• Journal of Chest Surgery
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• v.43 no.6
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• pp.588-595
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• 2010

Background: Base on types of tumor, the types of expressed tumor is diverse and the difference in its expression rate is even more various. Due to such reasons an animal model is absolutely needed for a clinical research of lung cancer. The author attempted oncogenesis by cultivating a cell line of non-small cell carcinoma and then injecting it inside thoracic cavities of nude mice. The author conducted quantitative analyses of HER2/neu tumor gene - an epidermal growth factor receptor (EGFR) related to lung cancer, and TGF-${\beta}_1$, which acts as a resistance to cell growth inhibition and malignant degeneration. In order to investigate achievability of the oncogenesis, histological changes and the expression of cancer gene in case of orthotopic lung cancer is necessary. Material and Method: Among 20 immunity-free male BALB/c, five nude mice were selected as the control group and rest as the experimental group. Their weights ranged from 20 to 25 gm (Orient, Japan). After injection of lung cancer line (SW900 G IV) into the pleural cavity of nude mice, They were raised at aseptic room for 8 weeks. HER2/neu was quantitatively analyzed by separating serum from gathered blood via chemiluminiscent immunoassay (CLIA), and immunosandwitch method was applied to quantitatively analyze TGF-${\beta}_1$. SPSS statistical program (SPSS Version 10.0, USA) was implemented for statistical analysis. Student T test was done, and cases in which p-value is less than 0.05 were considered significant. Result: Even after lung cancer was formed in the normal control group or after intentionally injected lung cancer cell line, no amplification of HER2/neu gene showed reaction. However, the exact quantity of TGF-${\beta}_1$ was $28,490{\pm}8,549pg/mL$, and the quantity in the group injected with lung cancer cell was $42,362{\pm}14,449pg/mL$, meaning 1.48 times highly Significant (p<0.483). It proved that HER2/neu gene TGF-${\beta}_1$ had no meaningful interconnection. Conclusion: TGF-${\beta}_1$ gene expressed approximately 1.48 times amplification in comparison to the control group. The amplification of TGF-${\beta}_1$ meant somatic recuperation inhibition mechanism due to carcinogenesis in nude mice was definitely working. It may be implemented as a quantitative analysis that allows early detection of lung cancer in human body.

• Journal of Digital Convergence
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• v.12 no.1
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• pp.467-473
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• 2014

The purpose of this study is to monitor the physiological changes by measuring EEG, blood pressure, heart rate, etc after applying progressive relaxation technique to university archery players in order to verify the effect of progressive relaxation through respiration, and, ultimately, improve an athlete's archery performance. This study chose 13 female archery athletes. The EEG, blood pressure, and heart rate of the athletes were measured before applying Jacobson's progressive relaxation technique for 12 weeks, during which the EEG, blood pressure, and heart rate were measured 3 times a week after 15 to 20 minutes of training before every measurement. We used the SPSS18.0 program for technical analysis to check the general features of the athletes and carried out the paired t-test to examine the changes made to the EEG, blood pressure, and heart rate of a single test group before and after the experiment. All statistical level of significance was maintained at ${\alpha}=0.5$. The results are as follows. First, after 12 weeks of appliance, between the targets' relative ${\alpha}$ wave and ${\beta}$ wave, the relative ${\alpha}$ wave showed a statistically significant increase while the relative ${\beta}$ wave showed no changes. Second, after 12 weeks of appliance, in terms of blood pressure, the systolic pressure showed no changes while the diastolic pressure showed a statistically significant change. Third, there was no statistically significant change to the heart rate. In conclusion, progressive relaxation through breathing has a positive effect on the archery athletes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.40-48
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• 2017

This study investigated the relationship among emotional regulation, coping strategies and satisfaction in clinical practice, and examined factors influencing satisfaction with clinical practice in nursing students. Data were collected through structured questionnaires from May 1 to June 30, 2016. The study participants were 201 third and fourth year nursing students at four departments of nursing located in B and K metropolitan city. Data were analyzed using t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients and stepwise multiple regression with SPSS WIN v 20.0. The mean emotional regulation score was $3.73{\pm}0.48$, active coping was $2.79{\pm}0.33$, passive coping was $2.53{\pm}0.36$, and practice satisfaction was $3.58{\pm}0.46$. Statistically significant relationships were noted between emotional regulation and satisfaction with clinical practice (r=.391, p<.001), between active coping and satisfaction with clinical practice (r=.361, p<.001), between passive coping and satisfaction with clinical practice (r=.276, p<.001). Factors influencing satisfaction with clinical practice were satisfaction with the nursing major (${\beta}=-.322$, p<.001) and emotional regulation (${\beta}=.232$, p<.001). These factors explained 28.1% of variance in participant's satisfaction with clinical practice. In conclusion, effective nursing educational programs need to be developed to enhance satisfaction with clinical practice and to foster positive emotional regulation in nursing students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.351-359
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• 2017

This study examined emotional labor, fatigue, and musculoskeletal pain in hospital nurses. The study sample included 235 hospital nurses. The data were collected by questionnaire and analyzed with descriptive statistics, t-test, ANOVA, Scheffe test, Pearson's correlation coefficients, and multiple regression.The average emotional labor score was 3.27, and of fatigue was 2.04. The musculoskeletal pain score was 4.43. Emotional labor and fatigue are significantly positively associated with musculoskeletal pain(r=.180, p=.006; r=.278, p<.001). Emotional labor was positively associated with the degree of fatigue(r=.353, p<.001). The significant predictors of musculoskeletal pain for nurses were physical fatigue(${\beta}=.324$, p<.001) and gender(female)(${\beta}=.171$, p=.009), explaining 13.7% of the variance in musculoskeletal pain(F=16.271, p<.001). The results suggest that engaging in emotional labor related to nursing tasks increases the risks of fatigue and musculoskeletal pain. Therefore, it is important to develop a management program to relieve the emotional labor, fatigue, and prevent musculoskeletal pain for clinical nurses.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.432-441
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• 2017

The aim of this study was to investigate the relationship among family function, intimacy risk with the opposite sex, and campus life satisfaction among college students. A descriptive study was conducted. Data were collected from May 11, 2017 to May 20, 2017 by using a structured questionnaire. The participants were 180 college students at two colleges in J-city. Data were analyzed using t-test, one way ANOVA, Scheffe test, pearson correlation coefficient, and multiple regression analysis with SPSS 20.0. The mean scores were as follows: family function $3.07{\pm}0.44$(5 points), intimacy risk with the opposite sex $2.03{\pm}0.59$(4 points), and campus life satisfaction $3.20{\pm}0.50$(5 points). There was a significant correlation between the family function, intimacy risk with the opposite sex, and campus life satisfaction variables. Multiple regression analysis showed that factors influencing campus life satisfaction were family communication(${\beta}=0.341$, p=.001) and parental economic activity type(${\beta}=0.161$, p=.007). The explanation power of this regression model was 13.1%. These results of this study indicate that effective campus life satisfaction should be developed by including improvement of family community of family function.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.12
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• pp.300-309
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• 2017

This study was conducted to investigate the mediated effects of self-efficacy in relation to communication competency within the medical team and turnover intention of hospital nurses. Data were collected from 208 nurses working at two university hospitals. In analyzing data using SPSS/WIN 23.0 program, descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and after analyzed with Multiple regression analysis using Baron & Kenny's 3 stage procedure, confirmed indirect effect with Sobel test. Evaluation of relationships among communication competency, turnover intention and self-efficacy of subjects revealed a negative relationship(r=-0.22, p=0.001) between communication competency and turnover intention, a positive relationship(r=0.61, p<0.001) between communication competency and self-efficacy and a negative relationship(r=-0.25, <0.001) between self-efficacy and turnover intention. Concerning the mediated effect of self-efficacy in the relationship between communication competency and turnover intention, the influence of communication competency at stage 1 on turnover intention was significant(${\beta}=-0.22$, p<0.001), but communication competency at stage 3 had no significant influence on turnover intention(${\beta}=-0.11$, p=0.194). Accordingly, the mediated effect of self-efficacy in the relationship between communication competency and turnover intention fully mediated and the mediated effect of self-efficacy was significant(z=-2.15, p=0.032). Heightening self-efficacy by improving communication competency could effectively reduce the turnover intention of nurses.

• Analytical Science and Technology
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• v.25 no.4
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• pp.207-213
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• 2012

Analysis of the aroma constituents present in the rose essential oil of Chinese Kushui type (Rosa sertata ${\times}$ Rosa rugosa) by GC-FID and GC-MS was performed independently as an expert for the inter-laboratory round-robin test to verify reproducibility according to the decision of the preliminary meeting of ISO/TC-54 (Shanghai, Sep. 14-15, 2010). Total 179 peaks (using SPB-1 apolar column), 165 peaks (using DB-624 intermediate polar column), and 162 peaks (using Supelcowax-10 polar column) were separated by GC-FID, respectively. Major constituents (over 5%) by GC-FID were ${\beta}$-citronellol (41.6~46.7%), geraniol (9.7~11.0%), and nerol (3.4~4.5%). ${\beta}$-Citronellol peak was overlapped with nerol peak on SPB-1 and DB-624 columns, whereas the two peaks were separated each other on Supelcowax-10 column. Our results were generally consistent with Chinese data (ISO/DIS 25175); however, a peak of phenethyl alcohol separated by using PEG (Supelco wax) column was found at the quite different retention time. Comparative analysis was conducted using Bulgarian rose (Rosa damascena Miller) oil and perfume. Bulgarian rose oil showed rich amounts of characteristic aroma constituents than the essential oil of Chinese Kushui type.

• The Korean Journal of Pesticide Science
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• v.15 no.3
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• pp.289-297
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• 2011

As part of safety evaluation of 2A (amono acid), PAT (phosphinotricin Acetyl-transferase), CtrI (Carotene desaturase) and PSY (phytoene synthase), the expressed proteins inserted to ${\beta}$-carotene Biofortified rice were tested for antigencity test. As a result, the group of administering high-concentration PAT, the expressed protein, showed a great content of total WBC; however, other expressed proteins did not show much difference. Against ASA (Active Systemic Anaphylaxis) test, the group of administering high-concentration PAT, the expressed protein, showed mild or medium degree of symptoms, but there was no dead entity. According to the result of the PCA (Passive Cutaneous Anaphylaxis test), the group of administering high-concentration PAT, 2A, PSY, and mixture of expressed proteins indicated positive response in low anti-serum concentration, and the group of administering the clinical concentration of mixture indicated mild positive response. However, because the group of administering the clinical concentration of expressed proteins, PAT, 2A, PSY, and CtrI, did not show positive response, it is thought that IgE is not generated. Further studies are needed to verify the safety of ${\beta}$-carotene Biofortified rice.

• Journal of Digital Convergence
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• v.15 no.1
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• pp.363-372
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• 2017

This study aimed to identify influences which nutritional status and depression have on satisfaction with life on middle-aged long-term care patients. This study is a descriptive study conducted with 120 patients aged 40-65 from February 1st to March 31th, 2015 in hospital. Data were analyzed using t-test, ANOVA, Scheff's test, Pearson's correlation coefficients, multiple regression. The average of nutrition status, depression, satisfaction of life was $15.85{\pm}3.85$, $24.70{\pm}15.85$, $3.54{\pm}1.22$ each. The findings show nutritional status(r=.281, p<.005) have correlation(+) with satisfaction of life, otherwise, nutritional status(r=.439, p<.001) and satisfaction of life(r=-.-574, p<.001) have correlation(-) with depression both. Influencing factors on satisfaction of life were subjective health(${\beta}=.387$, p=.000) and depression(${\beta}=.251$, p=.010), explained 36.0% of the variance. Therefore, management program for improving satisfaction of life is needed on middle-aged long term care patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.4
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• pp.149-159
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• 2019

This study was conducted to investigate that the mediating effect of interpersonal support in college students. Data were collected from the college located in G province, Korea from April, 1th to May 2th 2017. Data were analyzed by pearson correlation coefficients, and regression method of Baron & Kenny of SPSS 26.0 program, and Sobel test of Amos 16.0 program. The result were as follows; 1) The mean scores were college adaptation 5.30(.75), smartphone addiction 2.30(.48), interpersonal support 4.53(.75). 2) The college adaptation showed negative correlation with smartphone addiction(r=.328, p<.001) and positive correlation with interpersonal support(r=.490, p<.001) significantly. Interpersonal support showed significant negative correlation with smartphone addiction(r=-034, p=.04). 3) Interpersonal support had partial mediating effect(Z=2.16, p=.03) in the relationship between college adaptation and smartphone addiction. Baron & Kenny's three-step test showed that college adaptation(${\beta}=-.37$, p<.000) and interpersonal support (${\beta}=.30$, p=.15) were significant predictor variables for the smartphone addiction. Based on the results of this study, college program which is reinforce interpersonal support need to be applied and for the successful college adaptation and beneficial use of smartphone.