Do the Health Claims Made for Morinda citrifolia (Noni) Harmonize with Current Scientific Knowledge and Evaluation of its Biological Effects

  • Published : 2013.08.30


Morinda citrifolia, also known as Great Morinda, Indian Mulberry, or Noni, is a plant belonging to the family Rubiaceae. A number of major chemical compounds have been identified in the leaves, roots, and fruits of the Noni plant. The fruit juice is in high demand in alternative medicine for different kinds for illnesses such as arthritis, diabetes, high blood pressure, muscle ached and pains, menstrual difficulties, headache, heart diseases, AIDS, gastric ulcer, sprains, mental depression, senility, poor digestion, arteriosclerosis, blood vessel problems, and drug addiction. Several studies have also demonstrated anti-inflammatory, antioxidant and apoptosis-inducing effects of Noni in various cancers. Based on a toxicological assessment, Noni juice was considered as safe. Though a large number of in vitro, and, to a certain extent, in vivo studies demonstrated a range of potentially beneficial effects, clinical data are essentially lacking. To what extent the findings from experimental pharmacological studies are of potential clinical relevance is not clear at present and this question needs to be explored in detail before an recommendations can be made.


  1. Akihisa T, Matsumoto K, Tokuda H, et al (2007). Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni). J Nat Prod, 70, 754-7.
  2. Alitheen NB, Manaf AA, Yeap SK, et al (2010). Immunomodularory effects of Damnacanthal isolated from roots of Morinda elliptica. Pharm Biol, 48, 446-52.
  3. Alshatwi AA, Shafi G, Hasan TN, et al (2011). Apoptosis-mediated inhibition of human breast cancer cell proliferation by lemon citrus extract. Asian Pac J Cancer Prev, 12, 1555-9.
  4. Arpornsuwan T, Punjanon T (2006). Tumor cell-selective antiproliferative effect of the extract from Morinda citrifolia fruits. Phytother Res, 20, 515-7.
  5. Basar S, Uhlengut K, Hogger P, et al (2010). Analgesic and anti-inflammatory activity of Morinda citrifolia L. (Noni) fruit. Phytother Res, 24, 38-42.
  6. Brown AC (2012). Anticancer activity of Morinda citrifolia (Noni) fruit: a review. Phytother Res, 26, 1427-40.
  7. Bullo M, Lamuela-Raventos R, Salas-Salvado J, et al (2011). Mediterranean diet and oxidation: nuts and olive oil as important sources of fat and antioxidants. Curr Top med Chem, 11, 1797-810.
  8. Clafshenkel WP, King TL, Kotlarczyk MP, et al (2012). Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evid Based Complement Alternat Med, 487423.
  9. Dussossoy E, Brat P, Bony E, et al (2011). Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican Noni juice (Morinda citrifolia L.). Ethnopharmacol, 133, 108-15.
  10. Ernst E (2000). Prevalence of use of complementary/alternative medicine: a systematic review. Bull World Health Organiz, 78, 252-7.
  11. Furusawa E, Hirazumi A, Story S, et al (2003). Antitumour potential of a polysaccharide-rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytother Res, 17, 1158-64.
  12. Gilani AH, Mandukhail S-U-R, Iqbal J, et al (2010). Antispasmodic and vasodilator activities of Morinda citrifolia root extract are mediated through blockade of voltage dependent calcium channels. BMC Complement Altern Med, 10, 2.
  13. Harada S, Fujita-Hamabe W, Kamiya K, et al (2010). Morinda citrifolia fruit juice prevents ischemic neuronal damage through suppression of the development of post-ischemic glucose intolerance. J Nat Med, 64, 468-73.
  14. Hirazumi A, Furusawa E, Chou SC, et al (1994). Anticancer activity of Morinda citrifolia (Noni) on intraperitoneally implanted Lewis lung carcinoma in syngeneic mice. P W Pharmacol Soc, 37, 145-6.
  15. Hornick CA, Myers A, Sadowska-Krowicka H, et al (2003). Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (Noni). Angiogenesis, 6, 143-9.
  16. Li J, Stickel SL, Bouton-Verville H, et al (2008). Fermented Noni Exudate (fNE): a mediator between immune system and anti-tumor activity. Oncol Reports, 20, 1505-9.
  17. Lv L, Chen H, Ho CT, et al (2011). Chemical components of the roots of Noni (Morinda citrifolia) and their cytotoxic effects. Fitoterapia, 82, 704-8.
  18. Mandukhail S-ur R, Aziz N, Gilani A-H, et al (2010). Studies on antidyslipidemic effects of Morinda citrifolia (Noni) fruit, leaves and root extracts. Lipids Health Dis, 9, 88.
  19. Morton JF (1992). The ocean going Noni, or Indian Mulberry (Morinda citrifolia, Rubiaceae) and some of its 'colorful' relatives. Econ Bot, 46, 241-56.
  20. Muto J, Hosung L, Uwaya A, et al (2010). Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice. Physiol Behav, 101, 211-7.
  21. Nualsanit T, Rojanapanthu P, Gritsanapan W, et al (2011). Damnacanthal, a Noni component, exhibits antitumorigenic activity in human colorectal cancer cells. J Nutr Biochem.
  22. Olaku O, White JD (2011). Herbal therapy use by cancer patients: A literature review on case reports. Eur J Cancer, 47, 508-14.
  23. Palu A, Deng S, West B, et al (2009). Xanthine oxidase inhibiting effects of Noni (Morinda citrifolia) fruit juice. Phytother Health Claims Made for Noni and Current Scientific Knowledge Res, 23, 1790-1.
  24. Palu AK, West BJ, Jensen J, et al (2011). Noni-based nutritional supplementation and exercise interventions influence body composition. N Am J Med Sci, 3, 552-6.
  25. Pawlus AD, Su BN, Keller WJ, et al (2005). An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (Noni). J Nat Prod, 68, 1720-2.
  26. Potterat O, Hamburger M (2007). Morinda citrifolia (Noni) fruit--phytochemistry, pharmacology, safety. Planta Med, 73, 191-9.
  27. Gupta RK, Banerjee A, Pathak S, et al (2013). Induction of Mitochondrial-Mediated Apoptosis by Morinda citrifolia (Noni) in Human Cervical Cancer Cells. Asian Pac J Cancer Prev, 14, 237.
  28. Serafini MR, Santos RC, Guimaraes AG, et al (2011). Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration. J Med Food, 14, 1159-66.
  29. Stoner GD, Wang LS, Seguin C, et al (2010). Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Pharm Res, 27, 1138-45.
  30. Su BN, Pawlus AD, Jung HA, et al (2005). Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity. J Nat Prod, 68, 592-5.
  31. Taskin EI, Akgun-Dar K, Kapucu A, et al (2009). Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice. Cell Biochem Funct, 27, 542-6.
  32. Thani W, Vallisuta O, Siripong P, et al (2010). Anti-proliferative and antioxidative activities of Thai Noni/Yor (Morinda citrifolia Linn.) leaf extract. Southeast Asian J Trop Med Public Health, 41, 482-9.
  33. van der Vaart H, Postma DS, Timens W, et al (2004). Acute effects of cigarette smoke on inflammation and oxidative stress: a review. Thorax, 59, 713-21.
  34. Wanchai A, Armer JM, Stewart BR, et al (2010). Complementary and alternative medicine use among women with breast cancer: a systematic review. Clin J Oncol Nurs, 14, 45-55.
  35. Wang CY, Ng CC, Su H, et al (2009). Probiotic potential of noni juice fermented with lactic acid bacteria and bifidobacteria. Int J Food Sci Nutr, 1, 1-9.
  36. Wang M-Y, Anderson GL, Nowicki D, et al (2002). Preventative effect of Morinda citrifolia (Noni) at the initiation stage of mammary breast carcinogenesis induced by 7, 12-dimethylbenzo(a)anthracene (DMBA) in female Sprague-Dawley (SD) rats. Cancer Epidem Biomar, 11,1218.
  37. Wang MY, Lutfiyya MN, Weidenbacher-Hoper V, et al (2009). Antioxidant activity of Noni juice in heavy smokers. Chem Cent J, 3, 13.
  38. Wang MY, Su C (2001). Cancer preventive effect of Morinda citrifolia (Noni). Ann N Y Acad Sci, 952, 161-8.
  39. Westendorf J, Effengerger K, Iznaguen H, et al (2007). Toxicological and analytical investigations of Noni (Morinda citrifolia) fruit juice. J Agric Food Chem, 55, 529-37.
  40. Wolterbeek AP, Roggeband R, van Moorsel CJ, et al (1995). Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture. Cancer Lett, 91, 205-14.
  41. Wong YH, Abdul Kadir H (2012). Induction of mitochondria-mediated apoptosis in Ca Ski human cervical cancer cells triggered by mollic acid arabinoside isolated from Leea indica. Evid Based Complement Alternat Med, 2012, 684740.
  42. Yang J, Gadi R, Talene T, et al (2011). Antioxidant capacity, total phenols, and ascorbic acid content of Noni (Morinda citrifolia) fruits and leaves at various stages of maturity. Micronesica, 41, 167-76.

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