• Journal of Mechanical Science and Technology
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• 제20권2호
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• pp.251-261
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• 2006

The objective of this work is to apply artificial neural networks for solving inverse problems in the structural optimization of a fiber optic pressure sensor. For the sensor under investigation to achieve a desired accuracy, the change in the distance between the tips of the two fibers due to the applied pressure should not interfere with the phase change due to the change in the density of the air between the two fibers. Therefore, accurate dynamic analysis and structural optimization of the sensor is essential to ensure the accuracy of the measurements provided by the sensor. To this end, a normal mode analysis and a transient response analysis of the sensor were performed by combining commercial finite element analysis package, MSC/NASTRAN, and MATLAB. Furthermore, a parametric study on the design of the sensor was performed to minimize the size of the sensor while fulfilling a number of constraints. In performing the parametric study, the need for a relationship between the design parameters and the response of the sensor was fulfilled by using a neural network. The whole process of the dynamic analysis using commercial finite element analysis package and the parameter optimization of the sensor were automated within the MATLAB environment.

• 대한의용생체공학회:의공학회지
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• 제45권1호
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• pp.20-25
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• 2024

Extracellular vesicles (EVs) are nano-sized lipid bilayer vesicles released by cells. EVs act as messengers for cell-to-cell communication. Inside, it contains various substances that show biological activity, such as proteins, lipids, nucleic acids, and metabolites. The study of EVs extracted from terrestrial organisms and stem cells on inflammatory environments and tissue regeneration have been actively conducted. However, marine organisms-derived EVs are limited. Therefore, we have extracted EVs from sea urchins belonging to the Echinoderm group with their excellent regenerative ability. First, we extracted extracellular matrix (ECM) from sea urchin gonads treated with hypotonic buffer, followed by collagenase treatment, and filtration to collect ECM-bounded EVs. The size of sea urchin gonad-derived EVs (UGEVs) is about 20-100 nm and has a round shape. The protein content was higher after EVs burst than before, which is evidence that proteins are contained inside. In addition, proteins of various sizes are distributed inside. PKH-26 was combined with UGEVs, which means that UGEVs have a lipid membrane. PHK-26-labeled UGEVs were successfully uptaken by cells. UGEVs can be confirmed to have the same characteristics as traditional EVs. Finally, it was confirmed that Schwann cells were not toxic by increasing proliferation after treatment.

• 한국정밀공학회지
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• 제26권7호
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• pp.15-21
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• 2009

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.171-175
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• 2004

A tactile stimulator array using stacked PZT is fabricated and evaluated in this paper. The purpose of this research is the development of a tactile stimulator to represent the obstacle information for the visually disabled. As a first step of this research, we investigate the physiological characteristics of tactile stimuli and design a tactile stimulator based on the investigated results. Also we evaluated a fabricated tactile stimulator. The prototype of tactile stimulator which has 2x2 tactor elements with 3mm spacing is fabricated using stacked PZT actuator. In order to evaluate the characteristics of this tactile stimulator, physiological experiments are carried out. In the experiment, the threshold of tactile stimulus intensity within a frequency range of 5-500Hz and at various stimulus amplitudes are investigated. According to the obtained experimental result, the input signal of tactile stimulator for the transfer of obstacle information is determined. Also physiological experiments of multi-stimuli recognition such as shift and rotation are carried out.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2003년도 추계학술대회 논문집
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• pp.161-164
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• 2003

본 연구는 집중력, 기억력 및 학습 능력의 뇌기능 증진을 위한 의식적인 손 운동에 관련된 연구이다. 우선 효과적인 재활을 위한 손가락 운동 패턴을 연구하였다. 단순한 손가락 운동(Simple Finger Movement ; SFM) 패턴과 의식적인 손가락 운동(Intentional Finger Movement ; IFM)패턴을 비교하였다. 다음으로 각각 두 패턴 운동을 시켜 피험자의 집중력과 학습 능력의 증진을 검증하고자 한다. SFM 패턴과 IFM 패턴의 비교와 집중력과 학습 능력의 증진의 검증은 뇌파(mid $\alpha$파)를 이용하였다. 실험은 먼저 SFM 패턴의 운동을 시키고 다음에 IFM 패턴의 운동을 시키는 실험을 하였다. 결과적으로 IFM 패턴에서 mid $\alpha$ 파의 증가가 이루어졌음을 측정함으로써, IFM 패턴이 뇌의 집중력과 학습 능력을 증진시킨다는 결과를 얻었다.

• Nutrition Research and Practice
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• 제11권5호
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• pp.396-401
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• 2017

BACGROUND/OBJECTIVES: In this randomized, placebo-controlled, double-blind study, we evaluated the antihypertensive effects of enzymatic hydrolysate from Styela clava flesh tissue in patients with type 2 diabetes mellitus (T2DM) and hypertension. SUBJECTS/METHODS: S. clava flesh tissue hydrolysate (SFTH) (n = 34) and placebo (n = 22) were randomly allocated to the study subjects. Each subject ingested two test capsules (500 mg) containing powdered SFTH (SFTH group) or placebo capsules (placebo group) during four weeks. RESULTS: In the SFTH group, systolic and diastolic blood pressure decreased significantly 4 weeks after ingestion by 9.9 mmHg (P < 0.01) and 7.8 mmHg (P < 0.01), respectively. In addition, the SFTH group exhibited a significant decrease in hemoglobin $A_{1c}$ with a tendency toward improvement in homeostasis model assessment of insulin resistance, triglyceride, apolipoprotein B and plasma insulin levels after 4 weeks. No adverse effects were observed in other indexes, including biochemical and hematological parameters in both groups. CONCLUSION: The results of our study suggested that SFTH exerts a regulatory, antihypertensive effect in patients with T2DM and hypertension.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2005년도 ICCAS
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• pp.1400-1404
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• 2005

This paper presents the temperature control of aluminum plate by using Peltier element. Peltier effect is heat pumping phenomena by electric energy as one of the thermoelectric effect. So if current is charged to Peltier element, it absorbs heat from low temperature side and emits heat to high temperature side. In this experiment, Peltier element is used to control the temperature of small aluminum plate with current control and operating cooling fan only while cooling duration. Operating cooling fan only while cooling duration is proper to get more rapid heating and cooling duration. As a result of experiment, it takes about 100sec period to repeating temperature between $35^{\circ}C$ and $70^{\circ}C$ and about 80sec from $40^{\circ}C$ to $70^{\circ}C$ in ambient air temperature $25^{\circ}C$ and while operating cooling fan only in cooling duration. Future aim is to apply this temperature control method in actuating SMHA(special metal hydride actuator) which is applicable in Siver project acting in low frequency range by using Peltier element for heating and cooling.

• 제어로봇시스템학회논문지
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• 제20권8호
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• pp.795-800
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• 2014

In this paper, a vibrotactile pad system, T-mobile, is developed to provide vibrotactile cues for hand-held devices. A grooved and slim design is adapted to the back-side plane of the T-mobile, and the contact part consists of 12 vibrotactile panels which can operate independently and separately. To be isolated among vibrotactile actuators, the surface of the cover is divided into several pieces. Each vibrating module consists of a linear resonant actuator, a section of covering surface, and a vibration isolator. In order to provide spatial and directional information, sensory saltation and phantom sensation are applied to the T-mobile. To evaluate the developed device, two experiments were conducted to test whether directional information and spatial information can be successfully displayed by the device. Additionally, in order to find optimal stimulation by sensory saltation, an empirical test was conducted. As a result, spatial and directional information would be useful for displaying intuitive information for hand-held devices with vibrotactile feedback and reasonable near-optimal value for sensory saltation was obtained.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 춘계학술대회 논문집
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• pp.643-644
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• 2006

The purpose of this study is to experimentally analyze swing motion with soft golf clubs and compare with that with normal golf clubs. Soft golf is newly devised recreational sport based on golf but focus on the playability for the elderly. The subject fur the experiment performed swing motion using a normal golf club and a soft golf club in turn. The swing motion of the subjects was tracked using an opto-electric three-dimensional motion analysis system. The results were compared against those obtained with a normal golf club. The range of motion was analyzed along with top head speed for two cases. It was found that higher club head speed could be achieved with reduced range of motion at lumbar joint using soft golf club when compared against the swing using regular club. The lower range of motion fur lumbar bending means reduced risk of injury at the joint. So, it is projected that we can reduce the risk of injury with soft golf while maintaining the club head speed.

• 대한디지털의료영상학회논문지
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• 제5권1호
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• pp.26-31
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• 2002

본 연구의 목적은 복강경 수술환경에서 2D와 3D 내시경 비디오 영상이 수술에 미치는 영향을 평가하기 위한 연구이며, 이를 위해 3D 내시경 시스템을 구성하고 성능 평가를 수행하였다. 결과적으로 본 연구에서 제안한 3D 방식이 기존의 전자셔터 방식에 의한 3D 영상에 비해 화질과 시야각이 우수하며, 2종류의 모의 수술 실험 비교를 한 결과, 제안한 방식의 디지털 영상을 이용하는 경우가 성능이 가장 우수함을 정량적으로 확인하였다.