• Proceedings of the Zoological Society Korea Conference
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• 1999.10b
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• pp.297.1-297
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• 1999

No Abstract, See Full Text

• Animal cells and systems
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• v.12 no.4
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• pp.193-201
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• 2008

The eventual goal of tumor immunotherapy is to develop a vaccine inducing a specific anti-tumor immunity. Cytokine gene therapy is an effective way at least in animal models, but limited efficacy and various side effects obstruct clinical applications. In this study, we developed a tumor vaccine expressing a membrane-bound form of IL-2(mbIL-2) and SDF-1 in B16F10 melanoma cells. The tumor clones expressing mbIL-2 showed reduced tumorigenicity, and additional expression of SDF-1 to mbIL-2 expressing tumor cells caused more severe reduction in tumorigenicity. However, expression of the SDF-1 alone did not affect on the tumorigenicity, probably because of limited production of SDF-1 in the SDF-1 transfected clones. When the mice once rejected mbIL-2/SDF-1 expressing tumor clone were re-challenged with wild type B16F10 tumor cells, all of the mice survived. This result suggests that mbIL-2/SDF-1 tumor clone is effective in inducing systemic anti-tumor immunity against wild type B16 melanoma. Furthermore, culture supernatant of tumor clones expressing SDF-1 induced lymphocyte migration in vitro. These results, all together, suggest that expression of mbIL-2 and SDF-1 in tumor cells enhances anti-tumor immune responses through different roles; the secreted SDF-1 may function as a chemoattractant to recruit immune cells to tumor vaccine injection site, and the mbIL-2 on tumor cells may provide costimulatory signal for CTL activation in physical contacts.

• International Journal of Control, Automation, and Systems
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• v.6 no.6
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• pp.960-967
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• 2008

This paper shows that design of a robustly stable repetitive control system is equivalent to that of a feedback control system for an uncertain linear time-invariant system satisfying the well-known robust performance condition. Once a feedback controller is designed to satisfy the robust performance condition, the feedback controller and the repetitive controller using the performance weighting function robustly stabilizes the repetitive control system. It is also shown that we can obtain a steady-state tracking error described in a simple form without time-delay element if the robust stability condition is satisfied for the repetitive control system. Moreover, using this result, a sufficient condition is provided, which ensures that the least upper bound of the steady-state tracking error generated by the repetitive control system is less than or equal to the least upper bound of the steady-state tracking error only by the feedback system.

• Journal of the Korean Mathematical Society
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• v.54 no.2
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• pp.479-491
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• 2017

We investigate the zeros of Epstein zeta functions associated with positive definite quadratic forms with rational coefficients in the vertical strip ${\sigma}_1$ < ${\Re}s$ < ${\sigma}_2$, where 1/2 < ${\sigma}_1$ < ${\sigma}_2$ < 1. When the class number h of the quadratic form is bigger than 1, Voronin gave a lower bound and Lee gave an asymptotic formula for the number of zeros. Recently Gonek and Lee improved their results by providing a new upper bound for the error term when h > 3. In this paper, we consider the cases h = 2, 3 and provide an upper bound for the error term, smaller than the one for the case h > 3.

• Communications for Statistical Applications and Methods
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• v.6 no.2
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• pp.443-456
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• 1999

The estimation of mean lifetimes in presence of interval censoring with mixed replacement procedure are examined when the distribution s of lifetimes are exponential. it is assumed that due to physical restrictions and/or economic constraints the number of failures is investigated only at several inspection times during the lifetime test; thus there is interval censoring. Comparisons of mixed replacement designs are made with those with and without replacement The maximum likelihood estimator is found in an implicit form. The Cramer-Rao lower bound which is the asymptotic variance of the estimator is derived. The test conditions for minimizing the Cramer-Rao lower bound and minimizing the test costs within a desired width of the Cramer-Rao bound have been studied.

• Journal of Microbiology and Biotechnology
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• v.11 no.1
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• pp.72-78
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• 2001

It is possible ot prepare protoplasts of the zygomycete fungus, Phycomyces blakesleeanus, by digesting the cell wall of spore germlings with commercially available chitinase and chitosanase. However, the cells without any cell walls immediately form large aggregates, and thus, it is difficult to isolate the individually separated protoplasts. Inherent problem with the formation of aggregates in preparing protoplasts could be solved by the use of bovine serum albumin (BSA). As a result, we were able to prepare a large number of single protoplsts quickly and easily. We took time-lapse photomicrographs of the formation of protoplasts, and found that there were certain regions of the cell wall of spore germlings that were sensitive to chitinase and chitosanase, although the cell wall of the original spores is known to be insensitive to these enzymes. There are two kinds of cell walls on a spore germling; one with a bound wheat germ agglutinin (WGA), and the other a bound concanavalin A (ConA). Furthermore, only cells with walls which had bound WGA were able to regenerate, while those with walls with bound ConA were not able to regenerate.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.8
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• pp.937-943
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• 2017

This study was performed to investigate the changes between free and bound forms of bioactive compounds in germinated adzuki bean. Adzuki bean was germinated at $25^{\circ}C$ for 6 days, and then free and bound forms of bioactive compounds were extracted. Total free polyphenol and flavonoid contents in of raw adzuki bean increased from 0.91 mg/g and 0.60 mg/g in before germination to 2.37 mg/g and 3.03 mg/g in at 6 days after germination, respectively. Bound polyphenol, flavonoid, and phenolic acid contents also increased with increasing germination periods, whereas bound polyphenol and flavonoid contents slightly reduced in at 2 days after germination. The total phenolic acid contents, including ferulic acid, veratric acid, hesperidin, salicylic acid, naringenin, and hesperidin, increased during germination, and germination process can convert compounds to phenolic acid via anabolism and catabolism. Total anthocyanin and anthocyanidin contents of adzuki bean decreased during germination due to hydration by water during soaking or enzyme activation of anthocyanase during germination. These results suggest that the germination process increased utilization of functional compounds such as phenolic compound and isoflavones in black soybean.

• Journal of the Korean Geotechnical Society
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• v.22 no.9
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• pp.23-36
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• 2006

This study presents the development of a new closed-form analytical solution for the ultimate bearing capacity of an embedded wall in a granular mass. The closed-form analytical solution consists of upper and lower bound solutions (UB and LB). The calculated values from these bound solutions were compared with the author's two-dimensional laboratory wall model loading test and finite element analysis in the plastic region. The comparison showed that ultimate bearing loads from both the model test and finite element analysis are located between UB and LB. In particular, the ultimate bearing load from LB showed good agreement with the ultimate bearing load values from both the model test and finite element analysis. However, the calculated value from the conventional empirical form subjected to plane-strain conditions was shown to be much smaller than the LB.

• Journal of the Korean Society of Costume
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• v.27
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• pp.17-26
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• 1996

This thesis is to study the original form of Buckles of our country in ancient times On the upper garment bound the leather belts that was hanged a hook that shaped of animal form at the end. The background of Buckles was originated from those northern mounted normadic groups which was Scythe style costume culture. In Korea through the antique records and tombs bequests the styles of Buckles was divided into three groups horse-shaped tiger-shaped bar-shaped Buckle. These styles were influened by scythe style and developed greatly and trasmitted to Japan.

• Journal of Ginseng Research
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• v.8 no.2
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• pp.75-81
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• 1984

The effect of the saponin fraction extracted from Panax ginseng C.A. Meyer on the absorption of ${\alpha}$-tocopherol in rat has been investigated and realized that the saponin fraction stimulated not only the absorption of ${\alpha}$-tocopherol (1.5-2 times that of control) but also its transport and excretion. ${\alpha}$-tocopherol is known to be transported mainly in the form of ${\beta}$-lipoprotein but the present study showed that the ${\alpha}$-tocopherol was transported in the form of albumin bound or micellar structure as well.