• Genomics & Informatics
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• v.4 no.1
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• pp.40-44
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• 2006

Toxicogenomics combines transcriptome, proteome and metabolome profiling with conventional toxicology to investigate the interaction between biological molecules and toxicant or environmental stress in disease caution. Toxicogenomics faces the problems of comparison and integration across different sources of data. Cause of unusual characteristics of toxicogenomic data, researcher should be assisted by data analysis and annotation for getting meaningful information. There are already existing repositories which claim to stand for toxicogenomics database. However, those just contain limited abilities for toxicogenomic research. For supporting toxicologist who comes up against toxicogenomic data flood, now we propose novel toxicogenomics knowledgebase system, XPERANTO-TOX. XPERANTO-TOX is an integrated system for toxicogenomic data management and analysis. It is composed of three distinct but closely connected parts. Firstly, Data Storage System is for reposit many kinds of '-omics' data and conventional toxicology data. Secondly, Data Analysis System consists of analytical modules for integrated toxicogenomics data. At last, Data Annotation System is for giving extensive insight of data to researcher.

• 한국경영정보학회:학술대회논문집
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• 2007.06a
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• pp.614-618
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• 2007

데이터 마이닝 기법 중 순차 패턴 마이닝(Sequential Pattern Mining)은 연관 규칙에 시간의 개념을 추가하여 시간의 흐름에 따른 항목(item)들의 상호 연관성을 찾아내는 것이다. 본 연구의 목적은 순차적인 상병의 발생 가능성이 높은 상병 군의 패턴을 찾아내어 이를 모형화함으로써 차후에 발생된 상병을 예방하고 이를 통하여 환자와의 관계를 관리하여 보다 나은 의료서비스를 제공하는데 있다.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4897-4902
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• 2013

Here we assessed the effectiveness of cervical cancer screening using data from the Hiroshima Prefecture Cancer Registry regarding patient age at the start of screening and differences in screening intervals. A screening model was created to calculate the health status in relation to prognosis following cervical cancer screening and its influence on life expectancy. Epidemiological data on the mortality rate of cervical cancer by age groups and mortality rates from the Hiroshima Prefecture Cancer Registry were used for the model projections. Our results showed that life expectancy when screening rate was 100% compared with 0% was extended by approximately 1 month. Furthermore, when the incidence of cervical cancer was 0% compared with the screening rate was 100%, life expectancy was extended by a maximum of 3 months. Moreover, among individuals affected by cervical c ancer, a difference of 13 years in life expectancy was calculated between screened and unscreened groups.

• Molecular & Cellular Toxicology
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• v.3 no.sup4
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• pp.36.1-36.1
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• 2007

• Proceedings of the Korean Society of Toxicology Conference
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• 2005.11a
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• pp.47-75
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• 2005

• The Korea Genome Conference
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• 2005.09a
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• pp.70-70
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• 2005

• Genomics & Informatics
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• v.19 no.4
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• pp.50.1-50.3
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• 2021

• Korea Journal of Hospital Management
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• v.15 no.1
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• pp.1-12
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• 2010

This study was tried to evaluate the level of completeness and the accordance in electronic medical records by comparing paper-based medical record in doctor's admission records, discharge summary, and nursing information records. Medical records of inpatients of neurology department that the 100 paper-based medical records in 2004 and 100 electronic medical records in 2006 were targeted. Existence of record items and doctor-nurse record accordance were evaluated in doctor's admission record, discharge summary, admission nursing information record, and discharge nursing information record. There were not any differences between electronic medical records and paper-based medical records in doctor's admission record and discharge summary. Electronic medical records had less missing records than paper-based medical records in admission and discharge nursing information records. Electronic medical records showed higher accordance than the paper-based medical record in doctor-nurse record generally, but there were statistically differences in only medication, allergy, smoking, and drinking (p<0.05). In this study, it was verified that the quality of electronic medical records are better than paper-based records in nursing information record and doctor-nurse record agreement.

• Journal of Biomedical Engineering Research
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• v.28 no.3
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• pp.417-422
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• 2007

In this study, we investigated spatio-temporal eye-hand coordination by the "Global effect paradigm", a target-distracter configuration Global effect is observed a variety of visual tasks, for example, during rapid automatic tracking, scanning for target detail, and the comparison of target configurations. Global effect used to investigate eye-hand coordination with a task that presents a target close to a distracter. Eight young subjects participated in the experiments. The experiments consist of using a distracter less eccentric than the targe1 and using a distracter more eccentric than target. Each experiment consist of tasks which are making reference, pointing the target with watching visual stimulation(saccade) and pointing the target. The subject's task was to move towards the target as quickly as possible. We measured the eye movement by using EOG and the hand movement by using NDI Optotrak system. This study shows that eye and hand movement exists for global effect paradigm in spatio-temporal coordination.

• Molecules and Cells
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• v.37 no.9
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• pp.656-663
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• 2014

Gintonin, a novel, ginseng-derived G protein-coupled lysophosphatidic acid (LPA) receptor ligand, elicits $[Ca^{2+}]_i$ transients in neuronal and non-neuronal cells via pertussis toxin-sensitive and pertussis toxin-insensitive G proteins. The slowly activating delayed rectifier $K^+$ ($I_{Ks}$) channel is a cardiac $K^+$ channel composed of KCNQ1 and KCNE1 subunits. The C terminus of the KCNQ1 channel protein has two calmodulin-binding sites that are involved in regulating $I_{Ks}$ channels. In this study, we investigated the molecular mechanisms of gintonin-mediated activation of human $I_{Ks}$ channel activity by expressing human $I_{Ks}$ channels in Xenopus oocytes. We found that gintonin enhances $I_{Ks}$ channel currents in concentration- and voltage-dependent manners. The $EC_{50}$ for the $I_{Ks}$ channel was $0.05{\pm}0.01{\mu}g/ml$. Gintonin-mediated activation 1 of the $I_{Ks}$ channels was blocked by an LPA1/3 receptor antagonist, an active phospholipase C inhibitor, an $IP_3$ receptor antagonist, and the calcium chelator BAPTA. Gintonin-mediated activation of both the $I_{Ks}$ channel was also blocked by the calmodulin (CaM) blocker calmidazolium. Mutations in the KCNQ1 $[Ca^{2+}]_i$/CaM-binding IQ motif sites (S373P, W392R, or R539W)blocked the action of gintonin on $I_{Ks}$ channel. However, gintonin had no effect on hERG $K^+$ channel activity. These results show that gintonin-mediated enhancement of $I_{Ks}$ channel currents is achieved through binding of the $[Ca^{2+}]_i$/CaM complex to the C terminus of KCNQ1 subunit.