• 한국식품영양학회지
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• 제33권5호
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• pp.493-504
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• 2020

Gastrodia elata Bl. (GE) is a traditional herbal medicine used for the treatment hypertension and cerebrovascular disease. The purpose of this study was to investigate the antioxidant effect and blood pressure control ability of the GABA containing fermented Gastrodia elata Blume. The fermentation strain provided by Dr. Gi in Seoul National University is L. brevis GABA100, excellent strain of GABA production, which is involved in the ability to degrade gastrodin glycosides and activation of brain function. The Gastrodia elata Blume fermented by Lactobacillus brevis GABA 100 showed antioxidant activity (total phenolic contents, DPPH radical and ABTS anion scavenging activities) than unfermented Gastrodia elata Blume. In the spontaneously hypertensive rats (SHR), the concentration of fermented Gastrodia elata Blume was administered at 500, 1,000, and 2,000 mg/kg for 8 weeks. Systolic blood pressure decreased statistically significantly (p<0.05), especially 2 weeks after feeding fermented Gastrodia elata Blume. Also, it showed a significant decrease in low, medium, and high concentrations of fermented Gastrodia elata Blume at 4 weeks and 8 weeks. These results indicated that Gastrodia elata Blume fermented by the excellent strain of GABA production L. brevis GABA100 shows the antioxidant function and the effect of suppressing the increase in blood pressure.

• The Journal of Korean Physical Therapy
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• 제14권3호
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• pp.45-59
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• 2002

The purpose of this study was to investigate the effects of strengthening exercise program on the improvement of balance in the elderly Subjects were forty members living in Daegu (20 males, 20 females), between 65 and 81 years of age. The subjects were divided into two groups; an experimental group and a control group, and each group included 10 males and 10 females. The subjects for the experimental group were participated in the strengthening exercise program for 8 weeks, between April 2001 and June 2001 The results of this study were as follows: 1. General characteristics statistically significantly affecting for CTSIB were mental status; weight, height, vision, systolic blood pressure, diastolic blood pressure, pulse rate, mental status, obesity and thigh BMD were BBT; age, weight, height, vision, blood pressure systolic, blood pressure diastolic, blood pulse rate, mental status, obesity, spine BMD and thigh BMD were for OLST. 2. After the exercise program, there was no significant difference in the balance ability between the experimental group and the control group in CTSIB. However, there was a significant difference in OLSTR on the hard (p<0.05) and soft (p<0.05) surface with open eyes condition between the experimental group and the control group. In the case of OLSTL, there was a significant difference on the hard surface with open eyes condition (p<0.05), and on the soft surface with open eyes condition (p<0.05) and closed eyes condition (p<0.05) between the experimental group and the control group. There was no significant difference in the balance ability between the experimental group and the control group in BBT.

• 근관절건강학회지
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• 제14권2호
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• pp.158-168
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• 2007

Purpose: The purpose of this study was to determine the effects of exercise using Thera Band on body compositions, blood pressure and physical fitness in the elderly women. Method: The study was designed as a nonequivalent control group pretest-posttest quasi-experimental study. Twenty four subjects were assigned for experimental group and twenty one subjects were assigned for control group. The experimental group participated in Thera Band exercise program consisting of 60 minutes per session, 3 times a week during the period of 12 weeks. The effects of the program were assessed using the instruments measuring the body compositions, blood pressure and physical fitness before and after applying the program. Data were collected between April and June in 2006, and analyzed by $x^2$-test, t-test, ANCOVA using a SPSS 11.5 program. Results: There were statistically significant in percent of body fat, muscle strength, muscle endurance, flexibility, and balance ability, but no significant differences were found in body weight, systolic pressure and diastolic pressure. Conclusion: Exercise using Thera Band can be an effective nursing intervention to improve percent of body fat, muscle strength, muscle endurance, flexibility and balance ability in the elderly women.

• 대한의용생체공학회:의공학회지
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• 제45권3호
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• pp.128-137
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• 2024

It is necessary to develop a pulsatile Extracorporeal Membrane Oxygenator (p-ECMO) with counter-pulsation control(CPC), which ejects blood during the diastolic phase of the heart rather than the systolic phase, due to the known issues with conventional ECMO causing fatal complications such as ventricular dilation and pulmonary edema. A promising method to simultaneously detect the pulsations of the heart and p-ECMO is to analyze blood pressure waveforms using deep neural network technology(DNN). However, the accurate detection of cardiac rhythms by DNNs is challenging due to various noises such as pulsations from p-ECMO, reflected waves in the vessels, and other dynamic noises. This study aims to evaluate the accuracy of DNNs developed for CPC in p-ECMO, using human-like blood pressure waveforms reproduced in an in-vitro experiment. Especially, an experimental setup that reproduces reflected waves commonly observed in actual patients was developed, and the impact of these waves on DNN judgments was assessed using a multiple DNN (m-DNN) that provides accurate determinations along with a separate index for heartbeat recognition ability. In the experimental setup inducing reflected waves, it was observed that the shape of the blood pressure waveform became increasingly complex, which coincided with an increase in harmonic components, as evident from the Fast Fourier Transform results of the blood pressure wave. It was observed that the recognition score (RS) of DNNs decreased in blood pressure waveforms with significant harmonic components, separate from the frequency components caused by the heart and p-ECMO. This study demonstrated that each DNN trained on blood pressure waveforms without reflected waves showed low RS when faced with waveforms containing reflected waves. However, the accuracy of the final results from the m-DNN remained high even in the presence of reflected waves.

• 동의생리병리학회지
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• 제22권2호
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• pp.302-306
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• 2008

ChongMyeong-Tang(CMT) have been used clinically to treat patient with amnesia and dementia. In addition, CMT have been also used for examinee to improve learning ability in Korea. This experimental study was designed to investigate the effects of Gagam-ChongMeong-Tang(GCMT) to improve the retentive faculty and learning ability in terms of Cerebral blood flow(rCBF) and Mean Artery Blood Pressure(MABP) in rats. In our study, we investigated that increasing doses of GCMT (1 ug/ml, 10 ug/ml, 100 ug/ml, and 1000 ug/ml) affect the level of rCBF and MABP in rats. In our results, treatment with GCMT elevated level of rCBF in dose dependant manner. Cantraray, level of MABP was lowered by treatment with GCMT. The involved mechanisms in rCBF are guanylate cyclase pathway. During the period of cerebral re-perfusion, GCMT treated group showed stability of rCBF compared to control group. These results imply that GCMT increased rCBF through dilation of pial artery. And related mechanisms are involved in guanylate cyclase pathway.

• 약학회지
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• 제48권6호
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• pp.317-322
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• 2004

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is limited by their ability to induce gastrointestinal injury. It has been shown that nitric oxide (NO), similar to pro staglandins (PGs), appears to play an important role in gastric mucosal defence. We hypothesized that NSAIDs contained NO group would be less acutely toxic to the gastric mucosa, but would not interfere with their ability to suppress inflammatory process in rats. We have compared the ulcerogenic and anti-inflammatory effect of CW-501029 (NO-NSAIDs), CW-501027 (NSAIDs) and indomethacin. Both did not change mean blood pressure and heart rates, indicating that they had no side effect on cardiovascular system. We found that CW-501029 increased nitrite/nitrate levels without changing of blood pressure and heart rates. We suggest that it may help gastric mucosal blood flow, the which helps reducing the discomfort in astrointestinal system. Carrageenan-induced PGE2 increase was reduced in a similar tendency when compared CW-501027 or CW-501027 with control in back exudate of rats, but CW-501029 less reduced PGE2 than CW-502027 or indomethacin in gastric tissues. CW-501027 or CW-501029 reduced platelet aggregation. From these results we suggest that CW-501029 may improve the side effect by reduction of short-term gastric injury and less inhibition of PGs synthesis.

• 대한핵의학회지
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• 제12권1호
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• pp.9-16
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• 1978

It has been suggested that plasma renin activity (PRA) and its response to volume depletion may be abnormal in that it shows little or exaggerated change in patients with chronic renal failure and hypertension. Intravenous furosemide stimulation test was performed in 46 control subjects and 51 patients with chronic renal failure and/or malignant hypertension in order to evaluate PRA response. In contrast to the consistent increase in PRA in control subjects (from $2.5{\pm}1.95\;to\;4.5{\pm}2.51ng/ml/hr$), no consistent increase was observed in patients with chronic renal failure, especially in those who showed favorable response to antihypertensive therapy (from $2.5{\pm}2.21\;to\;2.9{\pm}2.46ng/ml/hr$). But poor responder to antihypertensive treatment showed considerably higher PRA before and after furosemide stimulation (from $4.9{\pm}1.96\;to\;6.4{\pm}1.71ng/ml/hr$) than the responder group did. Moreover, this group seemed to retain the ability to increase PRA in response to intravenous furosemide stimulation. Thus it became apparent that responder group was unable to increase PRA normally in response to furosemide as well as volume depletion, while poor responder seemed to retain that ability. Thus intravenous furosemode may serve as a convenient way to differenfiate those who might be benefited by conservative antihypertensive measures from those who would require more drastic measures such as bilateral nephrectomy for their optimal blood pressure control.

• 한국축산식품학회지
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• 제32권6호
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• pp.695-705
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• 2012

Dietary fiber naturally present in various sources of cereals, legumes, fruits and vegetables plays a physiological role in human health, such as lowering cholesterol and blood pressure, improving blood glucose control in diabetes, helping with weight loss and management, and reducing cancer risk. In addition, dietary fibers have has been added as a functional food ingredient to food products to provide water-holding capacity, viscosity, gel-forming ability, and fat-binding capacity to food products. These beneficial characteristics of dietary fiber components can improve the image of meat products to be healthy and functional food products. This article reviews the concept and current definition of dietary fibers in food products along with their health benefits and functional characteristics. Dietary fibers from different sources like cereals, legumes, fruits, and vegetables and soluble dietary fibers have been applied as functional ingredients to various types of meat products, such as beef patties, ground beef and pork, pork and chicken sausages, meatballs, and jerky etc. Based on the application of dietary fibers to different types of meat products, possible future characteristics in selecting appropriate dietary fiber ingredients and their proper incorporation are explored to develop and produce healthy and functional meat products with high dietary fiber contents.

• International Journal of Advanced Culture Technology
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• 제7권2호
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• pp.60-66
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• 2019

The purpose of this study was to compare the effect of educational smartphone app with the effect of learning using conventional paper material. We developed an educational app for nursing students to learn how to read blood pressure and how to take a pulse. Evaluated was the effect of the app-based education by measuring the short term memory (right after the education), the long term memory (a week later) and the satisfaction. 25 college nursing students participated for the experiment group using the app-based education and 25 for the control group using paper-based education. We applied for statistical analysis Fisher's exact test and Independent t-test. The satisfaction of the app user's appeared significantly higher than that of the paper material user's (t=2.322, p=0.024). The short term memory score was 0.23 points higher in the experimental group (6.46 points) than in the control group (6.23 points), which was not statistically significant (t =0.422, p =0.675). Similar result came for the long term memory (t=1.006, p=0.320). After adjusting for the effect of a college grade using ANCOVA, the effect on memory was significantly higher in the experiment group. There might be differences in learning ability between the experimental and the control groups.

• Archives of Plastic Surgery
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• 제32권1호
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• pp.5-11
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• 2005

Prostaglandin $E_1$($PGE_1$) is known to have various physiological action such as vasodilatation, decrease of blood pressure, angiogenesis, inhibition of platelet aggregation and so forth. $PGE_1$ has been developed in many different formulations in order to overcome its chemical instability and deactivation in the lungs when administered parenterally. Lipo-AS013 is a potent drug with higher chemical stability and greater vascular wall targeting than others. The study was done on $3{\times}10cm$ model flap of dorsal skin of Sprague-Dawley rats and the flap perfusion survival were observed and documented. The flap treated with Lipo-AS013 beforehand was given intravenously Sodium fluorescein 10 minutes later, and then Percent Dye Fluorescence Index(% DFI) was calculated. The results were compared to a control group and the group administered locally epinephrine.. In the control group, the % DFI and flap survival rate increased from $54.1{\pm}6.7$ to $65.0{\pm}2.6$(p<0.01) while in Lipo-AS013 group from $55.3{\pm}2.2$ to $67.4{\pm}1.9$(p<0.01), respectively. In the epinephrine group, the % DFI(p<0.05) and flap survival rate(p<0.001) decreased. In the both epinephrine and Lipo-AS013 group Percent DFI and flap survival rate are comparable with the control group.The result indicates that the potent Lipo-AS013 enhances the blood flow and flap survival. This highly potent Lipo-AS013 may have targeting ability and accumulate $PGE_1$ onto the vascular walls. A quantitative analysis of fluorescence on the skin surface is a reliable tool to measure the blood perfusion into an ischemic flap and its viability. Further comparative study with conventional $PGE_1$ and Lipo-$PGE_1$ is needed in order to clarify the action and efficiency of Lipo-AS013.