Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of cassia cinnamon intake on improvement of the glycemic response: An updated meta-analysis - Focus on preparation of dehydrated powder and water extract

계피의 혈당 개선 기능성 평가 : 메타분석 - 건조분말과 물추출물을 중심으로

  • Kwak, Jin Sook (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Park, Min young (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Kwon, Oran (Department of Nutritional Science and Food Management, Ewha Womans University)
  • 곽진숙 (이화여자대학교 식품영양학과) ;
  • 박민영 (이화여자대학교 식품영양학과) ;
  • 권오란 (이화여자대학교 식품영양학과)
  • Received : 2017.08.18
  • Accepted : 2017.09.27
  • Published : 2017.10.31
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Abstract

Purpose: This meta-analysis aimed to evaluate the effect of cassia cinnamon (Cinnamomum. cassia and C. aromaticum) on the glycemic response with a focus on the preparation of dehydrated powder and water extract. Methods: We searched Pubmed, Cochrane, EMBASE, Science Direct, and the Korean Studies Information Service System (KISS) through May 2017. In the meta-analysis for the preparation of powder, eight trials reporting fasting blood glucose (FBG), four trials reporting HbA1c, and three trials reporting the postprandial glycemic response were included. For the water extract, six trials reporting FBG and four trials reporting HbA1c were eligible for this study. A random-effects model was used to calculate the pooled effect size. Results: Cassia cinnamon powder intake significantly lowered FBG by -1.55 mmol/L (95% CI, -2.45, -0.64; p = 0.001) and the AUC of postprandial blood glucose level by $-51.8mmol/L{\cdot}min$ (95% CI, -85.5, -18.1; p = 0.003). There was a significant difference in FBG between water extract of cinnamon and placebo of -0.76 mmol/L (95% CI, -1.09, -0.43; p = 0.000). However, blood HbA1c level was not significantly altered by any preparation of cinnamon. No statistical heterogeneity was observed for any analysis except in the case of FBG for cinnamon powder. Results of funnel plots and Egger's regression suggest a low likelihood of publication bias in all biomarkers (p > 0.05). Conclusion: According to this meta-analysis, there was possible evidence to support a relationship between cassia cinnamon intake and fasting glucose in both preparation of powder and water extract. Furthermore, new evidence of the health benefits on postprandial glucose regulation of cinnamon powder was obtained.

'계피' 건조분말 및 물추출물의 혈당 개선 기능성을 평가하기 위하여 메타 분석을 실시하였다. 2017년 5월을 기준으로 DB 검색을 통해 4,688건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 14건 (n = 709)의 연구가 분석에 포함되었다. 건조분말의 경우 하루 1~6 g씩 섭취하였을 때, 공복혈당은 -1.55 mmol/L, 식후 혈당의 곡선하면적은 $-51.8mmol/L{\cdot}min$ 수준으로, 물추출물은 하루 0.1~0.5 g씩 섭취시 공복혈당이 -0.76 mmol/L 수준으로 개선시켰으며, 당화혈색소에는 영향이 없는 것으로 분석되었다.

Keywords

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