• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.137-141
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• 1997

In this study, in order to improve visualization and enhance the ability of the surgeon to perform delicate endoscopic surgery, three dimensional endoscopic system is designed. These 3D systems have our features of stereoendoscopic image processing: real time image capture and retrieve; presentation of left and right image on a single monitor; separable processing of the left and right eye images; coding of the 3D endoscopic video. For 3D endoscopic video coding, three approaches are presented based on interlaced picture structure, side-field format structure, and simulcast technique. Experimental results and performances comparisons are presented and analyzed or these approaches. Digital video coding techniques are presented or 3D endoscopic video sequences by means of an MPEG-2 video coding.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.67-70
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• 1997

In this paper, we evaluated the character of speech of hearing impaired person (HIP) who acquire his hearing loss after the youth. It is usually observed that severe HIP decreased not only speech perception but also vocalization. so there is a need for sensitive and quantitative measures or the assesment of the speech of the HIP to serve both diagnostic and prognosic purposes, 7 HIP and 12 normal hearing person(NHP) were studied with pure tone test and speaking test using word/sentence table which consists of vowel(a:), mono and two syllables and a sentence. we analyzed formant frequency, pitch, sound intensity, speech duration of HIP and NHP speech. According to the results, in the HIP's speech we find that formant frequency was shifted, first-formant prominence was reduced, the dynamic range of sound intensity was decreased, speech duration was prolonged. In the next, we expect the correlation between hearing and speech character of HIP is cleared through analysis of more acoustic parameters and precise selection of HIP group.

• Journal of Biomedical Engineering Research
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• v.31 no.4
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• pp.275-279
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• 2010

The purpose of this study was to quantify the clinical assessment of rigidity at wrist in patients with Parkinson's disease. The experimental system was designed that the effect of gravity was negated by restricting motion at the horizontal plane and inertia was predetermined from a biomechanical measurement. Forty five patients with Parkinson's disease participated in this study. Viscoelastic properties were calculated from the experimental data acquired during intermittent passive movement of wrist. Viscoelastic constants correlated well with the rigidity scores of UPDRS, i.e., Spearman's r=0.733 and 0.905 for spring and damping constants, respectively. The results suggest that viscoelastic properties can be used as quantitative measures of rigidity.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.05
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• pp.164-166
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• 1995

The objectives of study are to develop a peripheral device on the endoscopic surgery system. These systems are consist of the following units. They are a color monitor of high resolution, light source, computer system and endoscopic camera with a C-mount head, irrigator, color video printer, Super VHS recorder and a system rack. The color monitor is a NTSC monitor for monitoring the image projected of the surgical section. The lightsource is necessary to irradiate the interior of a body via an optic fiber, The light projector will adapt the brightness in accordance with changing distance from the object. A miniature camera using a color CCD chip and computer system is used to capture and control an image of the surgical section[1]. The video printer is a 300 DPI resolution using thermal sublimation methods, which is developed by Samsung Electronics Co., Ltd. The specification of the endoscopic data management system is consist of storage of a captured image and pathological database of patients [2-4].

• Proceedings of the Korean Society of Computer Information Conference
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• 2014.01a
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• pp.407-408
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• 2014

본 논문에서는 이동환경 및 이동부하를 측정하여 그 특성을 조사하기 위하여 간편하게 측정할 수 있는 휴대용 모니터링 장비를 개발하였다. 온습도 및 가속도, 생체신호를 동시에 측정할 수 있다. 본 장비의 현장적용실험을 위해 공항터미널 이용 시의 상태변화를 측정하였다. 그 결과, 이동환경에서 사용하는데 있어 간편성을 가지는 반면 추후 동잡음 제거, 피험자 편의성 등이 보완 되어야 할 것이다.

• IMMUNE NETWORK
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• v.13 no.1
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• pp.10-15
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• 2013

Aluminum hydroxide (alum) is the most widely used adjuvant in human vaccines. Nevertheless, it is virtually unknown whether alum acts on B cells. In the present study, we explored the direct effect of alum on Ig expression by murine B cells in vitro. LPS-activated mouse spleen B cells were cultured with alum, and the level of isotype-specific Ig secretion, IgG1 secreting cell numbers, and Ig germ-line transcripts (GLT) were measured using ELISA, ELISPOT, and RT-PCR, respectively. Alum consistently enhanced total IgG1 production, numbers of IgG1 secreting cells, and $GLT{\gamma}1$ expression. These results demonstrate that alum can directly cause IgG1 isotype switching leading to IgG1 production.

• Journal of Ginseng Research
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• v.41 no.1
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• pp.1-9
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• 2017

Panax ginseng Meyer, belonging to the genus Panax of the family Araliaceae, is known for its human immune system-related effects, such as immune-boosting effects. Ginseng polysaccharides (GPs) are the responsible ingredient of ginseng in immunomodulation, and are classified as acidic and neutral GPs. Although GPs participate in various immune reactions including the stimulation of immune cells and production of cytokines, the precise function of GPs together with its potential receptor(s) and their signal transduction pathways have remained largely unknown. Animal lectins are carbohydrate-binding proteins that are highly specific for sugar moieties. Among many different biological functions in vivo, animal lectins especially play important roles in the immune system by recognizing carbohydrates that are found exclusively on pathogens or that are inaccessible on host cells. This review summarizes the immunological activities of GPs and the diverse roles of animal lectins in the immune system, suggesting the possibility of animal lectins as the potential receptor candidates of GPs and giving insights into the development of GPs as therapeutic biomaterials for many immunological diseases.

• Molecules and Cells
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• v.40 no.7
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• pp.485-494
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• 2017

Oleanolic acid (OA) has neurotrophic effects on neurons, although its use as a neurological drug requires further research. In the present study, we investigated the effects of OA and OA derivatives on the neuronal differentiation of rat hippocampal neural progenitor cells. In addition, we investigated whether the class II histone deacetylase (HDAC) 5 mediates the gene expression induced by OA. We found that OA and OA derivatives induced the formation of neurite spines and the expression of synapse-related molecules. OA and OA derivatives stimulated HDAC5 phosphorylation, and concurrently the nuclear export of HDCA5 and the expression of HDAC5 target genes, indicating that OA and OA derivatives induce neural differentiation and synapse formation via a pathway that involves HDAC5 phosphorylation.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.304-306
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• 1996

Endoscopy has become a crucial diagnostic and theraputic procedure in clinical areas. Over the past three years, we have developed a computerized system to record and store clinical data pertaining to endoscopic surgery of laparascopic cholesystectomy, peviscopic endometriosis, and surgical arthroscopy. In this study, we are developed computer system, which is composed of frame grabber, sound board, VCR control board, LAN card and EDMS(endoscopic data management software). Also, computer system has controled over peripheral instruments as a color video printer, video cassette recorder, and endoscopic input/output signals(image and doctor's speech). Also, we are developed one body system of camels control unit including an endoscopic miniature camera and light source. Our system offer unsurpassed image quality in terms of resolution and color fidelity. Digital endoscopic data management system is based on open architecture and a set of widely available industry standards, namely: windows 3.1 as a operating system, TCP/IP as a network protocol and a time sequence based database that handles both an image and drctor's speech synchronized with endoscopic image.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.52-55
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• 1996

The spectra of whole blood EDTA samples from two people were generated using a CARY 5E (UV-VIS-NIR) spectrophotometer from 400 to 1000nm which contain visible and NIR region. Only the data between 400 and 800nm were used to analyze the components of blood. Using the same spectrophotometer, the spectra of Water, normal saline, plasma were generated These spectra were subtracted from each blood sample, and then the first derivative of each of the subtracted data was taken to minimize baseline variations and indicated the wavelength-shift of peak and valley. Normalization and division between two blood samples were used to correlate the quantity ratio of specific components with feature of spectra. Samples were controlled at $30^{\circ}C,\;37^{\circ}C$, ambient temperature.