• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6077-6081
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• 2012

Background: This study was performed to analyze the prognostic implications of pretreatment or preoperative thrombocytosis in women with gynecologic malignancies. Material and Methods: We surveyed 2 medical databases, PubMed and EMBASE, to identified all relevant studies. A total of 14 (n=3,490) that evaluated the link between thrombocytosis and 5-year survival were included. REVMAN version 5.1 was used for our analysis and publication bias was evaluated using the Begg's funnel plot and tested by STATA 11.0. Risk ratios (RRs) with 95% confidence intervals (CIs) generated by the random effect model were used to assess the strength of any association. Results: 709(20.3%) of the 3,490 patients exhibited thrombocytosis (platelet counts > $400{\times}10^9/L$) at primary diagnosis, and their mortality was 1.62-fold higher compared with the others (RR=1.62, 95%CI=[1.28-2.05], p<0.0001). Thrombocytosis failed to have a stronger effect on the survival of advanced patients of stages III to IV in our study (n=478, RR=1.29, 95% CI=[1.13-1.48], p=0.0003), nor in women with cervical cancer in stage IB (n=1371, RR=1.73, 95% CI=[1.71-2.58], p=0.007). In addition, when adjusted for different carcinoma, it was associated with worse prognosis for all except the ones with vulvar cancer (n=201, RR=0.43, 95% CI=[0.14-1.29], p=0.13). Conclusions: This meta-analysis indicated that thrombocytosis might be associated with a worse prognosis for patients with gynecologic malignancies but without specificity or sensitivity for the ones in advanced stage. When adjusted for different gynecologic malignancies, it showed a significant effect on survival of all except vulvar cancers.

• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.5125-5135
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• 2015

Background: Total fat intake may be associated with increased risk of breast cancer, and fish oil has been suggested as a protection factor to breast cancer. But the effect of vegetable oils is inconclusive. We aimed to investigate the association with high vegetable oils consumption and breast cancer risk, and evaluated their dose-response relationship. Design: We systematically searched the MEDLINE, EMBASE, Cochrane databases, and CNKI updated to December 2014, and identified all observational studies providing quantitative estimates between breast cancer risk and different vegetable oils consumption. Fixed or random effect models were used to estimate summary odds ratios for the highest vs. lowest intake, and dose-response relationship was assessed by restricted cubic spline model and generalized least-squares trend (GLST) model. Results: Five prospective cohort studies and 11 retrospective case-control studies, involving 11,161 breast cancer events from more than 150,000 females, met the inclusion criteria. Compared with the lowest vegetable oils consumption, higher intake didn't increased the risk of breast cancer with pooled OR of 0.88 (95% CIs:0.77-1.01), and the result from dose-response analyses didn't show a significant positive or negative trend on the breast cancer risk for each 10g vegetable oil/day increment (OR=0.98, 95% CIs: 0.95-1.01). In the subgroup analyses, the oils might impact on females with different strata of BMI. Higher olive oil intake showed a protective effect against breast cancer with OR of 0.74 (95% CIs: 0.60-0.92), which was not significant among the three cohort studies. Conclusions: This meta-analyses suggested that higher intake of vegetable oils is not associated with the higher risk of breast cancer. Olive oil might be a protective factor for the cancer occurrence among case-control studies and from the whole. Recall bias and imbalance in study location and vegetable oils subtypes shouldn't be ignored. More prospective cohort studies are required to confirm the interaction of the impact of vegetable oils on different population and various cancer characteristic, and further investigate the relationship between different subtype oils and breast cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup3호
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• pp.323-335
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• 2016

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

• 유통과학연구
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• 제16권1호
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• pp.87-99
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• 2018

Purpose - The Export Infrastructure Strengthening Program(EISP) is a project to expand exports of agri-food products through providing customized export information to food distribution companies and supporting overseas information activities. A total of 39.6 billion won was provided by 2016. So, the purpose of this study is to analyze whether EISP is effective for expanding exports of agri-food products. Research design, data, and methodology - A simple average difference between the export performance of the policy beneficiaries and the non-policy beneficiaries can be biased if the export capacity or inherent characteristics of the enterprise are not taken into consideration. In order to solve the problem of such a bias, the propensity score matching(PSM) method has been employed in this study. PSM is a method of converting the characteristics of an export company into an index through logit analysis and then reducing the matching to one dimension to improve the accuracy of the performance measurement. Results - The balancing test was conducted to determine how the characteristics of the policy beneficiary group and the matched policy non-beneficiary group corresponded to each other. As a result of the test, we could not reject the null hypothesis that there was no difference between the two groups, so that after the matching, the two groups were similar and the explanatory variables were well controlled. Using the nearest neighbor matching with propensity score estimating through logit analysis, we estimated average treatment effect on the treated(ATT). The food companies participating the EISP had the effect of increasing the exports of $ 5.88 million. As a result, the number of export contracts increased by 11.77, the number of exporting countries by 7.52, the number of export items by 47.51, and the number of buyers' consultation by 3.50. And overseas marketing expenses increased by 35.92 million won. Except for the number of export contracts, other export performance results showed statistically significant results. Conclusions - As the EISP has a positive effect on the expansion of agro-food exports, efforts should be made to find out the limitations or problems of the policy in the future and to make a greater contribution to the increase of exports.

• Journal of Nutrition and Health
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• 제47권4호
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• pp.236-246
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• 2014

호두의 혈중 지질 수준 및 혈관 건강 개선 기능성을 평가하기 위하여 메타 분석을 실시하였다. 2014년 7월 9일 기준으로 DB 검색을 통해 426건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 19건 (n = 1,040)의 연구가 분석에 포함되었다. 호두를 일상 식사에서 일부 지방 급원 또는 열량을 대체하여 섭취하였을 때, 총 콜레스테롤, 저밀도 콜레스테롤, 중성지방 수준 및 혈류 매개 혈관 확장능을 각각 -0.124 mmol/l, -0.085 mmol/l, -0.080 mmol/l, +1.313 % 수준으로 대조군 대비 유의하게 개선시키는 것으로 분석되었다.

• 한방재활의학과학회지
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• 제30권1호
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• pp.79-93
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• 2020

Objectives While sciatic neuropathy is one of the common symptoms which have the lifetime incidence of 13~40%, still there is no consensus about the standardized and the most effective conservative treatment. In addition, the importance of systematic review and meta-analysis of preclinical are growing as they could suggest possible effective treatment strategy for future studies. Therefore, we conducted systematic review and meta-analysis to estimate analgesic effect of acupuncture on sciatica in rat models. Methods Systematic search was conducted for all controlled comparative preclinical trials which assessed analgesic effect of acupuncture in sciatica rat models. Database of PubMed, EMBASE, Web of Science, CNKI and 6 Korean databases were used. The primary outcome was pain, which is evaluated by stimulus behavior tests in rat models. We assessed the methodological quality with Systematic Review Centre for Laboratory Animal Experimentation's risk of bias tool. RevMan 5.3 was used for meta-analysis and subgroup analysis was conducted according to treatment site, acupuncture point, treatment period and frequency used in electroacupuncture. Results 14 studies were finally included following our inclusion criteria. The data from meta-analysis indicated that the acupuncture significantly improved the result values of behavior tests for pain evaluation, compared to no-treatment control group in animal models (standardized mean difference=4.43, 95% confidence interval 3.16 to 5.69, Z=6.84, p<0.00001; χ²=68.02, p<0.00001; I²=82%). The results of subgroup analysis indicate that acupuncture treatment of unilateral site, distal acupoints, longer treatment period and applying 2/100 Hz frequency in electroacupuncture could be more effective. Conclusions Systematic review and meta-analysis of animal studies are getting important for the future clinical studies and the improvement of heatlh care. Therefore the results of the study would provide evidence and better design for the forthcoming studies.

• 벤처창업연구
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• 제9권3호
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• pp.119-128
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• 2014

인적자원개발이 기업의 성과로 연결되는 과정에서 주요한 매개변수로 연구되고 있는 학습문화는 그동안 자료의 한계로 인하여 대부분 개인수준에서 회귀분석을 통하여 연구되고 있다. 본 연구에서는 위계적 선형모형(hierarchical linear modeling)을 활용한 다수준분석(multi-level analysis)을 활용하여 조직수준의 2차변수와 개인수준의 1차변수를 통합하여 분석함과 동시에, 동일한 측정자로 인해 발생하는 동일방법편의(common method bias)를 해결하기 위해 독립변수와 종속변수의 원천을 분리함으로써 인적자원개발제도와 개인성과간의 관계를 보다 정교하게 분석하였다. 연구결과, 기업의 인적자원개발제도는 조직몰입 및 직무만족에 긍정적인 영향을 주며, 조직수준의 학습문화는 기업의 인적자원개발제도와 구성원의 태도(조직몰입, 직무만족) 간의 관계에서 완전매개역할을 수행하고 있었다. 또한 과거(2007년)의 인적자원개발제도는 시간이 경과하더라도 구성원의 태도(2009년)에 긍정적인 영향을 미치는 변수로 작용하고 있음을 실증적으로 확인할 수 있었다. 이러한 연구결과를 토대로 기업에서 조직구성원들의 성과(조직몰입, 직무만족)를 높이기 위해서는 교육훈련 등 체계적인 인적자원개발제도가 구축되어야하고 아울러 상시학습조직의 운영 및 학습조직에 대한 경영자의 지원 등 학습에 대한 긍정적인 문화를 정착시키고자 하는 노력이 강화되어야 한다는 결론을 도출하였다.

• 정보화정책
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• 제21권2호
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• pp.67-88
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• 2014

이 논문의 연구가설은 스마트기기 활용 교육이 장애인들의 교육 및 학습효과로 스마트기기에 대한 사용능력과 활용 정도의 수준을 높여줄 수 있을 것이라는 것이다. 한국정보화진흥원의 '2012년 정보격차 실태조사 원자료' 중 장애인 데이터를 사용하고, 표본선택편의문제 해결을 위해 Heckman의 2단계 추정법을 활용하였다. 실증 분석결과, 스마트기기 활용 교육을 받은 장애인일 경우 종합적인 스마트기기 사용능력과 활용도 수준이 각각 더 높다는 가설이 채택되었다. 스마트기기 사용능력 및 활용도 측면에서는 스마트기기 활용 교육과 높은 학력 가구소득, 전문사무직, 젊은 연령층 등이 긍정적인 유의미한 영향을 미쳤고, 특히 지체장애에 비해서 시각장애일 경우 스마트기기 사용능력 및 활용도 수준이 낮아지는 것으로 나타났다. 이는 시각장애의 경우 특수 보조기기 및 어플리케이션 없이는 생활이 거의 불가능하므로 지체장애의 경우 두 팔 또는 두 손 전체에 이상이 있는 중증장애가 아닌 한 스마트기기 활용 교육을 통해 스마트기기 사용능력 및 활용도 수준이 높아짐을 알 수 있었다. 본 연구결과는 장애인의 스마트기기 활용도를 높이기 위한 공공 정책 또는 민간 협력의 교육프로그램 진행이 그 목적을 달성하면서 교육의 긍정적인 효과를 보여주면서, 한편 장애유형에 따라 보다 정교한 교육내용과 방법이 필요하다는 것을 보여준다.

• Journal of Nutrition and Health
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• 제50권5호
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• pp.437-446
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• 2017

'계피' 건조분말 및 물추출물의 혈당 개선 기능성을 평가하기 위하여 메타 분석을 실시하였다. 2017년 5월을 기준으로 DB 검색을 통해 4,688건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 14건 (n = 709)의 연구가 분석에 포함되었다. 건조분말의 경우 하루 1~6 g씩 섭취하였을 때, 공복혈당은 -1.55 mmol/L, 식후 혈당의 곡선하면적은 $-51.8mmol/L{\cdot}min$ 수준으로, 물추출물은 하루 0.1~0.5 g씩 섭취시 공복혈당이 -0.76 mmol/L 수준으로 개선시켰으며, 당화혈색소에는 영향이 없는 것으로 분석되었다.

• 한국프랜차이즈경영연구
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• 제11권2호
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• pp.41-51
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• 2020

Purpose: Fast food franchise companies are trying a variety of innovative services to increase their competitiveness in response to changes in population composition in the fast food market and rapid changes in consumption trends due to technological development. From this point of view, franchise companies that have focused on offline store operations are providing O2O (offline to online) service as a core service for customer convenience. This new attempt is a strategy to increase loyalty by applying an interaction method based on understanding the characteristics of new generation consumers. However, existing studies are focused on the relationship between O2O service and acceptance, so very little is known about how O2O service affects customer loyalty. Therefore, this study examines the impacts of customer involvement and relative advantages of fast food O2O service on customer brand engagement (cognitive and affective engagement) and store loyalty for MZ(Millennials - Z) generations. Research design, data, and methodology: In order to achieve the purposes of this research, several hypotheses were developed. The data were collected from 247 questionnaires in their 16-30s and were analyzed using SPSS 22.0 and SmartPLS 3.0 program. Measurement model analysis was carried out to assess convergent and discriminant validity. Also, common method bias was tested using the values of VIF (variance inflation factor). The hypotheses was tested using structural equation modeling. Result: First, involvement has a positive effect on cognitive and affective engagement. Second, relative advantages have has a positive effect on cognitive and affective engagement. Third, cognitive influences affective engagement. Finally, both cognitive and affective engagement affect store loyalty, but affective engagement has a stronger effect on store loyalty than cognitive engagement. Conclusions: In the process of consumer-brand interaction, it was confirmed that store loyalty was influenced by cognitive and affective engagement sequentially. However, the results show that affective engagement has a relatively stronger on store loyalty than cognitive engagement. Therefore, it is necessary to establish an O2O service strategy to maintain long-term loyal customers by inducing cognitive participation with high-involved consumer, as well as affective interaction, in order to obtain new customers and increase customer loyalty.