• Title/Summary/Keyword: benzylation

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Thermoplasticization of Wood by Benzylation (벤질화에 의한 목재의 열가소화)

  • Han, Gyu-Seong;Kim, Eun-Kyoung
    • Journal of the Korean Wood Science and Technology
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    • v.22 no.3
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    • pp.32-38
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    • 1994

  • The methods in wood processing are so limited at present that a scope of its utilization is restricted. This often makes wood itself less valuable as a material comparing with other materials, that is, plastics, metals, and glass. Such differences are due to a lack of plasticity in wood, i.e. it cannot be melted, dissolved, or softened sufficiently for molding. However, once plastic properties are added to wood, it becomes more useful material. This further broadens the method in wood processing to a variety of fields. In this way, wooden material which is limited in use can be modified into a high quality product with additional value. Furthermore, utilization of wastes from wood, for example, would be made viable. In this study, thermoplasticization was carried out by benzylation of wood(sawdust). Various factors those affect the reaction were tested to produce benzylated wood with different degrees of substitution. Reaction temperature and time were the quite important factors. Optimum reaction temperature was 110$^{\circ}C$, and weight percent gains(WPG) of final products increased gradually with the increase of reaction time. The pretreatment (or preswelling) of wood with alkaline solution had a critical effect on benzylation. and the concentration of alkaline solution should be above 30% to obtain high weight percent gain. The thermal flow temperature of the benzylated wood decreased with the increase in weight percent gain, that of 80% weight percent gain is about 200$^{\circ}C$.

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Design and Synthesis of (${\pm}$) -3-Deoxygericudranin A as an Antitumour Agent (항암제로서의 (${\pm}$) -3-데옥시제리쿠드라닌 A의 설계 및 합성)

  • Choi, Yoon-Jung;Shim, Pil-Jong;Kim, Hee-Doo
    • YAKHAK HOEJI
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    • v.41 no.1
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    • pp.14-17
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    • 1997

  • (${\pm}$)-3-Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.

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Synthesis and Antitumor Activity of Novel Gericudranin E Derivatives (새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성)

  • 박재호;박경란;호현순;김희두;표명윤
    • YAKHAK HOEJI
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    • v.43 no.5
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    • pp.559-565
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    • 1999

  • The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their antitumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.

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