• Title/Summary/Keyword: baseline model

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Effects of photobiomodulation on different application points and different phases of complex regional pain syndrome type I in the experimental model

  • Canever, Jaquelini Betta;Barbosa, Rafael Inacio;Hendler, Ketlyn Germann;Neves, Lais Mara Siqueira das;Kuriki, Heloyse Uliam;Aguiar, Aderbal Silva Junior;Fonseca, Marisa de Cassia Registro;Marcolino, Alexandre Marcio
    • The Korean Journal of Pain
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    • v.34 no.3
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    • pp.250-261
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    • 2021
  • Background: Complex regional pain syndrome type I (CRPS-I) consists of disorders caused by spontaneous pain or induced by some stimulus. The objective was to verify the effects of photobiomodulation (PBM) using 830 nm wavelength light at the affected paw and involved spinal cord segments during the warm or acute phase. Methods: Fifty-six mice were randomized into seven groups. Group (G) 1 was the placebo group; G2 and G3 were treated with PBM on the paw in the warm and acute phase, respectively; G4 and G5 treated with PBM on involved spinal cord segments in the warm and acute phase, respectively; G6 and G7 treated with PBM on paw and involved spinal cord segments in the warm and acute phase, respectively. Edema degree, thermal and mechanical hyperalgesia, skin temperature, and functional quality of gait (Sciatic Static Index [SSI] and Sciatic Functional Index [SFI]) were evaluated. Results: Edema was lower in G3 and G7, and these were the only groups to return to baseline values at the end of treatment. For thermal hyperalgesia only G3 and G5 returned to baseline values. Regarding mechanical hyperalgesia, the groups did not show significant differences. Thermography showed increased temperature in all groups on the seventh day. In SSI and SFI assessment, G3 and G7 showed lower values when compared to G1, respectively. Conclusions: PBM irradiation in the acute phase and in the affected paw showed better results in reducing edema, thermal and mechanical hyperalgesia, and in improving gait quality, demonstrating efficacy in treatment of CRPS-I symptoms.

Characteristics of Measurement Errors due to Reflective Sheet Targets - Surveying for Sejong VLBI IVP Estimation (반사 타겟의 관측 오차 특성 분석 - 세종 VLBI IVP 결합 측량)

  • Hong, Chang-Ki;Bae, Tae-Suk
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.40 no.4
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    • pp.325-332
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    • 2022
  • Determination of VLBI IVP (Very Long Baseline Interferometry Invariant Point) position with high accuracy is required to compute local tie vectors between the space geodetic techniques. In general, reflective targets are attached on VLBI antenna and slant distances, horizontal and vertical angles are measured from the pillars. Then, adjustment computation is performed by using the mathematical model which connects measurements and unknown parameters. This indicates that the accuracy of the estimated solutions is affected by the accuracy of the measurements. One of issues in local tie surveying, however, is that the reflective targets are not in favorable condition, that is, the reflective sheet target cannot be perfectly aligned to the instrument perpendicularly. Deviation from the line of sight of an instrument may cause different type of measurement errors. This inherent limitation may lead to incorrect stochastic modeling for the measurements in adjustment computation procedures. In this study, error characteristics by measurement types and pillars are analyzed, respectively. The analysis on the studentized residuals is performed after adjustment computation. The normality of the residuals is tested and then equal variance test between the measurement types are performed. The results show that there are differences in variance according to the measurement types. Differences in variance between distances and angle measurements are observed when F-test is performed for the measurements from each pillar. Therefore, more detailed stochastic modeling is required for optimal solutions, especially in local tie survey.

CT Quantitative Analysis and Its Relationship with Clinical Features for Assessing the Severity of Patients with COVID-19

  • Dong Sun;Xiang Li;Dajing Guo;Lan Wu;Ting Chen;Zheng Fang;Linli Chen;Wenbing Zeng;Ran Yang
    • Korean Journal of Radiology
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    • v.21 no.7
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    • pp.859-868
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    • 2020
  • Objective: To investigate the value of initial CT quantitative analysis of ground-glass opacity (GGO), consolidation, and total lesion volume and its relationship with clinical features for assessing the severity of coronavirus disease 2019 (COVID-19). Materials and Methods: A total of 84 patients with COVID-19 were retrospectively reviewed from January 23, 2020 to February 19, 2020. Patients were divided into two groups: severe group (n = 23) and non-severe group (n = 61). Clinical symptoms, laboratory data, and CT findings on admission were analyzed. CT quantitative parameters, including GGO, consolidation, total lesion score, percentage GGO, and percentage consolidation (both relative to total lesion volume) were calculated. Relationships between the CT findings and laboratory data were estimated. Finally, a discrimination model was established to assess the severity of COVID-19. Results: Patients in the severe group had higher baseline neutrophil percentage, increased high-sensitivity C-reactive protein (hs-CRP) and procalcitonin levels, and lower baseline lymphocyte count and lymphocyte percentage (p < 0.001). The severe group also had higher GGO score (p < 0.001), consolidation score (p < 0.001), total lesion score (p < 0.001), and percentage consolidation (p = 0.002), but had a lower percentage GGO (p = 0.008). These CT quantitative parameters were significantly correlated with laboratory inflammatory marker levels, including neutrophil percentage, lymphocyte count, lymphocyte percentage, hs-CRP level, and procalcitonin level (p < 0.05). The total lesion score demonstrated the best performance when the data cut-off was 8.2%. Furthermore, the area under the curve, sensitivity, and specificity were 93.8% (confidence interval [CI]: 86.8-100%), 91.3% (CI: 69.6-100%), and 91.8% (CI: 23.0-98.4%), respectively. Conclusion: CT quantitative parameters showed strong correlations with laboratory inflammatory markers, suggesting that CT quantitative analysis might be an effective and important method for assessing the severity of COVID-19, and may provide additional guidance for planning clinical treatment strategies.

Assessing Future Climate Change Impact on Hydrologic Components of Gyeongancheon Watershed (기후변화가 경안천 유역의 수문요소에 미치는 영향 평가)

  • Ahn, So-Ra;Park, Min-Ji;Park, Geun-Ae;Kim, Seong-Joon
    • Journal of Korea Water Resources Association
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    • v.42 no.1
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    • pp.33-50
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    • 2009
  • The impact on hydrologic components considering future potential climate, land use change and vegetation cover information was assessed using SLURP (Semi-distributed Land-Use Runoff Process) continuous hydrologic model. The model was calibrated (1999 - 2000) and validated (2001 - 2002) for the upstream watershed ($260.4\;km^2$) of Gyeongancheon water level gauging station with the coefficient of determination and Nash-Sutcliffe efficiency ranging from 0.77 to 0.60 and 0.79 to 0.60, respectively. Two GCMs (MIROC3.2hires, ECHAM5-OM) future weather data of high (A2), middle (A1B) and low (B1) emission scenarios of the IPCC (Intergovernmental Panel on Climate Change) were adopted and the data was corrected by 20C3M (20th Century Climate Coupled Model) and downscaled by Change Factor (CF) method using 30 years (1977 - 2006, baseline period) weather data. Three periods data of 2010 - 2039 (2020s), 2040 - 2069 (2050s), 2070 - 2099 (2080s) were prepared. To reduce the uncertainty of land surface conditions, future land use and vegetation canopy prediction were tried by CA-Markov technique and NOAA NDVI-Temperature relationship respectively. MIROC3.2 hires and ECHAM5-OM showed increase tendency in annual streamflow up to 21.4 % for 2080 A1B and 8.9 % for 2050 A1B scenario respectively. The portion of future predicted ET about precipitation increased up to 3 % in MIROC3.2 hires and 16 % in ECHAM5-OM respectively. The future soil moisture content slightly increased compared to 2002 soil moisture.

Analgesic Effect of Grape Seed Proanthocyanidin Extract in Fibromyalgia Animal Model (섬유근통 동물 모델에서 포도씨 추출 proanthocyanidin의 진통 효과)

  • Mun, Hyun-Il;Kim, Seong-Ho;Jang, Tae-Jung;Moon, Il-Soo
    • Journal of Life Science
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    • v.20 no.4
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    • pp.496-502
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    • 2010
  • The acidic saline animal model of pain has been suggested to mimic fibromyalgia (FM). Oligomeric proanthocyanidin complexes (OPC) from grape seeds are known to act as an antioxidant. We studied the effects of OPC on the pain threshold in the acidic saline animal model of pain. The left gastrocnemius muscle was injected with $100\;{\mu}l$ of saline at pH 4.0 under brief isoflurane anesthesia on days 0 and 5. Control rats (n=5) received identical injections of physiological saline (pH 7.2) on the same schedule. Rats (n=10) with acidic saline injection were separated into two study subgroups. After measurement of pre-drug pain thresholds, rats were injected intraperitoneally with either saline or OPC 300 mg/kg. Paw withdrawal thresholds to pressure were again measured 60 min after intraperitoneal injection. Nociceptive thresholds were measured with a Dynamic Plantar Aesthesiometer by applying an increasing pressure to right or left hind paw until the rat withdrew the paw. Compared to baseline (day 0), acid injections produced mechanical hyper-responsiveness on day 7 (pre-drug) in these rats [p<0.05]. A potent antihyperalgesic effect was observed when rats were injected intraperitoneally with OPC 300 mg/kg [injected paw, p=0.001; contralateral paw, p=0.002]. OPC treatment decreased the expression of acid sensing ion channel 3 in the brain motor cortex area on immunohistochemical staining when OPC 300 mg/kg was administered intraperitoneally in the animal model of FM pain [p<0.05]. Further research is required to determine the efficacy of OPC treatments in FM pain in humans.

The Economic Impact of Government Purchases on the Price Volatility of Korean Dried Red Pepper (건고추 정부수매의 가격안정화효과에 대한 사후영향평가분석)

  • Park, Su-Yeon;Kim, In-Seck
    • The Journal of Industrial Distribution & Business
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    • v.9 no.10
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    • pp.73-82
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    • 2018
  • Purpose - Unstable vegetable prices have been one of the major concerns in Korean agricultural and food marketing system. The Korean government has implemented a number of policy instruments, including government purchasing programs in order to alleviate fluctuations in vegetable prices. The economic impact of policy instruments has been assessed based on the average monthly price change rate before and after the implementation of the policy. However, this approach failed to provide a net impact of policy measures on price stabilization in the vegetable markets, as policy impacts could not be successfully distinguished from other effects on price changes in the vegetable market. The purpose of this study is to evaluate the net impact of the government purchasing program on the price volatility of dried red pepper which is considered one of the major vegetables in Korea. Research design, data, and methodology - This study develops a monthly dynamic partial equilibrium model of Korean dried red pepper market. Behavioral equations in the model were estimated by OLS and synthetic method based on the annual and monthly time series data from 1993 to 2015. The model is first simulated to yield actual dried red pepper market conditions in 2015 as a baseline and then compared it to the scenario assuming that there were no government purchases of dried red pepper in 2015. Results - According to the ex-post scenario analysis using the developed model, without the government procurements in 2015, the average monthly price change rate and the value of coefficient of variation of dried red pepper in 2015 would be respectably 7.9 percent and 0.10. It is relatively higher than the actual average monthly price change rate and the value of coefficient of variation of dried red pepper in 2015 which were respectively 1.7 percent and 0.06. Conclusions - The ex-post simulation results in this study shows that if there were no government purchases of dried red pepper in 2015, the dried red pepper market would have had much higher volatile price movements. The results of this study would provide useful information for future price stabilization policy of vegetable markets in Korea.

Hybrid Method using Frame Selection and Weighting Model Rank to improve Performance of Real-time Text-Independent Speaker Recognition System based on GMM (GMM 기반 실시간 문맥독립화자식별시스템의 성능향상을 위한 프레임선택 및 가중치를 이용한 Hybrid 방법)

  • 김민정;석수영;김광수;정호열;정현열
    • Journal of Korea Multimedia Society
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    • v.5 no.5
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    • pp.512-522
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    • 2002
  • In this paper, we propose a hybrid method which is mixed with frame selection and weighting model rank method, based on GMM(gaussian mixture model), for real-time text-independent speaker recognition system. In the system, maximum likelihood estimation was used for GMM parameter optimization, and maximum likelihood was used for recognition basically Proposed hybrid method has two steps. First, likelihood score was calculated with speaker models and test data at frame level, and the difference is calculated between the biggest likelihood value and second. And then, the frame is selected if the difference is bigger than threshold. The second, instead of calculated likelihood, weighting value is used for calculating total score at each selected frame. Cepstrum coefficient and regressive coefficient were used as feature parameters, and the database for test and training consists of several data which are collected at different time, and data for experience are selected randomly In experiments, we applied each method to baseline system, and tested. In speaker recognition experiments, proposed hybrid method has an average of 4% higher recognition accuracy than frame selection method and 1% higher than W method, implying the effectiveness of it.

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Climate Change-induced High Temperature Stress on Global Crop Production (기후변화로 인한 작물의 고온 스트레스 전망)

  • Lee, Kyoungmi;Kang, Hyun-Suk;Cho, ChunHo
    • Journal of the Korean Geographical Society
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    • v.51 no.5
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    • pp.633-649
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    • 2016
  • Exposure to high temperatures during the reproductive period of crops decreases their productivity. The Intergovernmental Panel on Climate Change's (IPCC) fifth Assessment Report predicts that the frequency of high temperatures will continue to increase in the future, resulting in significant impacts on the world's food supply. This study evaluate climate change-induced heat stress on four major agricultural crops (rice, maize, soybean, and wheat) at a global level, using the coupled atmosphere-ocean model of Hadley Centre Global Environmental Model version 2 (HadGEM2-AO) and FAO/IIASA Global Agro-Ecological Zone (GAEZ) model data. The maximum temperature rise ($1.8-3.5^{\circ}C$) during the thermal-sensitive period (TSP) from the baseline (1961-1990) to the future (2070-2090) is expected to be larger under a Representative Concentration Pathway (RCP) 8.5 climate scenario than under a RCP2.6 climate scenario, with substantial heat stress-related damage to productivity. In particular, heat stress is expected to cause severe damage to crop production regions located between 30 and $50^{\circ}N$ in the Northern Hemisphere. According to the RCP8.5 scenario, approximately 20% of the total cultivation area for all crops will experience unprecedented, extreme heat stress in the future. Adverse effects on the productivity of rice and soybean are expected to be particularly severe in North America. In Korea, grain demands are heavily dependent on imports, with the share of imports from the U.S. at a particularly high level today. Hence, it is necessary to conduct continuous prediction on food security level following the climate change, as well as to develop adaptation strategy and proper agricultural policy.

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Grip Strength as a Predictor of Cerebrovascular Disease (뇌혈관질환의 예측인자로서의 악력)

  • Jung, Seok-Hwan;Kim, Jae-Hyun
    • Health Policy and Management
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    • v.29 no.3
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    • pp.303-311
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    • 2019
  • Background: Cerebrovascular disease is included in four major diseases and is a disease that has high rates of prevalence and mortality around the world. Moreover, it is a disease that requires a high cost for long-term hospitalization and treatment. This study aims to figure out the correlation between grip strength, which was presented as a simple, cost-effective, and relevant predictor of cerebrovascular disease, and cerebrovascular disease based on the results of a prior study. And furthermore, our study compared model suitability of the model to measuring grip strength and relative grip strength as a predictor of cerebrovascular disease to improve the quality of cerebrovascular disease's predictor. Methods: This study conducted an analysis based on the generalized linear mixed model using the data from the Korea Longitudinal Study of Ageing from 2006 to 2016. The research subjects consisted of 9,132 middle old age people aged 45 years or older at baseline with no missing information of education level, gender, marital status, residential region, type of national health insurance, self-related health, smoking status, alcohol use, and economic activity. The grip strength was calculated the average which measured 4 times (both hands twice), and the relative grip force was divided by the body mass index as a variable considering the anthropometric figure that affects the cerebrovascular disease and the grip strength. Cerebrovascular diseases, a dependent variable, were investigated based on experiences diagnosed by doctors. Results: An analysis of the association between grip strength and found that about 0.972 (odds ratio [OR], 0.972; 95% confidence interval [CI], 0.963-0.981) was the incidence of cerebral vascular disease as grip strength increased by one unit increase and the association between relative grip strength and cerebrovascular disease found that about 0.418 (OR, 0.418; 95% CI, 0.342-0.511) was the incidence of cerebral vascular disease as relative grip strength increased by unit. In addition, the model suitability of the model for each grip strength and relative grip strength was 11,193 and 11,156, which means relative grip strength is the better application to the predictor of cerebrovascular diseases, irrespective of other variables. Conclusion: The results of this study need to be carefully examined and validated in applying relative grip strength to improve the quality of predictors of cerebrovascular diseases affecting high mortality and prevalence.

The MeSH-Term Query Expansion Models using LDA Topic Models in Health Information Retrieval (MeSH 기반의 LDA 토픽 모델을 이용한 검색어 확장)

  • You, Sukjin
    • Journal of Korean Library and Information Science Society
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    • v.52 no.1
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    • pp.79-108
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    • 2021
  • Information retrieval in the health field has several challenges. Health information terminology is difficult for consumers (laypeople) to understand. Formulating a query with professional terms is not easy for consumers because health-related terms are more familiar to health professionals. If health terms related to a query are automatically added, it would help consumers to find relevant information. The proposed query expansion (QE) models show how to expand a query using MeSH terms. The documents were represented by MeSH terms (i.e. Bag-of-MeSH), found in the full-text articles. And then the MeSH terms were used to generate LDA (Latent Dirichlet Analysis) topic models. A query and the top k retrieved documents were used to find MeSH terms as topic words related to the query. LDA topic words were filtered by threshold values of topic probability (TP) and word probability (WP). Threshold values were effective in an LDA model with a specific number of topics to increase IR performance in terms of infAP (inferred Average Precision) and infNDCG (inferred Normalized Discounted Cumulative Gain), which are common IR metrics for large data collections with incomplete judgments. The top k words were chosen by the word score based on (TP *WP) and retrieved document ranking in an LDA model with specific thresholds. The QE model with specific thresholds for TP and WP showed improved mean infAP and infNDCG scores in an LDA model, comparing with the baseline result.