YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Design and Synthesis of (${\pm}$) -3-Deoxygericudranin A as an Antitumour Agent

항암제로서의 (${\pm}$) -3-데옥시제리쿠드라닌 A의 설계 및 합성

  • 최윤정 (숙명여자대학교 약학대학) ;
  • 심필종 (숙명여자대학교 약학대학) ;
  • 김희두 (숙명여자대학교 약학대학)
  • Published : 1997.02.01
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Abstract

(${\pm}$)-3-Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.

Keywords

References

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