• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.3
• /
• pp.605-611
• /
• 2005

Chronic fatigue refers to the tiredness which disturbs one's daily activities and lasts more than six months without the sign of improvement by rest or sleep. Male chronic fatigue is included in internal injuries due to overstrain and exhaustion and closely related to river, spleen, stomach and kidney out of five Jang organs. Male chronic fatigue is based on the deficiency of Yang and aggravated by liquor, sex and emotional depression. Chronic fatigue has the following features in Hyungsang ; an inclination for lying: unwillingness to everything; drooping eyes and feeble voice; yellow pale complexion; withered ears; redness on the tip of nose; cheekbone, and lips; blood shot eyes; dryness and loss of hair. Male chronic fatigue usually attacks the persons of horse type and bird type because they are hyperactive compared with what they eat. The following medicines are commonly prescribed for the treatment of male chronic fatigue. Ssangwhatang, Sokunzungtang, and Yanghyulsamultang are commonly prescribed to horse type. Jaumkangwhatang, Chungsimyunzaum, Yookmijiwhangtang to bird type. Palmiwhan, Gozinumja. and Shinkihwan to fish type. Bozungikkitang, Galwhahaesungtang, Samchulgunbitang and Sipjundaebotang to turtle type.

• Journal of Korean Academy of Fundamentals of Nursing
• /
• v.7 no.2
• /
• pp.192-207
• /
• 2000

The purpose of this study was to identify the effects of foot massage on the stress of student nurses in clinical practice. The research design was a nonequivalent control group pretest-posttest design. The subjects of this study were 52 student nurses from three junior colleges and one university. The subjects were assigned to one of two groups : the experimental group(26 students), and the control group(26 students). The study was conducted from October to November 1999. For the experimental group the foot massage was performed once a day for 3 days, starting from the first day of clinical practice. Subjects' mood, fatigue, blood pressure and pulse rate were measured as dependent variables. The Instrument for mood and fatigue state was a 100mm visual analogue scale. For the experimental group pre and post tests were done just before and after every 3 foot massages and on the 7th clinical practice day. For the control group pretest was done on 1st clinical day and posttest was done on clinical practice 7th day. The data was analyzed by the t-test and paired t-test and the results are summarized as follows: 1. The mood state scores were significantly higher for the experimental group as compared to the control group after the foot massage(t=13.73, p<.001). 2. The fatigue state scores were significantly lower for the experimental group as compared to the control group after the foot massage(t=8.69, p<.001). 3. The systolic blood pressure was significantly different between the experimental group and the control group after the foot massage(t=3.0073, p<.01). 4. The diastolic blood pressure was not significantly different between the experiment group and the control group after the foot massage. 5. The pulse rate was not significantly different between the experiment group and the control group after foot massage. 6. The mood state scores on the 1st, 2nd, 3rd massage day was significantly improved right after the foot massage. 7. The fatigue state scores on the 1st, 2nd, 3rd massage day were significantly lower right after the foot massage. 8. Systolic blood pressure on the 1st and 2nd massage day was significantly decreased right after the foot massage. Diastolic blood pressure and pulse rate were decreased right after massage but the change was not statistically significant. On the basis of the above findings, this study suggests that foot massage can be an effective stress relieving method for student nurses in clinical practice.

• The Korean Journal of Emergency Medical Services
• /
• v.12 no.3
• /
• pp.43-53
• /
• 2008

Purpose : This study was designed to examine physiological changes in the body of rescuers conduct CPR according to the 2005 new guideline from American Heart Association. The ratio of artificial respiration has changed from 15 : 2 into 30 : 2 in 2005. The researcher tried to know the correlation between the physiological changes and the accuracy of CPR. Method : The examinees of this study were 26 students (Dept. of Emergency Medical Service). After the training, participants conducted 10 minute CPR and soon after the CPR, their vital signs were checked, and lactic acid and concentration of ammonia were analysed from their blood samples. Questionnaires to ask their subjective fatigue level were filled out after blood samples and 10 minute - CPR was performed. Results : 1) After the CPR, concentrations of ammonia were $149.71{\mu}{\ell}/d{\ell}$ and $162.17{\mu}{\ell}/d{\ell}$ in 15 : 2 and 30 : 2, respectively. The number was higher in 30 : 2 but it wan not statistically meaningful (p = .493). Log value of lactic acid was a little higher in 30 : 2 with 42 log($mmol/{\ell}$) and 54 log($mmol/{\ell}$) in 15 : 2 and 30 : 2, respectively but it was not statistically meaningful (p = .113). 2) Blood pressure in 15 : 2 and 30 : 2 were 118.50 mmHg and 125.08 mmHg while pulse in two different cases were 96.14 and 97.25, showing no statistically significant differences (blood pressure : p = .155, pulse : p = .841). 3) Subjective fatigue was a bit high in 30 : 2 with 5.93 and 6.92 points in 15 : 2 and 30 : 2 respectively but it was not statistically meaningful (p = .142). 4) In the 10 minute CPR, respiration accuracy was 96.21% in 15 : 2 and 94.79% in 30 : 2. There was no statistical significances between the two(p = .225). In the meanwhile, chest compression accuracy was 92.57% in 15 : 2 and 91.83% in 30 : 2. From the beginning to the end of chest compression, there showed no difference(p = .425). the type of CPR did not influence upon the accuracy of chest compression(p = .756). Conclusion : In the CPR conducted by skilled rescuers for 10 minutes, there were no statistically meaningful differences between 15 : 2 and 30 : 2 in the concentration of fatigue element in a blood, subjective fatigue, vital signs and accuracy of CPR. Therefore, 30 : 2 CPR recommended by American Heart Association need to be recommended and performed in scene size up.

• Korean Journal of Pharmacognosy
• /
• v.44 no.1
• /
• pp.83-90
• /
• 2013

The aim of this study was to evaluate the effect of hot water extract of peduncle obtained from Hovenia dulcis Thunb (HD) which is commercially developed for the protective effect on the alcoholic hepatotoxicity, on the endurance capacity for weight loaded forced swimming mice. The swimming times to exhaustion in mice fed 100 and 200 mg/kg HD for 2 weeks were prolonged 3.6 and 3.7 fold, and for 4 weeks 1.9 and 2.7 fold compared with each vehicle control ($42.8{\pm}20.5$ min and $67.7{\pm}47.8$ min, for 2 and 4 weeks), respectively. Blood biochemical parameters for ALT, AST, creatinine and BUN were not significantly different between from HD fed or control mice. Although HD fed mice swam over 2 fold longer time than vehicle control mice at 4 weeks, blood biomarkers of physical fatigue such as glucose, triglyceride and free fatty acid, lactate were not significant different and even tended to ameliorate. Hepatic lipid peroxidation and SOD activity did not significantly change in HD fed- and vehicle control exhausted swimming mice at 2 or 4 weeks. However, catalase activity in HD-fed mice was significantly increased in a dose-dependent manner compared with vehicle control mice. The present study indicates that HD improved physical fatigue and exercise performance in mice. Therefore, it has a potential for the pharmacological effect of anti-fatigue.

• Korean Journal of Exercise Nutrition
• /
• v.24 no.1
• /
• pp.29-36
• /
• 2020

[Purpose] The purpose of this study was to investigate the effects of short-term creatine intake on muscle fatigue induced by resistance exercise in healthy adolescent men, i.e., lactic acid concentration and wrist and head tremor measured by an accelerometer. [Methods] Twelve healthy adolescent men who had no experience with creatine intake were included. The subjects were randomly assigned to the creatine group and the placebo group, followed by 5 days of creatine and placebo intake, and 5 times of 5 sets of leg press, leg extension, bench press, and arm curl exercises at 70% repetition maximum (RM). The lactic acid concentration before and after exercising, rate of perceived exertion (RPE), and accelerometer-based wrist tremor and head tremor during exercise were measured. Subsequently, after 7 days to allow for creatine washout, the same exercise treatment and measurement were performed in each group after switching drug and placebo between the groups. [Results] The level of lactic acid before and after the acute resistance exercise trial was significantly lower in the creatine group than in the placebo group (P <0.05). The mean RPE during the resistance exercise was significantly lower in the creatine group than in the placebo group (P <0.05). There was no difference between the two groups in the mean wrist tremor during resistance exercise, but the mean head tremor values were significantly lower in the creatine group than in the placebo group in the arm curl, the last event of the exercise trials (P <0.05). [Conclusion] Short-term creatine intake reduces the blood fatigue factor increased by resistance exercise, and is thought to suppress fatigue, especially in the latter half of resistance exercise. Therefore, these findings indicate that short-term creatine intake can have an improved effect on anaerobic exercise performance.

• Food Science and Biotechnology
• /
• v.18 no.1
• /
• pp.275-277
• /
• 2009

Swimming enhancing effects of ssanghwatang fermented with Saccharomyces cerevisae in mice were investigated, and then the blood biochemical parameters related to fatigue were measured. Compared to the control group, the swimming time was significantly increased in fermented ssanghwatang (FST) group from day 4 ($29.27{\pm}4.73$ vs. $50.27{\pm}9.05\;min$, p<0.05). The lactate level, an important indicator of fatigue, was drastically lower in FST group than in control group ($2.13{\pm}0.13$ vs. $1.40{\pm}0.12\;mmole/L$, p<0.01). These results suggest that FST possesses stimulatory effects which can enhance exercise performance and reduce fatigue.

• Annals of Clinical Neurophysiology
• /
• v.13 no.1
• /
• pp.61-63
• /
• 2011

Postural orthostatic tachycardia syndrome (POTS) is characterized by increased heart rate with preserved blood pressure on orthostatic stress. Many patients with postural orthostatic tachycardia syndrome can be misdiagnosed as neurosis, chronic fatigue or anxiety disorder. We report a patient with POTS who presented chronic dizziness and fatigue. In approaching to a patient with orthostatic or nonspecific chronic dizziness, the postural heart rate as well as blood pressure should be checked not to miss the diagnosis.

• Korean Journal of Adult Nursing
• /
• v.22 no.2
• /
• pp.153-160
• /
• 2010

Purpose: The purpose of this study was to investigate the effects of aromatherapy on stress, fatigue, mood, and vital signs of the nurses in the operating rooms. Methods: The data were collected from September 2007 to February 2008 in the operating room at K hospital located in Seoul, Korea. A total of 48 nurses were recruited. Among them, 25 nurses were randomly assigned to an experimental group and 23 were assigned to a control group. Experimental group was provided with aroma inhalation by necklace which had essential oil mixture of 0.2 cc. For aroma inhalation, Lavender, Zeranium and Mazoram were mixed in ratio of 5:3:2. In order to test the effectiveness of aroma inhalation, the pretest and posttest results for stress, fatigue, mood, and vital signs were compared between the experimental group and the control group. The data were analyzed by unpaired t-test and ANCOVA using the SPSS/WIN 15.0 program. Results: There were statistically significant decreases in the stress and fatigue scores, and increase in the mood scores and showed significant relaxation in the vital signs after the aroma inhalation. Conclusion: The aromatherapy had the positive effects on stress, fatigue, mood, and vital signs.

• The Journal of Korean Medicine
• /
• v.37 no.2
• /
• pp.76-84
• /
• 2016

Objectives: We evaluated the anti-fatigue effects of Rh2-enriched Korean ginseng (Ginseng Rh2+) using a forced exercise-induced chronic fatigue mouse model. Methods: ICR male mice were subjected to running wheel for 1 h, 5 days/week during 4 weeks, and running velocity was gradually increased. Each running session was followed by oral administration of distilled water, Ginseng Rh2+ (150 or 300 mg/kg), or N-acetyl-L-cysteine (NAC, 100 mg/kg) 1 h later. The exercise tolerance and forced swimming test were performed to evaluate the fatigue condition. Results: Chronic forced exercise reduced the physical activity, as evidenced by the behavioral tests, which were notably ameliorated by Ginseng Rh2+ treatment. Ginseng Rh2+ treatment also attenuated the alterations of energy metabolism and oxidative stress in skeletal muscle tissues and/or sera, including malondialdehyde (MDA), lactate concentration and its related factors (lactate dehydrogenase, blood urea nitrogen, and glucose levels). Conclusion: These findings strongly suggest that Ginseng Rh2+ exerts a potent anti-fatigue effect through modulation of energy metabolism and oxidative response.

• The Journal of Korean Medicine
• /
• v.34 no.3
• /
• pp.119-125
• /
• 2013

Objectives: Medically unexplained fatigue includes chronic fatigue syndrome (CFS) and idiopathic chronic fatigue (ICF). These disorders quite impair quality of life while no effective therapies exist. Therefore, patients with CFS or ICF frequently choose treatments based on traditional Korean medicine. The study aimed to analyze characteristic of patients visiting an Oriental clinic with CFS or ICF. Methods: Patients who met criteria for CFS or ICF were enrolled in this study, from March 2011 to Jun 2013. Clinical information focused on symptom differentiation and Sasang constitution was analyzed. Pearson's chi-square test was used to compare the frequency among sub-groups. Results: In total, 77 patients (49 male and 28 female) were diagnosed with CFS (17 male and 13 female) or ICF (32 male and 15 female). The symptom differentiation was 37.7%, 26.0%, 13.0%, and 23.3% for "Qi deficiency of both spleen and lung (脾肺氣虛)", "Yin deficiency of both liver and kidney (肝腎陰虛)", "Blood deficiency of both heart and spleen (心脾血虛)" and "Yang deficiency of both spleen and kidney (脾腎陽虛)", while Sasang constitutional distribution was 59.7%, 22.1% and 18.2% Soeumin, Taeumin and Soyangin, respectively. The fatigue severity was notably different between CFS ($63.7{\pm}12.1$) or ICF ($52.2{\pm}15.3$) according to the Chalder fatigue scale (10-point scale for eleven questions). There was statistical significance regarding symptom differentiation and Sasang constitution (p < 0.05). Conclusions: In the process of traditional Korean medicine-based development of therapeutics for patients with chronic fatigue or related conditions, this report can serve as reference data.