• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5665-5669
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• 2012

Background: The vascular endothelial growth factor (VEGF) mediates vasculogenesis and angiogenesis through promoting endothelial cell growth, migration and mitosis, and has involvement in cancer pathogenesis, progression and metastasis. However, the prognostic value of VEGF in patients with prostate cancer remains controversial. Objectives: The aim of our study was to evaluate the prognostic value of VEGF in prostate cancer, and summarise the results of related research on VEGF. Methods: In accordance with an established search strategy, 11 studies with 1,529 patients were included in our meta-analysis. The correlation of VEGF-expression with overall survival and progression-free survival was evaluated by hazard ratio, either given or calculated. Results: The studies were categorized by introduction of the author, demographic data in each study, prostate cancer-relatived information, VEGF cut-off value, VEGF subtype, methods of hazard ratio (HR) estimation and its 95% confidence interval (CI). High VEGF-expression in prostate cancer is a poor prognostic factor with statistical significance for OS (HR=2.32, 95%CI: 1.40-3.24). However, high VEGF-expression showed no effect on poor PFS (HR=1.30, 95%CI: 0.88-1.72). Using Begg's, Egger's test and funnel plots, we confirmed lack of publication bias in our analysis. Conclusion: VEGF might be regarded as a prognostic maker for prostate cancer, as supported by our meta-analysis. To achieve a more definitive conclusion enabling the clinical use of VEGF in prostate cancer, we need more high-quality interventional original studies following agreed research approaches or standards.

• Women's Health Nursing
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• v.19 no.2
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• pp.67-74
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• 2013

Purpose: Dysmenorrhea is a menstrual condition characterized by severe and frequent cramps and pain. Effective treatment methods for dysmenorrhea are not yet fully understood. This research compares the effects of pain killers and heated red bean pillows. Methods: Data were got on demographic data, menstrual cycle status, and activities of daily living (ADLs) limitations, dysmenorrhea severity and menstrual pain scores. Following a 10% drop-out rate, 44 young women satisfied the inclusion criteria. To prevent any bias, the experimental and control groups were selected from different campuses. We used two sizes of red bean pillows: $13{\times}11.5cm$, weighing 400g; and $15{\times}18cm$, weighing 220g. For analysis, we used IBM SPSS statistics 19.0. Results: Ninety-nine point seven percentage of total subjects reported moderate to severe dysmenorrhea and 63.6% reported as moderate to severe daily activities limitations. The mean pain score with visual analogue scale was $80.2{\pm}9.42$ of 100 and 86.4% used pain killers to alleviate menstrual discomfort in all the subjects. In both groups, all three variables showed significant improvement and the Moos's Menstrual Distress Questionnaire (MDQ) scores changed significantly between menstrual and post-menstrual time point at within groups and not significantly different at premenstrual and menstrual time point at between groups. However, the MDQ score was significantly higher in experimental group than control group at post-menstruation time point and the degree of satisfaction was higher in the control group. Conclusion: This research shows that red-bean pillows on the abdomen are effective in assisting the ADL and diminishing pain severity. With regard to its safety the study indicates it can be a convenient and safe option for female students with menstrual discomfort in schoolas a non-pharmacological self-help.

• Journal of Ocean Engineering and Technology
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• v.33 no.6
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• pp.564-572
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• 2019

Numerical simulation of the sediment by the Delft3d model was conducted to examine the changes in the sediment budget transport caused by long-term wave changes at the Maengbang beach. Representative waves were generated with input reduction tools using NOAA NCEP wave data for about 40 years, i.e., from January 1979 to May 2019. To determine the adequacy of the model, wave and depth changes were compared and verified using wave and depth data observed for about 23 months beginning in March 2017. As a result of the error analysis, the bias was 0.05 and the root mean square error was 0.23, which indicated that the numerical wave results were satisfactory. Also, the observed change in depth and numerical result were similar. In addition, to examine the effect due to long-term changes in the waves, the NOAA wave data classified into each of the representative wave grades, and then the annual trend of the representative wave was analyzed. After deciding the weight of each wave class considering the changed wave environment in 2100, the amounts of sedimentation, deposition, and the sediment transport budget were reviewed for the same period. The results indicated that the sedimentation pattern did not change significantly compared to the current state, and the amount of the local sediment budget shown in the present state was slightly less. And there has been a local increase in the number of sediment budget transport, but there is no significant difference in the net and amount of sediment movements.

• The korean journal of orthodontics
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• v.47 no.6
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• pp.401-413
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• 2017

Objective: The aim of this systematic review was to assess the occlusal outcome and duration of fixed orthodontic therapy from clinical trials in humans with the Objective Grading System (OGS) proposed by the American Board of Orthodontics. Methods: Nine databases were searched up to October 2016 for prospective/retrospective clinical trials assessing the outcomes of orthodontic therapy with fixed appliances. After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of the mean OGS score and treatment duration were performed and 95% confidence intervals (CIs) were calculated. Results: A total of 34 relevant clinical trials including 6,207 patients (40% male, 60% female; average age, 18.4 years) were identified. The average OGS score after treatment was 27.9 points (95% CI, 25.3-30.6 points), while the average treatment duration was 24.9 months (95% CI, 24.6-25.1 months). There was no significant association between occlusal outcome and treatment duration, while considerable heterogeneity was identified. In addition, orthodontic treatment involving extraction of four premolars appeared to have an important effect on both outcomes and duration of treatment. Finally, only 10 (39%) of the identified studies matched compared groups by initial malocclusion severity, although meta-epidemiological evidence suggested that matching may have significantly influenced their results. Conclusions: The findings from this systematic review suggest that the occlusal outcomes of fixed appliance treatment vary considerably, with no significant association between treatment outcomes and duration. Prospective matched clinical studies that use the OGS tool are needed to compare the effectiveness of orthodontic appliances.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.2
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• pp.81-92
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• 2017

Objectives: This review aims to report the efficacy and safety of electroacupuncture in the treatment of primary dysmenorrhea. Methods: We searched for randomized controlled studies (RCTs) using electroacupuncture on primary dysmenorrhea up to Dec 2016. The following databases were searched : OASIS, PubMED, EMBASE, CENTRAL. The results of the studies were analyzed and the risk of bias was assessed. Results: Five studies were included in this review. In most studies, the effect of electroacupuncture at Sameumgyo (SP6) was better than that of electroacupuncture at Hyeonjong (GB39), nonacupoint and no intervention about Visual analog scale (VAS), Verbal rating scale (VRS) and Retrospective symptom scale (RSS). But there were no significant effects on Resistance Index (RI) and S/D ratio (the ratio between peak systolic to end-diastolic flow velocity in uterine arteries). Serous adverse events were not reported. Conclusions: This review shows that electroacupuncture is effective on primary dysmenorrhea with no serious adverse events.

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.291.1-291.1
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• 2016

Graphene by one of the two-dimensional (2D) materials has been focused on electronic applications due to its ultrahigh carrier mobility, outstanding thermal conductivity and superior optical properties. Although graphene has many remarkable properties, graphene devices have low on/off current ratio due to its zero bandgap. Despite considerable efforts to open its bandgap, it's hard to obtain appropriate improvements. To solve this problem, heterojunction barristor was proposed based on graphene. Mostly, this heterojunction barristor is made by transition metal dichalcogenides (TMDs), such as molybdenum disulfide ($MoS_2$) and tungsten diselenide ($WSe_2$), which have extremely thickness scalability of TMDs. The heterojunction barristor has the advantage of controlling graphene's Fermi level by applying gate bias, resulting in barrier height modulation between graphene interface and semiconductor. However, charged impurities between graphene and $SiO_2$ cause unexpected p-type doping of graphene. The graphene's Fermi level modulation is expected to be reduced due to this p-doping effect. Charged impurities make carrier mobility in graphene reduced and modulation of graphene's Fermi level limited. In this paper, we investigated theoretically and experimentally a relevance between graphene's Fermi level and p-type doping. Theoretically, when Fermi level is placed at the Dirac point, larger graphene's Fermi level modulation was calculated between -20 V and +20 V of $V_{GS}$. On the contrary, graphene's Fermi level modulation was 0.11 eV when Fermi level is far away from the Dirac point in the same range. Then, we produced two types heterojunction barristors which made by p-type doped graphene and graphene treated 2.4% APTES, respectively. On/off current ratio (32-fold) of graphene treated 2.4% APTES was improved in comparison with p-type doped graphene.

• Fashion & Textile Research Journal
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• v.17 no.5
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• pp.793-799
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• 2015

Hanboks have evolved throughout time; for example, the curved Barae has changed into a more modern and sophisticated straight one. The development of staining techniques has increased color selections with more luxurious designs. I suggested a design of Dolbok that considers functionality, practicality and economic feasibility through a comparison of past and present designs. I suggested a fusion Hanbok based on a traditional Dolbok for baby boys and girls. An abundance of cheap resources has decreased the tradition of hand down clothes; therefore, I created functional and economic methods to adjust a Hanbok for kids to wear a long time. First, I made it possible to adjust the length of a skirt by a slip stitch (or catch) stitch with a Seurandan (ornate lower band) and placed the button on shoulder part of the skirt for baby girls. The width of skirt is designed for a 4 year old instead of 1 year old to adjust the size and compensate for growing kids; however, the clothes still look stylish despite the overlapped area. Second, I made a baby boy's vest with a belt that follows traditional methods that were comfortable for width variation. Third, I made Geodeulji (sleeve-ends trimmed with wide bias) that enabled long or short sleeves. Geodeulji made with a variety of fabric colors will enhance the decorative effect. Fourth, I made the width of clothes adjustable by putting Korum (tie) ON Jeogori for baby boys and girls. There are many studies on Hanboks but few reports on modern Dolbok. I believe that designers should further study fusion Hanboks within framework of traditional Hanbok designs to increase comfort and appeal.

• Journal of Korean Society of Transportation
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• v.23 no.8 s.86
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• pp.101-111
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• 2005

Various urban transport policies have an effect on urban transit riderships and accessibility. This study reports variations of metropolitan subway travel patterns affected by an enormous change in bus routes and transfer discount fare policy between subway and bus mode conducted by Seoul city in July 1st of 2004. In an effort to see the difference between the before and the after policies, two data sets are prepared. Firstly, on a daily bassis. an origin-destination trip table of May of 2004 is used. Secondly, on a daily bassis, an origin-destination trip table of August-September of 2004 is used as a counter measure. Even if seasonal variation was not considered, Seoul metropolitan area have experienced increasing riderships and accessibility. Finally, the effects of accessibility in spatial interaction model by rall service changes such as random shocks were scrutinized and interpreted in detail.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.4 s.334
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• pp.1-8
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• 2005

The increased effective impurity due to the pocket ion implantation is well blown to give rise to a reduction of the effective mobility of halo MOSFETs. However, further decrease of the effective mobility can be observed in pocket implanted MOSFETs above the mobility reduction due to the Coulomb impurity scattering and the gate bias dependency of the effective mobility can also differ from the simple model describing the mobility behavior in terms of the effective impurity. Phonon scattering and surface scattering as well as impurity Coulomb scattering are also shown to be effective in the degradation of the carrier mobility of pocket implanted MOSFETs. Using the 1-D regional approximation the effect of the distribution of the inversion charge density along the channel on the drain current is investigated. The inhomogeneous channel charge distribution due to pocket implantation is also shown to contribute to the further reduction of the effective mobility in halo MOSFETs.

• Journal of the Korean Institute of Telematics and Electronics D
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• v.36D no.2
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• pp.81-89
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• 1999

Among various wavelength conversion technologies, that using the cross-gain modulation in laser diode makes it possible to deal with the high speed signal quite simply and efficiently. In this paper, presented was the applicability of an improved time-domain large-signal dynamic model as a CAD tool to analyzed the characteristics of SSGDBR(Superstructure Grating Distributed Bragg Reflector) laser diodes used for wavelength converters. Using this model, it was shown that this kind of wavelength converter can provide the widely tunable wavelength conversion of the high speed data above 10 Gbps. We also investigated the effect of input optical power and the bias current on the characteristics of the device such as extinction ration and eye diagram. The modeling results show very similar trend to the experimental reports.