• Journal of Veterinary Science
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• v.24 no.6
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• pp.83.1-83.12
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• 2023

Background: Ellipticine (Ellip.) was recently reported to have beneficial effects on the differentiation of adipose-derived stem cells into mature chondrocyte-like cells. On the other hand, no practical results have been derived from the transplantation of bone marrow stem cells (BMSCs) in a rabbit osteoarthritis (OA) model. Objectives: This study examined whether autologous BMSCs incubated with ellipticine (Ellip.+BMSCs) could regenerate articular cartilage in rabbit OA, a model similar to degenerative arthritis in human beings. Methods: A portion of rabbit articular cartilage was surgically removed, and Ellip.+BMSCs were transplanted into the lesion area. After two and four weeks of treatment, the serum levels of proinflammatory cytokines, i.e., tumor necrosis factor α (TNF-α) and prostaglandin E2 (PGE2), were analyzed, while macroscopic and micro-computed tomography (CT) evaluations were conducted to determine the intensity of cartilage degeneration. Furthermore, immuno-blotting was performed to evaluate the mitogen-activated protein kinases, PI3K/Akt, and nuclear factor-κB (NF-κB) signaling in rabbit OA models. Histological staining was used to confirm the change in the pattern of collagen and proteoglycan in the articular cartilage matrix. Results: The transplantation of Ellip.+BMSCs elicited a chondroprotective effect by reducing the inflammatory factors (TNF-α, PGE2) in a time-dependent manner. Macroscopic observations, micro-CT, and histological staining revealed articular cartilage regeneration with the downregulation of matrix-metallo proteinases (MMPs), preventing articular cartilage degradation. Furthermore, histological observations confirmed a significant boost in the production of chondrocytes, collagen, and proteoglycan compared to the control group. Western blotting data revealed the downregulation of the p38, PI3K-Akt, and NF-κB inflammatory pathways to attenuate inflammation. Conclusions: The transplantation of Ellip.+BMSCs normalized the OA condition by boosting the recovery of degenerated articular cartilage and inhibiting the catabolic signaling pathway.

• Korean Journal of Culture and Social Issue
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• v.16 no.4
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• pp.469-485
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• 2010

The present research investigated the influence of the enlistment motivation on an image of military organization, soldier's stress, a confidence of social life after discharge from military service and military life satisfaction in Korean military service. Participants of this research were 257 soldiers (121 conscript Army soldiers and 136 voluntary Marines) from 2 companies in the army and 2 companies in the Marine Corps located in South Korea. Results of this study showed that 1) conscript Army group(M=2.39, SD=.71)had a significantly higher score than voluntary Marines group(M=1.95, SD=.63)in extrinsic enlistment motivation. On the contrary, Marines group(M=4.16, SD=.76) had a significantly higher score than Army group(M=3.62, SD=.87) in intrinsic enlistment motivation. 2) Enlistment by intrinsic motivation has positive influence on the military life. Result of Regression analysis showed that enlistment by intrinsic motivation significantly predicted a military life satisfaction(𝛽=.402, t=6.424, p<.001), a confidence of social life(𝛽=.528, t=9.836, p<.001), and an image of military organization(𝛽=.494, t=8.486, p<.001). On the other hand, enlistment by extrinsic motivation has negative influence on the military life. Result of Regression analysis showed that enlistment by extrinsic motivation significantly predicted the soldier's stress in military life(𝛽=.415, t=6.642, p<.001), and no confidence of social life(𝛽=-.177, t=-3.306, p<.001). These results suggest that Korean military needs to focus on enhancing intrinsic enlistment motivation of young men of conscription age before conscription by educating, and advertising etc. And also, we discuss that Korean military needs to consider how to boost intrinsic motivation of military life.

• Journal of Korean Dental Hygiene Science
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• v.1 no.1
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• pp.47-55
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• 2018

The purpose of this study was to examine the influence of oral health education experience on needs for oral health education in children and adolescents in elementary and secondary schools. A self-administered survey was conducted on the students in elementary, middle and high schools located in the city of Mokpo, South Jeolla Province, from October 1 to 31, 2018. The data that were collected from 327 students were analyzed by SPSS 21.0. Statistical data on frequency, percentage, mean and standard deviation were obtained, and t-test, one-way ANOVA, correlation analysis and logistic regression analysis were carried out. The findings of the study were as follows: First, the subjects got 2.25 on a three-point scale in self-rated oral health status. This score was above average, which indicated that the students thought they were in good oral health. As for problems with oral health, dental caries was given the highest score of 2.48 on a five-point scale, followed by oral malodor with 2.35. Second, the students who experienced oral health education accounted for 69.1 percent, and the students who felt the need for this education represented 82.6 percent. As for educational content desired, the biggest group of 57.8 percent hoped to learn about how to prevent and manage dental caries, and the second largest group of 17 percent wanted to learn about how to take care of oral health during orthodontic treatment. Third, as a result of investigating the state of oral health education by the grade of school, the elementary school students had more oral health education experience than the middle and high school students, and the middle school students placed the most importance on the necessity of oral health education. The differences were statistically significant. Fourth, as a result of analyzing the correlation between oral health education experience and the necessity of oral health education, the students who had more oral health education experience asked more for this education, which implies that there was a statistically significant positive correlation. The findings of the study ascertained that oral health education should be provided for students in childhood and adolescence to boost the level of their oral health knowledge and change their oral health attitude in a positive manner. If oral health practice programs that connect schools, local communities and families with one another are developed to guide the oral health behaviors of teenagers in the right direction, it will make a contribution to the promotion of oral health.

• Information Systems Review
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• v.20 no.2
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• pp.139-161
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• 2018

As Korea became one of the oldest countries in the world, successful aging emerged as an important issue to individuals as well as to society. This study aims to determine not only the Korean seniors' happiness and unhappiness factors but also the means to enhance their happiness and deal with unhappiness. We collected news articles related to the happiness and unhappiness of seniors with nine keywords based on Alderfer's ERG Theory. We then applied a topic modeling technique, Latent Dirichlet Allocation, to examine the main issues underlying the seniors' happiness and unhappiness. According to the analysis, we investigated the conditions of happiness and unhappiness by inspecting the topics based on each keyword. We also conducted a detailed analysis based on the main factors from topic modeling. We proposed specific ways to increase and overcome the happiness and unhappiness of seniors, respectively, in terms of government, corporate, family, and other social welfare organizations. This study indicates the major factors that affect the happiness and unhappiness of seniors. Specific methods to boost happiness and relief unhappiness are suggested from the additional analysis.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.9 no.5
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• pp.69-81
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• 2014

There is a growing interest in the technology transfer and commercialization both at home and abroad. Accordingly, this study looked at the concept of technology transfer and commercialization, identified the factors that should be taken into account in order to facilitate technology transfer and commercialization, and then performed a empirical analysis. As for the conventional technology transfer and commercialization, there was a tendency to limit its scope to the exploration, transfer and commercialization of technology itself. Here in this research, technology transfer and commercialization is defined the category to expand as various activities implemented in order to make sure that intellectual properties such as intangible technological developments, know-how, and knowledge are transferred between the relevant parties through a contract or negotiation, and the party to which the transfer is made can then further develop and exploit the technology into tangible products and other activities to obtain economic benefit out of that. In addition, the findings of the positive analysis of technology transfer and commercialization revealed that the focus of facilitating technology transfer has been on the technology itself, its management and securing efficiency of the systems and institutions involved in the technology transfer and commercialization. So there was lack of recognition as to the importance of financial support given to the phase of technology commercialization. This indicates that when it comes to the technology transfer and commercialization, quantitative performance has been the focus of interest such as patent application, registration, number of technology transfers, royalty, etc. So there was not enough understanding as to the issues of starting up a business, creating quality jobs through technology transfer and commercialization, which are directly related to the realization of the creative economy. In this regard, this research is expected to be used for the development for the future policies to boost technology transfer and commercialization as it suggests not only simply ensuring quantitative performance but also necessary to create the environment for the creation of the stable ecosystem for the parties involved in the technology transfer and commercialization and then to build circumstances in which creative economy can be realized.

• Journal of dental hygiene science
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• v.10 no.1
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• pp.1-9
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• 2010

The purpose of this study was to examine the cognition-perception factors and oral health promotion behavior of dental hygiene and non-dental hygiene students in an effort to find out factors affecting their oral health promotion behavior. After a survey was conducted, the collected data were analyzed. The findings of the study were as follows: 1. In regard to cognition-perception factors of oral health, the dental hygiene students were ahead of the others in self-efficacy, control of oral health and benefits of oral health behavior. The latter felt there were more barriers to their oral health behavior than the former. 2. As to the practice of oral health promotion behavior, that behavior was more prevailing among the dental hygiene students than the others. Both groups restrained themselves from liquor and cigarettes. 3. Concerning the correlation between oral health promotion behavior and related variables, self-efficacy and control of oral health had a significant correlation to oral health promotion behavior. Better self-efficacy and better control of oral health led to better oral health promotion behavior and better practice of its subfactors 1, 2 and 3. 4. As a result of checking the variables affecting oral health promotion behavior and the subfactors of the variables, self-efficacy had the largest impact on factor 1, factor 2, factor 3 and oral health promotion behavior, and factor 2 was under the greatest influence of control of oral health. Based on above-mentioned findings, self-efficacy was identified as the cognition-perception factor that had the largest impact on oral health behavior. Therefore how to boost self-efficacy should be considered when oral health promotion programs are developed, and research efforts should be channeled into finding out in which way self-efficacy could be bolstered in association with each kind of oral health promotion behavior.

• Journal of dental hygiene science
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• v.12 no.4
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• pp.383-391
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• 2012

The purpose of this study was to examine the ethical dilemma of dental hygienists and the level of empowerment among them in an attempt to provide some information on how to alleviate the ethical dilemma of dental hygienists to boost their empowerment. The findings of the study were as follows: The dental hygienists got a mean of 1.58 out of possible four points in ethical dilemma. Among the subfactors of ethical dilemma, they scored highest in ethical dilemma about dental hygienists and profession (1.79), followed by dental hygienists and patients (1.53), life reverence and respect for human rights (1.51) and dental hygienists and cooperators (1.49). As for the general characteristics of the dental hygienists, those who were better educated and who intended to temporarily work just until marriage fell into a more ethical dilemma. The dental hygienists got a mean of 3.05 out of possible five points in empowerment. Among the subfactors of it, they scored highest in support structure (3.52), opportunity structure (3.18), information structure (3.08) and resources structure (3.04). There were significant gaps among the dental hygienists in empowerment according to their attitude toward the dental hygienist job as a profession. There was a significant negative correlation between ethical dilemma and empowerment. Regarding influential factors for the ethical dilemma of the dental hygienists, marital status and empowerment were identified as significantly influential factors, and empowerment had a significant relationship to age, academic credential and ethical dilemma. Given the findings of the study, the development of various intervention programs and empowerment-boosting strategies is required to relieve dental hygienists of ethical dilemma.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.33 no.2
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• pp.78-88
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• 2015

In the 1920s, the period of cultural governance ruled by Japan, the diverse media were founded and various events were conducted to boost circulation. Under the Japanese colonial period in 1920s, a number of media - newspapers and magazines - were published and often they carried out entertaining events in order to obtain more subscribers. A hobby magazine, Samchunri, for instace, set up a media event to selecting Korea's eight beautiful scenary (Bandopalgyong) for the first edition in 1929. The paper aims to analyse and understand the perception of landscape in 1929 through the media event carried out by Samchunri. In particular, the selection was made by well-known writers within Japanese colonial period 1910 - 1945). The selection process and views from the writers on landscape were analysed; firstly, the selection of Bandopalgyong was carried out by questionnaires to writers in 1929 where Korea is under Japanese colonial rules. The conditions of the selection were unknown; however, the purpose was enlightening the people specially the youngs and introduction of beautiful places in Korea. As a result, views and opinions on Bandopalgyong by the writers were progressed. Secondly, within the Bandopalgyong, the natural landscape areas include Gumgansan(金剛山), Daedonggang(大洞江), Buyeo(扶餘), Gyongju(慶州), Myongsasipri (明沙十里), Haundae(海雲臺), Baekdusan(白頭山), and Choksukru(矗石樓). Those chosen places were not cohesive nor did not have any consistant reasons to be chosen in terms of size and location; however, some writers claimed that there were other places to match the chosen ones and therefore, the selection process was highly dependent on access (i.e. transport). Thirdly, the travelogue on Baekdusan and Nackwhaam(洛花岩) illustrated interesting views on landscape in particular. Baekdusan landscape were described in overlaping with long history and national soul. In the Nackwhaam travelogue, it described 'Buyeo (夫餘) was an ancient capital of Backjae Dynasty and empty place' as well as denying Chosun Dynasty. It was assumed that the two places weren't visited but rewritten with existing literatures. Fourthly, edited by Kim Dong Whan, a travelogue style book, 'Bandosanha' was published in 1941. It did repeat the selection of Bandopalgyong, but this time, it was classified the eight beautiful landscape into two categories; historic/cultural places and natural landscape. This paper was able to analyse and understand the perception of landscape in 1929 through the travelogue of Samchunri. It is an empirical study on the process and perception on Korea landscape under Japanese colonical period by views of the selected writers.

• Radiation Oncology Journal
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• v.3 no.2
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• pp.95-101
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• 1985

From July 1979 through March 1985,112 patients with carcinoma of the uterine cervix were treated by whole pelvis irradiation and intracavitary radiation with Cs-137. The treatment consisted of 3600rad-5200rad to the whole pelvis by parallel opposing portals, 5 days per week, 180-200rad per day. Parametrial boost with 400-800rad was given in 60 patients. 2 intracavitary Cs-137 radiation using TAO applicator were done with 7-10 days interval. Total treatment times were 40-65 days with average 52 days. Total dose of radiation to point A varied from 6820 to 10500rad with average 8388rad and to point B from 4850 to 6899ra0 with average 5898rad. All patients had follow up from 6 months to 75 months and median follow up of 31 months. $9(8\%)$ had stage $14(12.5\%)$ had stage IIa, $50(44.6\%)$ had stage IIb, $33(29.5\%)$ had stage III, $6(5.4\%)$ had stage IV. 110 patients had squamous cell carcinoma and 2 patients had adenocarcinoma. 5 year actuarial survival rates were $61.8\%$ for the entire group, $84.6\%$ for stage Ib,$77.8\%$ for stage IIa, $56.7\%$ for stage IIb, $60\%$ for stage III, $33.3\%$ for stage IV. RT dose to medial parametrium (point A) below 8000rad resulted in $7/18(38.9\%)$ failure (=death) in contrast to 25/94 $(26.5\%)$ failure with dose over 8000rad. RT dose to lateral parametrium (point B) below 6000ra0 yielded 20/63 $(34.9\%)$ failure compared to $10/49(20.4\%)$ failure with dose over 6000rad. Poor survival group of age were between 40-49 years with failure of $14/41(34.1\%)$. There was no increased failure rate below age of 40 with failure of $2111(13.9\%)$. The results suggest that survival is as good as other published data, and that higher doses over 8000rad to point A and 6000rad to point B should be delivered.

• Radiation Oncology Journal
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• v.10 no.1
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• pp.7-14
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• 1992

Between August 1988 and December 1991, 24 patients with intracranial tumors were treated with stereotactic radiosurgery(RS) using a 10 MV linear accelerator at Severance Hospital, Yonsei University College of Medicine. There were 5 meningiomas, 3 craniopharyngiomas, 9 glial tumors, 2 solitary metastases, 2 acoustic neurinomas, 2 pineal tumors, and 1 non-Hodgkin's lymphoma. Ten patients were treated as primary treatment after diagnosis with stereotactic biopsy or neuroimaging study. Nine patients underwent RS for post-op. residual tumors and three patients as a salvage treatment for recurrence after external irradiation. Two patients received RS as a boost followed by fractionated conventional radiotherapy. Among sixteen patients who were followed more than 6 months with neuroimage, seven patients (2 meningiomas, 4 benign glial tumors, one non-Hodgkin's lymphoma) showed complete response on neuroimage after RS and nine patients showed decreased tumor size. There was no acute treatment related side reaction. Late complications include three patients with symptomatic peritumoral brain edema and one craniopharyngioma with optic chiasmal injury. Through this early experience, we conclude that stereotactically directed single high doses of irradiation to the small intracranial tumors is effective for tumor control. However, in order to define the role of radiosurgery in the management of intracraniai tumors, we should get the long-term results available to demonstrate the benefits versus potential complications of this therapeutic modality.