• Title/Summary/Keyword: biomedical

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Flow Visualization Using Texture Fields

  • Om, K.S.;Lee, D.H.;Kim, J.W.;Kim, J.H.;Kim, H.C.;Min, B.G.
    • Proceedings of the KOSOMBE Conference
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    • v.1996 no.05
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    • pp.69-72
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    • 1996
  • A new flow visualization image processing technique was studied. Our approach is based on texture fields and has higher performance than similar methods. We tested our method to flow visualization of Total Artificial Heart.

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The Relationships between the Perception of Biomedical Ethics and Nursing Ethics in Nursing Students (간호대학생의 생명의료윤리와 간호윤리의 관계)

  • Cha, NamHyun
    • Journal of East-West Nursing Research
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    • v.24 no.2
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    • pp.154-162
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    • 2018
  • Purpose: This study identifies the relationships between the perception of nursing ethics and biomedical ethics in Korean nursing students. Methods: A total of 311 participants with a mean of 20.93 years were recruited using a convenient sampling method. Data were collected using a self-reported questionnaire from May 2 to May 16, 2016. Results: Biomedical ethics were significantly different according to education of ethics. Nursing ethics among nursing students were significantly different according to gender and a view of the occupation. Positive correlations were found between the perception of biomedical ethics and nursing ethics. The perception of biomedical ethics was a significant predictor of nursing ethics with an explanatory power of 16.0% of the variance. Conclusion: The findings of this study may provide a basic data to understand the biomedical ethics among Korean nursing students.

Synthesis of Size Controllable Silk Fibroin Microparticles and Their Stability on Different Solutions

  • Aryal, Susmita;Yu, Chan Yeong;Cho, Hyeyoun;Choi, Seung Ho;Key, Jaehong
    • Journal of Biomedical Engineering Research
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    • v.43 no.4
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    • pp.251-258
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    • 2022
  • Silk fibroin microparticles were fabricated using a phase separation technique between silk fibroin solution and polyvinyl alcohol. We found that the concentration of polyvinyl alcohol determines the size of microparticles. The mean diameter of the silk fibroin microparticles varied from 3.48 ㎛ to 4.05 ㎛. The silk fibroin microparticle size increased as a function of the concentration of PVA in aqueous silk solution. The resulting silk fibroin microparticles have narrow size distribution (i.e. monodisperse) and smooth/spherical surface. Also, we studied the effects of mouse serum, sodium phosphate buffer (PBS), and pH on the stability of the silk fibroin microparticles. Overall, we demonstrated the simple method to fabricate and to control the silk fibroin microparticles that makes our silk microparticles to be usable for a potential drug delivery carrier.

Protective Effect of Aqueous Extract from Erigeron annuus Against Cell Death Induced by Free Radicals

  • Myeongguk Jeong;Hyeokjin Kwon;Youngdon Ju;Go-Eun Choi;Kyung-Yae Hyun
    • Biomedical Science Letters
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    • v.28 no.4
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    • pp.307-311
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    • 2022
  • The extract of EA lacks studies showing its efficacy other than that it contains caffeic acid, an active compound that has antioxidant and neuroprotective effects on nerve cells. Therefore, in this study, we attempted to determine the effectiveness of EA extraction. In this study, we performed a DPPH assay to determine the antioxidant potential of EA. And then, the cytotoxic concentration of EA in HaCaT keratinocytes was determined, and the antioxidant effect was determined by measuring the malondialdehyde (MDA). The results of DPPH, a chemical antioxidant assay, clearly demonstrated the antioxidant capacity of EA extracted with distilled water. In addition, cell-based assays provide useful information on the protective effect of EA on oxidative stress-induced apoptosis.

Parkin-induced Decrease of ${\beta}$-catenin is Mediated by Protein Kinase C in TNF-${\alpha}$-treated HeLa Cells

  • Lee, Min Ho;Jung, Byung Chul;Kim, Sung Hoon;Lee, Juyeon;Jung, Dongju;Cho, Jang-Eun;Rhee, Ki-Jong;Kim, Yoon Suk
    • Biomedical Science Letters
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    • v.19 no.2
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    • pp.83-89
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    • 2013
  • Parkin is a protein known to have tumor suppressive functions. In a previous study, we determined that Parkin expression restores susceptibility to TNF-${\alpha}$-induced death in HeLa cells. ${\beta}$-catenin is a key protein in the Wnt signaling pathway and excessive activation of the ${\beta}$-catenin pathway can promote cancer development. In this study, we found that ${\beta}$-catenin levels decreased dramatically in Parkin over-expressing HeLa cells treated with TNF-${\alpha}$. We used chemical inhibitors of cell signaling pathways to identify the signaling molecules involved in ${\beta}$-catenin down-regulation. Our results indicate that the PKC inhibitor (RO-31-7549) blocked parkin-induced down-regulation of ${\beta}$-catenin. We also show that Parkin-induced decrease in cell viability in TNF-${\alpha}$-treated HeLa cells is alleviated upon treatment with a PKC inhibitor. Taken together, these results suggest the possibility that ${\beta}$-catenin reduction may be associated with Parkin-induced decrease of cell viability in TNF-${\alpha}$ treated HeLa cells.