• 대한기계학회논문집A
• /
• 제37권3호
• /
• pp.429-436
• /
• 2013

본 논문에서는 고주파 열처리된 SAE1055 베어링강의 경도에 따른 피로 거동 및 이의 확률론적 평가를 수행하였다. 이를 위하여 경도 수준에 따른 5 종류의 시험편(A : 원재료, B : HV390-전경화, C : HV510-전경화, D : HV700-전경화 및 E : HV-700 표면경화)를 준비하였다. 피로시험은 4 점 회전굽힘 피로시험기를 이용하여 응력비 R=-1 의 조건하에서 수행하였다. 그 결과, SAE1055 강의 피로 거동은 경도에 따라 크게 변화하였으나 HV510 수준이상에서는 피로한도의 증가는 관찰되지 않았다. 또한 피로 파손기구에 대한 경도의 영향을 평가하기 위하여 SEM(scanning electron microscope)을 이용한 파면 관찰을 수행하였다. 피로수명의 통계적 특성은 P-S-N(probabilistic S-N) 곡선을 이용하여 평가되었으며 이에 대한 경도의 영향은 잔류치 해석(residue analysis)을 통하여 수행하였다.

• 정보저장시스템학회논문집
• /
• 제5권2호
• /
• pp.96-101
• /
• 2009

In recent years, the demand for portable digital devices such as cellular phone, digital camera, and MP3 player has been largely increased. To meet the requirements of such portable applications the information storage devices with smaller size, higher capacity, and lower power consumption are needed. A small form factor (SFF) HDD using a load/unload (L/UL) system is one of the appropriate alternatives to satisfy these requirements. Due to complexity of L/UL process and mechanism, it is required to investigate for better understanding the effects of design parameters. Among the various design parameters, flexible cable and friction force on the L/UL ramp become important to the dynamic characteristics of L/UL process as the system is miniaturized. The program for L/UL simulation which considers the effect of flexible cable and L/UL ramp is needed. Unfortunately, there is hardly any commercial program for the L/UL simulation except the Computer Mechanics Laboratory (CML) air bearing design program and the CML L/UL simulation code. Furthermore, the design parameters such as flexible cable and the L/UL ramp are not considered in the CML L/UL simulation code. So we embody the L/UL simulation considering flexible cable and an L/UL ramp by using the ANSYS/LS-DYNA. In this thesis, the effects of flexible cable and friction force on the dynamic characteristics and the performances of the L/UL process are studied. Numerical simulation and related experiments are carried out and compared each other.

• Geomechanics and Engineering
• /
• 제20권2호
• /
• pp.87-101
• /
• 2020

The construction of combined pile-raft foundations is considered as the main option in designing foundations in high-rise buildings, especially in soils close to the ground surface which do not have sufficient bearing capacity to withstand building loads. This paper deals with the geotechnical report of the Northern Fereshteh area of Tabriz, Iran, and compares the characteristics of the single pile foundation with the two foundations of pile group and geogrid. Besides, we investigate the effects of five principal parameters including pile diameter and length, the number of geogrid layers, the depth of groundwater level, and pore water pressure on vertical consolidation settlement and pore water pressure changes over a year. This study assessed the mechanism of the failure of the soil under the foundation using numerical analysis as well. Numerical analysis was performed using the two-dimensional finite element PLAXIS software. The results of fifty-four models indicate that the diameter of the pile tip, either as a pile group or as a single pile, did not have a significant effect on the reduction of the consolidation settlement in the soil in the Northern Fereshteh Street region. The optimum length for the pile in the Northern Fereshteh area is 12 meters, which is economically feasible. In addition, the construction of four-layered ten-meter-long geogrids at intervals of 1 meter beneath the deep foundation had a significant preventive impact on the consolidation settlement in clayey soils.

• 한국해안·해양공학회논문집
• /
• 제28권4호
• /
• pp.202-211
• /
• 2016

본 연구는 해상풍력지지구조물로 적용되는 석션기초의 지진하중에 대한 동적거동 분석을 목적으로 하였다. 이를 위하여 동적원심모형실험을 수행하였다. 석션기초의 스커트길이는 외력에 대한 지지거동에 중요한 역할을 한다. 스커트길이/석션기초외경 비가 0.5, 0.75, 1의 3가지 석션기초 모형이 조밀한 모래지반에 설치된 경우에 대하여 동적원심모형실험 결과를 제시하였다. 실험결과로 스커트길이에 따른 석션기초에서의 가속도증폭특성, 잔류침하량, 잔류회전각을 비교하였다.

• 한국구조물진단유지관리공학회 논문집
• /
• 제10권6호
• /
• pp.197-204
• /
• 2006

최근 시공의 합리화와 경제성의 목적으로 한 다양한 연구가 진행되고 있다. 철근 콘크리트 기둥과 철골 보로 이루어진 RCS 구조의 개발에 대한 연구 역시 활발해지고 있다. RCS 구조 보-기둥 접합부 패널존의 저항기구는 내부패널에서 외부패널로 응력이 전달될 때 직교보의 영향을 받지만, 기존연구에는 직교보의 영향을 고려하지 않고 있다. 본 연구에서는 웨브, 플랜지, 직교보의 두께, FBP의 유뮤등 다양한 변수들을 가지는 5개의 철근콘크리트 기둥과 철골보로 이루어진 보-기둥 내부접합부 실험체의 실험을 통해 직교보들의 영향과 구조적 성능을 조사하고자 한다. 이러한 실험결과들로부터, 보-기둥 접합부의 직교보가 전단내력과 구조성능을 향상시키는데 효과적이라는 것을 알 수 있다.

• Metals and materials international
• /
• 제24권6호
• /
• pp.1376-1385
• /
• 2018

Ultrasonic melt treatment (UST) was applied to an A390 hypereutectic Al-Si alloy in a temperature range of $750-800^{\circ}C$ and its influence on the solidification structure and the consequent increase in strength was investigated. UST at such a high temperature, which is about $100^{\circ}C$ above the liquidus temperature, had little effect on the grain refinement but enhanced the homogeneity of the microstructure with the uniform distribution of constituent phases (e.g. primary Si, ${\alpha}-Al$ and intermetallics) significantly refined. With the microstructural homogeneity, quantitative analysis confirmed that UST was found to suppress the formation of Cu-bearing phases, i.e., $Q-Al_5Cu_2Mg_8Si_6$, $Al_2Cu$ phases that form in the final stage of solidification while notably increasing the average Cu contents in the matrix from 1.29 to 2.06 wt%. A tensile test exhibits an increase in the yield strength of the as-cast alloy from 185 to 208 MPa, which is mainly associated with the solute increment within the matrix. The important role of UST in the microstructure evolution during solidification is discussed and the mechanism covering the microstructure-strengthening interrelationship of the ultrasonically treated A390 alloy is proposed.

• Biomolecules & Therapeutics
• /
• 제27권1호
• /
• pp.63-70
• /
• 2019

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Our studies demonstrate that PD-1 expression is markedly increased in tumor-infiltrating MDSCs compared to expression in bone marrow and spleens and that it can be induced by LPS that is able to mediate $NF-{\kappa}B$ signaling. Moreover, expression of PD-L1 and CD80 on $PD-1^+$ MDSCs was higher than on $PD-1^-$ MDSCs and proliferation of MDSCs in a tumor microenvironment was more strongly induced in $PD-1^+$ MDSCs than in $PD-1^-$ MDSCs. Although we could not characterize the inducer of PD-1 expression derived from cancer cells, our findings indicate that the study on the mechanism of PD-1 induction in MDSCs is important and necessary for the control of MDSC activity; our results suggest that $PD-1^+$ MDSCs in a tumor microenvironment may induce tumor development and relapse through the modulation of their proliferation and suppressive molecules.

• BMB Reports
• /
• 제54권9호
• /
• pp.470-475
• /
• 2021

Low-dose metronomic chemotherapy has been introduced as a less toxic and effective strategy to inhibit tumor angiogenesis, but its anti-angiogenic mechanism on endothelial progenitor cells (EPCs) has not been fully elucidated. Here, we investigated the functional role of regulated in development and DNA damage response 1 (REDD1), an endogenous inhibitor of mTORC1, in low-dose doxorubicin (DOX)-mediated dysregulation of EPC functions. DOX treatment induced REDD1 expression in bone marrow mononuclear cells (BMMNCs) and subsequently reduced mTORC1-dependent translation of endothelial growth factor (VEGF) receptor (Vegfr)-2 mRNA, but not that of the mRNA transcripts for Vegfr-1, epidermal growth factor receptor, and insulin-like growth factor-1 receptor. This selective event was a risk factor for the inhibition of BMMNC differentiation into EPCs and their angiogenic responses to VEGF-A, but was not observed in Redd1-deficient BMMNCs. Low-dose metronomic DOX treatment reduced the mobilization of circulating EPCs in B16 melanoma-bearing wild-type but not Redd1-deficient mice. However, REDD1 overexpression inhibited the differentiation and mobilization of EPCs in both wild-type and Redd1-deficient mice. These data suggest that REDD1 is crucial for metronomic DOX-mediated EPC dysfunction through the translational repression of Vegfr-2 transcript, providing REDD1 as a potential therapeutic target for the inhibition of tumor angiogenesis and tumor progression.

• Computers and Concrete
• /
• 제26권6호
• /
• pp.547-563
• /
• 2020

In this paper, the influence of axial compression ratio on the mechanical properties of new type joints of side span of rectangular concrete-filled steel tubular column-H-type steel beam is studied. Two new types of side-span joints of rectangular concrete-filled steel tubular column-H-type steel beam are designed and quasi-static tests of five new type joints with 1:2 scale reduction ratios are performed. The axial compression ratio of joint JD1 is 0.3, 0.4 and 0.5, and the axial compression ratio of joint JD2 is 0.3 and 0.5. In the joint test, different axial forces were applied to the top of the column according to different axial compression ratios, and low-cyclic reciprocating load was applied on the beam. The stress and strain distribution, beam and column deformation, limit state, failure process, failure mechanism, stiffness degradation, ductile deformation and energy dissipation capacity of the joint were measured and analyzed. The results show that: with the increase of axial compression ratio, the ultimate bearing capacity of the joint decreases slightly, the plastic deformation decreases, and the stiffness and ductility decrease. According to the energy dissipation curve of the specimen, the equivalent damping coefficient also increases with the increase of axial compression ratio in a certain range, indicating that the increase of axial compression ratio can improve the seismic performance of the joint to a certain extent. The finite element method is used to simulate the joint test, and the test results are in good agreement with the simulation results.

• 한국전산구조공학회논문집
• /
• 제35권3호
• /
• pp.149-158
• /
• 2022

교량은 사용년한이 증가함에 따라 노후화로 인해 역학적인 성질과 구조적인 성능이 저하되고, 이로 인해서 강진 시에 내진성능이 저하된다. 교각과 교량받침에 대한 노후화를 몇 가지 단계로 정량화하여 해석모델에 반영하였고, 노후화된 교각과 교량받침에 대하여 부재-수준의 지진취약도를 평가하였다. 교량 시스템의 파괴 메카니즘을 직렬시스템으로 가정하여, 부재-수준의 지진취약도 해석 결과로부터 시스템-수준의 지진취약도를 평가하는 방법을 제안하였다. 노후도에 취약한 부재인 교각과 교량받침에 대하여 5가지 정량적인 노후도(0, 5, 10, 25, 40%)를 가정하여 부재-수준의 지진취약도를 평가하였고, 이 결과로부터 시스템-수준의 지진취약도 평가를 수행하였다. 시스템-수준의 지진취약도는 교량받침 보다는 교각이 지배적인 영향을 줌을 알 수 있었다. 이는 보다 취약한 구조부재의 지진취약도가 전체 교량시스템의 지진취약도에 지배적인 영향을 주는 것을 의미한다.