• 한국축산식품학회지
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• 제33권2호
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• pp.229-238
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• 2013

Lactic acid bacteria (LAB) are added to different food products for a long time due to health beneficial effects on human host. LAB is applied in dairy products, such as yoghurt, cheese, and various fermented products, and also in non-dairy products, such as sausages. However, reaching the human gut alive as well as in a sufficient cell amount to exert positive health effects is still a big challenge, due to LAB sensitive character and vulnerability against harsh and detrimental conditions in human digestive system. Keeping physiological activity of sensitive LAB strains alive is for the formulation of novel food products with a probiotic health claim of utmost interest, thus microencapsulation has been applied and investigated as a promising technique for a good and reliable protection. Microencapsulation allows reduced cell injury or cell loss by retaining cells within the encapsulating membrane and can be enforced by spray-drying, emulsion, extrusion, and a range of other technologies in combination with an appropriate coating material, such as alginate, chitosan, and mixture of these two polymers. In this review, established and well-studied microencapsulation techniques with their favored coating materials, as well as the recent applications of microencapsulated LAB into dairy products will be discussed.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4495-4499
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• 2013

Morinda citrifolia, also known as Great Morinda, Indian Mulberry, or Noni, is a plant belonging to the family Rubiaceae. A number of major chemical compounds have been identified in the leaves, roots, and fruits of the Noni plant. The fruit juice is in high demand in alternative medicine for different kinds for illnesses such as arthritis, diabetes, high blood pressure, muscle ached and pains, menstrual difficulties, headache, heart diseases, AIDS, gastric ulcer, sprains, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, and drug addiction. Several studies have also demonstrated anti-inflammatory, antioxidant and apoptosis-inducing effects of Noni in various cancers. Based on a toxicological assessment, Noni juice was considered as safe. Though a large number of in vitro, and, to a certain extent, in vivo studies demonstrated a range of potentially beneficial effects, clinical data are essentially lacking. To what extent the findings from experimental pharmacological studies are of potential clinical relevance is not clear at present and this question needs to be explored in detail before an recommendations can be made.

• Journal of Ginseng Research
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• 제41권4호
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• pp.589-594
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• 2017

Ginseng effectively regulates the immune response and the hormonal changes due to stress, thus maintaining homeostasis. In addition to suppressing the occurrence of psychological diseases such as anxiety and depression, ginseng also prevents stress-associated physiological diseases. Recent findings have revealed that ginseng is involved in adjusting the hypothalamic-pituitary-adrenal axis and controlling hormones, thus producing beneficial effects on the heart and brain, and in cases of bone diseases, as well as alleviating erectile dysfunction. Recent studies have highlighted the potential use of ginseng in the prevention and treatment of chronic inflammatory diseases such as diabetes, rheumatoid arthritis, and allergic asthma. However, the mechanism underlying the effects of ginseng on these stress-related diseases has not been completely established. In this review, we focus on the disease pathways caused by stress in order to determine how ginseng acts to improve health. Central to our discussion is how this effective and stable therapeutic agent alleviates the anxiety and depression caused by stress and ameliorates inflammatory diseases.

• 항공우주의학회지
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• 제28권1호
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• pp.6-8
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• 2018

It is essential to study the effects of hypergravity on the human body in the research field of aerospace medicine. Previous studies have shown that hypergravity could act in a harmful way to the human body. However, recent studies have shown that moderate degree of hypergravity can act in a beneficial way to the human body. The authors have in particular been studying the effects of hypergravity on immune diseases, especially allergic asthma and rhinitis. Therefore, this review paper will introduce the results of recent studies on hormetic (health promotion) effect of hypergravity. In addition, this review paper also examines the mechanism by which hormetic effect of hypergravity could be possible. Furthermore, we will also discuss how to apply these hormetic effects in clinical practice.

• 한국융합학회논문지
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• 제6권6호
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• pp.131-137
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• 2015

본 연구는 유치원 아동들의 구강보건교육 효과를 파악하기 위해 K지역 유치원 2곳의 6-7세 아동 214명을 대상으로 2015년 7월 주 1회 4주간 구강보건교육과 설문을 실시하였다. 그 결과 구강건강관리 실태 중 정기검진을 받는 아동(p<0.05), 불소도포경험이 있는 아동(p<0.05), 치아우식증 진단을 받은 경험이 없는 아동(p<0.001), 어머니가 구강보건교육을 받은 경험이 있는 아동(p<0.05)의 구강보건행위 점수가 높아 통계적으로 유의한 차이를 보였다. 구강보건교육 후 구강보건지식은 6점 만점에 교육 전 4.96점에서 교육 후 5.54점으로 향상되었고, 구강보건행위도 11점 만점에 교육 전 7.18점에서 교육 후 7.75점으로 향상되었다(p<0.001). 따라서 아동의 올바른 구강보건행위을 이끌어 갈 수 있는 다양한 구강보건교육 프로그램의 개발과 교육 주기를 짧게 하여 체계적이고 반복적인 실천교육이 이루어져야 할 것으로 생각된다.

• 대한간호학회지
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• 제33권5호
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• pp.570-579
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• 2003

Purpose: The purpose of this study is to exam the effects of a short-term pulmonary program on lung function, exercise tolerance, and quality of life in chronic lung patients. Method: Randomized controlled pre-post test design was used. The outcome measures were forced expiratory volume in one second (FEV1, % predicted), 6 min walking distance (6MWD), Borg score after 6MWD, and Chronic Respiratory Disease Questionnaire (CRDQ). Experimental group performed the 4-week home-based pulmonary rehabilitation program composed of inspiratory muscle training, upper and lower extremity exercise, relaxation, and telephone visit. Patients in control group were only given education about self-management strategies. Thirty four patients with moderate-to-severe respiratory impairment were recruited, and 28 patients (19 in experiments, 15 in control) completed the study. Result: Significant improvements in lung function, exercise tolerance, and health related quality of life were found only in the experiment group. Conclusion: This study yielded evidence for the potential and beneficial effects of home-based pulmonary rehabilitation program in patients with moderate to severe chronic lung disease. The program could be adequately utilized for improvement of health related quality of life in chronic lung patients.

• Journal of Dairy Science and Biotechnology
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• 제32권1호
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• pp.1-6
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• 2014

Probiotics have been extensively studied for their beneficial effects on human health. In particular, Lactobacillus and Bifidobacterium strains have gained considerable attention as major groups of probiotic bacteria that improve gastrointestinal health. However, emerging evidence suggests that probiotics offer benefits beyond those observed in the gut recent studies suggest that probiotics and/or their components exert favorable effects on alcoholic liver disease (ALD) pathogenesis such as decreasing intestinal permeability, inhibiting pathogenic bacteria growth, increasing the activity of alcohol metabolism enzymes, modulating the adaptive immune system, and suppressing fatty acid synthesis genes. In this review, we discuss the results of in vivo and in vitro studies that have examined the use of probiotics to prevent ALD, primarily focusing on those that explore the cellular and molecular mechanisms underlying the activities of promising probiotic strains. The evidence presented in this review could help in screening for probiotic strains that have protective effects in ALD patients and in further elucidating the mechanisms of their actions.

• 대한임상검사과학회지
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• 제52권1호
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• pp.36-44
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• 2020

With the advent of westernized diet and a lack of exercise, young female college students are paying more attention to their bodyweight and health. Whole-body vibration has been demonstrated to be a suitable training method for improving knee extension maximal strength in young female athletes, as well as the gait performance in elderly women. This study aimed to evaluate the effects of a vertical vibration intervention on the physical fitness and postural balance in young females. Fifty-four young women were recruited; all subjects were randomly assigned to the intervention group and control group. The intervention group underwent vertical vibration with a platform for 12 weeks. The results showed that body mass index and body fat percentage had decreased (P<0.05). In addition, their muscle endurance as indicated by a sit-up test and their flexibility as indicated by a sit-and-reach test were both increased. With regard to postural balance, their 30-second sit-to-stand and timed up and go test results were improved. At the same time, their mean single-leg stance with eyes closed time increased (P<0.05). However, there were no significant differences, meanwhile, for the control group. Overall, the results showed that the whole body vibration (WBV) intervention had some beneficial effects on physical fitness and postural balance in young women.

• Clinical Nutrition Research
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• 제3권2호
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• pp.106-114
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• 2014

It is generally accepted that diet modification provides beneficial effects on the management of diabetes. In the present study, we evaluated the effects of diet modification on nutrient intake and quality of life in a large sample of diabetic patients. This study was conducted using data from the Korea National Health and Nutrition Examination Survey IV and V (2007-2010). A total of 2,484 of diabetic patients were included in the analysis. Then, we compared the overall quality of dietary intake between diabetic patients with diet modification and those without dietary modification. The result showed that subjects on diabetic diet (DDG) showed lower levels of total cholesterol, triglyceride, and AST before and after the adjustment for covariates (all p < 0.05). The results of nutrient assessment showed that DDG had lower intakes of total energy, fat, and carbohydrate (all p < 0.05), but higher intakes of energy from protein, vitamin B1, vitamin B2, niacin and vitamin C than NDG. (all p < 0.05). In addition, nutritional adequacy ratio of calcium and vitamin B2 were significantly higher in DDG than those in normal diet group (NDG) (p < 0.05). However, we observed no significant differences in quality of life between two groups. In conclusion, diet modification in diabetic patients seemed to be effective to improve blood lipid profile and the adequacy of nutrient intake without sacrificing the quality of life.

• 대한화장품학회지
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• 제48권3호
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• pp.197-212
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• 2022

본 연구는 우리나라 국민 20 ~ 49 세 연령군 가운데 289 명을 대상으로 피부 마이크로바이옴의 요인들인 유익균, 상재균, 여드름균이 유해균에 미치는 영향과 상호작용을 실증적으로 분석하기 위해 수행되었다. 피부 마이크로바이옴의 바이오 빅데이타를 활용하여 다중회귀모형으로 분석한 결과, 연구대상의 성별과 연령에 따른 피부 마이크로바이옴의 차이를 통제한 경우, 유익균은 유해균에 부(-)의 영향을 나타내었고, 상재균과 여드름균은 정(+)의 영향을 나타냈다. 특히 유익균이 유해균에 미치는 부(-)의 영향은 상재균의 수준에 따라 여드름균과의 상호작용을 통해 다르게 나타났다. 이러한 결과는 유익균의 활성화가 유해균을 억제하며, 피부 마이크로바이옴이 유해균에 미치는 영향은 독립적인 영향과 함께 상호작용을 통해서 피부 마이크로바이옴의 균형을 이루고 있음을 실증적으로 검증한 것이다. 따라서 개인 맞춤형 화장품 제조산업에서 유익균의 증식을 돕고 유해균을 억제하는 피부 환경을 조성하기 위한 피부 마이크로바이옴 제품을 연구할 때, 반드시 피부 마이크로바이옴 요인들의 독립적인 영향과 상호작용을 함께 고려해야 함을 시사한다.