• Korean Journal of Veterinary Service
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• v.19 no.2
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• pp.154-162
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• 1996

The effcets of adenosine 5'-triphosphate(ATP) were investigated on the uterine smooth muscle motility in the pig. The results were summarized as follows: 1. The effects of the porcine uterine smooth muscle and the contractile responses increased between the concentration of ATP $10^{-5}$ and $10^{-3}$ M with a dose-dependent manner. 2. The contractile response induced by ATP($10^{-4}$ M) was not blocked by pretreatment with cholinergic receptor blocker, atropine ($10^{-6}$ M) 3. The contractile response induced by ATP ($10^{-4}$ M) was not blocked by pretreatment with $\alpha$ -adrenergic receptor blocker, phentolamine(10$^{-6}$ M) and ${\beta}$-adrenergic blocker, propranolol ($10^{-6}$ M). 4. The contractile response induced by ATP($10^{-4}$ M) was not appeared in 4Ca^{++}$ -free medium. As the concentration of $Ca^{++}$ in $Ca^{++}$ -free medium was increased, the contractile response induced by ATP ($10^{-4}$ M) was enhenced but was completely inhibited by pretreatment with $Ca^{++}$ -channel blocker, papaverine($10^{-6}$ M) or verapamil($10^{-6}$ M). From these results, it was conclued that the effects of ATP were the contraction mediated by purinergic receptor in uterine smooth muscle of pig.

• Journal of Sensor Science and Technology
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• v.20 no.4
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• pp.221-225
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• 2011

Intensity-based optical fiber sensors are devised using a blocker which is located between two polymer optical fibers(POFs), one fiber is light-in and the other is light-out. This blocker is moved by an external displacement. Therefore, finding a general formulation of the relation between this displacement and transmission light intensity of various blockers is important to help develop intensity-based optical fiber sensors. In this paper, we consider blockers with arbitrary shapes from circular holes to inclined angled blockers. The transmission light intensities of such blockers should be determined by this generalized equation. In order to verify this equation, the calculated intensities of the blockers are compared with the values acquired from experiment. In the comparison, it is shown that the analytic equation can give the exact values of the transmitted light intensities for the assorted blockers. The range of the displacement measurement is also shown to be about 6 times of the radius of the hole in the case of a 9 degree inclined angle blocker.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.1101-1104
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• 2004

A brake spider in an irregular shape, which is used as a part in the braking system of a vehicle like a big truck and a trailer, is subjected to a large torque and hence requires both strength and endurance over the brake heat. Manufacture of this product in practice is generally composed of hot forging processes and machining. At the present study, two or more processes were considered for the hot forging. With an initial circular billet, blocker and finisher processes were analyzed using the rigid-plastic finite element method and also in addition to the preforming process. Proper forging processes to manufacture an irregular product without forging defects, which are preforming, blocker and finisher, were discussed and commented upon.

• The Korean Journal of Pain
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• v.18 no.2
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• pp.259-262
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• 2005

Facial blushing is a personally disabling condition, which can result in emotional disturbance and be an impediment to social life. Although numerous treatment options exist, including beta blocker, cognitive behavioral therapy and sympathetic neurolysis, no generally accepted form of treatment has been established. Herein, we report two cases of successful reduction of facial blushing following the administration of beta blocker and a minor tranquillizing antianxiety drug.

• Archives of Pharmacal Research
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• v.25 no.3
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• pp.349-356
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• 2002

The present study was performed to examine the effect of fangchinoline, a bis- benzylisoquinoline alkaloid, which exhibits the characteristics of a $Ca^{2+}$ channel blocker, on cyanide-induced neurotoxicity using cultured rat cerebellar granule neurons. NaCN produced a concentration-dependent reduction of cell viability, which was blocked by MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, verapamil, L-type$Ca^{2+}$channel blocker, and L-NAME, a nitric oxide synthase inhibitor. Pretreatment with fangchinoline over a concentration range of 0.1 to 10 $\mu$M significantly decreased the NaCN-induced neuronal cell death, glutamate release into medium, and elevation of $[Ca^{2+}]_i$ and oxidants generation. These results suggest that fangchinoline may mitigate the harmful effects of cyanide-induced neuronal cell death by interfering with $[Ca^{2+}]_i$influx, due to its function as a $Ca^{2+}$ channel blocker, and then by inhibiting glutamate release and oxidants generation.

• Journal of Chest Surgery
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• v.33 no.9
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• pp.766-769
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• 2000

The long QT syndromes have been classified into acquired or inheritary forms, both of which are associated with a characteristic type of life-threatening polymorphic ventricular tachycardia called torsade de points. Beta-adrenergic blocker is the first cholic treatment, but in those whom cardiac events are not prevented by $\beta$-blockade, left thoracic sympathetic ganglionectomy may be useful in selected cases. A 50-year-old woman had an recurrent syncopal attack in which she was unconscious for 1-2 min and 1-2 times a month for 10 years. The EKG revealed that QT & QTc intervals were 744 and 632 msec respectively. Treatment with Beta-adrenergic blocker and calcium channel blocker was ineffective in preventing recurrence of syncopal spell. Therefore, she underwent left thoracic sympathetic ganglionectomy with thoracoscope. During the 9 months after operation, she was free of syncopal episodes and is doing well.

• Journal of the Optical Society of Korea
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• v.15 no.2
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• pp.202-206
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• 2011

We propose a tunable flat-top bandpass filter to pass light in a customized wavelength band by using long-period fiber gratings (LPFG) structure. The LPFG structure is composed of a core mode blocker in between two LPFGs. The bandpass spectrum of the proposed structure is obtained in overlapped wavelength band of two LPFGs operating on the same modes. To analyze the properties, we introduce a mathematical matrix model for the structure. We theoretically demonstrate flexibility of the flat-top bandpass filter with various bandwidths.

• YAKHAK HOEJI
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• v.47 no.4
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• pp.200-205
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• 2003

The stability constants for the inclusion complexes between carboxymethyl-$\beta$-cyclodextrin (CM-$\beta$-CD) and five $\beta$-blockers, such as atenolol (ATE), bisoprolol (BIS), metoprolol (MET), pindolol (PIN) and propranolol (PRO) were determined by capillary electrophoresis. The magnitude of stability was decreased as following order; PRO＞MET＞BIS＞ATE＞PIN. Among them PRO showed the highest affinity towards CM-$\beta$-CD with stability constants of 383 and 371 $M^{-l}$ for (R)- and (S)-enantiomer, respectively. PIN enantiomers showed the lowest stability towards CM-$\beta$-CD, while the selectivity between (R)- and (S)-enantiomer was higher than any other tested $\beta$-blocker.r.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.103-105
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• 2005

최근 RFID에 대한 관심이 높아지고 있다. RFID 사용량도 증가하는 추세에 있으며, 앞으로는 생활 전반에서 RFID를 이용하게 될 것으로 전망한다. 그러나 사용자 프라이버시 보호 기법의 개발은 아직 해결해야 할 문제이다. 저가형 태그에는 기존 다른 시스템에서 사용되던 여러 가지 암호시스템의 적용이 어렵다. 그래서 많은 사람들이 RFID 태그에 적용 가능한 여러 가지 기법을 제시하였다. 그 중 Blocker 태그를 사용해서 프라이버시 보호와 범죄방지를 하는 기법이 있다. 그러나 Blocker 태그 기법에서는 쓰기 능력을 가지고 있는 태그에 적용 가능하다는 단점이 있다. 본 논문에서는 읽기만 가능한 저가형 태그에서도 Blocker 기능을 수행할 수 있는 새로운 기법을 제안하였다. 제안하는 기법은 현재 태그에서 최소한의 변경으로 프라이버시 보호와 범죄방지를 위한 실질적인 해결책으로 사용이 가능하다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.2
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• pp.389-396
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• 2002

In the present work, we examined the mechanism of vasorelaxant effect of scopoletin, an active constituent of Artemisia capillaris on rat thoracic descending aortic rings. Scopoletin induced a concentration-dependent relaxation in rat thoracic descending aortic rings pre-contracted with phenylephrine (EC/sub 50/ = 238.94±37.4 μM), while it was less effective in rat thoracic descending aortic rings precontracted with high potassium solution (KCI 30 mM). Vasorelaxation by scopoletin was significantly inhibited after endothelial removal, but recovered at high concentration. Pretreatment of rat thoracic descending aortic rings with N/sup G/-nitro-L-arginine (100 μM), a nitric oxide synthase inhibitor, and atropine (1 μM), a muscarinic receptor antagonist, significantly inhibited scopoletin-induced relaxation of rat thoracic descending aortic rings. Neither indomethacin (3 μM), an inhibitor of cydooxygenase, nor propranolol (1 μM), a β -adrenoceptor antagonist, modified the effect of scopoletin. The combination of N/sup G/ -nitro-L-arginine (100 μ M) and miconazole (10 μ M), an inhibitor of cytochrome P 450, did not modify the effect of scopoletin, when compared with pretreatment with N/sup G/-nitro-L-arginine(100 μM) alone. Vasorelaxant effect of scopoletin was inverted by pretreatment with diltiazem (10 μM), a Ca/sup 2+/-channel blocker, at low concentration, while restored at high concentration. Apamin (K/sub ca/-channel blocker, 1 μM), 4-aminopyridine (4-AP, K/sub v/-channel blocker, 1 mM), and tetrodotoxin (TTX, Na/sup +/-channel blocker 1 μM) potentiated the vasorelaxant effect of scopoledn, but glibendamide (K/sub ATP/-channel blocker, 10 μM), tetraetylammonium(TEA, non-selective K-channel blocker, 10 mM) did not affect the relaxation of scopoletin. Free radical scavengers (TEMPO, catalase, mannitol) did not modify vascular tone. These results suggest that nitric oxide, Ca/sup 2+/ -channels play a role in endothelium-dependent relaxations to scopoletin in rat aortas, that apamin, 4-AP, TTX but not glibenclamide, TEA potentiated relaxation to scopoletin mediated by these channels, and that free radicals do not concern to the vasorelaxant effect of scopoletin.