• Proceedings of the KIEE Conference
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• 2001.07d
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• pp.2075-2077
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• 2001

For precise positioning, GPS carrier measurements are often used. In this case, accurate position having mm${\sim}$cm error can be obtained. For 3D positioning, in CDGPS, more than five carrier phase measurements are required. When GPS signals are blocked or carrier phase measurements are insufficient, it cannot provide positioning solution. By integrating CDGPS with INS, continuity of positioning solution can be guaranteed. However, when a vehicle moves in low speed or in stationary, the CDGPS/INS integrated system is difficult to compensate INS attitude errors because GPS velocity error become relatively lange. In this paper, we used the 3D attitude GPS receiver to compensate the INS attitude error. By field experiments, it is shown that the proposed integration system maintains the navigation performance even when a vehicle is in low speed or GPS signal is blocked for a period of time.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2006.04a
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• pp.151-158
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• 2006

As GPS 'selective availability' was turned off in 2000, GPS related fields and markets are explosively extended. In mapping area, GPS/INS aided photogrammetry proved it is much cost and time effective method keeping enough accuracy as compared with traditional photogrammetry works. The advantage of GPS/INS integration is interdependence. Even if GPS signal was blocked in some time, the position accuracy is not affected. In this study, various GPS signal time gap was used in GPS/INS AT process. Field surveyed ground points were used in accuracy check with GPS/INS AT check points. And the result showed enough accuracy of photogrammetry work rule of NGII. y.

• Bulletin of the Korean Mathematical Society
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• v.53 no.4
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• pp.985-1004
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• 2016

We consider the MAP/PH/c/K queue in which blocked customers retry to get service and servers may take vacations. The time interval between retrials and vacation times are of phase type (PH) distributions. Using the method of mean drift, a sufficient condition of ergodicity is provided. A condition for the system to be unstable is also given by the stochastic comparison method.

• Journal of Life Science
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• v.25 no.2
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• pp.231-236
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• 2015

Angiotensin II (AngII) is an essential hormone that affects vascular physiology. For example, stimulation of vascular smooth muscle cells (VSMCs) rapidly induces vasoconstriction and results in the up-regulation of blood pressure. Chronic stimulation of VSMCs with AngII also results in hypertrophy. In this study, we confirmed an involvement of phosphatidylinositol 3-kinase (PI3K)-dependent calcium mobilization in AngII-induced generation of reactive oxygen species (ROS). Stimulation of rat aortic smooth muscle cells (RASMCs) with AngII significantly induced the generation of ROS in a dose- and time-dependent manner. AngII-induced generation of ROS was completely abolished by pharmacological inhibition of PI3K (with LY294002), but inhibition of the ERK signaling pathway had no effect. AngII-induced calcium mobilization was completely blocked by inhibition of PI3K, whereas inhibition of the ERK signaling pathway by PD98059 was ineffective. Depletion of extracellular calcium or inhibition of the L-type calcium channel by nifedipine completely blocked AngII-induced calcium mobilization. Depletion of extracellular calcium by EGTA and incubation of RASMCs with calcium-free medium both significantly blocked AngII-induced ROS generation. Inhibition of the L-type calcium channel also significantly blocked AngII-induced ROS generation. These results suggest that AngII-induced ROS generation is regulated by calcium mobilization, which, in turn, is modulated by a PI3K/L-type calcium channel signaling pathway.

• Journal of the Korean Solar Energy Society
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• v.32 no.2
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• pp.74-86
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• 2012

For the improvement of environmental comfort in the buildings with the blind control, the objective of this study is to prevent the direct glare caused by the daylight inlet. During the process of solar profile prediction, time are significant factors that may cause error and glare during the blind control. This research proposes and evaluates the correction and control method to minimize prediction error. For the local areas with different longitude and local standard meridian, error occurred in the process of the time conversion from local standard time to apparent solar time. In order to correct error in time conversion, apparent solar time should be recalculated after adjusting the day of year and the equation of time. To solve the problems by the potential time errors, control method is suggested to divide the control sections using the calibrated fitting-curve and this method is verified through simulations. The proposed correction and control method, which considered potential time errors by loop lop leap years, could solve the problems about direct glare caused by daylight inlet on the work-plane according to the prediction errors of solar profile. And also these methods could maximize daylight inlet and solar heat gain, because the blocked area on windows could be minimized.

• Honam Mathematical Journal
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• v.30 no.1
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• pp.75-89
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• 2008

Interrupted blood flow diminishes the concentration of oxygen in tissues. Hypoxia first appears in the region distal to the capillaries and grows throughout the entire t issue. However, the time-wise evolution of hypoxic area is diverse when some of capillaries are blocked in a multi-capillary domain with different oxygen squirt. The process of the development of hypoxia through time course is analyzed mathematically in the domain. Each source in steady state is controlled by a time sensitive function to simulate the occlusion.

• Biomolecules & Therapeutics
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• v.12 no.4
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• pp.242-249
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• 2004

The main aim of this study was to investigate stress related activities of Sun-ginseng extract as a candidate for anti-stress-related functional supplement by comparing its effect to those of red ginseng, which is also known to alleviate stress. Normal group was not exposed to stress while the control group was exposed to stress. Rats were orally administered once a day with 200 mg red ginseng (RG) extract, 100 or 200 mg Sun-ginseng (SG) extract/kg body weight. Mice were given water containing 400 mg red ginseng extract, 200 or 400 mg SG/100 mL potable water. Rats were given supplements for 5 days without stress, and 5 days with restraint and electroshock stress. After final stress, stress-related behavioral changes of experimental animals were recorded and levels of blood corticosterone were measured. Mice were given supplements for 5 days through drinking water, and then fatigue related motor activity were recorded. SG-supplementation partially blocked stress effect on locomotion and elevated plus maze test in rats, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling, facewashing, grooming and rearing behavior in rats. SG-supplementation decreased blood corticosterone level which is increased by stress in rats. Effects of SG may not be modulated by GABAnergic nervous system. SG-supplementation prolonged swimming time and staying time on the wire and rotarod wheel in mice. These results suggest that SG partially protects living organisms from stress attack in some cases and thus has the potential to be used as a functional food to alleviate stress response.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.6
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• pp.353-361
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• 2005

The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at +50 mV in a reversible concentrationdependent manner with an apparent $IC_{50}$ of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA. Fast application of CsA led to a rapid and reversible block of Kv1.5, and the onset time constants of the CsA-induced block were decreased in a concentration-dependent manner. The CsA-induced block of Kv1.5 channels was voltage-dependent, with a steep increase over the voltage range of channel opening. However, the block exhibited voltage independence over the voltage range in which channels were fully activated. The rate constants for association and dissociation of CsA were $7.0{\mu}M{-1}s^{-1}$ and $8.1s^{-1}$, respectively. CsA slowed the deactivation time course, resulting in a tail crossover phenomenon. Block of Kv1.5 by CsA was use-dependent. CsA also blocked Kv1.3 currents at +50 mV in a reversible concentration-dependent manner with an apparent $IC_{50}$ of $1.1{\mu}M$. The same effects of CsA on Kv1.3 were also observed in excised inside-out patches when applied to the internal surface of the membrane. The present results suggest that CsA acts directly on Kv1.5 currents as an open-channel blocker, independently of the effects of CsA on calcineurin activity.

• Journal of Internet Computing and Services
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• v.15 no.6
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• pp.55-64
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• 2014

In a Web application, you can pass without restrictions special network security devices such as IPS and F/W, URL parameter, which is an important element of communication between the client and the server, is forwarded to the Web server. Parameters are modulated by an attacker requests a URL, disclose confidential information or through e-commerce, can take financial gain. Vulnerability parameter manipulation thereof cannot be able to determine whether to operate in only determined logical application, blocked with Web Application Firewall. In this paper, I will present a technique OTACUS(One-Time Access Control URL System) to complement the shortcomings of the measures existing approaches. OTACUS can be effectively blocked the modulation of the POST or GET method parameters passed to the server by preventing the exposure of the URL to the attacker by using clean URL technique simplifies complex URL that contains the parameter. Performance test results of the actual implementation OTACUS proves that it is possible to show a stable operation of less than 3% increase in the load.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.6
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• pp.545-553
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• 2020

Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage-gated ion channels such as transient A-type K⁺ channels, which are important for the repolarization of cardiac and neuronal action potentials. Here, we investigated the effects of aripiprazole on Kv1.4 currents expressed in HEK293 cells using a whole-cell patch-clamp technique. Aripiprazole blocked Kv1.4 channels in a concentration-dependent manner with an IC₅₀ value of 4.4 μM and a Hill coefficient of 2.5. Aripiprazole also accelerated the activation (time-to-peak) and inactivation kinetics. Aripiprazole induced a voltage-dependent (δ = 0.17) inhibition, which was use-dependent with successive pulses on Kv1.4 currents without altering the time course of recovery from inactivation. Dehydroaripiprazole, an active metabolite of aripiprazole, inhibited Kv1.4 with an IC₅₀ value of 6.3 μM (p < 0.05 compared with aripiprazole) with a Hill coefficient of 2.0. Furthermore, aripiprazole inhibited Kv4.3 currents to a similar extent in a concentration-dependent manner with an IC₅₀ value of 4.9 μM and a Hill coefficient of 2.3. Thus, our results indicate that aripiprazole blocked Kv1.4 by preferentially binding to the open state of the channels.