• Biomolecules & Therapeutics
• /
• 제27권1호
• /
• pp.71-77
• /
• 2019

Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this study is to investigate the effects of spinosin on the improvement of cognitive impairment in model mice with Alzheimer's disease (AD) induced by $A{\beta}_{1-42}$ and determine the underlying mechanism. Spontaneous locomotion assessment and Morris water maze test were performed to investigate the impact of spinosin on behavioral activities, and the pathological changes were assayed by biochemical analyses and histological assay. After 7 days of intracerebroventricular (ICV) administration of spinosin ($100{\mu}g/kg/day$), the cognitive impairment of mice induced by $A{\beta}_{1-42}$ was significantly attenuated. Moreover, spinosin treatment effectively decreased the level of malondialdehyde (MDA) and $A{\beta}_{1-42}$ accumulation in hippocampus. $A{\beta}_{1-42}$ induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment. These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression,suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제30권1호
• /
• pp.42-44
• /
• 2019

Hashimoto's encephalopathy (HE) is a rare and underdiagnosed neuropsychiatric illness. We present the case of a 17-year-old girl who was admitted to a tertiary-care psychiatric center with acute onset psychosis and fever. Her psychotic symptoms were characterized by persecutory and referential delusions, as well as tactile and visual hallucinations. Her acute behavioral disturbance warranted admission and treatment in a psychiatric setting (risperidone tablets, 3 mg/day). She had experienced an episode of fever with a unilateral visual acuity defect approximately 3 years before admission, which was resolved with treatment. Focused clinical examination revealed an enlarged thyroid, and baseline blood investigations, including thyroid function test results were normal. Abnormal laboratory investigations revealed elevated anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-TG) levels (anti-TPO of 480 IU/mL; anti-TG of 287 IU/mL). Results of other investigations for infection, including cerebrospinal fluid examination, electroencephalography, and brain magnetic resonance imaging were normal. She was diagnosed with HE and was treated with intravenous corticosteroids (methylprednisolone up to 1 g/day; tapered and discontinued after a month). The patient achieved complete remission of psychotic symptoms and normalization of the anti-thyroid antibody titers. Currently, at the seventh month of follow-up, the patient is doing well. This case highlights the fact that in the absence of well-defined clinical diagnostic criteria, a high index of suspicion is required for early diagnosis of HE. Psychiatrists need to explore for organic etiologies when dealing with acute psychiatric symptoms in a younger age group.

• 대한간호학회지
• /
• 제49권3호
• /
• pp.317-328
• /
• 2019

Purpose: The purpose of this study was to identify the effect of ghrelin on memory impairment in a rat model of vascular dementia induced by chronic cerebral hypoperfusion. Methods: Randomized controlled groups and the posttest design were used. We established the representative animal model of vascular dementia caused by bilateral common carotid artery occlusion and administered $80{\mu}g/kg$ ghrelin intraperitoneally for 4 weeks. First, behavioral studies were performed to evaluate spatial memory. Second, we used molecular biology techniques to determine whether ghrelin ameliorates the damage to the structure and function of the white matter and hippocampus, which are crucial to learning and memory. Results: Ghrelin improved the spatial memory impairment in the Y-maze and Morris water maze test. In the white matter, demyelination and atrophy of the corpus callosum were significantly decreased in the ghrelin-treated group. In the hippocampus, ghrelin increased the length of hippocampal microvessels and reduced the microvessels pathology. Further, we confirmed angiogenesis enhancement through the fact that ghrelin treatment increased vascular endothelial growth factor (VEGF)-related protein levels, which are the most powerful mediators of angiogenesis in the hippocampus. Conclusion: We found that ghrelin affected the damaged myelin sheaths and microvessels by increasing angiogenesis, which then led to neuroprotection and improved memory function. We suggest that further studies continue to accumulate evidence of the effect of ghrelin. Further, we believe that the development of therapeutic interventions that increase ghrelin may contribute to memory improvement in patients with vascular dementia.

• 한국융합학회논문지
• /
• 제10권4호
• /
• pp.219-227
• /
• 2019

본 연구는 심리적 과정에 따른 운동행동의 변화를 알아보기 위해 운동변화단계와 운동자기도식, 운동중단유혹의 관계를 분석하는데 목적이 있다. 연구목적 달성을 위하여 공공스포츠센터를 이용하는 성인을 대상으로 총 297부의 최종자료를 사용하였다. 자료처리는 SPSS 18.0을 이용하여 탐색적 요인분석 후 다변량분석, 중다회귀분석, 판별분석을 통해 검증하였다. 연구결과는 첫째, 운동변화단계에 따라서 운동자기도식은 차이가 있는 것으로 나타났다. 둘째, 운동변화단계에 따라서 운동중단유혹은 지도자와 의욕상실에서 차이가 있는 것으로 나타났다. 셋째, 행동적 자기도식과 의욕상실은 운동변화단계를 판별하는데 주요 요인인 것으로 나타났다. 넷째, 운동자기도식은 의욕상실에 부적 영향을 미치는 것으로 나타났고, 감정에는 인지-감정적 자기도식이 부적 영향을 미치는 것으로 나타났다.

• 생물치료정신의학
• /
• 제24권3호
• /
• pp.156-162
• /
• 2018

Objectives : This study aimed to investigate the relationship between the level of ego-resilience and depression, anxiety, conduct problems and self-esteem in a large sample of Korean adolescents. Methods : A total 4508(2036 males and 2472 females) middle and high school students in Gwang-ju metropolitan city were included in this study. Subjects were asked to complete a self-reported questionnaire, including Ego-Resilience(ER) scale, Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Self-Esteem Scale(SES), 15 items in Korean-Youth Self Report(K-YSR) to measure conduct problems and demographic variables. Subjects were classified into three high, intermediate and low ER group according to total ER scale scores. Results : Total ER scores was positively correlated with total SES scores and negatively correlated with total BDI, BAI, and conduct problem scores. Using analysis ANOVA(analysis and variance) and post hoc test, significant mean differences in BDI, BAI, SES and conduct problem scores were observed among the three groups. High ER group showed that SES scores were significantly higher and BDI, BAI and conduct problem scores were significantly lower than that observed in middle and lower ER group. Using multiple regression analysis, the results showed that depression, low self-esteem were significant factors affecting ego-resilience in adolescents. Conclusion : Our findings indicate that depression, anxiety, behavioral problem such as conduct problems and low self-esteem are associated with low ego-resilience.

• 복식문화연구
• /
• 제29권5호
• /
• pp.719-734
• /
• 2021

The aim of this study was to determine the therapeutic effects of beauty care on negative mental health, including stress and depression. Nail care, massage care, and makeup were used as programs for beauty therapy. Qualitative research was conducted with six female participants over five-month period. After interviewing the subjects in advance, beauty care treatments were performed every week 4 weeks in the following order: nail care, massage, and makeup. The results are as follows, First, the participants perceived beauty care in the form of 4 concepts: "courtesy in social life," "investment in oneself," "self-satisfaction," and "self-care." Second, the effects of beauty therapy were categorized as "psychological effects," "confidence," "behavioral changes," "evaluation of others," and "positive social effects." Third, each subject showed different psychological effects during the process when the function of the therapy took effect through the beauty care treatment. It was confirmed that confidence levels increased as a result of treatment through the process of becoming re-aware of oneself. Positive statements from the participants included: "I want to go out," "I have become kind and positive to others," "I have become more active in a given task," and "It seems that my work ability is improving." Finally, t-test results for self-esteem, depression, and stress showed there were significant differences in self-esteem and depression. This confirmed that self-esteem increased, and depression decreased after the beauty care treatment.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제15권6호
• /
• pp.1957-1980
• /
• 2021

The significant aim of this research has always been to evaluate the mechanism for efficient and inherently aware usage of vitality in-home devices, thus improving the information of smart metering systems with regard to the usage of selected homes and the time of use. Advances in information processing are commonly used to quantify gigantic building activity data steps to boost the activity efficiency of the building energy systems. Here, some smart data mining models are offered to measure, and predict the time series for energy in order to expose different ephemeral principles for using energy. Such considerations illustrate the use of machines in relation to time, such as day hour, time of day, week, month and year relationships within a family unit, which are key components in gathering and separating the effect of consumers behaviors in the use of energy and their pattern of energy prediction. It is necessary to determine the multiple relations through the usage of different appliances from simultaneous information flows. In comparison, specific relations among interval-based instances where multiple appliances use continue for certain duration are difficult to determine. In order to resolve these difficulties, an unsupervised energy time-series data clustering and a frequent pattern mining study as well as a deep learning technique for estimating energy use were presented. A broad test using true data sets that are rich in smart meter data were conducted. The exact results of the appliance designs that were recognized by the proposed model were filled out by Deep Convolutional Neural Networks (CNN) and Recurrent Neural Networks (LSTM and GRU) at each stage, with consolidated accuracy of 94.79%, 97.99%, 99.61%, for 25%, 50%, and 75%, respectively.

• 한국정보통신학회논문지
• /
• 제25권1호
• /
• pp.1-7
• /
• 2021

최근 코로나 19발생과 동시에 소셜 미디어의 투자자 정서가 증시 가격 움직임을 주도해 관심을 모으고 있다. 본 연구는 행동금융 이론 기반 빅 데이터 분석을 활용하여 소셜 미디어에서 추출한 정서가 중국 증시의 실시간 및 단기적 가격 모멘텀을 예측하는데 활용될 수 있는 기법을 제안한다. 이를 위해, COVID-19와 관련 200만 건 이상의 시나 웨이보 빅 데이터를 키워드 방식으로 수집 및 분석하고 시간이 따른 영향력이 높은 감정 요인을 추출한다. 최종 결과 도출을 위해 다양한 지도 및 비지도 학습 모델을 다 각도에서 구현 및 성능평가를 비교 분석 후, BiLSTM mdoel이 최적의 결과를 낼 수 있음을 증명했다. 또한, 제안하는 기법을 통해 주가변동과 심리요인 간에도 비슷한 움직임을 보이고 있음을 제안했고 소셜미디어에서 추출한 공공분위기가 어느 정도 투자자들의 심리를 대변할 수 있고, 주식시장에 영향을 미칠 수 있는 특수행사에 몰두할 때 증시변동에 차이를 만들 수 있음을 증명했다.

• 지역사회간호학회지
• /
• 제32권2호
• /
• pp.175-185
• /
• 2021

Purpose: Influenza immunization among health personnel is of particular importance given their elevated risk of influenza infection, role in transmission and influence on patients' immunization status. The purpose of this study is to identify factors associated with the influenza vaccination intention among health personnel based on the theory of planned behavior. Methods: The research was a cross-sectional, descriptive design using questionnaires. The participants were 131 health personnel in five general hospitals in two cities in South Korea. The data were analyzed using descriptive statistics, t-test, ANOVA and multiple regression with the SPSS 26.0 program. Results: There were statistically significant differences in influenza vaccination intention according to the high-risk group in the family, occupation, length of employment, and influenza vaccination status within a year. The influenza vaccination intention of these health personnel showed significant positive correlations with attitude, subjective norms, and perceived behavioral control towards influenza vaccination. Multiple regression analysis for influenza vaccination intention revealed that the significant predictors were attitude, subjective norms, influenza vaccination within a year and physician in occupation. These factors explained 41.4% of the variance. Conclusion: The results suggest a need to strengthen attitude and subjective norms. The findings also suggest that their characteristics through influenza vaccination status within a year and occupation should be considered for tailored interventions related to the intention. Furthermore, it is necessary to develop programs strengthening attitude and subjective norms to enhance influenza vaccination intention among health personnel.

• 한국융합학회논문지
• /
• 제13권5호
• /
• pp.267-278
• /
• 2022

본 연구는 목격자 증언 맥락에서 진술 정확성에 영향을 미치는 정서의 기능에 관한 문헌 고찰을 시도하였다. 목격자 증언의 정확성과 정서 간의 관계를 살펴본 연구에서 소개된 주요 이론과 개념들, 연구 방법을 토대로 살펴보았다. 해당 결과는 정서의 정의, 정서 유도 방식, 정서 측정 방식 순으로 제시하였다. 구체적으로 부정 정서, 각성, 스트레스, 기분을 중심으로 정서의 정의를 기술하였고, 정서 유도 방식은 실험실에서 주로 사용되는 영상, 가상현실, 연구자가 연출한 모의 사건을 중심으로 기술하였다. 정서 측정 방식은 자기보고식, 행동 측정, 정신생리학을 중심으로 기술하였다. 또한, 객관적이고 과학적 정서 연구를 위한 접근 방식, 적절한 실험 설계와 기억 검사, 개인차 통제의 필요성에 대해 논의하였다. 본 연구는 목격자 증언 맥락에서 진술 정확성에 미치는 정서의 기능을 살펴봄으로써 선행 연구의 비일관된 결과를 검토하고, 관련 연구들을 비교 분석하는 구조를 제시하는 데 의의를 두었다. 이와 같은 지식은 목격자 증언의 신뢰성 판단에 기초 자료로도 활용될 수 있을 것이다.