• 대한화학회지
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• 제33권1호
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• pp.97-105
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• 1989

CTABr 미셀용액 속에서의 2-alkylbenzimidazole(R-BI) 및 sodium 2-alkylbenzimidazole-5-sulfonate(R-BISO$_3$Na)에 의해 추진되는 p-nitrophenyl carboxylic esters(p-NPCE)들의 가수분해반응에 대한 미셀효과를 다루었다. 이들 반응은 각각 BI 및 BISO$_3$Na에 의해 추진되는 반응의 속도보다 현저히 감소하고, 알킬기가 methyl에서 heptyl로 길어질수록 감소의 정도가 더욱 크다. 이것은 CTABr을 포함하지 않는 수용액속에서의 BISO$_3$Na와 R-BISO$_3$Na에 의한 가수분해 반응속도가 별차이가 없음을 감안 할 때, 미셀의사층(micellar pseudophase) 내에서 이들 친핵체의 알킬기가 입체장해(steric hindrance)로 작용하기 때문이다. 이것은 수용액과 미셀용액 속에서의 반응의 측정된 홀성화에너지(${\Delta}H{\neq},\;{\Delta}G{\neq}$ 및 ${\Delta}S{\neq}$)의 값과도 정성적으로 일치하고 있다. 한편, nonyl기에서 pentadecyl기까지의 긴 알킬기를 갖고 있는 R-BISO$_3$Na는 그것의 imidazole 부분(BI moiety)이 친핵체로 작용할 뿐 아니라, 이들은 CTABr을 포함하지 않는 수용액속에서 미셀을 형성하고, 그 결과 기질인 p-NPCE를 쉽게 수용하여 반응속도를 촉진시키는 것으로 판단된다. R-BISO$_3$Na에 의한 이들 p-NPCE들의 가수분해반응의 mechanism을 알기위하여 중수소 동위원소효과(kinetic isotope effect)를 측정하였다. $k'_{H_2O}/K'_{D_2O}$값이 약 2.5∼3.2의 범위로서, 이 값은 R-BISO$_3$Na가 친핵체로만 작용한다고 보기에는 너무 높고, 일반염기로 작용한다고 보기에는 너무 낮다. 따라서 CTABr 미셀용액 속에서의 이 반응은 이 두 mechanism에 의해 동시적으로 진행된다고 생각된다.

• Journal of Acupuncture Research
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• 제32권1호
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• pp.133-140
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• 2015

Objectives : The purpose of this study is to report a case of Brown-Sequard syndrome caused by traumatic cervical fracture, presenting pain in the right upper extremity and back of the left hand, motor weakness in the right side and diminished pain and temperature in the left side. Methods : A patient received Korean medical treatment(acupuncture, electroacupuncture, herbal medicine, cupping, moxibustion, Silver Spike point electrotherapy(SSP)) and rehabilitation treatment. We evaluated pain with the Numeric Rating Scale(NRS), motor grade with a Medical Research Council(MRC) scale, sensory function and Modified Barthel Index(MBI). Results : After treatment, the patient showed considerable improvement in NRS, motor & sensory function, and MBI. Conclusions : Korean medical and rehabilitation treatments could be effective for Brown-Sequard syndrome patients. More extensive studies should be carried out.

• 한국식품조리과학회지
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• 제10권3호
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• pp.260-266
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• 1994

The object of this study was investigation of the appreciable cooking condition in seven wild grasses, an evening primerose(Oenothera lamarckiana Seringe, S$_1$), a spiderwort(Commelina Communis L. S$_2$), the flower of a convolvulus(Calystegia Ja-ponica form Vulgaris gaea, S$_3$), So Ru Jaeng Yi(Portulaca Oleracea, S$_4$), Shoe Bi Rum(Portulacae Oleracea L, S$_5$), O Yi Pul(Sanguisorb aOfficinalis, S$_6$), Jip Sin Na Mul(Agrimonia poisa var. Japonica Nakai, S$_7$), in order to find out the importance as an useful vegetables. In this work 7 wild grasses with different soaking solutions and boiling conditions were examined to investigation the preference factors by sensory evaluation. Results of sensory evaluation for samples showed a significant difference at 1% and 5% level There were high significant differents in samples boiled for different time about astringent taste, bitter taste, perfume, green color and grassy smell at 1% and 5% level. In cooking methods of 7 samples, Namul was liked best and Guk, Salad and Fritter were followed. The condiments which were used for seasoning Namul were Gochujang. Soy Paste, Salt. Gochujang was most preferred.

• 한국한의학연구원논문집
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• 제2권1호
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• pp.71-83
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• 1996

Hyang-Yack-Ku-Keup-Bang(鄕藥救急方) is our own, medical work written about the middle of the time of Korea Dynasty. I restored and researched this book because it needed to be illuminated about its medico-historic value and then I came to some conclusions as follows. 1. Hyang-Yack-Ku-Keup-Bang was published in Dae-jang-do-kam(大藏都監) of Kanghaw island(江華島) about the middle of Korea Dynasty. Choi Ja-ha(崔自河) republished it on original publication ground in Euiheung(義興) of Kyungsang-Province(慶尙道) in July, Taejong's(太宗) 17th year of Chosen Dynasty (A.D.1417) and this book was published again in Chungcheng Province(忠淸道) in Sejong's(世宗) 9th year(A.D.1427). The book published in Taejong's days was in the possession of books department of Kung-nae-cheng(宮內廳) in Japan and was the oldest medical book of existing ones. 2. Bang-Jung-Hyang-Yack-Mock-Cho-Bu(方中鄕藥目草部) of this book was originally intended to be adjusted in each division with the title of Bang-Jung-Hyang-Yack-Mock(方中鄕藥目). But Herb part(草部) only followed editing progress of Jeung-Lew-Bon-Cho(證類本草), the rest is not divided into each part and is together arranged at the below of Herb part with the title of Bang-Jung-Hyang-Yack-Mock-Cho-Bu. The Korean inscriptions on some drugstuffs in this book are different between Native Name(鄕名) of three volumes of provisions and general-spoken(俗云) of Bang-Jung-Hyang-Yack-Mock-Cho-Bu. In this, it is estimated that the publishing time and editor of tile volume of provisions and Bang-Jung-Hyang-Yack-Mock-Cho-Bu are different. I think Choi Ja-ha compiled this behind three volumes of provisions when he published. 3. This book picked some prescriptions which consisted of obtainable drugs with ease in Korea in the books of Chell-Keum-Yo-Bang(千金要方), Oi-Dae-Bi-Yo(外臺秘要), Tae-Peong-Sung-Hye-Bang(太平聖惠方), Ju-Hu-Bang(?後方), Kyung-Hum-Yang- Bang(經驗良方) Bo-Je-Bon-Sa-Bang(普濟本事方) Bi-Ye-Baik-Yo-Bang(備預百要方) and so on and got together our own prescriptions. On the whole Bi-Ye-Baik-Yo-Bang was a chief referrence book, On this, other books referred to and corrected. 4. In provisions quoted from Hyang-Yack-Jip-Sung-Bang(鄕藥集成方), there are seven provisions; leg-paralysis part, coughing part, headache part, obstetrics part, etc. don't show in this book. This is why Choi Ja-ha published only certain texts on Dae-jang-do-kam edition his own posession. So we can think the existing edition has a little misses compared with original edition. 5. This book recorded only names of drugstuffs in animal drug department like fowls, crab, goldbug, earthworm, etc. and didn't tell us ways of taking those. This is effect of Buddhist culture on medicine. This is efforts to practice 'Don't murder';one of Five Prohibition of Buddhism. 6. Beacause this book was published at the time, when our originative medicine would be set forth. This followed the Chinese ways in Theory, Treatment, Prescription and used 'Hyang Yack' in Medication out of theory of Korean medicine, which was a transitional form. So this is all important material which tell us aspects of development of 'Hyang Yack' the middle of Korea Dynasty.and this is also the beginning of originative, medical works like Dong-Eui-Bo-Kam(東醫寶鑑), Dong-Eui-Su-Bo-Won(東醫壽世保元). 7. There are few contents based on 'Byen-Jeung-Lon-Chi(辨證論治)'in this book. So we can see this book is not for doctors who study medical thoughts but for general public who suffer from diseases resulted from war. Because this book was written for a first-aid treatmeant, this is an index of medical service for the people those days. And this is also an useful datum for first-aid medicine or military medicine in these modern days. 8. Nowadays, parts of learned world of Korean medicine disregard essential theories and want to explain Korean medicine only by the theories or the methods of Western medicine. Moreover they don't adopt Chinese and Japanese theorys & thoughts about Oriental medicine in our own style and just view in there level. What was worse, there is a growing tendency for them to indulge in a trimming policy of scholarship and to take others' ideas. I think these trends to ignore our own medical thoughts involving growth of 'Hyang Yack' in the middle of Korea Dynasty, Dong-Eui-Bo-Kam and Dong-Eui-Su-Se-Bo-Won. So we, as researchers of Korean medicine, must get out of this tendency, and take over brilliant tradition and try to develop originative Korean medicine.

• 대한한방내과학회지
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• 제18권2호
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• pp.332-357
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• 1997

The purpose of study is for the defining the diagnostic criteria of Jung-Pung (中風) which are confused or unclear partially or Oriental Medicine. The results were obstained as follows ; 1. The Diagnosis of Jung-Pung (中風) can be accomplished by the name of disease, symptomatic classification, Byun-Jeung (辨證), stage, assessment of neurological deficit. 2. The various expressive way on the names of Jung-Pung (中風) can be unified as Jung-Pung (中風). 3. The symptomatic classification of Jung-Pung (中風) can be Jung-Kyung-Rak (中經絡) and Jung-Jang-Bu (中臟腑) by unconsciousness. 4. The subclassification of Jung-Kyung-Rak(中經絡) is Kanyangpokhang Punghwa sangyo (肝陽暴亢 風火上擾證), PungDamErHyul BiJoMaecRak (風痰瘀血 痺阻脈絡證), DamYeolBusil PoongDamSangYo (痰熱腑實 風痰上擾證), KiHerhyulEr (氣虛血瘀證), YeumHer PungDong (陰虛風動證) and Jung-Jang-Bu (中臟腑) is PungHwa SangYo CheongGeu (風火上擾淸竅證), DamSeupMongSac ShimSin (痰濕蒙塞心神證), DamYeolNaeFe ShimGeu (痰熱內閉心竅證), WonKiFaeTal ShimSinChakRan(元氣敗脫心神錯亂證) 5. The classification of stages can be divided as stroke stage, convalescent stage, complicated deficit stage. 6. In Oriental Medicine there were few assessment methods of neurological deficit. Therefore we need to develop new assessment system or modification of Western Medicine. The Standardization in the diagnosis of Jung-Pung (中風) has not been well established, even though we had have many clinical experiences. So it is necessary to make a accurate diagnosis that can be done by multiple diagnostic assessment. Therefore the accurate diagnosis of Jung-Pung (中風) can be done by 5 factors, they are the name of diagnosis, symptomatic classification, Byun-Jeung (辨證), stage, the assessment of neurological dificit. And it can be applied in the planning of treatment.

• 한국환경과학회지
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• 제17권5호
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• pp.509-516
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• 2008

New functional surfactant, N,N-dimethyl-N-dodecyl-N-(2-methyl benzimidazoyl) ammonium chloride(DDBAC) having benzimidazole(BI) functional group have been synthesized and the critical micellar concentration of DDBAC measured by surface tentiometry and electric conductivity method was $8.9{\times}10^{-4}M$. Micellar effects in DDBAC functional surfactant solution on the hydrolysis of p-nitrophenylacetate(p-NPA), p-nitro-phenylpropionate(p-NPP) and p-nitrophenylvalerate(p-NPV) were observed with change of various pH (Tris-buffer). The pseudo first rate constants of hydrolysis of p-NPA, p-NPP and p-NPV in optimum concentration of DDBAC solution increase to about 160, 280 and 600 times, respectively, as compared with those of aqueous solution at pH 8.00(Tris-buffer). It is considered that benzimidazole functional moiety accelerates the reaction rates of hydrolysis because they act as nucleophile or general base. In optimum concentration of DDBAC solution, the rate constants of hydrolysis of p-NPP and p-NPV increase to about 1.5 and 3.0 times, respectively, as compared with that of p-NPA. It means that the more the carbon numbers of alkyl group of substrates, the larger the binding constants between DDBAC micelle and substrates are. To know the hydrolysis mechanism of p-NPCE(p-NPA, p-NPP and p-NPV), the deuterium kinetic isotope effects were measured in $D_2O$ solutions. Consequently the pseudo first order rate constant ratios in $H_2O$ and $D_2O$ solution, $k_{H_2O}/k_{D_2O}$, were about $2.8{\sim}3.0$ range. It means that the mechanism of hydrolysis were proceeded by nucleophile and general base attack in approximately same value.

• 혜화의학회지
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• 제10권1호
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• pp.337-364
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• 2001

Clinically the arthritis occupies much part of musculoskeletal diseases. The arthritis is subordinate to Bi-jeung in the oriental medicine. No matter what is the cause of the diseases, the lesions of the arthritis are mostly cartilages and bursa. But in process of the depravation bones, muscles, tendons, ligaments and blood are influenced and become new the lesions of the arthritis. it is important that the treatments of the oriental medicine must be objectified and we must absorb a good of the western medical treatments and understand the excellent study of the arthritis in the western medicine. This study was done to comply a reference of 56 master's theses on the cartilage of the western medicine. And these theses were classified by the college, time, treatments and topics. The following results were obtained in this study: 1. Whereas In the theses on the cartilages of the western medicine, Jung-ang and Catholic university have the more theses than any other universities. 2. Analysing the theses on the cartilages of the western medicine, we can classify them by the topics with the influence on the regeneration and culture of the cartilages, observation of the historical structure and the influence on the cartilages by the operation. 3. The theses of the influence on the regeneration and culture of the cartilages were the most, 48%, and the seceond was the influence on the cartilages by the operation.(22%) However the theses on the observation of the historical structure occupied 16%.

• 한국조경학회지
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• 제26권3호
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• pp.52-65
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• 1998

It has been recognized that the cityscate identity is a very important factor in a modern city. It is necessary to have a variable view to urban comunities for understanding the cityscape identity. We have investigated the contents of archaic texts such as the geography for tracing a cityscape identity to its origin in a city. Because it has been written about politics, economics and culture of a specific area in the geography based on deep interest to the city, we can look into the early image of the cityscape closely after searching of archaic texts. It is also significant to stdy with archaic texts of geography since these studies have a correlatio to the understand of an area and the keeping of historical conscious which are fundamental of cityscape identity. We have studieds on the area of Cheongju from the middle of Chosun dynasty to the end of this kingdom, since that many geographies were described those days. It was selected "Go-Reo-Sa" and "Se-Jong-Sil-Lok" Geography, "Sin-Jeung-Dong-Guk-Y대-Ji-Seung-Lam" "Dae-Dong-Ji-Ji" "Dong-Guk- Yeo-Ji-Ji", "Jeug-Bo-Mun-Heon-Bi-Go Yeo-Ji-Go", and "Taek-Li-Ji", as archaic texts of geography because these texts described in detail about city and gave a clue to speculate an image of city. The major results are as follows; 1) It was described about the cityscape in those archaic texts are metaphysical image, existing and usable elements of cityscape, lost resources of cityscape. 2) The metaphysical images are neither objective nor consistent in the each archaic texts. But the metaphysical image of old city suggests good insight for the application to the modern city image. 3) It is necessary to the careful onsideration about the existing elements. 4) There are variable programs about the lost resources of the cityscape, in accordance with the possibility of the restoraton. 5) The physical and visible factors and non-physical and invisible factors are equally important elements of the cityscape identity. Our research suggests that it is necessary to understand in detail how those factors of cityscape identity have changed with the changes of the times, and how those factors affect the modern cityscape identity.

• 동아시아식생활학회지
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• 제19권5호
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• pp.713-722
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• 2009

Vitamin D levels have been reported to be associated with diabetes, obesity and metabolic syndrome. There have been studies on the nutritional status of vitamin D in postmenopausal women at Seoul and premenopausal women at Busan, and these studies showed that nearly no relationship between serum vitamin D levels and the obesity index existed. However, there have been no studies that examined about the relationship between serum vitamin D levels and insulin resistance in Korea. In this study, we investigated serum vitamin D levels and the relationship between serum vitamin D levels and insulin resistance (homeostasis model assessment of insulin resistance), obesity index (body mass index, percentage of body fat and waist circumference) in 180 premenopausal women (non-obese women 87.8%, obese women 12.2%) in spring (March~April), fall (September~October) and winter (January~February) at Daejeon. Serum vitamin D levels were lower in winter than in spring-fall, after adjusting for age and the obesity index. The frequency of vitamin D inadequacy (serum vitamin D levels were $\leq$ 20 ng/mL) was 45.5% in winter and, 23.5% in spring-fall, and which showed that vitamin D inadequacy was higher in winter than in spring-fall. Multiple regression analysis showed that serum vitamin D levels had no relationship with the obesity index or insulin resistance. There was no difference in the obesity index or insulin resistance between the vitamin D inadequacy and normal group, and there was no relationship between serum vitamin D levels and the obesity index or insulin resistance in non-obese and obese premenopausal women, respectively. In conclusion, serum vitamin D levels in premenopausal women at Daejeon were lower in winter than in spring-fall, and the frequency of vitamin D inadequacy was higher in winter than in spring-fall. Serum vitamin D levels had no relationship with the obesity index or insulin resistance in premenopausal women, most of whom were not obese.