• Journal of Periodontal and Implant Science
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• v.53 no.5
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• pp.347-361
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• 2023

Purpose: Exosomes are membrane vesicles that are present in body fluids and contain proteins, lipids, and microRNA (miRNA). Periodontal tissue examinations assess the degree of periodontal tissue destruction according to the probing depth (PD), clinical attachment loss (CAL), bleeding on probing, and X-ray examinations. However, the accurate evaluation of the prognosis of periodontitis is limited. In this study, we collected saliva from patients before and after initial periodontal therapy (IPT) and compared changes in the clinical parameters of periodontitis with changes in the components of salivary exosomes. Methods: Saliva was collected from patients with stage III and IV periodontitis at the first visit and post-IPT. Exosomes were purified from the saliva, and total protein and RNA were extracted. Changes in expression levels of C6, CD81, TSG101, HSP70, and 6 kinds of miRNA were analyzed by western blots and real-time polymerase chain reaction. Results: Patients with increased C6 expression after IPT had significantly higher levels of periodontal inflamed surface area (PISA), miR-142, and miR-144 before and after IPT than patients with decreased C6 expression after IPT. Patients with decreased and unchanged CD81 expression after IPT showed significantly higher PD, CAL, and PISA before IPT than after IPT. Patients with decreased and unchanged TSG101 expression after IPT had significantly higher PD before IPT than after IPT. Patients with increased HSP70 expression after IPT had significantly higher PD and PISA before and after IPT than patients with unchanged HSP70 after IPT. The expression levels of miR-142, miR-144, miR-200b, and miR-223 changed with changes in the levels of C6, CD81, TSG101, and HSP70 in the salivary exosomes of periodontitis patients before and after IPT. Conclusions: The expression levels of proteins and miRNAs in salivary exosomes significantly changed after IPT in periodontitis patients, suggesting that the components of exosomes could serve as biomarkers for periodontitis.

• The Journal of the Korean dental association
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• v.22 no.12 s.187
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• pp.1043-1046
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• 1984

The clinical and statistical evaluation on the patients of maxillofacial deformities who were operated by author were analyzed after several month or years or se. Pre and post operative cephalometric radiographs of 45 orthognathic surgery patients were compared. The post operative radiographs had been taken at least 9 month to several years. Measurements were made between constructed hard tissue and soft tissue points located on each before and after film tracing. The items studied and evaluated are as follows: 1) Classification and divid of patients 2) Operation technic adopted by operator. 3) Motives of patients for operation and their untowards. 4) Self satisfication of patients after operation. 5) Post operative changes of soft and hard tissue. 6) Side action during and after operation.

• Journal of Acupuncture Research
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• v.24 no.3
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• pp.1-8
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• 2007

Objectives : This study was to evaluate the influence of dysgeusia on prognosis of peripheral facial paralysis. Methods: We investigated 40 cases of patients with Peripheral Facial Paralysis, and classified them as existence of dysgeusia. we evaluated the treatment effect of each group by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System before treatment and after final treatment. Results: 1. Postauricular pain showed the highest frequency in symptoms at onset. 2. As a result of evaluation by using Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System, treatment score after final treatment was marked higher than that before treatment within each group. 3. After final treatment, non-dysgeusia group showed signficant difference on Gross Grading System of House-Brackmann, Yanagihara's Unweighed Grading System compared with dysgeusia group. Conclusions: These results suggested that non-dysgeusia group should be get better than dysgeusia group in the patient with peripheral facial paralysis.

• Korean Management Science Review
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• v.23 no.3
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• pp.209-224
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• 2006

The mobile communication technology would be one of the most appropriate means for achieving process innovation in the actual business area. This article performs a simulation study to examine the effect of introducing a mobile technology to the after-sales service and its logistics process. The performances of the two different systems, before and after introducing a mobile technology, are examined based on operational cost, operational efficiency, and customer service level using a discrete event simulation. The real-world data, extracted from a leading Korean electronics firm, was collected for this study. The results show that the TO-BE(after) model outperforms the AS-IS(before) model over all the performance indices. And the effects of introducing the mobile technology are more significant on the more tightly controlled inventory policy.

• Journal of People, Plants, and Environment
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• v.22 no.4
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• pp.365-373
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• 2019

This study was conducted to determine the effects of horticultural therapy on self-esteem of women with hearing impairment. Ten women with hearing impairment registered in the Mokpo Branch of the Korean Association of the Deaf participated in the horticultural therapy programs (HTP) for self-esteem. The self-esteem scale was used to evaluate the effects of the programs and scores were compared to determine the difference before and after the programs. Self-esteem was improved in all 10 subjects, and its mean value increased with statistical significance from 22.5 points before the programs to 29.8 points after the programs. The programs preferred by women with hearing impairment included 'making a centerpiece using scented candles and flowers', 'packing and planting pot spray chrysanthemum', 'making a topiary', 'planting Hedera helix', and 'planting cyclamen'. Therefore, it was suggested that self-esteem of women with hearing impairment were improved by increasing social and family support, emotional stability, positive feedback, and self-expression through horticultural therapy programs.

• YAKHAK HOEJI
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• v.53 no.3
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• pp.107-113
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• 2009

Since 2006, the Computerized Restricted Antibiotic Control Program (CRACP) has been incorporated to facilitate a more efficient approval process of vancomycin use at the Chonbuk National University Hospital. The purposes of the study were to evaluate proper use of vancomycin and to examine if there is any improvement when administering the CRACP. The use of vancomycin was retrospectively reviewed by a medical record review based on the American Society of Hospital Pharmacists (ASHP) criteria (i.e., indication, use of critical process indicators and use of outcome measurements) and compared before (Group I) and after the CRACP (Group II). Two hundred fifty six patient records were evaluated (138 in Group I and 118 in Group II). There was a statistically significant improvement in the report of justification for vancomycin use after CRACP (42.0% vs. 62.7%, p=0.001). Out of eight critical process indicators, two indicators (appropriate cultures prior to medication [68.8% vs. 85.6%, p=0.002] and serum vancomycin level measurement [0% vs. 7.6%, p=0.001]) were significantly improved after CRACP. The total incidence of adverse effects was decreased from 14.5% to 6.8%. In addition, there was a statistically significant difference in WBC count reduction within normal range (52.8% vs. 73.1%, p=0.024). The CRACP appears to be a promising approach to improve use of vacomycin in a hospital setting. However, further evaluation for the long-term period should be performed to confirm the performance of the program.

• The Journal of Korean Obstetrics and Gynecology
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• v.20 no.3
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• pp.129-136
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• 2007

Purpose: We intended to observe the usefulness of far-infrared radiation functional under inner-wear for dysmenorrhea. Methods: We introduced far-infrared radiation functional under inner-wear to women in childbearing-age by internet portal site. Then, we preliminarily examined dysmenorrhea severity by VAS(visual analogue scale) questionnaire to women interested in far-infrared radiation functional under inner-wear. We selected women scored 5 and above of 10 measurement VAS score. Finally, 121 women were the subject of study and used far-infrared radiation functional under inner-wear for one menstrual cycle. Before and after use of far-infrared radiation functional under inner-wear, we conducted a questionnaire survey of dysmenorrhea severity by VAS. After that, we compared VAS score before and after use. Also, we studied correlation between frequency of far-infrared radiation functional under inner-wear use and ${\Delta}VAS$(VAS score before use minus VAS score after use). For statistics, we used Paired samples test and Spearman's rho correlations, SPSS 13.0 for windows. Results: Before and after use of far-infrared radiation functional under inner-wear, VAS score means were different. Frequency of far-infrared radiation functional under inner-wear use was correlated to ${\Delta}VAS$. Statistically they showed significant result (p<0.05>. Conclusion: The results showed that dysmenorrhea severity by VAS decreased after far-infrared radiation functional under inner-wear use. As frequency of use increased, ${\Delta}VAS$ increased. So we can consider far-infrared radiation functional under inner-wear effects dysmenorrhea severity.

• The Journal of Advanced Prosthodontics
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• v.7 no.3
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• pp.257-263
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• 2015

PURPOSE. In this study, we aimed to evaluate the amount of marginal gap with two different substructure materials using identical margin preparations. MATERIALS AND METHODS. Twenty stainless steel models with a chamfer were prepared with a CNC device. Marginal gap measurements of the galvano copings on these stainless steel models and Co-Cr copings obtained by a laser-sintering method were made with a stereomicroscope device before and after the cementation process and surface properties were evaluated by scanning electron microscopy (SEM). A dependent t-test was used to compare the mean of the two groups for normally distributed data, and two-way variance analysis was used for more than two data sets. Pearson's correlation analysis was also performed to assess relationships between variables. RESULTS. According to the results obtained, the marginal gap in the galvano copings before cementation was measured as, on average, $24.47{\pm}5.82{\mu}m$ before and $35.11{\pm}6.52{\mu}m$ after cementation; in the laser-sintered Co-Cr structure, it was, on average, $60.45{\pm}8.87{\mu}m$ before and $69.33{\pm}9.03{\mu}m$ after cementation. A highly significant difference (P<.001) was found in marginal gap measurements of galvano copings and a significant difference (P<.05) was found in marginal gap measurements of the laser-sintered Co-Cr copings. According to the SEM examination, surface properties of laser sintered Co-Cr copings showed rougher structure than galvano copings. The galvano copings showed a very smooth surface. CONCLUSION. Marginal gaps values of both groups before and after cementation were within the clinically acceptable level. The smallest marginal gaps occurred with the use of galvano copings.

• Korean Journal of Clinical Laboratory Science
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• v.36 no.2
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• pp.137-143
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• 2004

Erythrocyte sedimentation rate(ESR) measurements were performed in a total of 191 blood samples from patients below a hematocrit of 35% by both the Test-1(SIRE Analytical Systems, Udine, Italy) and the Westergren method, endorsed as the reference method for ESR by the International Council for Standardization in Hematology(ICSH). The corrected Westergren ESR values were also obtained applying the formula of Fabry (corrected ESR = ESR measured x 15/55-Hct). Linear regression analysis showed a close correlation (r=0.85) between the two methods both before and after ESR correction in total samples. There was no significant correlation difference between two methods in both two groups with hemoglobin $${\geq_-}9g/dl$$ and <9g/dl before and after ESR correction (r=0.873, r=0.827 respectively before correction and r=0.867, r=0.830 respectively after correction). Also, for two groups with hematocrit $${\geq_-}24%$$ and <24%, no significant difference was observed (r=0.859, r=0.792 respectively before correction and r=0.782, r=0.842 respectively after correction). However, for samples with <60mm of Westergren ESR before correction, a better correlation coefficient was obtained than samples with $${\geq_-}60mm$$(r=0.701, r=0.541 respectively). In corrected Westergren ESR, also samples that were obtained with <40mm showed better correlation than samples with $${\geq_-}40mm$$ (r=0.690, r=0.347 respectively). In conclusion, we found a good correlation between Test-1 and Westergren measurements in patients with anemia but an expert group discussion is required to solve discrepancy between two methods in blood samples with very high ESR.

• The Korean Journal of Emergency Medical Services
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• v.11 no.2
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• pp.51-66
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• 2007

Purpose: With a view to providing basic data to develop cardiopulmonary resuscitation education suitable for elementary students, the cardiopulmonary resuscitation education was conducted to grasp students' knowledge, skills accuracy and the attitude change before and after the education. Methods: Convenience sampling was made on fourth and fifth graders(total-35 students) of S elementary school located in K city, Chungcheongnam-do, and this was a pre-experiment research designed before and after choosing a single group. In terms of methods, specifically we, researchers ; 1) Handed out questionnaires to students directly to make them fill in firsthand and collected the questionnaires. 2) Utilized PPT materials based on 2005 AHA guideline and DVD materials of AHA, to give students theoretical education of cardiopulmonary resuscitation. We used Anne/SkillReporter$^{(R)}$ torso produced by Leardal Inc, and Little Anne to conduct practical education individually. 3) Asked students to give Anne/SkillReporter$^{(R)}$ torso cardiopulmonary resuscitation five times with the ratio of 30 : 2, and then one of researchers filled in the evaluation sheet individually. 4) Evaluated the accuracy of students' ability to perform the resuscitation based on the record of Anne/SkillReporter$^{(R)}$ integrated printer(which was the objective tool to grasp students' skills accuracy). 5) Gave out questionnaires to make students fill them in and then collected them. after completing the practical evaluation. Results: 1) In case of the attitude about cardiopulmonary resuscitation, Students' confidency rose from 19.28%(before the education) to 93.57(after the education)- which is a positive change. 2) As the result of the education, some elementary students scored 11 points (full score-16 points), up from 5 points before the education, in terms of the knowledge about cardiopulmonary resuscitation. The average point also reached 13.14 points(after the education), jump from 8.37(before the education), which was the rise of 29.8%. 3) When it comes to the practical performance, the skills accuracy was 80.93% on average, and the calculation method was as follows: total items were 16, and each item was marked form 0 to 2 points, meaning the full score was 32 points. The minimum score was 19 points and the maximum was 32($M{\pm}SD=25.90{\pm}2.88$), which was calculated based on percentage. 4) Regarding skills accuracy, respiration accuracy(%)($M{\pm}SD=30.20{\pm}27.16$) was higher than pressure accuracy(%) ($M{\pm}SD=15.34{\pm}25.27$). Conclusion: The result showed that students' attitude on cardiopulmonary resuscitation changed positively. and meaningful difference(p = .00) existed in the change of students' knowledge. In terms of skills accuracy. chest compression and airway control showed high accuracy, but the result of Anne/SkillReporter$^{(R)}$ performance showed that the accuracy of chest compression was lower than that of mouth-to-mouth resuscitation.