• Journal of Periodontal and Implant Science
• /
• 제38권2호
• /
• pp.163-170
• /
• 2008

Purpose: Biphasic calcium phosphates have been of great interest recently. Mixing adequate ratios of hydroxyapatite(HA) and beta-tricalcium phosphate($\beta$-TCP) allowed to control the resorption rate without distorting its osteoconductive property. This study evaluated the bone formation effect of newly developed biphasic calcium phosphate(BCP) in calvarial defect of rabbits. Materials and Methods: 6 male New Zealand rabbits were used. Four defects with 8mm in diameter were created on each animal. BCP with HA/$\beta$-TCP ratio of 7:3 and particle size of $0.5{\sim}1.0\;mm$ was used as the test group and bovine bone with $0.25{\sim}1.0\;mm$ particle size, as the control group. Both test and control group materials were randomly implanted in the calvarial defects and were covered witha polymer membrane. The animals were sacrificed after 12, 24, and 48 weeks of implantation under general euthanasia. Resin blocks were obtained and were stained by masson's trichrome for histological observation. Results: Overall results were uneventful without any defect exposure or inflammation. The amount of new bone formation and bone maturity increased with increase in healing period at both groups. New bone in test group was mostly formed along the material particle surrounded by osteoblasts, and observation of osteoblastic stream was also present. Bone maturity increased as it was closer to thedefect margins. Under the same healing period, the test group showed more bone formation than the control group with more stable bovine bone particles remaining even after 48 weeks, whereas considerable resorption took place in BCP. Almost total defect closure was observed in test group with new bone formation in the central part of the defect. However, limited new bone formation was observed in the control group. Conclusion: Within the limits of the study, the present study reveals the newly developed BCP to be a good osteoconductive material. However, further studies are needed to be conducted in a different study model with a larger sample size.

• 대한의생명과학회지
• /
• 제5권2호
• /
• pp.181-190
• /
• 1999

한국인의 대표적인 성인 고형 종양인 위암, 간암, 유방암과 소아 백혈병 및 2종의 소아 고형 종양 환자로부터 혈장 transforming growth factor-$\beta$1 (TGF-$\beta$1) 농도를 sandwich ELISA 분석법을 이용해 측정함으로써 TGF-$\beta$1을 이 질환들에 대한 새로운 종양표지자 (tumor marker)로 사용할 수 있는지 검토하였다. 토한 연령 및 성별에 따른 혈장 TGF-$\beta$1 농도의 정상치를 조사하였다. 신생아에서 70대까지 혈장 TGF-$\beta$1 농도의 차이는 없었고 남녀간의 차이도 없었다. 위암 환자의 혈장 TGF-$\beta$1 농도는 16.0$\pm$6.8 ng/ml (평균$\pm$표준편차)로 정상 대조군의 TGF-$\beta$1 농도 (8.3$\pm$5.0 ng/ml) 보다 유의하게 높았으나 간암, 유방암 환자의 혈장 TGF-$\beta$1 농도는 대조군과 차이가 없었다. 그리고 위암 환자 16명 ,간암 환자 8명, 유방암 환자 7명 중 각각 7명 (43.7%), 1명 (12.5%), 1명 (14.3%)에서만 혈장 TGF-$\beta$1 농도가 증가되었다. 5명의 소아 백혈병 환자에서는 관해 (remission)여부와 상관없이 혈장TGF-$\beta$1농도가 모두 정상 범위에 있었으나 2명의 소아 고형암 환자에서는 종양 절제 전에는 혈장 TGF-$\beta$1농도가 높았다가 절제 후 정상으로 떨어졌다. 결론적으로 1)정상인의 혈장 TGF-$\beta$1 농도는 연령 및 성별에 따른 차이가 없다는 것을 알 수 있었고, 2)성인 고형암인 위암, 간암, 유방암에서는 낮은 민감도로 인해 TGF-$\beta$1을 진단을 위한 선별 검사로 이용하기에는 부적절한 것으로 판단되었으며, 3)정상 대조군보다 혈장 TGF-$\beta$1 농도가 높았던 위 암 환자와 종양 절제 전후로 혈장 TGF-$\beta$1 농도가 민감하게 변했던 소아 고형암 환자에 대 해서는 향후 표본 수를 늘려 부가적인 연구를 해야 할 것으로 사료된다.

• East Asian Economic Review
• /
• 제20권1호
• /
• pp.37-65
• /
• 2016

This research intends to investigate the progress made in East Asian bond market integration thus far. Price-based measures (AAD indicator and beta-convergence measure), quantity-based measures and econometric techniques (co-integration test, error correction model based Granger causality test) are employed in the analysis. Even though East Asian government bond markets have become more integrated since 2001, the differentials among the markets still remain significantly high. The bond market integration process seems slow. The convergence of bond markets sped up in 2003 and after the 2008 world financial crisis, implying the important role of government policies in integrating the regional bond markets. East Asian bond market integration may need more government-directed measures.

• 펄프종이기술
• /
• 제38권4호
• /
• pp.24-30
• /
• 2006

Formation which is an indicator of nonuniformity in fiber distribution is concerned with small scale variation in roughness, optical properties, print density, and so on. This study evaluated the formation of sheets which were made usning handsheet former and paper-machine with hydraulic headbox. Optical method and ${\beta}-ray$ method were used for formation test. The fiber type, freeness and basis weight of sheet were considered as variables. The formation of handsheet was affected by fiber type and freeness, and floe size distribution was influenced by basis weight. For machine made sheet, its formation seemed to be dependent on the hydraulic forces in headbox and former. When two formation test methods were compared, there was the highest relationship between optical formation index and normalized standard deviation from ${\beta}-ray$ method.

• Preventive Nutrition and Food Science
• /
• 제12권2호
• /
• pp.119-121
• /
• 2007

The tyrosinase inhibition activity and mutagenicity as assessed by the Ames test on phenolic antioxidants (5-Caffeoyl quinic acid, 3,4-Dihydroxy cinnamic acid, Quercetin 3-O-${\beta}$-D-glucopyranose, Kaempferol 3-O-${\beta}$- D-glucopyranose) and the ethyl acetate fraction isolated from mulberry leaves were examined. The ethyl acetate fraction and chlorogenic acid exhibited weaker tyrosinase inhibitory activities than kojic acid. In addition, the ethyl acetate fraction from mulberry leaves, containing phenolic antioxidants, showed no mutagenicity by the Ames test.

• 보건교육건강증진학회지
• /
• 제30권2호
• /
• pp.11-21
• /
• 2013

Objectives: The objective of this paper is to study influence of self esteem, family support and adaptation to school life on adolscents' suicidal ideation adjsuted for general characteristics effect. Methods: Using cluster sampling, 318 high school freshmen from T city were extracted as survey subjects. Independent t-test, ANOVA, Duncan test, Pearson's correlation coefficients and multiple regression analysis were applied for statistical analysis. Results: Among general characteristics, religion, family income, single-parentedness, health status and school grades were statistically significant with suicidal ideation. Controlling the above variables, increase in self-esteem (${\beta}$=-.300) and family support (${\beta}$=-.267) showed statistically significant decrease in suicidal ideation but adaptation to school life did not. Conclusions: Therefore, it is proposed that measures for enhancement of self esteem and family support to be included in development of suicide prevention programs.

• 성인간호학회지
• /
• 제29권3호
• /
• pp.323-331
• /
• 2017

Purpose: The purpose of this study was to examine whether the uncertainty mediates relationship between rehabilitation motivation and social support. Methods: Participants were 123 adults patients diagnosed as stroke in a hospital located in a Metropolitan City. Data were collected by self-administered questionnaires measuring uncertainty, family support and medical team support as social support, rehabilitation motivation. Data were analyzed using t-test, one-way ANOVA, Pearson's correlation, and multiple regression analyses. The significance of mediating effect was analyzed by Sobel test. Results: Family support and uncertainty, respectively, were influential on rehabilitation motivation (${\beta}=.39$, p<.001, ${\beta}=-.18$, p=.011). Uncertainty showed partial mediating effect on relationship between family support and rehabilitation motivation, however, the effect was not significant (Z=1.63, p=.103). Conclusion: Interventions improving family support and decreasing uncertainty may be helpful in enhancing rehabilitation motivation.

• Natural Product Sciences
• /
• 제11권2호
• /
• pp.92-96
• /
• 2005

The antifungal activities of essential oils from the leaves of Glehnia littoralis, which is cultivated in Korea, were evaluated against pathogenic Trichophyton species by the broth dilution method and the disk diffusion test. Additionally, the effects of the oils together with ketoconazole were tested by the checkerboard titer test. The essential oil fraction and its main components showed significant inhibition of the tested Trichophyton fungi, with minimal inhibitor concentrations (MICs) in the range of 16-32 mg/ml. The results suggest that activities of this oil are based mainly on the contents of ${\alpha}-pinene$ (22.17%), the next prominent component of the oil fraction, while the first main components ${\beta}-pinene$ (57.83%) have relatively mild activity. The MICs of ${\alpha}-pinene$ and ${\beta}-pinene$ were 1-4 mg/ml and 4-32 mg/ml, respectively. Additionally the Glehnia oil fraction and its main components as well, exhibited significant synergism with ketoconazole against Trichophyton rubrum.

• International Journal of Reliability and Applications
• /
• 제2권4호
• /
• pp.263-268
• /
• 2001

Shanmugam(1991) generalized the Poisson distribution to capture a restriction on the incidence rate $\theta$ (i.e. $\theta$ ＜ $\beta$, an unknown upper limit), and named it incidence rate restricted Poisson (IRRP) distribution. Using Neyman's C($\alpha$) concept, Shanmugam then devised a hypothesis testing procedure for $\beta$ when $\theta$ remains unknown nuisance parameter. Shanmugam's C ($\alpha$) based .results involve inverse moments which are not easy tools, This article presents an alternate testing procedure based on likelihood ratio concept. It turns out that likelihood ratio test statistic offers more power than the C($\alpha$) test statistic. Numerical examples are included.

• 유기물자원화
• /
• 제21권3호
• /
• pp.99-107
• /
• 2013

본 연구에서는 축분자원화물의 총량관리지침에 의한 배출구조계수[(${\beta}4$), (${\beta}5$), (${\beta}8$)]를 산정하고자 축산농가 및 축분처리 현장시설을 방문하여 조사 및 분석하였으며 결과는 다음과 같다. 공공처리장 및 개별처리장에서의 폐수개별 삭감량 계수(${\beta}4$)는 수질분석항목인 BOD, COD, SS, T-N, T-P, TOC에 대하여 공공처리장은 0.94-0.75의 범위로 산정되었고, 개별처리장은 0.99-0.83의 범위로 산정되어 개별처리장이 더 높게 산정되었다. 폐수처리 농지환원량 계수(${\beta}_5$)의 경우 공공처리장이 0.40-0.24, 개별처리장이 0.75-0.16의 범위로 나타나 다른 처리방법보다 월등히 낮게 나타났다. 그렇지만, SS와 T-P의 경우는 개별처리에 의한 농지환원율이 공공처리에 의한 환원율보다 월등히 높게 나타났다. 공공처리량 계수(${\beta}_8$)를 산정한 결과 공공처리장에서의 축분자원화물의 처리는 T-P의 경우 공공처리량 계수(${\beta}_8$)의 평균치가 0.75로 나타났으나, 대부분 90%이상의 처리율을 보이며 0.2이하를 나타내는 처리장이 있는 등 처리장별로 편차가 큰 것으로 조사되었다.