• Title/Summary/Keyword: baseline model

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Kinetics of HMGB1 level changes in a canine endotoxemia model

  • Yu, Do-Hyeon;Park, Jinho
    • Korean Journal of Veterinary Research
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    • v.51 no.3
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    • pp.239-241
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    • 2011
  • In this study, we investigated the kinetics of tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-6 and high mobility group box 1 (HMGB1) concentrations in a 48-h model of canine endotoxemia by lipopolysaccharide (LPS) injection. Four healthy beagles were slowly administered 1 mg/kg of LPS diluted in normal saline, while two others were administered normal saline as controls. Blood collection was performed at 0 h (baseline), 1 h and 3 h (for TNF-${\alpha}$), 6 h, 12 h, 24 h and 48 h of the experiment, and cytokine levels were determined using the sandwich ELISA method. Early increments of TNF-${\alpha}$ and IL-6 were observed (< 3 h), but HMGB1 levels increased the most at 12 h of the experiment and gradually decreased until 48 h. During the whole experiment, IL-6 and HMGB1 were sustained over 12 h of LPS injection, whereas TNF-${\alpha}$ decreased within 6 h of LPS injection. Taken together, canine HMGB1 levels increase relatively late (< 12 h) and sustained longer than TNF-${\alpha}$ and IL-6 in response to endotoxin. This is the first study to evaluate canine HMGB1 cytokine from endotoxemia in dogs.

Effects of Sex Education on Condom Attitudes and Condom Use Intention among Undergraduate Students - Dramaturgical interaction approach - (연극학적 상호작용 모델에 근거한 성교육이 남녀 대학생의 콘돔에 대한 태도와 콘돔사용의향에 미치는 효과)

  • Cho, Eun-Jung
    • Research in Community and Public Health Nursing
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    • v.17 no.2
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    • pp.223-234
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    • 2006
  • Purpose: This study was conducted to identify the effects of sexual health education guided by dramaturgical interaction on condom attitudes and intention to use a condom among undergraduate students. Method: Seventy-one female and 23 male volunteers at a university in D metropolitan city participated in the study with an one group pretest-posttest design. The intervention was implemented for five weeks in October 2003 with a short course including group works to encourage university students' social skills In condom use negotiations and condom purchase by using a dramaturgical interaction model. A confidential questionnaire was administered at baseline and post-intervention, and changes in condom attitudes and intention to use a condom were measured. Result: The self-report of female subjects showed significant positive changes in two out of the five condom attitudes domains, such assailability and effectiveness(p<.001) embarrassment about negotiation and use(p<.05), while male subjects showed no change in each of the condom attitudes domains. No significant difference was found in intention to use a condom after the intervention. Conclusion: Sexual health education planned to encourage social skills in condom use by using the dramaturgical interaction model was found to have positive effects on female university students' condom attitudes. A more rigorously designed trial is needed to develop a comprehensive sexual health promotion programme that targets both cognitive and behavioral changes among sexually active Young adults within community.

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Dynamic Response Analysis of Caisson Structure by Acceleration Measurement (가속도 계측을 통한 항만시설용 케이슨 구조체의 동적응답 분석)

  • Lee, So-Young;Kim, Jeong-Tae;Kim, Heon-Tae;Park, Woo-Sun
    • Journal of Ocean Engineering and Technology
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    • v.23 no.1
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    • pp.114-121
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    • 2009
  • In this study, acceleration responses of caisson structures under various environmental conditions are experimentally examined as a basic study to develop the health assessment technique for harbor structures. To achieve the objective, three approaches are implemented. Firstly, a target caisson structure is selected and its small-scaled caisson is constructed in the laboratory. Secondly, a finite element model of the caisson is generated to identify dynamic responses of the baseline structure. Thirdly, experimental tests are performed on the caisson model to examine dynamic responses under various boundary conditions and impact locations. Four different boundary conditions, 'standing on concrete floor', 'standing on styrofoam block', 'standing on sand-mat' and 'hanging by crane', are considered and correlation coefficients of frequency response functions between four states are analyzed.

Design of Guidance and Control Algorithm for Autolanding In Windshear Environment Using Fuzzy Gain Scheduling (퍼지 게인스케듈링을 적용한 자동착륙 유도제어 알고리즘 설계 : 윈쉬어 환경에서의 착륙)

  • Ha, Cheol-Keun;Ahn, Sang-Woon
    • Journal of Institute of Control, Robotics and Systems
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    • v.14 no.1
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    • pp.95-103
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    • 2008
  • This paper deals with the problem of autolanding for aircraft under windshear environment for which the landing trajectory is given. It is well known that the landing maneuver in windshear turbulence is very dangerous and hard for the pilot to control because windshear is unpredictable in when and where it happens and its aerodynamic characteristics are complicated. In order to accomplish satisfactory autolanding maneuver in this environment, we propose a gain-scheduled controller. The proposed controller consists of three parts: PID controller, called baseline controller, which is designed to satisfy requirements of stability and performance without considering windshear, gain scheduler based on fuzzy logic, and safety decision logic, which decides if the current autolanding maneuver needs to be aborted or not. The controller is applied to a 6-DOF simulation model of the associated airplane in order to illustrate the effectiveness of the proposed control algorithm. It is noted that a cross wind in the lateral direction is included to the simulation model. From the simulation results it is observed that the proposed gain scheduled controller shows superior performance than the case of controller without gain scheduling even in severe downburst and tailwind region of windshear. In addition, touchdown along centerline of the runway is more precise for the proposed controller than for the controller without gain scheduling in the cross wind and the tailwind.

Structural Dynamics Analyses of a 5MW Floating Offshore Wind-Turbine Using Equivalent Modeling Technique (등가모델링기법을 이용한 5MW급 부유식 해상용 풍력발전기 구조동역학해석)

  • Kim, Myung-Hwan;Kim, Dong-Hyun;Kim, Dong-Hwan;Kim, Bong-Yung
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2011.10a
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    • pp.614-622
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    • 2011
  • In this study, the computational structural dynamic modeling of floating offshore wind turbine system is presented using efficient equivalent modeling technique. Structural dynamic behaviors of the offshore floating platform with 5MW wind turbine system have been analyzed using computational multi-body dynamics based on the finite element method. The considered platform configuration of the present offshore wind turbine model is the typical spar-buoy type. Equivalent stiffness and damping properties of the floating platform were extracted from the results of the baseline model. Dynamic responses for the floating wind turbine models are presented and compared to investigate its structural dynamic characteristics. It is important shown that the results of the present equivalent modeling technique show good and reasonable agreements with those by the fully coupled analysis considering complex floating body dynamics.

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DIFFERENTIATION OF BASIC EMOTIONS BY EEG AND AUTONOMIC RESPONSES (뇌파 및 자율신경계 반응특성에 의한 기본정서의 구분)

  • 이경화;이임갑;손진훈
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 1999.03a
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    • pp.11-15
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    • 1999
  • The discrete state theory on emotion postulated that there existed discrete emotions, such as happiness, anger, fear, disgust, and so forth. Many investigators who emphasized discreteness of emotions have suggested that discrete emotions entailed their specific activities in the autonomic nervous system. The purposes of this study were to develop a model of emotion-specific physiological response patterns. The study postulated six emotions (i.e., happiness, sadness, anger, disgust, fear, and surprise) as the basic discrete emotions. Thirty eight college students participated in the present study. Twelve slides (2 for each emotion category) were presented to the subjects in random order. During resting period of 30 s prior to the presentation of each slide, four presentation of each slide, four physiological measures (EEG, ECG, EDA, and respiration) were recorded to establish a baseline. The same physiological measures were recorded while each slide was being presented for 60 s (producing an emotional sate). Then, the subjects were asked to rate the degree of emotion induced by the slide on semantic differential scales. This procedure was repeated for every slide. Based upon the results, a model of emotion-specific physiological response patterns was developed: four emotion (fear, disgust, sadness, and anger) were classified according to the characteristics of EEG and autonomic responses. However, emotions of happiness and surprise were not distinguished by any combination of the physiological measures employed in this study, suggesting another appropriate measure should be adopted for differentiation.

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차세대 고속전철 시스템 시험검증 체계 구축 및 적용

  • Choe Jong Min;Yu Il Sang;Kim Yeon Tae;Park Yeong Won
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • 2002.05a
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    • pp.1079-1084
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    • 2002
  • Systems engineering technology development program for Korea next-generation high-speed railway(KNHR) system in progress is a national large-scale system development program that is not only a large-size and complex but also multi-disciplinary in nature. Using the RDD-IOO, a systems engineering tool, the KNHR program can establish requirements traceability and development process management in the course of development. This paper presents the results from a computer-aided systems engineering application to KNHR system technology development project over the three years of activities. The traceability among the system design database in the vertical direction of SE process, as the results of the first year and the second year research was accomplished. The database in both the requirement management domain and the project management domain was developed and set up the traceability between them in the horizontal direction of the SE process in the V model as the results of the third year research. Therefore, KNHR design database was built to support the life-cycle management of the system as well as to reuse the knowledge in future programs. In the following development phase, this database will be utilized to accomplish the test and integration activities providing a baseline database. The outcome of the study contributes to the establishment of the model-based systems engineering approach as a best practice in the accumulation and advancement of systems engineering technology for railway system development.

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Using Light Travel Time Effect to Detect Circumbinary Planets with Ground-Based Telescopes

  • Hinse, Tobias Cornelius
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.2
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    • pp.109.1-109.1
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    • 2012
  • In the past few years, two-planet circumbinary systems (e.g., HW Vir, NN Ser, DP Leo and HU Aqr) have been detected around short-period eclipsing binaries using ground-based telescopes. The existence of these planets has been inferred by interpreting the O-C variations of the mid-eclipse times. We have tested the orbital stability of these systems and propose to use Light Travel Time Effect (LITE) to detect such circumbinary planets from the ground. We generated synthetically the LITE signal of a two-planet circumbinary system with the aim to apply an analytic LITE model to recover the underlying synthetic system. To mimic a degree of realism inherent to ground-based observations, we added to the synthetic LITE data white noise with a Gaussian distribution and sampled the synthetic LITE signal randomly. We successfully recovered the original system demonstrating that two-planet circumbinary systems can be detected using ground-based telescopes, provided the timing measurements of the mid-eclipses are sufficiently accurate and the observing baseline is long enough to ensure a sufficient coverage of all involved periods. We used HU Aqr as a test system and applied our model to its proposed planetary bodies considering near-circular orbits. We present the results of our calculations and discuss the LITE-detectability of a HU Aqr-like system.

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Active mass damper control for cable stayed bridge under construction: an experimental study

  • Chen, Hao;Sun, Zhi;Sun, Limin
    • Structural Engineering and Mechanics
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    • v.38 no.2
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    • pp.141-156
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    • 2011
  • A cable stayed bridge under construction has low structural damping and is not as stable as the completed bridge. Control countermeasures, such as the installation of energy dissipating devices, are thus required. In this study, the general procedure and key issues on adopting an active control device, the active mass damper (AMD), for vibration control of cable stayed bridges under construction were studied. Taking a typical cable stayed bridge as the prototype structure; a lab-scale test structure was designed and fabricated firstly. A baseline FEM model was then setup and updated according to the modal parameters measured from vibration test on the structure. A numerical study to simulate the bridge-AMD control system was conducted and an efficient LQG-based controller was designed. Based on that, an experimental implementation of AMD control of the transverse vibration of the bridge model was performed. The results from numerical simulation and experimental study verified that the AMD-based active control was feasible and efficient for reducing dynamic responses of a complex structural system. Moreover, the discussion made in this study clarified some critical problems which should be addressed for the practical implementation of AMD control on real cable-stayed bridges.

Numerical Analysis of the Ballistic Performance and Behavior of STF-Impregnated Multi-layer Fabrics (전단농화유체 함침 다층직물의 방탄성능 및 거동 수치해석)

  • Mun, Sang Ho;Son, Kwon Joong;Cho, Hee Keun;Park, Jong Kyoo;Jeong, Euigyung;Lee, Man Young;Kim, See Jo
    • Journal of the Korea Institute of Military Science and Technology
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    • v.19 no.3
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    • pp.330-338
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    • 2016
  • Impregnation of shear-thickening fluid(STF) into high-strength fabrics makes a considerable improvement on the ballistic performance of fabric armors. Understanding dissipation augmentation due to shear thickening effects on yarn-yarn and yarn-projectile friction is of great importance in liquid armor research. This paper takes a shearthickening effect into account in numerical simulations by using a velocity-dependent friction model. Impact simulations were performed to validate the friction model as well as to evaluate the ballistic performance of STF-fabrics. Impact simulations on neat fabrics were also conducted to provide baseline results for comparison.