• The Journal of Pediatrics of Korean Medicine
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• v.22 no.2
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• pp.69-80
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• 2008

Objectives : The purpose of this study was to evaluate the correlation of 3 methods of bone age measurements. Methods : 102 children(49 boys, 53 girls) were involved in this study. We measured the height, weight and bone age based when they visited for the first time. We measured bone age using BoneAge of Sunlight Co.,Ltd. Two of the bone age measurement methods, Greulich-Pyle and Tanner-Whitehouse, were used to analyze the left dorsopalmar hand-wrist radiographs of 102 children who visited in Department of Pediatrics, O O University Oriental Hospital. This study was designed to investigate the correlation of the bone age between two methods. Results : The bone ages were related with age, height, weight and BMI according to this study(P<0.01). Each bone age assessment method had statistically significant correlation to each other(P<0.01). Conclusions : The ultrasound transonic velocity of inferior radiocarpal joint will become a sufficient diagnostic tool of bone age assessment if measurement error can be minimized by proper effort.

• The Journal of Pediatrics of Korean Medicine
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• v.20 no.3
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• pp.23-32
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• 2006

Objectives : The object of this study was to evaluate the effect of oriental medical treatment to the growth of children using bone age as measurer. Methods : This clinical study has been carried out with 32 cases(male 15, female 17 of children) aging from 7 to 15 years old, who visited to the Department of Pediatrics growth clinic, ○○ medical center from January 2004 to August 2006 and were treated for more than 12 months. Their height, body weight, body mass index(BMI) and bone age were estimated at two points: Before and after oriental medical treatment was applied. Bone age is measured by X-ray image of growth plate in inferior radiocarpal joint. Results : Bone age correlated with choronological age, height, weight. Difference between bone and choronological age was correlated with percentile of height and weight. The mean growth of children showed 4.03 percentile upwardly(p=.046), and difference between bone and choronological age was reduced from $0.23{\pm}1.62$ to $-0.026{\pm}1.64(p=.040)$ after treatment. Conclusions : This study shows that oriental medical treatment helped growth of children using bone age as measurer.

• The Journal of Pediatrics of Korean Medicine
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• v.37 no.3
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• pp.111-120
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• 2023

Objectives The purpose of this study is to analyze the characteristic of the 157 pediatric patients who visited a Korean medical hospital for bone age (BA) measurement and to compare the BA measurement using Tanner-Whitehouse 3-based analysis software and specialists in pediatric Korean medicine to determine the relationships. Methods The study included 157 pediatric patients who visited a Korean medicine hospital for BA measurements from June 2021 to June 2023. They were analyzed to determine the characteristics and agreement of BA measurements using Tanner-Whitehouse 3-based analysis software and specialists using classification by age, intraclass correlation coefficient (ICC), and Bland-Altman plots. Results In total, 61.8% of the study population were boys and 38.2%, girls, with an average age of 11.32 ± 1.87. The types of growth were various, and the average of bone maturity was 0.48 ± 1.13 as concluded by analysis software and 0.38 ± 1.15 as concluded by the specialists. The ICC of two methods were excellent: 0.995 (overall), 0.996 (boys) and 0.994 (girls). However, BA determined by analysis software tended to be higher than that determined by specialists when the patients were young. Conclusions This study showed that patients visited the hospital for BA measurement regardless of their height, and the agreement of BA between the two methods can be used as a reference. However, there was differences in the trends between age and sex, which should be interpreted with caution.

• Preventive Nutrition and Food Science
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• v.10 no.1
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• pp.40-45
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• 2005

Age-related changes in bone metabolism are well established by biochemical markers of bone matrix in serum and urine, but analysis of the residual bone matrix, which is still turning over, has not been investigated. In the present study, we measured in vivo rates of bone protein synthesis using a precursor-product method based on the exchange of ²H from ²H₂O into amino acids. Four percent ²H₂O was administered to mice in drinking water after intraperitonial (i.p) bolus injection of 99.9% ²H₂O. Mice were divided into the two groups: growing young mice were administered 4% ²H₂O for 12 weeks after an i.p bolus injection at 5 week of age, whereas weight stable adult mice started drinking 4% ²H₂O 8 weeks later than the growing group and continued 4% ²H₂O drinking for 8 weeks. Mass isotopomer abundance in alanine from bone protein was analyzed by gas chromatography/mass spectrometry. Body ²H₂O enrichments were in the range of 1.88-2.41% over the labeling period. The fractional synthesis rates (ks) of bone protein were 2.000±0.071%/d for growing mice and 0.243±0.014%/d for adult mice. These results demonstrate that the bone protein synthesis rate decreases with age and present direct evidence of age-related changes in bone protein synthesis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.6
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• pp.1279-1284
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• 1998

This study was conducted to investigate the effect of physiological and behavioral factors on the bone density of 125 middle aged women who visited Saint Bundo Hospital. 16.1% of subjects had osteoporosis and 40.3% had osteopenia according to the measurement of the bone density of lumbar spine. Mean age was 56.9 in osteoporosis group and 53.7 in osteopenia group. It was significantly different from the mean age of control group, 50.7. The mean bone density of the women who had menarche after 15 years old was significantly lower than that of the women who had menarche before 15. But the age of menopause, the total year of menstruation, irregularity of the menstrual cycle and percentage of subjects who had ovariectomy were not significantly different among osteoporosis, osteopenia and control group. The use of medication such as oral contraceptive, steroid, depressant, diuretic, and Ca supplement and the preference of salty food were not significantly different among three groups. The percentage of subjects who had rheumatism, gastric ulcer, and pain in neck or shoulder was higher in osteoporosis and osteopenia group than in control group. This study shows that the age and the age of menarche affect the bone density, and that behavioral factors were not sig nificantly different in osteoporosis and osteopenia group compared to the control group. Further researches are needed to find out the effective way to minimize the effect of age and other physiological conditions on the decrease of bone density.

• Korean Journal of Community Nutrition
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• v.12 no.5
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• pp.559-568
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• 2007

Weight control diets induce reducing women' bone mineral density (BMD) that has a close relationship to risk in osteoporosis. This study was carried out to identify bone density risk factors affecting women's BMD, and to examine the relationship age, lifestyle and dietary habits for bone health by physical measurement and questonnaies. The subjects of this study were 194 women living on the Seoul area. When the subjects were divided into 4 age groups, BMI was the highest in the 50 years group (24.8) and the lowest in the 20 years group (21.63). Average T-score, which is BMD of forearm bone and calcaneus was the highest in the 40 years (-0.07) and the lowest in the 20 years (-0.59). The rate of eating breakfast was shown significantly higher in the 50 years group than that in the younger group. The frequencies of eating out, fried food intakes, and alcohol drinks were shown significantly different by age (p < 0.01). In conclusion, the risk rate of BMD was high in the 20syears and 50 years groups. It may due to the 20s' weight-control diet. Breakfast eating, exercise, intakes of anchovies, radishes, carrots, zucchinis and tomatoes were significantly important factors to prevent bone density risk.

• Journal of the Korean Society of Radiology
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• v.9 no.6
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• pp.349-356
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• 2015

The study is to recognize the interactions with bone ages by measuring the length between the end of the bone and the growth plate on selected highest weight of regions of seven for bone maturity in TW3 method. The experiment is subjected on seventy-two children (36 males, 36 females) who have examined the growth plate test from March, 2014 to March, 2015 and implemented a regression analysis by measuring the length between the end of the bone and the growth plate in Hand AP image of the children. In result, each bone age has produced a mean value and a standard deviation corresponding to the specific range and as bone age increases the length between the end of the bone and the growth plate decreased. In addition, female children showed lower mean value in comparison to male and also the measurement of the length between the end of the bone and the growth plate and its bone age are shown to be statistically valid(p<0.001) according to the results of regression analysis using its result value. Therefore, the probability of prediction on the bone age read off through the applied TW3 method and regression equation in the Hand AP image of the children.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.11
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• pp.200-208
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• 2004

In ultrasonic bone densitometry, the positioning of measurement site is decisive in precision and reproducibility. In this study, automatic Region of Interest (ROI) detection algorithm is suggested and adopted the method using the local minimum value by ultrasonic image. The preprocess before the local minimum method extracts out the bone area and calculates the geometrical information of bone. The developed ROI detection algorithm was applied to the clinical test for the subject of 305 female patients in the range of 22-88 years old. As the results, the accuracy of the algorithm was shown to be 98.3％. It was also found that bone density parameter was significantly correlated with age(r=0.85, p<0.0001).

• Journal of Audiology & Otology
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• v.24 no.1
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• pp.17-23
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• 2020

Background and Objectives: We aimed to measure the head dimensions on computed tomography (CT) images, to compare them to directly measured head dimensions, and to predict a new parameter of bone thickness for aiding bone conduction implant (BCI) placement. Subjects and Methods: We reviewed the facial and mandibular bone CT images of 406 patients. Their head sizes were analyzed using five parameters included in the 6th Size Korea project, and they were divided into age groups (ranging from the 10s to the 80s). We compared the head length, head width, sagittal arc, bitragion arc, and head circumference in the CT and Size Korea groups. We also added the parameter bone thickness for aiding BCI placement. Results: All the head size parameters measured using CT were significantly smaller than those measured directly, with head length showing the smallest difference at 7.85 mm. The differences in the other four parameters between the two groups according to patient age were not statistically significantly different. Bone thickness had the highest value of 4.89±0.93 mm in the 70s and the lowest value of 4.10±0.99 mm in the 10s. Bone thickness also significantly correlated with head width (p=0.038). Conclusions: Our findings suggested that the CT and direct measurements yielded consistent data. Moreover, CT enabled the measurement of bone sizes, including bone thickness, that are impossible to measure directly. CT measurements may complement direct measurements in the Size Korea data when used for developing bone conduction hearing devices (BCIs and headsets) for the Korean population.

• Korean Journal of Audiology
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• v.24 no.1
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• pp.17-23
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• 2020

Background and Objectives: We aimed to measure the head dimensions on computed tomography (CT) images, to compare them to directly measured head dimensions, and to predict a new parameter of bone thickness for aiding bone conduction implant (BCI) placement. Subjects and Methods: We reviewed the facial and mandibular bone CT images of 406 patients. Their head sizes were analyzed using five parameters included in the 6th Size Korea project, and they were divided into age groups (ranging from the 10s to the 80s). We compared the head length, head width, sagittal arc, bitragion arc, and head circumference in the CT and Size Korea groups. We also added the parameter bone thickness for aiding BCI placement. Results: All the head size parameters measured using CT were significantly smaller than those measured directly, with head length showing the smallest difference at 7.85 mm. The differences in the other four parameters between the two groups according to patient age were not statistically significantly different. Bone thickness had the highest value of 4.89±0.93 mm in the 70s and the lowest value of 4.10±0.99 mm in the 10s. Bone thickness also significantly correlated with head width (p=0.038). Conclusions: Our findings suggested that the CT and direct measurements yielded consistent data. Moreover, CT enabled the measurement of bone sizes, including bone thickness, that are impossible to measure directly. CT measurements may complement direct measurements in the Size Korea data when used for developing bone conduction hearing devices (BCIs and headsets) for the Korean population.