• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.11-14
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• 1996

Biomagnetic measurements provide superior spatial and temporal resolutions compared with the present electric measurements. We developed a SQUID system for biomagnetic applications. A magnetic field from the spontaneous ${\tau}$-rhythm activity and an auditory evoked magnetic field have been measured. And a measurement of magnetocardiogram and its field mapping have been done.

• 한국초전도학회:학술대회논문집
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• v.11
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• pp.6-6
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• 2001

• 한국초전도학회:학술대회논문집
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• 2008.08a
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• pp.57-57
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• 2008

• 한국초전도학회:학술대회논문집
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• 2009.07a
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• pp.61-61
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• 2009

• Journal of Magnetics
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• v.11 no.4
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• pp.189-194
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• 2006

The recent development of bio-conjugated magnetic nanoparticles offers many opportunities for applications in the field of biomedicine. In particular, the use of magnetic nanoparticles for biosensing has generated widespread research efforts following the progress of various magnetic field sensors. Here we demonstrate substrate-free biosensing approaches based on the Brownian rotation of ferromagnetic nanoparticles suspended in liquids. The signal transduction is through the measurement of the magnetic ac susceptibility as a function of frequency, whose peak position changes due to the modification of the hydrodynamic radius of bio-conjugated magnetic nanoparticles upon binding to target bio-molecules. The advantage of this approach includes its relative simplicity and integrity compared to methods that use substrate-based stray-field detectors.

• Progress in Superconductivity and Cryogenics
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• v.9 no.2
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• pp.1-6
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• 2007

As very sensitive magnetic field sensors, superconducting quantum interference devices (SQUIDs) are used to measure magnetic field signals from the human heart. By analyzing these cardiomagnetic signals, functional diagnoses of heart can be done. In order to measure weak biomagnetic signals, we need a multichannel SQUID array with sensor coverage large enough to cover the whole heart to enable the measurement in a single position setting. In this paper, we review the recent development of SQUID systems for measuring cardiomagnetic fields, with special emphasis on SQUID types.

• Progress in Superconductivity
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• v.10 no.2
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• pp.139-143
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• 2009

We have fabricated a low-noise 61-channel axial-type first-order gradiometer system for measuring fetal magnetocardiography(MCG) signals. Superconducting quantum interference device(SQUID) sensor was based on double relaxation oscillation SQUID(DROS) for detecting biomagnetic signal, such as MCG, magnetoencphalogram(MEG) and fetal-MCG. The SQUID sensor detected axial component of fetal MCG signal. The pickup coil of SQUID sensor was wound with 120 ${\mu}m$ NbTi wire on bobbin(20 mm diameter) and was a first-order gradiometer to reject the environment noise. The sensors have low white noise of 3 $fT/Hz^{1/2}$ at 100 Hz on average. The fetal MCG was measured from $24{\sim}36$ weeks fetus in a magnetically shielded room(MSR) with shielding factor of 35 dB at 0.1 Hz and 80 dB at 100 Hz(comparatively mild shielding). The MCG signal contained maternal and fetal MCG. Fetal MCG could be distinguished relatively easily from maternal MCG by using independent component analysis(ICA) filter. In addition, we could observe T peak as well as QRS wave, respectively. It will be useful in detecting fetal cardiac diseases.

• Journal of the Korean Magnetics Society
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• v.16 no.1
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• pp.102-106
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• 2006

Magnetic nanoparticles can be used for a variety of biomedical applications. They can be used in the targeted delivery of therapeutic agents in vivo, in the hyperthermic treatment of cancers. in magnetic resonance (MR) imaging as contrast agents and in the biomagnetic separations of biomolecules. We have synthesized magnetite $(Fe_3O_4)$ nanoparticles using chemical coprecipitation technique with sodium oleate as surfactant. Nanoparticle size can be varied from 2 to 8nm by controlling the sodium oleate concentration. Magnetite phase nanoparticles could be observed from X-ray diffraction. Magnetic colloid suspensions containing particles with sodium oleate and chitosan have been prepared. Nanoparticles, both oleate-coated and chitosan-coated, have been characterized by several techniques. Atomic farce microscope (AFM) was used to image the coated nanoparticles. Magnetic hysteresis measurement were performed using a superconducting quantum interference device (SQUID) magnetometer at room temperature to investigate the magnetic properties of the magnetite nanoparticles. The SQUID measurements revealed superparamagnetism of nanoparticles.