relational equation according to the boundary box size and strut radius of the unit cell was derived. Simple cubic (SC), body-centered cubic (BCC), and face-centered cubic (FCC) with a controlled relative density were designed using modeling software. The accuracy of the equations for calculating the relative density proposed in this study secured 98.3%, 98.6%, and 96.2% reliability in SC, BCC, and FCC, respectively. A simulation of the lattice structure revealed an increase in compressive yield load with increasing relative density under the same cell arrangement condition. The compressive yield load decreased in the order of SC, BCC, and FCC under the same arrangement conditions. Finally, structural optimization for the compressive load of a 20 mm × 20 mm × 20 mm structure was possible by configuring the SC unit cells in a 3 × 3 × 3 array.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.2
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• pp.90-98
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• 2011

This study aims to discuss the characteristics of garden architecture in Italian Renaissance Villa Lante that was constructed by the cardinal in Bagnaia at 16th century through actual survey and analysis of the garden's elements. To do this, it was studied in two ways: Analysis of the present conditions and review historical documents. The results are as follows. First, the buildings, the gardens and the surrounding landscapes are visually connected each other in relations between the topography and the surrounding landscapes. Second, the spatial composition accepted Neoplatonic law of multiple proportions and was influenced by ancient myth and "Liber ruralium commodorum" of Pietro de Crescenzi(1305). Third, the garden's elements consist of plants, buildings and items. In plants, the upper plants are fir tree, cypress and pine tree and the lower plants are english holly, box tree and sweet oleander. The buildings are casino, loggia and terrace. The items are pot, sundial, chair, viewing platform and fountain. The result of this study, the political and social, technical phenomena which constitute construction pattern affected the locational property and the spatial organization of the neighbor on Villa Lante.