• Interdisciplinary Bio Central
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• 제4권4호
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• pp.13.1-13.6
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• 2012

The advanced glycation endproducts receptor (AGER) is a multiligand signal transduction receptor. One of its ligands, S100b molecules activates vascular smooth muscle cells and endothelial cells via its receptor, thus triggering activation of signaling cascades and generation of cytokines and proinflammatory molecules. Ubiquitin-conjugating enzyme Ubc9 is an E2 conjugating enzyme that transfers the activated small ubiquitin-related modifier to protein substrates, and thus it plays a critical role in SUR-Mylation-mediated cellular pathways. Previous studies have shown that both AGE-R and Ubc9 play roles in diverse cellular signaling pathways. However, until recently, little attention has been paid to interactions between AGE-R and Ubc9. In this study, sequence database searches allowed us to identify a potential interaction motif between AGE-R and Ubc9. The subsequent biochemical and molecular biological analysis suggested that there may be specificity in AGE-R and Ubc9 complex signaling in atherosclerosis and cancer cells in a cell-type specific manner. Although the determinant for specificity in AGE-R and Ubc9 complex signaling in cancer cells and atherosclerosis is yet to be determined, this study provides the basis to develop a specific therapeutic application of AGE-R, SURM (small ubiquitin-related modifier)-1, and Ubc9 complex activation pathways in atherosclerosis, diabetes, cancer and inflammatory diseases.

• Interdisciplinary Bio Central
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• 제2권3호
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• pp.7.1-7.3
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• 2010

Stroke, also called an attack on the brain, is a complex disease that results from the interaction of many genetic and environmental factors. StrokePortal is a comprehensive resource for information on stroke that integrates and provides essential findings regarding stroke pathology, diagnostics, and treatments, based on Oriental and Western medicine. The stroke information was collected from various sources, such as journal articles, books, websites, and news stories, and it was refined, classified, and stored into a relational database system by automatic classification and manual curation. To provide the stored information effectively to users, a specialized retrieval system, based on web interfaces, was implemented. StrokePortal provides cutting-edge information to experts; interested people, including patients and their families; and investigators to broaden their knowledge of effective treatments for patients and offer many preventive measures. It provides a specialized feature with which users can upload their information and opinions to StrokePortal, which will enrich and mature the content even further. StrokePortal is freely accessible at http://genomics.kribb.re.kr/StrokePortal/.

• Journal of Biosystems Engineering
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• 제35권5호
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• pp.302-309
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• 2010

Aerial application using an unmanned agricultural helicopter would allow precise and timely spraying. The attitude of a helicopter depends on a number of dynamic variables for roll-balanced flight. Laterally tilting behavior of a helicopter is a physically intrinsic phenomenon while hovering and forwarding. In order to balance the fuselage, the rotor should be counter-tilted, resulting in the biased down-wash. The biased spraying toward right side causes uneven spray pattern. In this study, a raised tail rotor system for the roll-balanced helicopter was studied. Thrust of the tail rotor system was measured and theoretically estimated for the fundamental database of the roll-balanced helicopter design. The estimated tail thrust and roll-moment would be used to design the raising height of tail rotor and roll balancing dynamics. The unmanned agricultural helicopter required the tail rotor thrust of about 39.2 N (4.0 kgf) during hovering with a payload of 235.4 N (24 kgf). A raised tail rotor system would compensate for the physical tilt phenomena. A further attitude control system of helicopter would assist roll-balanced aerial spray application.

• Asian-Australasian Journal of Animal Sciences
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• 제21권10호
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• pp.1383-1388
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• 2008

Because of high growth rate and large deposition of fat in the abdomen, the chicken has been used as a model organism for understanding lipid metabolism, fattening and growing. In this study, differentially expression of proteins in chicken liver, one of the important organs for lipid metabolism, has been investigated at four different growing stages. After separation of proteins using two-dimensional electrophoresis (2-DE), more than 700 protein spots were detected. Among them, 13 growing stage specific proteins in chicken liver were selected and further investigated by matrix-assisted laser adsorptions ionization-time of flight mass spectrometry (MALDI-TOF MS). Of these, 12 proteins were matched to existing proteins based on a database search. The identified fat-related proteins in this study were fatty acid synthase (FASN) and malic enzyme (ME1). These proteins were more highly expressed at week 32 than at other weeks. In order to confirm the differential expression, one of the proteins, FASN, was confirmed by western blotting. The identified proteins will give valuable information on biochemical roles in chicken liver, especially for lipid metabolism.

• 한국미생물·생명공학회지
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• 제46권3호
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• pp.288-299
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• 2018

Food bio preservation is of major interest in the food industry. Many types of antimicrobial compounds can be produced by lactic acid bacteria (LAB), including bacteriocins. Bacteriocins increase the shelf-life of food by decreasing some food-borne diseases. In this study, a multi-coding sequence of bacteriocin genes was used for primer design to produce bacteriocin genes in Enterococcus faecium AH2 strain and Pediococcus pentosaceus AH1. Multi-coding sequences were aligned to detect conserved sequences in the bacteriocin gene. Eight genes encoding proteins involved in bacteriocin production were isolated and sequenced, including six from E. faecium AH2 (entA, entI, entF, entR, orfA2, orfA3) and two from P. pentoceseus AH1 (papA, pedB), and all gene sequences were deposited in the Gen Bank database under accession numbers LC064146-LC064151, LC101300, and LC101789, respectively. P. pentosaceus AH1 and E. faecium AH2 strains displayed bacteriocin activities of $2610AU\;mL^{-1}$ and $690AU\;mL^{-1}$ and inhibition zones of 26 mm and 19 mm, respectively. Overexpression of entA in E. faecium AH2 increased the bacteriocin and antimicrobial activities.

• 대한전자공학회논문지TE
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• 제42권3호
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• pp.1-6
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• 2005

개발된 24 채널 경락 전위측정 시스템의 구성은 마이컴 제어부, 생체신호 아날로그 증폭부, 인터페이스부, 전원장치, personal computer 등 이다. 사용자 인터페이스 프로그램은 이용자를 편리하게 구성하였으며, 측정의 편리성으로 calibration기능 및 자료의 저장 과 검색 기능을 하게 하였다. 경락 전위를 측정하기 위한 프로그램을 구성하여 제어 할 수 있게 하였다. 측정된 생체 전기 신호 자료의 분석을 통하여 각각의 위치에 대한 전위의 상호 분포를 비교하여 결과를 체계적으로 나타낼 수 있게 프로그램 처리 하였다. 다양한 종류의 측정 조건을 변화 할 수 있게 구성하여 경락 전위를 측정을 위한 이용자에게 유리한 측정 환경이 되게 하였다.

• 한국의류산업학회지
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• 제11권5호
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• pp.840-845
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• 2009

The purpose of this study is to analyze the trends of technique development of domestic textile industry and to guide the directions for researches to secure competitiveness of textile industry by analyzing domestic patent applications. This research used patent literature from Korean Patent Information database provided by Korea Intellectual Property Rights Information Service(KIPRIS), and the patent search scope, based on the application year, was from 1980 to 2007. The number of patents by natives was lower than that of foreigners in 1980's, but from the mid 90's, that number grew larger than that of foreigners. Also the number of patents by natives have shown steadily increasing tendency. However, the number of foreigner's patent in D03, D04, D05 of class was higher than the number of patents by natives. The technical fields where the patent application ratio is high varied from one country to another. In Korea, D01F of subclass had the most number of patents, and D05B, D04B had the most number of patents in Japan and Germany.

• Interdisciplinary Bio Central
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• 제3권2호
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• pp.6.1-6.3
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• 2011

Diabetes Mellitus (DM), often simply referred to as diabetes, has developed into a major health concern affecting more than 200 million people worldwide with approximately 4 million deaths per year attributed to the presence of the disease. Diabetes mellitus is categorized as Type 1 and Type 2, where Type 1 diabetes represents a lack of insulin production, and Type 2 diabetes is characterized by a relative lack of insulin receptor (i.e., decreased sensitivity to the effect of insulin) and cased by a complex interplay between genetic factors and environmental factors. Up to date, various studies on the pathology and mechanism in terms of genetic experiments have been conducted and approximately hundreds of genes were reported as diabetes mellitus associated genes. At this point, to support studies on the cause and mechanism of diabetes mellitus, an efficient database system to provide genetic variants related to diabetes mellitus is needed. DMBase is an integrated web-based genetic information resource for diabetes mellitus designed to service genomic variants, genes, and secondary information derived for diabetes mellitus genetics researchers. The current version of DMBase documents 754 genes with 3056 genetic variants and 66 pathways. It provides many effective search interfaces for retrieving diabetes mellitus and genetic information. A web interface for the DMBase is freely available at http://sysbio.kribb.re.kr/dmBase.

• 스마트미디어저널
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• 제3권4호
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• pp.35-40
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• 2014

바이오센서와 디지털 섬유의 개발로 생체신호를 측정할 수 있는 디지털 의류는 개인의 건강, 독거노인 관리와 스포츠 활동 등 여러 분야에서 사용할 수 있다. 본 논문은 디지털 의류를 착용하여 24시간 측정된 생체신호와 GPS 정보 기반의 사용자의 스트레스 상태, 맥박, 위치, 운동량을 분석하기 위한 데이터베이스 구조와 표준 HL7 메타모델기반의 XML 문서로 저장하는 저장소를 설계한다. 저장된 정보를 분석하여 사용자의 시간에 따른 스트레스 상태 및 운동량 등을 확인 할 수 있다. 또한, 실시간으로 사용자의 맥박, 위치, 운동 강도, 응급상황을 파악할 수 시스템이다. 본 논문은 생체신호를 수집하여 분석하는 시스템구현에 대하여 기술한다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2014년도 추계 종합학술대회 논문집
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• pp.299-300
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• 2014

생명과학분야에서는 생명현상을 이해하기 위해 신호 전달 네트워크에 대한 연구가 진행되고 있다. 하지만 신호전달 네트워크와 임상 정보를 결합하여 질병관점에서 신호 전달 네트워크를 통합하고 결합하는 관점의 연구가 부족하다. 따라서 본 논문에서는 빅데이터 기술을 활용하여 임상 및 신호전달 정보를 연계 분석할 수 있는 시스템을 구축하고자 빅데이터 분석을 위한 임상 및 바이오 정보 통합 데이터베이스를 설계한다. 설계한 임상 및 바이오 정보 통합 데이터베이스는 빅데이터 분석 기술을 적용한 확장 분석 기법 및 통합 분석 시스템 개발에 활용할 수 있다.