• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.12 no.sup1
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• pp.6-11
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• 2009

Nutritional assessment is based on anthropometric, clinical, dietary and biochemical data. There is a lack of studies about the propriety of biochemical indexes for the nutritional assessment in children despite biochemical data in pediatric population are different from them in adult's in many respects. Serum albumin is useful index to evaluate the severity of malnutrition. Hemoglobin and hematocrit tend to decrease in malnutrition on account of defect of iron metabolism and to increase in metabolic syndrome on account of enhancement of erythropoiesis. But, unlike adult, total lymphocyte count is not so useful biochemical indexes in children. We should consider pediatric characteristic when interpret biochemical indexes for nutritional assessment in children, and nutritional status in children should be assessed comprehensively with anthropometric, clinical, dietary and biochemical data.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.383-387
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• 2005

One of the most important issues in post-genome era is identifying functions of genes and understanding the interaction among them. Such interactions from complex biochemical pathways, which are very useful to understand the organism system. We present an integrated biochemical pathway database system with a set of software tools for reconstruction, visualization, and simulation of the pathways from the database. The novel features of the presented system include: (a) automatic integration of the heterogeneous biochemical pathway databases, (b) gene ontology for high quality of database in the integration and query (c) various biochemical simulations on the pathway database, (d) dynamic pathway reconstruction for the gene list or sequence data, (e) graphical tools which enable users to view the reconstructed pathways in a dynamic form, (f) importing/exporting SBML documents, a data exchange standard for systems biology.

• Journal of muscle and joint health
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• v.12 no.1
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• pp.48-56
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• 2005

Purpose: This study was measured to the bone mineral density(BMD) and biochemical bone markers in young women in order to identify the relationship between bone mineral density and biochemical bone markers. Methods: Forty two healthy young women were enrolled. BMD were checked Dual Energy X-ray Absorptiometry and biochemical bone markers were checked ELSA-OSTEO(CIS bio international, France)analyzed kit, Pyrilinks-D(Metra Biosystems Inc., U.S.A)analyzed kit. Data were analyzed with frequencies, percentages, means, and Pearson correlation coefficients. Results: 1) Young women forearm(radius & ulnar) BMD was $0.55g/cm^2$, lumbar($1{\sim}4$) BMD was $0.92g/cm^2$, neck of femur BMD was $0.75g/cm^2$, trochanter of femur BMD was $0.61g/cm^2$, ward's triangle of femur BMD was $0.68g/cm^2$. In biochemical bone marker, Osteocalcin was 21.94ng/ml, Deoxypyridinoline was 11.94nmol/nmolCr. 2) There was no significant correlation between BMD and biochemical bone markers. Conclusion: Results not indicated association between bone mineral density and biochemical markers. As seen in the small sample, future research on BMD and biochemical markers need to studies to the large sample.

• Journal of Community Nutrition
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• v.6 no.3
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• pp.155-163
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• 2004

In our country, cardiovascular disease (CVD) and Coronary heart diseases (CHD) are the leading causes of death. It is well known that CHD is multifactorial, involving environmental factors such as diet, level of exercise and cigarette smoking, and inherited factors. According to the statistical data in 2003, the cause of death with the highest mortality was including hypertension, ischemic heart disease and atherosclerosis, which accounted for $24.7\%$ of total mortality. In spite of, there have been few study reports on the change of biochemical markers and mechanisms concerned. The development of biochemical markers is required for an early diagnosis and treatment of cardiovascular diseases that are related with dietary habits of Korean people enjoying mixtures of traditional dietary style and westernized food-styles. Therefore, the most efficient cost-saving biochemical marker was established in this study, through analysis of biochemical markers related with dietary habits which are susceptibly being changed in association to cardiovascular diseases from the pre-disease phase, and through reanalysis and assessment of early diagnosis of and preventive effects of diagnosis of cardiovascular diseases by demographical character including sex, age, and socioeconomic level with use of biochemical markers that are identified and selected among the parameters in consideration of the effectiveness and appropriateness of early diagnosis of diseases. The appropriateness of biochemical markers was reviewed by professionals (medical, pharmaceutical area and food/ nutrition area) and CRP(C-Reactive Protein) and was identified to be possible in Korea. It is thought that these biochemical markers may be used as the basic data for early diagnosis and prevention of cardiovascular diseases (CVD) which may be used for Korean people.

• Transactions of the Korean hydrogen and new energy society
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• v.34 no.2
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• pp.212-225
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• 2023

This study presents a modularized process of a hybrid renewable energy system that combines photovoltaic power and wind power to supply stable power in a unit area (1 km²). The water electrolysis process and fuel cells process also contributes to the supply of the stable power. The entire system can constantly supply power of 4.39 MW/km². Actual meteorological data is used for simulation.

• Natural Product Sciences
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• v.16 no.4
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• pp.228-232
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• 2010

Bioactivity-guided fractionation using on-line HPLC biochemical detection system on $CHCl_3$-soluble fraction of Lycoris radiata led to the isolation of deoxylycorenine (1), O-demethylhomolycorine (2), galanthamine (3), lycoramine (4), mixture of $6{\alpha}$-and $6{\beta}$-haemanthidine (5), and lycorine (6), identified by spectroscopic data and physicochemical property. Among the isolated compounds, 1, 3 and 6 showed acetylcholinesterase inhibitiory activities with $IC_{50}$ values of 18.0, 12.0 and $16.6\;{\mu}M$, respectively, in in vitro colorimetric microplate assay.

• Korean Journal of Veterinary Service
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• v.31 no.1
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• pp.137-147
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• 2008

Investigations for hematologic and biochemical values and the differential count of WBC for Korean indigenous cattle (KIC)is rarely performed. Therefore, when the index of complete blood counts (CBC) and biochemical analysis of KIC was requested, it had many difficulties to make the results for blood condition since the standard hematologic and biochemical values of KIC are lacking. In the present study, we have investigated the hematologic and biochemical values and the differential count of WBC for blood of total 252 KIC and 17 striped cattle (SC) as a control. As a result, the mean values of RBC and platelet of KIC were significantly decreased by age (P<0.05). The mean values of RBC, HCT, MCV and MCHC between KIC and SC of the same age (2 - 3 years) showed the statistical significance (P<0.05). Also, in the WBC of KIC, the mean values were decreased according to the age from $12.8{\times}10^3/{\mu}l$ under 1 year to $8.5{\times}10^3/{\mu}l$ over 5 years. In the differential count of WBC of KIC, it showed generally the rates of 45% lymphocyte and 35% segmented neutrophil. In the biochemical analysis, the mean values of BUN and globulin were significantly increased according to the age (P<0.05). Additionally, in comparative analysis between pregnant and non-pregnant group of KIC, the mean values of Hg and HCT in pregnant group were significantly decreased (P<0.05). In conclusion, data obtained from this study may be valuable as a standard for interpretation of the results in hematologic and biochemical analysis of KIC.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.6
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• pp.1391-1397
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• 1999

This study was conducted to assess the biochemical nutritional status of 310 elderly(males: 130, females : 180) residing in Puchon City. Subjects were apparently healthy, home staying and aged over 60. Average height of males and females were 163.2cm and 148.5cm, respectively. Female aged over 80 showed 148.5cm, which was significantly lower than that of group aged 60~69. The rate of moderate obesity for males assessed with BMI($\geq$27) was 7.7%, and 23.4% for females. The hypertension rate assessed by SBP($\geq$160mmHg) was 8.0% and 10.5% for males and females, respectively. The proportion of hypertension with indice of DBP( 95mmHg) was 9.4% and 23.4%. The lower concentration of Hb(males: <13g/dl, females: <12g/dl) occurred in 10.7% for males and 11.7% for females. No one except a few was found with protein deficiency assessed with serum albumin, serum protein and the ratio of urinary nitrogen to creatinin. Twenty five percent of males and 35.2% of females belonged to hypercholesterolemia($\geq$ 240mg/dl). The proportion of elderly whose fasting blood sugar was higher than 140mg/dl was 23.7% and 23.2%.

• The Journal of the Korean dental association
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• v.52 no.4
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• pp.203-217
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• 2014

Bisphosphonates are widely used in the treatment of many medical conditions, such as osteoporosis, multiple myeloma, Paget's disease, etc. However, side effect has been documented in the published data during the past years, osteonecrosis of the jaw in patients receiving long-term bisphosphonate therapy. Although pathogenesis of BRONJ(bisphophonate-related osteonecrosis of the jaw) is not yet fully understood, it is currently known to be a disease associated with suppressed bone turnover by bisphopbonate. Recent literature has indicated a similar association with nonbisphosphonate drugs used in cancer therapy including monoclonal antibodies denosumab and bevacizumab and multikinase inhibitor sunitinib. Accordingly, many studies have been carried out on the biochemical markers examination to assess the risk for BRONJ. The treatment of BRONI is reported with a review of the relevant literature. However, there is still a controversial discussion about the adequate treatment. It is necessary to accumulate further studies in order to establish more useful biochemical markers and effective treatment for BRONJ.

• The Korean Journal of Nuclear Medicine
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• v.33 no.4
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• pp.341-351
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• 1999

Biochemical markers of bone turnover has received increasing attention over the past few years, because of the need for sensitive and specific tool in the clinical investigation of osteoporosis. Bone markers should be unique to bone, reflect changes of bone loss, and should be correlated with radiocalcium kinetics, histomorphometry, or changes in bone mass. The markers also should be useful in monitoring treatment efficacy. Although no bone marker has been established to meet all these criteria, currently osteocalcin and pyridinium crosslinks are the most efficient markers to assess the level of bone turnover in the menopausal and senile osteoporosis. Recently, N-terminal telopeptide (NTX), C-terminal telopeptide (CTX) and bone specific alkaline phosphatase are considered as new valid markers of bone turnover. Recent data suggest that CTX and free deoxypyridinoline could predict the subsequent risk of hiP fracture of elderly women. Treatment of postmenopausal women with estrogen, calcitonin and bisphosphonates demonstrated rapid decrease of the levels of bone markers that correlated with the long-term increase of bone mass. Factors such as circadian rhythms, diet, age, sex, bone mass and renal function affect the results of biochemical markers and should be appropriately adjusted whenever possible. Each biochemical markers of bone turnover may have its own specific advantages and limitations. Recent advances in research will provide more sensitive and specific assays.