• Journal of Korean Public Health Nursing
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• v.31 no.2
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• pp.341-351
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• 2017

Purpose: The aim this study was to identify the factors that influence the social adjustment of North Korean defectors. The participants were 156 North Korean defectors over 20 years old residing in G and C cites. Methods: The data were collected from August 1 to October 31, 2014, and analyzed using the SPSS/WIN 21.0 program with one-way ANOVA, t-test, Pearson correlation coefficients and multiple stepwise regression. Results: The general characteristics, such as family, health status, and job, had a significant influence on social adjustment. The level of depression and anxiety was less than moderate and the levels of self-esteem, hope, and social adjustment were moderate. The correlations among depression, anxiety, self-esteem, hope, and social adjustment were significant. These variables showed an explanation rate 28% and self-esteem (${\beta}=.17$), depression (${\beta}=-.15$), anxiety (${\beta}=-.15$), hope (${\beta}=.14$), job (temporary)(${\beta}=-.10$), health status (bad)(${\beta}=-.07$), job (no)(${\beta}=-.04$) were statistically significant among the variables that influenced social adjustment. Conclusion: A program of nursing intervention is needed to care for the mental and physical health problems as well as social education to reduce the negative perception of North Korean defectors.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2006.04a
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• pp.123-135
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• 2006

Alzheimer's disease (AD) is the most common form of dementia in the aging population and is clinically characterized by a progressive loss of cognitive abilities. Pathologically, it is defined by the appearance of senile plaques - extracellular insoluble, congophilic protein aggregates composed of amyloid $\beta$ (A$\beta$) and neurofibrillary tangles (NFTs) - inyracellular lesions consisting of paired helical filaments from hyperphosphorylated cytoskeletal tau protein as described by Alois Alzheimer a century ago. These hallmarks still serve as the major criteria for a definite diagnosis of the disease. Consequently, one of the key strategy for drug development in this disease area focuses on reducing the concentration of cerebral A$\beta$ plaque by using substances that inhibit A$\beta$ fibril formation. We focused on developing inhibitors by synthesizing several kinds of aromatic molecules. The synthetic compounds were initially screened to evaluate the effective compound by tioflavin T fluorescence assay. The selected effective compounds were tested cytotoxicity and protective effect from A$\beta$-induced neuronal toxicity by cell based MTT assay with HT22 hippocampal neurons. The BBB permeability on effectors was also tested in in vitro co-culture model(HUVEC/C6 cell line). The behavior test wea carried out in mutant APP/PS1 transgenic mouse model of Alzheimer's disease. And inhibition of A$\beta$ fibril formation by the effective compound was monitored with transmitted electron microscopic images.

• International Journal of Oral Biology
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• v.34 no.3
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• pp.137-142
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• 2009

Whole-body $\gamma$-irradiation(WBI), which produces an oxidative stress, is reported to attenuate the acute antinociceptive action of morphine (a $\mu$-opioid receptor agonist), but not DPLPE (a $\delta$-opioid receptor agonist), in mice. Recently, we also reported that antinociceptive effect of morphine, but not $\beta$-endorphin (a novel $\varepsilon$-opioid receptor agonist), was attenuated by oxidative stress. These findings prompted us to investigate the effect of WBI on the antinociception of morphine and $\beta$-endorphin in mice. Mice were exposed to WBI (5 Gy) from a $^{60}Co$ gamma-source and tested 2 hours later for antinociception produced by intracerebroventricular administration of morphine or $\beta$-endorphin using the hot water tail-immersion and the writhing tests. WBI significantly attenuated the antinociception produced by morphine only in the hot water tail-immersion test, whereas the antinociception of $\beta$-endorphin was significantly potentiated by WBI in both tests. These results demonstrate a differential sensitivity of $\mu$- and $\varepsilon$-opioid receptors to WBI, and support the hypothesis that morphine and $\beta$-endorphin administered supraspinally produce antinociception by different neuronal mechanisms.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.25 no.2
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• pp.289-295
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• 2001

The aim of this study is to investigate the ductile fracture behaviour under pure Mode II loading using A533B pressure vessel steel. Single punch shear(SPS) test was performed to obtain the J-R curve under pure Mode II loading which was compared with that of the Model I loading. Simulation using Rousellier Ductile Damage Theory(RDDT) was carried out with 4-node quadrilateral element(L(sub)c=0.25mm). For the crack advance, the failed element removal technique was adopted with a $\beta$ criterion. Through the $\beta$ value tuning-up procedures, $\beta$(sub)crit(sup)II was determined as 1.5 in contrast with $\beta$(sub)crit(sup)I=5.5. In conclusion, it was found that the J-R curve under Mode II loading was located at lower part than that under Mode I loading obtained from the previous study and that the $\beta$ values strongly depended on the loading type. In addition, the predicted result using RDDT showed a good agreement with the SPS experimental one under pure Mode II loading.

• The Journal of Korean Academic Society of Nursing Education
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• v.22 no.2
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• pp.210-219
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• 2016

Purpose: The purpose of this study was to contribute to career counseling and career guidance for nursing students by examining students' career decision-making styles and career decision levels and the relationship between self-efficacy and career decision-making styles and career decision levels. Methods: A descriptive survey design was used and data were collected using questionnaires from a sample of 469 nursing students. The data were analyzed using frequencies means, Kruskal-Wallis test, Pearson correlation coefficient, and multiple regression analysis with SPSS 21.0. Results: Career decision level had a significant correlation with self-efficacy and decision-making styles. Self-efficacy (${\beta}=.143$, p<.001), type of decision-making styles rational type (${\beta}=.180$, p<.001), intuitive type (${\beta}=.137$, p<.001), dependent type (${\beta}=-.236$, p<.001) and sex (${\beta}=-.086$, p=.023), school grades (${\beta}=.086$, p=.033), and satisfaction of nursing major (${\beta}=.209$, p<.001) were significant predictors of career decision level. Conclusion: It is necessary to develop effective career support programs according to type of decision-making styles, sex, school grades, motivation to improve nursing students' self-efficacy and satisfaction in the nursing major.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.561-568
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• 2016

The purpose of this study was to investigate the influence of SNS addiction tendency, pathological narcissism, social support, and stress among university students. Data were collected via questionnaires from 385 students and were analyzed by descriptive statistics, t-test, ANOVA, Scheffe's test, Pearson's correlation coefficients, and Stepwise multiple regression analysis using SPSS/WIN 19.0 program. The levels of SNS addiction tendency depended on gender, SNS usage time, SNS over-usage, health problem, and household economic status. SNS addiction tendency was significantly correlated with pathological narcissism, social support, and stress. Influential factors that affect SNS addiction tendency were pathological narcissism, SNS usage time, SNS over-usage, gender, social support, and academic performance, which explained about 39.4% of the variance. The results of this study indicate that nursing interventions are necessary to improve SNS addiction tendency, and also suggesting that such variables should be carefully considered in intervention programs for university students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.9
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• pp.243-250
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• 2018

This descriptive study was conducted to investigate the factors affecting the mental health of university students. Data were collected from 312 university students by questionnaires and analyzed by t-test, ANOVA, Scheffe's test, correlation analysis, and multiple regression analysis. The mean scores were 1.69, 1.87 and 2.21 out of 5 on Likert scales for mental health, campus life stress and employment stress, respectively. The mean score for self-esteem was 2.27 out of 4 on a Likert scale. Gender and number of close friends affected mental health significantly. Moreover, there was a negative correlation between mental health and self-esteem(r=-.426, p<0.001), while a positive correlation was observed between mental health and campus life stress (r=0.660, p<0.001), and mental health and employment stress(r=.517, p<0.001). Multiple regression analysis showed that campus life stress (${\beta}=.545$), self-esteem(${\beta}=-.145$), and employment stress (${\beta}=0.067$) affected mental health in order, and the three research variables led to a 45.2% prediction for mental health of university students. Based on the results of this study, effective systematic plans for decreasing campus life stress and employment stress and increasing self-esteem are needed to improve the mental health of university students.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.259-266
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• 2019

This study aimed to identify factors that had an influence on preventive behaviors of Emergency Medical Service students against tuberculosis to promote their preventive behavior. The subjects of the study were 314 students studying emergency medical service from one 4-year college and two 3-year colleges in Jeollabukdo and they were researched with the use of a questionnaire from June 25, to July 6, 2018. For a statistical analysis of the data obtained, this study used SPSS 18.0 and conducted a t-test, an ANOVA, a Pearson's correlation coefficient and a multi-regression test to analyze the data. Pearson's correlation coefficient analysis showed that the preventive behavior levels was significantly correlated with knowledge of tuberculosis (r = 0.268, p <0.001) and attitude (r = 0.394, p<0.001). As results of the multi-regression test, the higher the knowledge of tuberculosis(${\beta}=0.152$, p<0.001) and the higher the attitude(${\beta}=0.052$, p<0.001), the higher the preventive behavior levels. In addition, Students who have experienced tuberculosis in their own or relative's relatives have a high level of prevention behavior(${\beta}=-0.186$, p=0.001). Therefore, it is suggested that organized and consistent education programs to promote knowledge on tuberculosis, change negative perception on it and improve preventive behavior levels should be developed and provided.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.194-202
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• 2019

This study examined the emotional intelligence and social support in relation to resilience in order to identify the factors influencing resilience in student nurses. The participants were 228 student nurses from two colleges in B City. The data were analyzed using a t-test, ANOVA, Pearson correlation coefficient, Scheffe test and multiple regression analysis by SPSS ver. 21.0. The mean score for emotional intelligence, social support, and resilience level was 5.36 out of 7 points, 4.13 out of 5 point, and 2.68 out of 4 points, respectively. Resilience was positively correlated with emotional intelligence (r=.665, p<.001) and social support (r=.495, p<.001). The results of this research suggest that social support is an important variable affecting resilience in student nurses. The factors affecting resilience were social support (${\beta}=.464$, p<.001), emotional intelligence (${\beta}=.169$, p=.004), and aptitude (${\beta}=.162$, p=.006). Resilience explained 50.4% of the variance in social support, emotional support, and aptitude. To increase the resilience of student nurses, managers need to develop resilience programs and training for managing social support, emotional intelligence, and aptitude.

• The Korean Journal of Nuclear Medicine
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• v.19 no.1
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• pp.127-136
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• 1985

To evaluate change of serum $beta_2-microglobulin$ concentration$(s\beta_2-MG)$ and the usefulness of $s\beta_2-MG$ and $s\beta_2-MG/serum$ creatinine concentration(sCr) ratio in various renal diseases, $s\beta_2-MG$ and sCr were measured in 25 normal controls and 90 patients of various renal diseases(16 cases of glomerulonephritis, 12 cases of acute renal failure, 8 cases of chronic renal failure, 24 cases of nephrotic syndrome, 15 cases of tubulointerstitial diseases and 15 cases of lupus nephritis) using $Phadebas^\circledR$ $Beta_2-Micro$ Test kits. The results were as follows; 1) In normal control, the mean value of $s\beta_2-MG$ was $1.65{\pm}0.41mg/l$ and the mean value of $s\beta_2-MG/sCr$ ratio was $0.14{\pm}0.05$. 2) In various renal diseases, the mean value of $s\beta_2-MG$ was $6.74{\pm}5.47mg/l$. The mean value of $s\beta_2-MG/sCr$ ratio was $0.24{\pm}0.11$ and significantly elevated than that of normal control. (p<0.05) 3) The correlation between $s\beta_2-MG$ and sCr in glomerular and tubulointerstitial disease was log $s\beta_2-MG-0.90$ log sCr-0.48 and its correlation coefficient was 0.78(p<0.05). 4) In glomerular disease, the correlation between $s\beta_2-MG$ and sCr was log $s\beta_2-MG-0.89$ log sCr-0.46(r - 0.76) and in tubulointerstitial disease, it was log, $s\beta2-MG-0.95$ log sCr-0.59 (r-0.87). There was no significant difference between the two groups(p<0.05). 5) Among 32 cases of glomerular and tubulointerstitial disease patients, whose sCr was within normal range, 17 cases showed elevated $s\beta_2-MG$. The mean values of $s\beta_2-MG/sCr$ ratio in these patients was $0.30{\pm}0.14$ and significantly elevated than that of normal control(p<0.05). 6) In 15 cases of lupus nephritis, 12 cases showed elevated $s\beta_2-MG$ with normal sCr and 12 cases showed elevated $s\beta_2-MG/sCr$ ratio. With above results, it was found that the $s\beta_2MG$ can be used as an index of glomerular filtration rate as in the case of sCr and that $s\beta_2-MG/sCr$ ratio can be used as a tool in early detection of slightly decreased glomerular filtration rate and in detection of the renal disease of increased $\beta_2-MG$ production.