• Title/Summary/Keyword: biological monitoring

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Optimal Monitoring Frequency Estimation Using Confidence Intervals for the Temporal Model of a Zooplankton Species Number Based on Operational Taxonomic Units at the Tongyoung Marine Science Station

  • Cho, Hong-Yeon;Kim, Sung;Lee, Youn-Ho;Jung, Gila;Kim, Choong-Gon;Jeong, Dageum;Lee, Yucheol;Kang, Mee-Hye;Kim, Hana;Choi, Hae-Young;Oh, Jina;Myong, Jung-Goo;Choi, Hee-Jung
    • Ocean and Polar Research
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    • v.39 no.1
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    • pp.13-21
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    • 2017
  • Temporal changes in the number of zooplankton species are important information for understanding basic characteristics and species diversity in marine ecosystems. The aim of the present study was to estimate the optimal monitoring frequency (OMF) to guarantee and predict the minimum number of species occurrences for studies concerning marine ecosystems. The OMF is estimated using the temporal number of zooplankton species through bi-weekly monitoring of zooplankton species data according to operational taxonomic units in the Tongyoung coastal sea. The optimal model comprises two terms, a constant (optimal mean) and a cosine function with a one-year period. The confidence interval (CI) range of the model with monitoring frequency was estimated using a bootstrap method. The CI range was used as a reference to estimate the optimal monitoring frequency. In general, the minimum monitoring frequency (numbers per year) directly depends on the target (acceptable) estimation error. When the acceptable error (range of the CI) increases, the monitoring frequency decreases because the large acceptable error signals a rough estimation. If the acceptable error (unit: number value) of the number of the zooplankton species is set to 3, the minimum monitoring frequency (times per year) is 24. The residual distribution of the model followed a normal distribution. This model can be applied for the estimation of the minimal monitoring frequency that satisfies the target error bounds, as this model provides an estimation of the error of the zooplankton species numbers with monitoring frequencies.

Application of Physiologically Based Pharmacokinetic Modeling with Biological Monitoring Data for Risk Assessment (생물학적 모니터링 데이터를 기초한 PBPK 모델의 활용)

  • Yang, Mi-Hi;Yang, Ji-Yeon;Yi, Bit-Na;Lee, Ho-Sun
    • Environmental Analysis Health and Toxicology
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    • v.22 no.1 s.56
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    • pp.1-8
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    • 2007
  • Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of the belt approaches for risk assessment. As the amount detected in human samples is generally very low, typically in the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such at HPLC, GC/MS, LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposure biomarkers have been developed for proper biological monitoring. PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretation of biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPK dosimetry models for toxicology research and risk assessment in Korea.

BIOLOGICAL HUMAN MONITORING OF CARCINOGEN EXPOSURE: A NEW STRATEGY IN CANCER PREVENTION

  • Lee, Byung-Mu
    • Toxicological Research
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    • v.6 no.1
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    • pp.63-73
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    • 1990
  • Human exposure to environmental carcinogens can be detected by a number of methods including immunoassay, $^{32}P-postlabeling$ assay, and fluorescence technique. These assays have been applied to measure biological markers of carcinogen-adducts formed with macromolecules such as DNA, RNA and protein. In an attempt to investigate causal relationships between carcinogen exposure and tumor formation, specific carcinogen-adducts have been quantitated from human tissues and body fluids of cancer patients, occupational workers heavily exposed to certain carcinogens, smokers and controls. Carcinogens studied for biological human monitoring include benzo(a)pyrene, aflatoxin B1, UV light, ethylene oxide, 8-methoxypsoralen, 4-aminobiphenyl, vinyl choride, N-nitrosamine, cisplatin and other chemotherapeutic agents. Relevance of human monitoring for cancer research, progress in this field, methods to detect carcinogen-adducts are reviewed here. It is hoped that these approaches will be used for the risk assessment of carcinogen exposure, cancer etiology study and cancer prevention in humans.

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BIOLOGICAL HUMAN MONITORING OF CARCINOGEN EXPOSURE: A NEW STRATEGY IN CANCER PREVENTION

  • Lee, Byung-Mu
    • Toxicological Research
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    • v.6 no.1
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    • pp.61-61
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    • 1990
  • Human exposure to environmental carcinogens can be detected by a number of methods including immunoassay, $^{32}P$-postlabeling assay, and fluorescence technique. These assays have been applied to measure biological markers of carcinogen-adducts formed with macromolecules such as DNA, RNA and protein. In an attempt to investigate causal relation ships between carcinogen exposure and tumor formation, specific carcinogen-adducts have been quantitated from human tissues and body fluids of cancer patients, occupational workers heavily exposed to certain carcinogens, smokers and controls. Carcinogens studied for biological human monitoring include benzo(a)pyrene, aflatoxin B1, UV light, ethylene oxide, 8-methoxypsoralen, 4-aminobiphenyl, vinyl chloride, N-nitrosamine, cisplatin and other chemotherapeutic agents. Relevance of human monitoring for cancer research, progress in this field, methods to detect carcinogen-adducts are reviewed here. It is hoped that these approaches will be used for the risk assessment of carcinogen exposure, cancer etiology study and cancer prevention in humans.

Benford's Law and its Potential for Data Verification in Ecological Monitoring

  • Tae-Jun Choi;Woong-Bae Park;Dae-Hee Kim;Dohee Lee;Yuno Do
    • Proceedings of the National Institute of Ecology of the Republic of Korea
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    • v.5 no.2
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    • pp.43-49
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    • 2024
  • Ecological monitoring provides indispensable data for biodiversity conservation and sustainable resource management. However, the complexity and variability inherent in ecological monitoring data necessitate robust verification processes to ensure data integrity. This study employed Benford's Law, a statistical principle traditionally used in fields such as finance and health sciences, to evaluate the authenticity of ecological monitoring data related to the abundance of migratory bird species across various locations in South Korea. Benford's Law anticipates a specific logarithmic distribution of leading digits in naturally occurring numerical datasets. Our investigation involved two stages of analysis: a first-order analysis considering the leading digit and a second-order analysis examining the first two digits of bird population counts. While the first-order analysis displayed moderate conformity to Benford's Law that suggested overall data integrity, the second-order analysis revealed more pronounced deviations, indicating potential inconsistencies or inaccuracies in certain subsets of the data. Although our data did not perfectly align with Benford's Law, these deviations underscore the complex nature of ecological research, which is influenced by a multitude of environmental, methodological, and human factors.

Influencing Factors that Affect the Biological Monitoring of Workers Exposed to N,N-Dimethylformamide in Textile Coating Factories (섬유코팅업종사 근로자에서 디메틸포름아미드의 폭로에 의한 생물학적 모니터링에 영향을 미치는 인자)

  • Chung, In-Sung;Kim, Jong-Ghan;Choi, Sang-Kug;Bae, Jong-Youn;Lee, Mi-Young
    • Journal of Preventive Medicine and Public Health
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    • v.39 no.2
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    • pp.171-176
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    • 2006
  • Objectives : The objective of this study is to assess the factors influencing biological monitoring of textile coating factory workers exposed to N,N-dimethylformamide(DMF). Methods : We studied 35 workers who were occupationally exposed to DMF from 9 textile coating factories. The study was carried out in two phases; summer and winter. While air concentration of DMF, temperature and humidity were assessed in order to monitor the atmospheric conditions, biological monitoring was done to determine the internal dose by analyzing the N-methylformamide(NMF) collected from urine at the beginning and end of the shift. Questionnaires and medical surveillance were also obtained during the two phases. Results : Median air concentrations of DMF in winter and summer were 1.85 ppm and 2.78 ppm respectively. Also the difference between the urinary NMF concentration at the beginning and end of the shift $({\Delta}NMF)$ was always significant in each season (P < 0.001). The correlations between log DMF in air, log end-of-shift urinary NMF (r=0.555, P < 0.001) and log ${\Delta}NMF$ (r = 0.444, P < 0.001) was statistically significant in summer. The temperature, humidity, a shift system and different styles of clothing worn were significantly different during the two phases. In a multivariate analysis, temperature and the concentration of DMF in the air were the main factors influencing biological monitoring of textile coating factory workers. Conclusions : Concerning more comprehensive prevention measures to reduce exposure for those workers occupationally exposed to DMF, dermal exposure conditions such as temperature and humidity together with the air concentration of DMF should be assessed and biological monitoring is necessary to reduce adverse health effects, especially during the summer.

Application of Echo-Sounder Monitoring Technique as Ecological Impact Assessments of Fish on Artificial Weir Construction (인공보의 어류생태영향 평가를 위한 Echo-sounder 모니터링 기법 적용)

  • Han, Jeong-Ho;Lee, Jae Hoon;Choi, Ji-Woong;Lim, Byung Jin;Park, Jong-Hwan;An, Kwang-Guk
    • Journal of Environmental Impact Assessment
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    • v.21 no.6
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    • pp.859-877
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    • 2012
  • In this study, Echo-sounder($E_s$) monitoring methodology was applied to test environmental impacts of artificial weirs(SCW and JSW) in the Yeongsan River on fish community and habitat structures at first time, and was compared with conventional fish sampling methodologies($C_s$). For the Es monitoring in the fields, parallel transect methods was employed in determining the survey distance interval with every 125 m within the upper-lower 2 km of the weirs. Four different fish sampling gears such as casting nets, kick nets, fyke nets, and gill nets were used for applications of $C_s$ monitoring methodology. According to the Echo-sounder monitoring, fish density, expressed as a number of individuals per square meter, along the longitudinal axis of the weir was significantly greater(JSW, t = 3.506, n = 30, p < 0.001) in the down-river reach of the weir than in the up-river reach. Also, fish density along the vertical water column was highest at mid-depths of Seungchon weir, which has simple habitat substrates, while fish density was highest at hypolimnetic depth of Juksan weir. According to fish sampling by the $C_s$ methodology, the fish compositions decreased as the river goes upward, and significant differences(JSW, t = 0.248, n = 30, p < 0.05) in the compositions of fish species occurred between up-reach and down-reach of the weirs. The dominant species near the two weirs were Opsarichthys uncirostris amurensis, Hemiculter eigenmanni and Coilia nasus. Overall, our fish and habitat data, based on $E_s$ and $C_s$ monitoring methodologies, suggest that the weirs disturbed the rivers due to initial habitat disturbances by the weir constructions as well as the barrier roles of weirs on fish passage and migrations. More long-term scientific and systematic fish impact monitoring and assessments($E_s$ and $C_s$) are required in the future to predict changes of ecological structures and functions on the constructions of the weirs.

Environmental and biological monitoring of workers exposed to methyl bromide through quarantine fumigation (방역작업자의 브롬화메틸(methyl bromide) 노출수준과 생물학적 모니터링)

  • Lee, Jong-Seong;Lee, Yong-Hag;Shin, Jae-Hoon;Choi, Jung-Keun;O, Cha-Jae;Jung, Ho-Keun
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.11 no.3
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    • pp.212-218
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    • 2001
  • This study was performed to estimate environmental and biological monitoring of workers exposed to methyl bromide through quarantine fumigation. Airborne methyl bromide and it's metabolites were analyzed by gas chromatography and ion chromatography, respectively. The results are as followings; airborne concentration of methyl bromide(TWA) was $2.08{\pm}1.56ppm$(N=8). Dispersion and setting/degas groups were $0.67{\pm}0.12ppm$(N=2) and $2.54{\pm}1.53ppm$(N=6), respectively. Bromide ion concentration in serum was $23.40{\pm}14.91mg/{\ell}$(N=10) in the exposed workers and $4.74{\pm}0.82mg/{\ell}$(N=21) in the non-exposed workers. Bromide ion concentration in urine was $35.56{\pm}26.89mg/{\ell}$(N=11) in exposed group and $6.62{\pm}2.31mg/{\ell}$(N=21) in non-exposed group. Good correlation was observed between concentration of serum and urine ($r^2$=0.890 p<0.01). No significant correlations of other determinants were observed. Calculated from a regressive curve, the biological half lifes of serum and urine were 10.7 and 5.9 days. In these results, biological monitoring of bromide ion of serum and urine provided useful information for evaluating exposure of workers to methyl bromide, so that an availability of bromide ion of biological samples was showed as biological monitoring indices for methyl bromide.

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Biological Monitoring of Arsenic Concentrations According to Exposure to Arsenic-contaminated Ground Water (모 지역 소규모급수시설 비소검출에 따른 생물학적 노출 평가)

  • Seo, Jeong-Wook;Choi, Jae-Won;Oh, Yu-jin;Hong, Young-Seoub
    • Journal of Environmental Health Sciences
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    • v.46 no.5
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    • pp.513-524
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    • 2020
  • Objective: The main purpose of this study is to evaluate the environmental and biological exposure of local residents who consumed arsenic-contaminated drinking water for less than one year. Methods: As a part of water quality inspections for small-scale water supply facilities, surveys were conducted of residents of two villages that exceeded the arsenic threshold for drinking water. The environmental impact survey consisted of surveys on water quality, soil, and crops in the surveyed area. Biological monitoring was performed by measuring the separation of arsenic species in urine and total arsenic in hair. Results: In the results of biological monitoring, the concentrations of AsIII and AsV were 0.08 and 0.16 ㎍/L, respectively. MMA and DMA were 0.87 and 36.19 ㎍/L. There was no statistically significant difference between the group who drank arsenic-removed groundwater or water from the small-scale supply facility and the group who drank tap water, purified water, or commercial bottled water. Some of the water samples exceeded the arsenic threshold for drinking water. There were no samples in the soil or rice that exceeded the acceptable threshold. Conclusion: In the case of short-term exposure to arsenic-contaminated drinking water for less than one year, there were no significant problems of concern from the evaluation of biological monitoring after arsenic was removed.

Continuous Water Toxicity Monitoring Using Immobilized Photobacterium phosphoreum

  • Kim, Se-Kwon;Lee, Baek-Seok;Lee, Jeong-Gun;Seo, Hyung-Joon;Kim, Eun-Ki
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.8 no.2
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    • pp.147-150
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    • 2003
  • Water toxicity monitoring based on the continuous cultivation of Photobacterium phorphoreum is presented. Normally, after 10 days of operation, a dark variant, which emits no light, appears and dominates the population, resulting in a rapid decrease in bioluminescence. Therefore, to overcome this problem, a fluidized-bed reactor is used in which alginate-immobilized cells are grown and leaking cells are continuously released into the effluent Experimental results revealed that the dominance of dark variants was suppressed inside the immobilized beads, thereby mitigating the rapid loss of bioluminescence. Plus, a high dilution rate (1.2 h$\^$-1/) prevented the occurrence of other microbial contamination in the reactor The concentration and bioluminescence of the released cells were sufficient to measure the water toxicity for more than 4 weeks.