Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Antihypertensive effect of an enzymatic hydrolysate from Styela clava flesh tissue in type 2 diabetic patients with hypertension

  • Ko, Seok-Chun (Marine-Integrated Bionics Research Center, Pukyong National University) ;
  • Jung, Won-Kyo (Marine-Integrated Bionics Research Center, Pukyong National University) ;
  • Lee, Seung-Hong (Department of Pharmaceutical Engineering, Soonchunhyang University) ;
  • Lee, Dae Ho (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Jeon, You-Jin (Department of Marine Life Science, Jeju National University)
  • Received : 2017.05.02
  • Accepted : 2017.07.20
  • Published : 2017.10.02
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Abstract

BACGROUND/OBJECTIVES: In this randomized, placebo-controlled, double-blind study, we evaluated the antihypertensive effects of enzymatic hydrolysate from Styela clava flesh tissue in patients with type 2 diabetes mellitus (T2DM) and hypertension. SUBJECTS/METHODS: S. clava flesh tissue hydrolysate (SFTH) (n = 34) and placebo (n = 22) were randomly allocated to the study subjects. Each subject ingested two test capsules (500 mg) containing powdered SFTH (SFTH group) or placebo capsules (placebo group) during four weeks. RESULTS: In the SFTH group, systolic and diastolic blood pressure decreased significantly 4 weeks after ingestion by 9.9 mmHg (P < 0.01) and 7.8 mmHg (P < 0.01), respectively. In addition, the SFTH group exhibited a significant decrease in hemoglobin $A_{1c}$ with a tendency toward improvement in homeostasis model assessment of insulin resistance, triglyceride, apolipoprotein B and plasma insulin levels after 4 weeks. No adverse effects were observed in other indexes, including biochemical and hematological parameters in both groups. CONCLUSION: The results of our study suggested that SFTH exerts a regulatory, antihypertensive effect in patients with T2DM and hypertension.

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References

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